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Entry version 154 (16 Oct 2019)
Sequence version 5 (16 Jan 2019)
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Protein

Scavenger receptor class F member 2

Gene

SCARF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable adhesion protein, which mediates homophilic and heterophilic interactions. In contrast to SCARF1, it poorly mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL) (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processCell adhesion

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Scavenger receptor class F member 2
Alternative name(s):
SRECRP-1
Scavenger receptor expressed by endothelial cells 2 protein
Short name:
SREC-II
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SCARF2
Synonyms:SREC2, SREPCR
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:19869 SCARF2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
613619 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96GP6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini44 – 441ExtracellularSequence analysisAdd BLAST398
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei442 – 462HelicalSequence analysisAdd BLAST21
Topological domaini463 – 871CytoplasmicSequence analysisAdd BLAST409

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Van den Ende-Gupta syndrome (VDEGS)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA syndrome characterized by craniofacial and skeletal abnormalities that include blepharophimosis, a flat and wide nasal bridge, narrow and beaked nose, hypoplastic maxilla with or without cleft palate and everted lower lip, prominent ears, down-slanting eyes, arachnodactyly, and camptodactyly. Patients present congenital joint contractures that improve without intervention, and normal growth and development. Intelligence is normal. Rarely, enlarged cerebella can be present. Some patients experience respiratory problems due to laryngeal abnormalities.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_065302258C → Y in VDEGS. 1 PublicationCorresponds to variant dbSNP:rs387907086EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
91179

MalaCards human disease database

More...
MalaCardsi
SCARF2
MIMi600920 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000244486

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
2460 Van den Ende-Gupta syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134908523

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96GP6

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SCARF2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
380865486

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 43Sequence analysisAdd BLAST43
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000773944 – 871Scavenger receptor class F member 2Add BLAST828

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi75 ↔ 86PROSITE-ProRule annotation
Disulfide bondi80 ↔ 98PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi83N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi100 ↔ 109PROSITE-ProRule annotation
Disulfide bondi126 ↔ 134PROSITE-ProRule annotation
Disulfide bondi128 ↔ 141PROSITE-ProRule annotation
Disulfide bondi143 ↔ 152PROSITE-ProRule annotation
Disulfide bondi156 ↔ 163PROSITE-ProRule annotation
Disulfide bondi158 ↔ 170PROSITE-ProRule annotation
Disulfide bondi172 ↔ 181PROSITE-ProRule annotation
Disulfide bondi185 ↔ 193PROSITE-ProRule annotation
Disulfide bondi187 ↔ 200PROSITE-ProRule annotation
Disulfide bondi202 ↔ 211PROSITE-ProRule annotation
Disulfide bondi215 ↔ 222PROSITE-ProRule annotation
Disulfide bondi217 ↔ 229PROSITE-ProRule annotation
Disulfide bondi231 ↔ 240PROSITE-ProRule annotation
Disulfide bondi244 ↔ 251PROSITE-ProRule annotation
Disulfide bondi246 ↔ 258PROSITE-ProRule annotation
Disulfide bondi260 ↔ 269PROSITE-ProRule annotation
Glycosylationi310N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi365N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi376 ↔ 384PROSITE-ProRule annotation
Disulfide bondi379 ↔ 391PROSITE-ProRule annotation
Disulfide bondi393 ↔ 402PROSITE-ProRule annotation
Glycosylationi403N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei551PhosphoserineBy similarity1
Modified residuei613PhosphoserineCombined sources1
Modified residuei628PhosphotyrosineBy similarity1
Modified residuei651PhosphoserineCombined sources1
Modified residuei653PhosphoserineCombined sources1
Modified residuei710PhosphoserineBy similarity1
Modified residuei718PhosphoserineCombined sources1
Modified residuei742PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96GP6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q96GP6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96GP6

PeptideAtlas

More...
PeptideAtlasi
Q96GP6

PRoteomics IDEntifications database

More...
PRIDEi
Q96GP6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
76651 [Q96GP6-1]
76652 [Q96GP6-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96GP6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96GP6

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q96GP6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Predominantly expressed in endothelial cells. Expressed in heart, placenta, lung, kidney, spleen, small intestine and ovary.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000244486 Expressed in 105 organ(s), highest expression level in tibial artery

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q96GP6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96GP6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA035079

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homophilic and heterophilic interaction via its extracellular domain.

Interacts with SCARF1. The heterophilic interaction with SCARF1, which is stronger than the homophilic interaction with itself, is suppressed by the presence of SCARF1 ligand such as Ac-LDL (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
NCK1P163332EBI-1752088,EBI-389883

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
124803, 7 interactors

Protein interaction database and analysis system

More...
IntActi
Q96GP6, 8 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000477564

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96GP6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini71 – 110EGF-like 1PROSITE-ProRule annotationAdd BLAST40
Domaini122 – 153EGF-like 2PROSITE-ProRule annotationAdd BLAST32
Domaini148 – 182EGF-like 3PROSITE-ProRule annotationAdd BLAST35
Domaini183 – 212EGF-like 4PROSITE-ProRule annotationAdd BLAST30
Domaini213 – 241EGF-like 5PROSITE-ProRule annotationAdd BLAST29
Domaini236 – 270EGF-like 6PROSITE-ProRule annotationAdd BLAST35
Domaini372 – 403EGF-like 7PROSITE-ProRule annotationAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi652 – 852Pro-richAdd BLAST201

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1218 Eukaryota
ENOG410XQWV LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183101

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000015093

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96GP6

Identification of Orthologs from Complete Genome Data

More...
OMAi
CERYCQC

Database of Orthologous Groups

More...
OrthoDBi
110992at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96GP6

TreeFam database of animal gene trees

More...
TreeFami
TF332598

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR009030 Growth_fac_rcpt_cys_sf
IPR002049 Laminin_EGF
IPR033327 Scarf2
IPR042635 SREC1/2

The PANTHER Classification System

More...
PANTHERi
PTHR24043 PTHR24043, 1 hit
PTHR24043:SF5 PTHR24043:SF5, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00181 EGF, 7 hits
SM00180 EGF_Lam, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57184 SSF57184, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00022 EGF_1, 7 hits
PS01186 EGF_2, 4 hits
PS50026 EGF_3, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q96GP6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEGAGPRGAG PARRRGAGGP PSPLLPSLLL LLLLWMLPDT VAPQELNPRG
60 70 80 90 100
RNVCRAPGSQ VPTCCAGWRQ QGDECGIAVC EGNSTCSENE VCVRPGECRC
110 120 130 140 150
RHGYFGANCD TKCPRQFWGP DCKELCSCHP HGQCEDVTGQ CTCHARRWGA
160 170 180 190 200
RCEHACQCQH GTCHPRSGAC RCEPGWWGAQ CASACYCSAT SRCDPQTGAC
210 220 230 240 250
LCHAGWWGRS CNNQCACNSS PCEQQSGRCQ CRERTFGARC DRYCQCFRGR
260 270 280 290 300
CHPVDGTCAC EPGYRGKYCR EPCPAGFYGL GCRRRCGQCK GQQPCTVAEG
310 320 330 340 350
RCLTCEPGWN GTKCDQPCAT GFYGEGCSHR CPPCRDGHAC NHVTGKCTRC
360 370 380 390 400
NAGWIGDRCE TKCSNGTYGE DCAFVCADCG SGHCDFQSGR CLCSPGVHGP
410 420 430 440 450
HCNVTCPPGL HGADCAQACS CHEDTCDPVT GACHLETNQR KGVMGAGALL
460 470 480 490 500
VLLVCLLLSL LGCCCACRGK DPTRRPRPRR ELSLGRKKAP HRLCGRFSRI
510 520 530 540 550
SMKLPRIPLR RQKLPKVVVA HHDLDNTLNC SFLEPPSGLE QPSPSWSSRA
560 570 580 590 600
SFSSFDTTDE GPVYCVPHEE APAESRDPEV PTVPAEAPAP SPVPLTTPAS
610 620 630 640 650
AEEAIPLPAS SDSERSASSV EGPGGALYAR VARREARPAR ARGEIGGLSL
660 670 680 690 700
SPSPERRKPP PPDPATKPKV SWIHGKHSAA AAGRAPSPPP PGSEAAPSPS
710 720 730 740 750
KRKRTPSDKS AHTVEHGSPR TRDPTPRPPG LPEEATALAA PSPPRARARG
760 770 780 790 800
RGPGLLEPTD AGGPPRSAPE AASMLAAELR GKTRSLGRAE VALGAQGPRE
810 820 830 840 850
KPAPPQKAKR SVPPASPARA PPATETPGPE KAATDLPAPE TPRKKTPIQK
860 870
PPRKKSREAA GELGRAGAPT L
Length:871
Mass (Da):92,384
Last modified:January 16, 2019 - v5
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE41852FABD1E47AD
GO
Isoform 2 (identifier: Q96GP6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     474-478: Missing.

Show »
Length:866
Mass (Da):91,721
Checksum:iB677511EFC9CDF87
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAN45861 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti629 – 641ARVAR…RPARA → PTTTWITHSTAAS in AAH00584 (PubMed:15489334).CuratedAdd BLAST13

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059274174P → S1 PublicationCorresponds to variant dbSNP:rs361566Ensembl.1
Natural variantiVAR_065302258C → Y in VDEGS. 1 PublicationCorresponds to variant dbSNP:rs387907086EnsemblClinVar.1
Natural variantiVAR_055776425T → S. Corresponds to variant dbSNP:rs2241230Ensembl.1
Natural variantiVAR_035837499R → C in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_055777522H → L. Corresponds to variant dbSNP:rs12484828Ensembl.1
Natural variantiVAR_015148778E → D1 PublicationCorresponds to variant dbSNP:rs759611Ensembl.1
Natural variantiVAR_015149779L → V1 PublicationCorresponds to variant dbSNP:rs759612Ensembl.1
Natural variantiVAR_015150820A → G. Corresponds to variant dbSNP:rs874100EnsemblClinVar.1
Natural variantiVAR_015151838A → G. Corresponds to variant dbSNP:rs874101EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_042462474 – 478Missing in isoform 2. 3 Publications5

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB052951 mRNA Translation: BAC53753.1
AF522196 mRNA Translation: AAN45861.1 Frameshift.
AB024433 mRNA Translation: BAD93345.1
AC007731 Genomic DNA No translation available.
CH471176 Genomic DNA Translation: EAX02965.1
BC000584 mRNA Translation: AAH00584.2
BC009326 mRNA Translation: AAH09326.2

The Consensus CDS (CCDS) project

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CCDSi
CCDS13779.2 [Q96GP6-1]
CCDS46666.1 [Q96GP6-2]

NCBI Reference Sequences

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RefSeqi
NP_699165.3, NM_153334.6 [Q96GP6-1]
NP_878315.2, NM_182895.4 [Q96GP6-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000622235; ENSP00000477564; ENSG00000244486 [Q96GP6-2]
ENST00000623402; ENSP00000485276; ENSG00000244486 [Q96GP6-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
91179

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:91179

UCSC genome browser

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UCSCi
uc062bsr.1 human [Q96GP6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB052951 mRNA Translation: BAC53753.1
AF522196 mRNA Translation: AAN45861.1 Frameshift.
AB024433 mRNA Translation: BAD93345.1
AC007731 Genomic DNA No translation available.
CH471176 Genomic DNA Translation: EAX02965.1
BC000584 mRNA Translation: AAH00584.2
BC009326 mRNA Translation: AAH09326.2
CCDSiCCDS13779.2 [Q96GP6-1]
CCDS46666.1 [Q96GP6-2]
RefSeqiNP_699165.3, NM_153334.6 [Q96GP6-1]
NP_878315.2, NM_182895.4 [Q96GP6-2]

3D structure databases

SMRiQ96GP6
ModBaseiSearch...

Protein-protein interaction databases

BioGridi124803, 7 interactors
IntActiQ96GP6, 8 interactors
STRINGi9606.ENSP00000477564

PTM databases

iPTMnetiQ96GP6
PhosphoSitePlusiQ96GP6
SwissPalmiQ96GP6

Polymorphism and mutation databases

BioMutaiSCARF2
DMDMi380865486

Proteomic databases

jPOSTiQ96GP6
MassIVEiQ96GP6
PaxDbiQ96GP6
PeptideAtlasiQ96GP6
PRIDEiQ96GP6
ProteomicsDBi76651 [Q96GP6-1]
76652 [Q96GP6-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
91179

Genome annotation databases

EnsembliENST00000622235; ENSP00000477564; ENSG00000244486 [Q96GP6-2]
ENST00000623402; ENSP00000485276; ENSG00000244486 [Q96GP6-1]
GeneIDi91179
KEGGihsa:91179
UCSCiuc062bsr.1 human [Q96GP6-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
91179
DisGeNETi91179

GeneCards: human genes, protein and diseases

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GeneCardsi
SCARF2
HGNCiHGNC:19869 SCARF2
HPAiHPA035079
MalaCardsiSCARF2
MIMi600920 phenotype
613619 gene
neXtProtiNX_Q96GP6
OpenTargetsiENSG00000244486
Orphaneti2460 Van den Ende-Gupta syndrome
PharmGKBiPA134908523

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1218 Eukaryota
ENOG410XQWV LUCA
GeneTreeiENSGT00950000183101
HOGENOMiHOG000015093
InParanoidiQ96GP6
OMAiCERYCQC
OrthoDBi110992at2759
PhylomeDBiQ96GP6
TreeFamiTF332598

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SCARF2 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
91179
PharosiQ96GP6

Protein Ontology

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PROi
PR:Q96GP6

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000244486 Expressed in 105 organ(s), highest expression level in tibial artery
ExpressionAtlasiQ96GP6 baseline and differential
GenevisibleiQ96GP6 HS

Family and domain databases

InterProiView protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR009030 Growth_fac_rcpt_cys_sf
IPR002049 Laminin_EGF
IPR033327 Scarf2
IPR042635 SREC1/2
PANTHERiPTHR24043 PTHR24043, 1 hit
PTHR24043:SF5 PTHR24043:SF5, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 7 hits
SM00180 EGF_Lam, 6 hits
SUPFAMiSSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 7 hits
PS01186 EGF_2, 4 hits
PS50026 EGF_3, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSREC2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96GP6
Secondary accession number(s): E5RFB8
, Q58A83, Q8IXF3, Q9BW74
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 17, 2003
Last sequence update: January 16, 2019
Last modified: October 16, 2019
This is version 154 of the entry and version 5 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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