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UniProtKB - Q96GN5 (CDA7L_HUMAN)

Entry version 149 (10 Feb 2021)
Sequence version 2 (01 Mar 2004)
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Protein

Cell division cycle-associated 7-like protein

Gene

CDCA7L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1.3 Publications

Miscellaneous

Cells lacking CDCA7L display a reduction of 25-30% of colony formation in medulloblastoma cell lines. CDCA7L overexpression induces colony formation.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q96GN5

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q96GN5

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cell division cycle-associated 7-like protein
Alternative name(s):
Protein JPO2
Transcription factor RAM2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CDCA7L
Synonyms:HR1, JPO2, R1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:30777, CDCA7L

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		609685, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q96GN5

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000164649.19

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi16I → A: Significant loss of interaction with PSIP1; when associated with A-17. Complete loss of interaction with PSIP1; when associated with A-17, A-72 and A-73. 1 Publication1
Mutagenesisi17F → A: Significant loss of interaction with PSIP1; when associated with A-16. Complete loss of interaction with PSIP1; when associated with A-16, A-72 and A-73. 1 Publication1
Mutagenesisi21S → D: Phosphomimetic mutant. Increased interaction with PSIP1; when associated with D-77, D-79 and D-81. 1 Publication1
Mutagenesisi72I → A: Significant loss of interaction with PSIP1; when associated with A-73. Complete loss of interaction with PSIP1; when associated with A-16, A-17 and A-73. 1 Publication1
Mutagenesisi73F → A: Significant loss of interaction with PSIP1; when associated with A-72. Complete loss of interaction with PSIP1; when associated with A-16, A-17 and A-72. 1 Publication1
Mutagenesisi77T → D: Phosphomimetic mutant. Increased interaction with PSIP1; when associated with D-21, D-79 and D-81. 1 Publication1
Mutagenesisi79S → D: Phosphomimetic mutant. Increased interaction with PSIP1; when associated with D-21, D-77 and D-81. 1 Publication1
Mutagenesisi81T → D: Phosphomimetic mutant. Increased interaction with PSIP1; when associated with D-21, D-77 and D-79. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		55536

Open Targets

More...OpenTargetsi		ENSG00000164649

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA142672139

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q96GN5, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CDCA7L

Domain mapping of disease mutations (DMDM)

More...DMDMi		74751890

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002493131 – 454Cell division cycle-associated 7-like proteinAdd BLAST454

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei21PhosphoserineCombined sources1 Publication1
Modified residuei77PhosphothreonineCombined sources1 Publication1
Modified residuei79PhosphoserineCombined sources1 Publication1
Modified residuei81Phosphothreonine1 Publication1
Modified residuei88Phosphothreonine1 Publication1
Modified residuei105PhosphoserineCombined sources1
Modified residuei108PhosphoserineCombined sources1
Modified residuei117PhosphoserineCombined sources1
Modified residuei138PhosphoserineCombined sources1
Modified residuei139PhosphoserineCombined sources1
Modified residuei162PhosphoserineCombined sources1
Modified residuei195PhosphoserineBy similarity1
Modified residuei197PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki222Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki225Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei261PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation increases its interaction with PSIP1.1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q96GN5

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q96GN5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q96GN5

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q96GN5

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q96GN5

PeptideAtlas

More...PeptideAtlasi		Q96GN5

PRoteomics IDEntifications database

More...PRIDEi		Q96GN5

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		12602
76648 [Q96GN5-1]
76649 [Q96GN5-2]
76650 [Q96GN5-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q96GN5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q96GN5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous. Overexpressed in medulloblastoma.2 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By MYC overexpression in a concentration dependent manner in neuroblastoma cell line.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000164649, Expressed in female gonad and 205 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q96GN5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q96GN5, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000164649, Tissue enhanced (lymphoid)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with MYC (PubMed:15994933, PubMed:16829576).

Interacts (via IBM motifs) with PSIP1 (via IBD domain); phosphorylation increases its affinity for PSIP1 (PubMed:16735438, PubMed:25082813, PubMed:29997176).

5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q96GN5
With#Exp.IntAct
ABT1 [Q9ULW3]3EBI-5278764,EBI-2602396
ANKRD1 [Q15327]3EBI-5278764,EBI-5653378
ANKRD11 [X5D778]3EBI-5278764,EBI-17183751
ANKRD23 [Q86SG2]3EBI-5278764,EBI-5661893
AVPI1 [Q5T686]3EBI-5278764,EBI-8640233
BAG5 [Q9UL15]3EBI-5278764,EBI-356517
BEND7 - isoform 2 [Q8N7W2-2]3EBI-5278764,EBI-10181188
BHLHB9 [Q6PI77]3EBI-5278764,EBI-11519926
BRPF1 - isoform 2 [P55201-2]3EBI-5278764,EBI-12065306
BYSL [Q13895]5EBI-5278764,EBI-358049
CARD9 [Q9H257]4EBI-5278764,EBI-751319
CAVIN1 [Q6NZI2]3EBI-5278764,EBI-2559016
CCDC116 [Q8IYX3]3EBI-5278764,EBI-744311
CEP70 [Q8NHQ1]7EBI-5278764,EBI-739624
CTNNBL1 [Q8WYA6]4EBI-5278764,EBI-748128
DAXX [Q9UER7]3EBI-5278764,EBI-77321
DMAP1 [Q9NPF5]3EBI-5278764,EBI-399105
EIF4A3 [P38919]3EBI-5278764,EBI-299104
FAM217B [Q9NTX9]3EBI-5278764,EBI-19153639
FAM9B [Q8IZU0]3EBI-5278764,EBI-10175124
GOLGA2 [Q08379]3EBI-5278764,EBI-618309
HSF2BP [O75031]3EBI-5278764,EBI-7116203
ING5 [Q8WYH8]3EBI-5278764,EBI-488533
JADE2 [A0A0C4DFT8]3EBI-5278764,EBI-12094820
KRTAP10-7 [P60409]3EBI-5278764,EBI-10172290
LMO1 [P25800]3EBI-5278764,EBI-8639312
MCRS1 [Q96EZ8]6EBI-5278764,EBI-348259
MDFI [Q99750]6EBI-5278764,EBI-724076
MEOX2 [Q6FHY5]3EBI-5278764,EBI-16439278
MFAP1 [P55081]3EBI-5278764,EBI-1048159
MLH1 [P40692]3EBI-5278764,EBI-744248
MORN3 [Q6PF18]3EBI-5278764,EBI-9675802
MRPL28 [Q13084]3EBI-5278764,EBI-723426
NDUFB7 [P17568]3EBI-5278764,EBI-1246238
NOL12 [Q9UGY1]3EBI-5278764,EBI-716098
NOP2 [P46087]3EBI-5278764,EBI-356811
PBX1 [P40424]3EBI-5278764,EBI-301611
PBX2 [P40425]3EBI-5278764,EBI-348489
PICK1 [Q9NRD5]3EBI-5278764,EBI-79165
PIH1D1 [Q9NWS0]3EBI-5278764,EBI-357318
PIP4K2B - isoform 2 [P78356-2]3EBI-5278764,EBI-11532361
PPP1R16A [Q96I34]3EBI-5278764,EBI-710402
PPP1R16B [Q96T49]3EBI-5278764,EBI-10293968
PRDM14 [Q9GZV8]6EBI-5278764,EBI-3957793
PRPF31 [Q8WWY3]3EBI-5278764,EBI-1567797
RRP7A [Q9Y3A4]3EBI-5278764,EBI-7223720
SNRNP48 [Q6IEG0]3EBI-5278764,EBI-2876632
SSX1 [Q16384]3EBI-5278764,EBI-10237585
SSX2IP [Q9Y2D8]3EBI-5278764,EBI-2212028
STX11 [O75558]3EBI-5278764,EBI-714135
TADA2A [O75478]3EBI-5278764,EBI-742268
TFPT - isoform 2 [P0C1Z6-2]3EBI-5278764,EBI-10178002
TNNI1 [P19237]3EBI-5278764,EBI-746692
TRAF3IP3 [Q9Y228]3EBI-5278764,EBI-765817
TRIM42 [Q8IWZ5]3EBI-5278764,EBI-5235829
UBL4A [P11441]3EBI-5278764,EBI-356983
UTP3 [Q9NQZ2]3EBI-5278764,EBI-714067
ZGPAT - isoform 2 [Q8N5A5-2]9EBI-5278764,EBI-10183064
ZNF250 - isoform 3 [P15622-3]3EBI-5278764,EBI-10177272
ZNF438 [Q7Z4V0]3EBI-5278764,EBI-11962468
ZNF620 [Q6ZNG0]3EBI-5278764,EBI-4395669
ZNF821 [O75541]3EBI-5278764,EBI-740865
Isoform 2 [Q96GN5-2]
With#Exp.IntAct
AXIN1 [A0A0S2Z4M1]3EBI-9091443,EBI-16429430
FGFR3 [P22607]3EBI-9091443,EBI-348399
HRAS [P01112]3EBI-9091443,EBI-350145
LMNA [P02545]3EBI-9091443,EBI-351935
PRPF31 [Q8WWY3]3EBI-9091443,EBI-1567797
SPRED1 [Q7Z699]3EBI-9091443,EBI-5235340
ZDHHC17 [Q8IUH5]2EBI-9091443,EBI-524753

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		120705, 79 interactors

Database of interacting proteins

More...DIPi		DIP-61218N

Protein interaction database and analysis system

More...IntActi		Q96GN5, 77 interactors

Molecular INTeraction database

More...MINTi		Q96GN5

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000383986

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q96GN5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1454
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q96GN5

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni213 – 235MYC-bindingAdd BLAST23

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi9 – 33Integrase domain-binding motif 1 (IBM1)1 PublicationAdd BLAST25
Motifi65 – 91Integrase domain-binding motif 2 (IBM2)1 PublicationAdd BLAST27

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QWH1, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159108

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_035988_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q96GN5

Identification of Orthologs from Complete Genome Data

More...OMAi		EGFTQND

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q96GN5

TreeFam database of animal gene trees

More...TreeFami		TF101076

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR040221, CDCA7/CDA7L
IPR033578, CDCA7L
IPR018866, Znf-4CXXC_R1

The PANTHER Classification System

More...PANTHERi		PTHR31169, PTHR31169, 1 hit
PTHR31169:SF4, PTHR31169:SF4, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF10497, zf-4CXXC_R1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96GN5-1) [UniParc]FASTAAdd to basket
Also known as: Variant C

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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MELATRYQIP KEVADIFNAP SDDEEFVGFR DDVPMETLSS EESCDSFDSL 
        60         70         80         90        100
ESGKQQDVRF HSKYFTEELR RIFIEDTDSE TEDFAGFTQS DLNGKTNPEV 
       110        120        130        140        150
MVVESDLSDD GKASLVSEEE EDEEEDKATP RRSRSRRSSI GLRVAFQFPT 
       160        170        180        190        200
KKLANKPDKN SSSEQLFSSA RLQNEKKTIL ERKKDCRQVI QREDSTSESE 
       210        220        230        240        250
DDSRDESQES SDALLKRTMN IKENKAMLAQ LLAELNSMPD FFPVRTPTSA 
       260        270        280        290        300
SRKKTVRRAF SEGQITRRMN PTRSARPPEK FALENFTVSA AKFAEEFYSF 
       310        320        330        340        350
RRRKTIGGKC REYRRRHRIS SFRPVEDITE EDLENVAITV RDKIYDKVLG 
       360        370        380        390        400
NTCHQCRQKT IDTKTVCRNQ GCCGVRGQFC GPCLRNRYGE DVRSALLDPD 
       410        420        430        440        450
WVCPPCRGIC NCSYCRKRDG RCATGILIHL AKFYGYDNVK EYLESLQKEL 

VEDN
Length:454
Mass (Da):52,206
Last modified:March 1, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1FAFEC7DBD763C85
GO
Isoform 2 (identifier: Q96GN5-2) [UniParc]FASTAAdd to basket
Also known as: Variant B

The sequence of this isoform differs from the canonical sequence as follows:
     55-55: Missing.

Show »
Length:453
Mass (Da):52,078
Checksum:i4C7B2BF1134CFB74
GO
Isoform 3 (identifier: Q96GN5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-34: Missing.

Show »
Length:420
Mass (Da):48,309
Checksum:iD77BFB88C7605E4A
GO
Isoform 4 (identifier: Q96GN5-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     56-101: Missing.

Show »
Length:408
Mass (Da):46,779
Checksum:i688FC9D4ED534E39
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9IZR6C9IZR6_HUMAN
Cell division cycle-associated 7-li...
CDCA7L
156Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J8L0C9J8L0_HUMAN
Cell division cycle-associated 7-li...
CDCA7L
113Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JFL7C9JFL7_HUMAN
Cell division cycle-associated 7-li...
CDCA7L
96Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C1J6H7C1J6_HUMAN
Cell division cycle-associated 7-li...
CDCA7L
98Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB14330 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti46S → G in BAG62445 (PubMed:14702039).Curated1
Sequence conflicti340V → A in CAB94887 (PubMed:17974005).Curated1
Sequence conflicti345Y → C in AAH32576 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_08347545D → N1 PublicationCorresponds to variant dbSNP:rs937337760Ensembl.1
Natural variantiVAR_050776187R → S. Corresponds to variant dbSNP:rs35281045Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0438061 – 34Missing in isoform 3. 1 PublicationAdd BLAST34
Alternative sequenceiVSP_02039855Missing in isoform 2. 2 Publications1
Alternative sequenceiVSP_04627056 – 101Missing in isoform 4. 1 PublicationAdd BLAST46

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY161168 mRNA Translation: AAO17570.1
AY161169 mRNA Translation: AAO17571.1
AK022955 mRNA Translation: BAB14330.1 Frameshift.
AK095965 mRNA Translation: BAG53177.1
AK300781 mRNA Translation: BAG62445.1
AC074379 Genomic DNA No translation available.
AC099653 Genomic DNA No translation available.
CH236948 Genomic DNA Translation: EAL24271.1
CH471073 Genomic DNA Translation: EAW93741.1
CH471073 Genomic DNA Translation: EAW93743.1
BC009352 mRNA Translation: AAH09352.2
BC014630 mRNA Translation: AAH14630.2
BC025242 mRNA Translation: AAH25242.1
BC032576 mRNA Translation: AAH32576.1
BC039823 mRNA Translation: AAH39823.1
AL359619 mRNA Translation: CAB94887.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS47558.1 [Q96GN5-5]
CCDS47559.1 [Q96GN5-4]
CCDS5374.1 [Q96GN5-1]

Protein sequence database of the Protein Information Resource

More...PIRi		T50635

NCBI Reference Sequences

More...RefSeqi		NP_001120842.1, NM_001127370.2 [Q96GN5-4]
NP_001120843.1, NM_001127371.2 [Q96GN5-5]
NP_061189.2, NM_018719.4 [Q96GN5-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000356195; ENSP00000348523; ENSG00000164649 [Q96GN5-4]
ENST00000373934; ENSP00000363045; ENSG00000164649 [Q96GN5-5]
ENST00000406877; ENSP00000383986; ENSG00000164649 [Q96GN5-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		55536

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:55536

UCSC genome browser

More...UCSCi		uc003sve.5, human [Q96GN5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY161168 mRNA Translation: AAO17570.1
AY161169 mRNA Translation: AAO17571.1
AK022955 mRNA Translation: BAB14330.1 Frameshift.
AK095965 mRNA Translation: BAG53177.1
AK300781 mRNA Translation: BAG62445.1
AC074379 Genomic DNA No translation available.
AC099653 Genomic DNA No translation available.
CH236948 Genomic DNA Translation: EAL24271.1
CH471073 Genomic DNA Translation: EAW93741.1
CH471073 Genomic DNA Translation: EAW93743.1
BC009352 mRNA Translation: AAH09352.2
BC014630 mRNA Translation: AAH14630.2
BC025242 mRNA Translation: AAH25242.1
BC032576 mRNA Translation: AAH32576.1
BC039823 mRNA Translation: AAH39823.1
AL359619 mRNA Translation: CAB94887.1
CCDSiCCDS47558.1 [Q96GN5-5]
CCDS47559.1 [Q96GN5-4]
CCDS5374.1 [Q96GN5-1]
PIRiT50635
RefSeqiNP_001120842.1, NM_001127370.2 [Q96GN5-4]
NP_001120843.1, NM_001127371.2 [Q96GN5-5]
NP_061189.2, NM_018719.4 [Q96GN5-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5YI9NMR-A56-91[»]
6EMONMR-A1-32[»]
SMRiQ96GN5
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi120705, 79 interactors
DIPiDIP-61218N
IntActiQ96GN5, 77 interactors
MINTiQ96GN5
STRINGi9606.ENSP00000383986

PTM databases

iPTMnetiQ96GN5
PhosphoSitePlusiQ96GN5

Genetic variation databases

BioMutaiCDCA7L
DMDMi74751890

Proteomic databases

EPDiQ96GN5
jPOSTiQ96GN5
MassIVEiQ96GN5
MaxQBiQ96GN5
PaxDbiQ96GN5
PeptideAtlasiQ96GN5
PRIDEiQ96GN5
ProteomicsDBi12602
76648 [Q96GN5-1]
76649 [Q96GN5-2]
76650 [Q96GN5-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		11993, 230 antibodies

The DNASU plasmid repository

More...DNASUi		55536

Genome annotation databases

EnsembliENST00000356195; ENSP00000348523; ENSG00000164649 [Q96GN5-4]
ENST00000373934; ENSP00000363045; ENSG00000164649 [Q96GN5-5]
ENST00000406877; ENSP00000383986; ENSG00000164649 [Q96GN5-1]
GeneIDi55536
KEGGihsa:55536
UCSCiuc003sve.5, human [Q96GN5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		55536
DisGeNETi55536

GeneCards: human genes, protein and diseases

More...GeneCardsi		CDCA7L
HGNCiHGNC:30777, CDCA7L
HPAiENSG00000164649, Tissue enhanced (lymphoid)
MIMi609685, gene
neXtProtiNX_Q96GN5
OpenTargetsiENSG00000164649
PharmGKBiPA142672139
VEuPathDBiHostDB:ENSG00000164649.19

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QWH1, Eukaryota
GeneTreeiENSGT00940000159108
HOGENOMiCLU_035988_0_0_1
InParanoidiQ96GN5
OMAiEGFTQND
PhylomeDBiQ96GN5
TreeFamiTF101076

Enzyme and pathway databases

PathwayCommonsiQ96GN5
SIGNORiQ96GN5

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		55536, 4 hits in 880 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CDCA7L, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		CDCA7L

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		55536
PharosiQ96GN5, Tbio

Protein Ontology

More...PROi		PR:Q96GN5
RNActiQ96GN5, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000164649, Expressed in female gonad and 205 other tissues
ExpressionAtlasiQ96GN5, baseline and differential
GenevisibleiQ96GN5, HS

Family and domain databases

InterProiView protein in InterPro
IPR040221, CDCA7/CDA7L
IPR033578, CDCA7L
IPR018866, Znf-4CXXC_R1
PANTHERiPTHR31169, PTHR31169, 1 hit
PTHR31169:SF4, PTHR31169:SF4, 1 hit
PfamiView protein in Pfam
PF10497, zf-4CXXC_R1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCDA7L_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96GN5
Secondary accession number(s): A4D141
, A6NF50, B3KTR5, B4DUT3, C9K0Y1, Q6PIL4, Q86YT0, Q8IXN5, Q96C70, Q9H9A2, Q9NPV2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: March 1, 2004
Last modified: February 10, 2021
This is version 149 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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