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Entry version 137 (08 May 2019)
Sequence version 2 (01 Mar 2004)
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Protein

Cell division cycle-associated 7-like protein

Gene

CDCA7L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1.3 Publications

Miscellaneous

Cells lacking CDCA7L display a reduction of 25-30% of colony formation in medulloblastoma cell lines. CDCA7L overexpression induces colony formation.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q96GN5

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cell division cycle-associated 7-like protein
Alternative name(s):
Protein JPO2
Transcription factor RAM2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CDCA7L
Synonyms:HR1, JPO2, R1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30777 CDCA7L

Online Mendelian Inheritance in Man (OMIM)

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MIMi
609685 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96GN5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
55536

Open Targets

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OpenTargetsi
ENSG00000164649

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142672139

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CDCA7L

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74751890

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002493131 – 454Cell division cycle-associated 7-like proteinAdd BLAST454

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei21PhosphoserineCombined sources1
Modified residuei77PhosphothreonineCombined sources1
Modified residuei79PhosphoserineCombined sources1
Modified residuei105PhosphoserineCombined sources1
Modified residuei108PhosphoserineCombined sources1
Modified residuei117PhosphoserineCombined sources1
Modified residuei138PhosphoserineCombined sources1
Modified residuei139PhosphoserineCombined sources1
Modified residuei162PhosphoserineCombined sources1
Modified residuei195PhosphoserineBy similarity1
Modified residuei197PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki222Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki225Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei261PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96GN5

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q96GN5

MaxQB - The MaxQuant DataBase

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MaxQBi
Q96GN5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96GN5

PeptideAtlas

More...
PeptideAtlasi
Q96GN5

PRoteomics IDEntifications database

More...
PRIDEi
Q96GN5

ProteomicsDB human proteome resource

More...
ProteomicsDBi
76648
76649 [Q96GN5-2]
76650 [Q96GN5-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96GN5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96GN5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous. Overexpressed in medulloblastoma.2 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By MYC overexpression in a concentration dependent manner in neuroblastoma cell line.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000164649 Expressed in 193 organ(s), highest expression level in female gonad

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q96GN5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96GN5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA027169

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with MYC and PSIP1.

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120705, 48 interactors

Database of interacting proteins

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DIPi
DIP-61218N

Protein interaction database and analysis system

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IntActi
Q96GN5, 68 interactors

Molecular INTeraction database

More...
MINTi
Q96GN5

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000383986

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1454
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q96GN5

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni58 – 119PSIP1-bindingAdd BLAST62
Regioni213 – 235MYC-bindingAdd BLAST23

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IYXY Eukaryota
ENOG410XQV7 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159108

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231812

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96GN5

Identification of Orthologs from Complete Genome Data

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OMAi
VLGSTCH

Database of Orthologous Groups

More...
OrthoDBi
1462540at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96GN5

TreeFam database of animal gene trees

More...
TreeFami
TF101076

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR040221 CDCA7/CDA7L
IPR033578 CDCA7L
IPR018866 Znf-4CXXC_R1

The PANTHER Classification System

More...
PANTHERi
PTHR31169 PTHR31169, 1 hit
PTHR31169:SF4 PTHR31169:SF4, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10497 zf-4CXXC_R1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96GN5-1) [UniParc]FASTAAdd to basket
Also known as: Variant C

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MELATRYQIP KEVADIFNAP SDDEEFVGFR DDVPMETLSS EESCDSFDSL
60 70 80 90 100
ESGKQQDVRF HSKYFTEELR RIFIEDTDSE TEDFAGFTQS DLNGKTNPEV
110 120 130 140 150
MVVESDLSDD GKASLVSEEE EDEEEDKATP RRSRSRRSSI GLRVAFQFPT
160 170 180 190 200
KKLANKPDKN SSSEQLFSSA RLQNEKKTIL ERKKDCRQVI QREDSTSESE
210 220 230 240 250
DDSRDESQES SDALLKRTMN IKENKAMLAQ LLAELNSMPD FFPVRTPTSA
260 270 280 290 300
SRKKTVRRAF SEGQITRRMN PTRSARPPEK FALENFTVSA AKFAEEFYSF
310 320 330 340 350
RRRKTIGGKC REYRRRHRIS SFRPVEDITE EDLENVAITV RDKIYDKVLG
360 370 380 390 400
NTCHQCRQKT IDTKTVCRNQ GCCGVRGQFC GPCLRNRYGE DVRSALLDPD
410 420 430 440 450
WVCPPCRGIC NCSYCRKRDG RCATGILIHL AKFYGYDNVK EYLESLQKEL

VEDN
Length:454
Mass (Da):52,206
Last modified:March 1, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1FAFEC7DBD763C85
GO
Isoform 2 (identifier: Q96GN5-2) [UniParc]FASTAAdd to basket
Also known as: Variant B

The sequence of this isoform differs from the canonical sequence as follows:
     55-55: Missing.

Show »
Length:453
Mass (Da):52,078
Checksum:i4C7B2BF1134CFB74
GO
Isoform 3 (identifier: Q96GN5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-34: Missing.

Show »
Length:420
Mass (Da):48,309
Checksum:iD77BFB88C7605E4A
GO
Isoform 4 (identifier: Q96GN5-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     56-101: Missing.

Note: No experimental confirmation available.
Show »
Length:408
Mass (Da):46,779
Checksum:i688FC9D4ED534E39
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9IZR6C9IZR6_HUMAN
Cell division cycle-associated 7-li...
CDCA7L
156Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J8L0C9J8L0_HUMAN
Cell division cycle-associated 7-li...
CDCA7L
113Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JFL7C9JFL7_HUMAN
Cell division cycle-associated 7-li...
CDCA7L
96Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C1J6H7C1J6_HUMAN
Cell division cycle-associated 7-li...
CDCA7L
98Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB14330 differs from that shown. Reason: Frameshift at position 260.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti46S → G in BAG62445 (PubMed:14702039).Curated1
Sequence conflicti340V → A in CAB94887 (PubMed:17974005).Curated1
Sequence conflicti345Y → C in AAH32576 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_050776187R → S. Corresponds to variant dbSNP:rs35281045Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0438061 – 34Missing in isoform 3. 1 PublicationAdd BLAST34
Alternative sequenceiVSP_02039855Missing in isoform 2. 2 Publications1
Alternative sequenceiVSP_04627056 – 101Missing in isoform 4. 1 PublicationAdd BLAST46

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AY161168 mRNA Translation: AAO17570.1
AY161169 mRNA Translation: AAO17571.1
AK022955 mRNA Translation: BAB14330.1 Frameshift.
AK095965 mRNA Translation: BAG53177.1
AK300781 mRNA Translation: BAG62445.1
AC074379 Genomic DNA No translation available.
AC099653 Genomic DNA No translation available.
CH236948 Genomic DNA Translation: EAL24271.1
CH471073 Genomic DNA Translation: EAW93741.1
CH471073 Genomic DNA Translation: EAW93743.1
BC009352 mRNA Translation: AAH09352.2
BC014630 mRNA Translation: AAH14630.2
BC025242 mRNA Translation: AAH25242.1
BC032576 mRNA Translation: AAH32576.1
BC039823 mRNA Translation: AAH39823.1
AL359619 mRNA Translation: CAB94887.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS47558.1 [Q96GN5-5]
CCDS47559.1 [Q96GN5-4]
CCDS5374.1 [Q96GN5-1]

Protein sequence database of the Protein Information Resource

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PIRi
T50635

NCBI Reference Sequences

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RefSeqi
NP_001120842.1, NM_001127370.2 [Q96GN5-4]
NP_001120843.1, NM_001127371.2 [Q96GN5-5]
NP_061189.2, NM_018719.4 [Q96GN5-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000356195; ENSP00000348523; ENSG00000164649 [Q96GN5-4]
ENST00000373934; ENSP00000363045; ENSG00000164649 [Q96GN5-5]
ENST00000406877; ENSP00000383986; ENSG00000164649 [Q96GN5-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
55536

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:55536

UCSC genome browser

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UCSCi
uc003sve.5 human [Q96GN5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY161168 mRNA Translation: AAO17570.1
AY161169 mRNA Translation: AAO17571.1
AK022955 mRNA Translation: BAB14330.1 Frameshift.
AK095965 mRNA Translation: BAG53177.1
AK300781 mRNA Translation: BAG62445.1
AC074379 Genomic DNA No translation available.
AC099653 Genomic DNA No translation available.
CH236948 Genomic DNA Translation: EAL24271.1
CH471073 Genomic DNA Translation: EAW93741.1
CH471073 Genomic DNA Translation: EAW93743.1
BC009352 mRNA Translation: AAH09352.2
BC014630 mRNA Translation: AAH14630.2
BC025242 mRNA Translation: AAH25242.1
BC032576 mRNA Translation: AAH32576.1
BC039823 mRNA Translation: AAH39823.1
AL359619 mRNA Translation: CAB94887.1
CCDSiCCDS47558.1 [Q96GN5-5]
CCDS47559.1 [Q96GN5-4]
CCDS5374.1 [Q96GN5-1]
PIRiT50635
RefSeqiNP_001120842.1, NM_001127370.2 [Q96GN5-4]
NP_001120843.1, NM_001127371.2 [Q96GN5-5]
NP_061189.2, NM_018719.4 [Q96GN5-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5YI9NMR-A56-91[»]
6EMONMR-A1-32[»]
SMRiQ96GN5
ModBaseiSearch...

Protein-protein interaction databases

BioGridi120705, 48 interactors
DIPiDIP-61218N
IntActiQ96GN5, 68 interactors
MINTiQ96GN5
STRINGi9606.ENSP00000383986

PTM databases

iPTMnetiQ96GN5
PhosphoSitePlusiQ96GN5

Polymorphism and mutation databases

BioMutaiCDCA7L
DMDMi74751890

Proteomic databases

EPDiQ96GN5
jPOSTiQ96GN5
MaxQBiQ96GN5
PaxDbiQ96GN5
PeptideAtlasiQ96GN5
PRIDEiQ96GN5
ProteomicsDBi76648
76649 [Q96GN5-2]
76650 [Q96GN5-4]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
55536
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000356195; ENSP00000348523; ENSG00000164649 [Q96GN5-4]
ENST00000373934; ENSP00000363045; ENSG00000164649 [Q96GN5-5]
ENST00000406877; ENSP00000383986; ENSG00000164649 [Q96GN5-1]
GeneIDi55536
KEGGihsa:55536
UCSCiuc003sve.5 human [Q96GN5-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
55536
DisGeNETi55536

GeneCards: human genes, protein and diseases

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GeneCardsi
CDCA7L
HGNCiHGNC:30777 CDCA7L
HPAiHPA027169
MIMi609685 gene
neXtProtiNX_Q96GN5
OpenTargetsiENSG00000164649
PharmGKBiPA142672139

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IYXY Eukaryota
ENOG410XQV7 LUCA
GeneTreeiENSGT00940000159108
HOGENOMiHOG000231812
InParanoidiQ96GN5
OMAiVLGSTCH
OrthoDBi1462540at2759
PhylomeDBiQ96GN5
TreeFamiTF101076

Enzyme and pathway databases

SIGNORiQ96GN5

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CDCA7L human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
CDCA7L

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
55536

Protein Ontology

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PROi
PR:Q96GN5

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000164649 Expressed in 193 organ(s), highest expression level in female gonad
ExpressionAtlasiQ96GN5 baseline and differential
GenevisibleiQ96GN5 HS

Family and domain databases

InterProiView protein in InterPro
IPR040221 CDCA7/CDA7L
IPR033578 CDCA7L
IPR018866 Znf-4CXXC_R1
PANTHERiPTHR31169 PTHR31169, 1 hit
PTHR31169:SF4 PTHR31169:SF4, 1 hit
PfamiView protein in Pfam
PF10497 zf-4CXXC_R1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCDA7L_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96GN5
Secondary accession number(s): A4D141
, A6NF50, B3KTR5, B4DUT3, C9K0Y1, Q6PIL4, Q86YT0, Q8IXN5, Q96C70, Q9H9A2, Q9NPV2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: March 1, 2004
Last modified: May 8, 2019
This is version 137 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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