UniProtKB - Q96GM5 (SMRD1_HUMAN)
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1
SMARCD1
Functioni
GO - Molecular functioni
- chromatin binding Source: Ensembl
- molecular adaptor activity Source: UniProtKB
- signaling receptor binding Source: Ensembl
- transcription coactivator activity Source: BHF-UCL
GO - Biological processi
- cellular response to fatty acid Source: Ensembl
- chromatin-mediated maintenance of transcription Source: UniProtKB
- chromatin remodeling Source: BHF-UCL
- nervous system development Source: UniProtKB-KW
- nucleosome disassembly Source: BHF-UCL
- regulation of transcription by RNA polymerase II Source: BHF-UCL
Keywordsi
Molecular function | Chromatin regulator |
Biological process | Neurogenesis |
Enzyme and pathway databases
Reactomei | R-HSA-3214858 RMTs methylate histone arginines R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known |
SIGNORi | Q96GM5 |
Names & Taxonomyi
Protein namesi | Recommended name: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1Alternative name(s): 60 kDa BRG-1/Brm-associated factor subunit A BRG1-associated factor 60A Short name: BAF60A SWI/SNF complex 60 kDa subunit |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11106 SMARCD1 |
MIMi | 601735 gene |
neXtProti | NX_Q96GM5 |
Subcellular locationi
Nucleus
- Nucleus Curated1 Publication
Nucleus
- nBAF complex Source: UniProtKB
- npBAF complex Source: UniProtKB
- nucleoplasm Source: HPA
- SWI/SNF complex Source: UniProtKB
Other locations
- intracellular membrane-bounded organelle Source: HPA
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 6602 |
OpenTargetsi | ENSG00000066117 |
PharmGKBi | PA35956 |
Miscellaneous databases
Pharosi | Q96GM5 |
Polymorphism and mutation databases
BioMutai | SMARCD1 |
DMDMi | 238054318 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000071983 | 1 – 515 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1Add BLAST | 515 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 68 | Asymmetric dimethylarginineBy similarity | 1 | |
Modified residuei | 88 | Asymmetric dimethylarginineBy similarity | 1 | |
Cross-linki | 101 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 203 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 223 | N6-acetyllysineBy similarity | 1 |
Keywords - PTMi
Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q96GM5 |
jPOSTi | Q96GM5 |
MassIVEi | Q96GM5 |
MaxQBi | Q96GM5 |
PaxDbi | Q96GM5 |
PeptideAtlasi | Q96GM5 |
PRIDEi | Q96GM5 |
ProteomicsDBi | 76645 [Q96GM5-1] 76646 [Q96GM5-2] |
PTM databases
iPTMneti | Q96GM5 |
PhosphoSitePlusi | Q96GM5 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000066117 Expressed in 218 organ(s), highest expression level in left adrenal gland |
ExpressionAtlasi | Q96GM5 baseline and differential |
Genevisiblei | Q96GM5 HS |
Organism-specific databases
HPAi | HPA004101 |
Interactioni
Subunit structurei
Component of the multiprotein chromatin-remodeling complexes SWI/SNF: SWI/SNF-A (BAF), SWI/SNF-B (PBAF) and related complexes. The canonical complex contains a catalytic subunit (either SMARCA4/BRG1/BAF190A or SMARCA2/BRM/BAF190B), and at least SMARCE1, ACTL6A/BAF53, SMARCC1/BAF155, SMARCC2/BAF170, and SMARCB1/SNF5/BAF47. Other subunits specific to each of the complexes may also be present permitting several possible combinations developmentally and tissue specific (PubMed:8895581).
Component of the BAF complex, which includes at least actin (ACTB), ARID1A/BAF250A, ARID1B/BAF250B, SMARCA2/BRM, SMARCA4/BRG1/BAF190A, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57, SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C (PubMed:18765789). In muscle cells, the BAF complex also contains DPF3.
Component of neural progenitors-specific chromatin remodeling complex (npBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A and actin.
Component of neuron-specific chromatin remodeling complex (nBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B and actin (By similarity).
Component of the SWI/SNF-B (PBAF) chromatin remodeling complex, at least composed of SMARCA4/BRG1, SMARCB1/BAF47/SNF5, ACTL6A/BAF53A or ACTL6B/BAF53B, SMARCE1/BAF57, SMARCD1/BAF60A, SMARCD2/BAF60B, perhaps SMARCD3/BAF60C, SMARCC1/BAF155, SMARCC2/BAF170, PBRM1/BAF180, ARID2/BAF200 and actin (ACTB) (PubMed:22952240, PubMed:26601204).
Component of SWI/SNF (GBAF) subcomplex, which includes at least BICRA or BICRAL (mutually exclusive), BRD9, SS18, SMARCA2/BRM, SMARCA4/BRG1/BAF190A, ACTL6A/BAF53, SMARCC1/BAF155, and SMARCD1/BAF60A (PubMed:29374058). Specifically interacts with the VDR heterodimer complex (PubMed:14698202).
Interacts with ESR1, NR3C1, NR1H4, PGR, SMARCA4, SMARCC1 and SMARCC2 (PubMed:12917342).
Interacts with DPF2 (PubMed:20460684).
2 PublicationsBy similarity6 PublicationsBinary interactionsi
GO - Molecular functioni
- signaling receptor binding Source: Ensembl
Protein-protein interaction databases
BioGridi | 112486, 133 interactors |
ComplexPortali | CPX-1164 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA2 variant CPX-1194 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA2 variant CPX-1195 Embryonic stem cell-specific SWI/SNF ATP-dependent chromatin remodeling complex CPX-1196 Polybromo-associated SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B variant CPX-1199 Polybromo-associated SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A variant CPX-1201 Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA2 variant CPX-1202 Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA2 variant CPX-1204 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA4 variant CPX-1205 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA2 variant CPX-1206 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA4 variant CPX-1207 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA2 variant CPX-1209 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA4 variant CPX-1210 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA2 variant CPX-1211 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA4 variant CPX-1212 Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA4 variant CPX-1213 Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA2 variant CPX-1215 Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA4 variant CPX-1216 Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA4 variant CPX-1217 Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA2 variant CPX-1218 Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA4 variant CPX-1222 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA4 variant CPX-1223 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA2 variant CPX-1224 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA4 variant CPX-1225 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA2 variant CPX-1226 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA4 variant CPX-1227 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA2 variant CPX-1228 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA4 variant CPX-4084 GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6A-BICRA-SMARCA2 variant CPX-4203 GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6A-BICRAL-SMARCA2 variant CPX-4206 GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6A-BICRA-SMARCA4 variant CPX-4207 GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6A-BICRAL-SMARCA4 variant CPX-4223 GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6B-BICRA-SMARCA2 variant CPX-4224 GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6B-BICRAL-SMARCA2 variant CPX-4225 GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6B-BICRA-SMARCA4 variant CPX-4226 GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6B-BICRAL-SMARCA4 variant |
CORUMi | Q96GM5 |
DIPi | DIP-33390N |
IntActi | Q96GM5, 189 interactors |
MINTi | Q96GM5 |
STRINGi | 9606.ENSP00000378414 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 291 – 390 | SWIBAdd BLAST | 100 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 43 – 167 | Interaction with ESR1, NR1H4, NR3C1, PGR and SMARCA41 PublicationAdd BLAST | 125 | |
Regioni | 168 – 474 | Interaction with SMARCC1 and SMARCC21 PublicationAdd BLAST | 307 | |
Regioni | 180 – 515 | Necessary for GR/NR3C1-mediated remodeling and transcription from chromatin; required for GR/NR3C1 interaction with the BRG1/SMARCA4 complex in vivoAdd BLAST | 336 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 412 – 440 | Sequence analysisAdd BLAST | 29 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 124 – 127 | Poly-Lys | 4 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG2570 Eukaryota COG5531 LUCA |
GeneTreei | ENSGT00940000156629 |
HOGENOMi | HOG000240746 |
InParanoidi | Q96GM5 |
KOi | K11650 |
OMAi | MNITINL |
OrthoDBi | 1027566at2759 |
PhylomeDBi | Q96GM5 |
TreeFami | TF106486 |
Family and domain databases
Gene3Di | 1.10.245.10, 1 hit |
InterProi | View protein in InterPro IPR038041 SMARCD1 IPR019835 SWIB_domain IPR036885 SWIB_MDM2_dom_sf IPR003121 SWIB_MDM2_domain |
PANTHERi | PTHR13844:SF1 PTHR13844:SF1, 1 hit |
Pfami | View protein in Pfam PF02201 SWIB, 1 hit |
SMARTi | View protein in SMART SM00151 SWIB, 1 hit |
SUPFAMi | SSF47592 SSF47592, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAARAGFQSV APSGGAGASG GAGAAAALGP GGTPGPPVRM GPAPGQGLYR
60 70 80 90 100
SPMPGAAYPR PGMLPGSRMT PQGPSMGPPG YGGNPSVRPG LAQSGMDQSR
110 120 130 140 150
KRPAPQQIQQ VQQQAVQNRN HNAKKKKMAD KILPQRIREL VPESQAYMDL
160 170 180 190 200
LAFERKLDQT IMRKRLDIQE ALKRPIKQKR KLRIFISNTF NPAKSDAEDG
210 220 230 240 250
EGTVASWELR VEGRLLEDSA LSKYDATKQK RKFSSFFKSL VIELDKDLYG
260 270 280 290 300
PDNHLVEWHR TATTQETDGF QVKRPGDVNV RCTVLLMLDY QPPQFKLDPR
310 320 330 340 350
LARLLGIHTQ TRPVIIQALW QYIKTHKLQD PHEREFVICD KYLQQIFESQ
360 370 380 390 400
RMKFSEIPQR LHALLMPPEP IIINHVISVD PNDQKKTACY DIDVEVDDTL
410 420 430 440 450
KTQMNSFLLS TASQQEIATL DNKIHETIET INQLKTQREF MLSFARDPQG
460 470 480 490 500
FINDWLQSQC RDLKTMTDVV GNPEEERRAE FYFQPWAQEA VCRYFYSKVQ
510
QRRQELEQAL GIRNT
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF8VUB0 | F8VUB0_HUMAN | SWI/SNF-related matrix-associated a... | SMARCD1 | 289 | Annotation score: | ||
F8VZ70 | F8VZ70_HUMAN | SWI/SNF-related matrix-associated a... | SMARCD1 | 278 | Annotation score: | ||
F8VW95 | F8VW95_HUMAN | SWI/SNF-related matrix-associated a... | SMARCD1 | 113 | Annotation score: | ||
F8VRQ4 | F8VRQ4_HUMAN | SWI/SNF-related matrix-associated a... | SMARCD1 | 313 | Annotation score: | ||
H0YHV1 | H0YHV1_HUMAN | SWI/SNF-related matrix-associated a... | SMARCD1 | 115 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 349 | S → T in AAC50695 (PubMed:8804307).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_004179 | 423 – 463 | Missing in isoform 2. 1 PublicationAdd BLAST | 41 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF109733 mRNA Translation: AAD23390.1 Different initiation. U66617 mRNA Translation: AAC50695.1 Frameshift. AC025154 Genomic DNA No translation available. BC009368 mRNA Translation: AAH09368.3 Different initiation. |
CCDSi | CCDS8797.2 [Q96GM5-1] CCDS8798.2 [Q96GM5-2] |
RefSeqi | NP_003067.3, NM_003076.4 [Q96GM5-1] NP_620710.2, NM_139071.2 [Q96GM5-2] |
Genome annotation databases
Ensembli | ENST00000381513; ENSP00000370924; ENSG00000066117 [Q96GM5-2] ENST00000394963; ENSP00000378414; ENSG00000066117 [Q96GM5-1] |
GeneIDi | 6602 |
KEGGi | hsa:6602 |
UCSCi | uc001rvx.5 human [Q96GM5-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF109733 mRNA Translation: AAD23390.1 Different initiation. U66617 mRNA Translation: AAC50695.1 Frameshift. AC025154 Genomic DNA No translation available. BC009368 mRNA Translation: AAH09368.3 Different initiation. |
CCDSi | CCDS8797.2 [Q96GM5-1] CCDS8798.2 [Q96GM5-2] |
RefSeqi | NP_003067.3, NM_003076.4 [Q96GM5-1] NP_620710.2, NM_139071.2 [Q96GM5-2] |
3D structure databases
SMRi | Q96GM5 |
ModBasei | Search... |
Protein-protein interaction databases
BioGridi | 112486, 133 interactors |
ComplexPortali | CPX-1164 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA2 variant CPX-1194 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA2 variant CPX-1195 Embryonic stem cell-specific SWI/SNF ATP-dependent chromatin remodeling complex CPX-1196 Polybromo-associated SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B variant CPX-1199 Polybromo-associated SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A variant CPX-1201 Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA2 variant CPX-1202 Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA2 variant CPX-1204 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA4 variant CPX-1205 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA2 variant CPX-1206 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA4 variant CPX-1207 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA2 variant CPX-1209 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA4 variant CPX-1210 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA2 variant CPX-1211 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA4 variant CPX-1212 Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA4 variant CPX-1213 Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA2 variant CPX-1215 Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA4 variant CPX-1216 Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA4 variant CPX-1217 Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA2 variant CPX-1218 Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA4 variant CPX-1222 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA4 variant CPX-1223 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA2 variant CPX-1224 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA4 variant CPX-1225 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA2 variant CPX-1226 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA4 variant CPX-1227 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA2 variant CPX-1228 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA4 variant CPX-4084 GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6A-BICRA-SMARCA2 variant CPX-4203 GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6A-BICRAL-SMARCA2 variant CPX-4206 GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6A-BICRA-SMARCA4 variant CPX-4207 GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6A-BICRAL-SMARCA4 variant CPX-4223 GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6B-BICRA-SMARCA2 variant CPX-4224 GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6B-BICRAL-SMARCA2 variant CPX-4225 GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6B-BICRA-SMARCA4 variant CPX-4226 GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6B-BICRAL-SMARCA4 variant |
CORUMi | Q96GM5 |
DIPi | DIP-33390N |
IntActi | Q96GM5, 189 interactors |
MINTi | Q96GM5 |
STRINGi | 9606.ENSP00000378414 |
PTM databases
iPTMneti | Q96GM5 |
PhosphoSitePlusi | Q96GM5 |
Polymorphism and mutation databases
BioMutai | SMARCD1 |
DMDMi | 238054318 |
Proteomic databases
EPDi | Q96GM5 |
jPOSTi | Q96GM5 |
MassIVEi | Q96GM5 |
MaxQBi | Q96GM5 |
PaxDbi | Q96GM5 |
PeptideAtlasi | Q96GM5 |
PRIDEi | Q96GM5 |
ProteomicsDBi | 76645 [Q96GM5-1] 76646 [Q96GM5-2] |
Protocols and materials databases
DNASUi | 6602 |
Genome annotation databases
Ensembli | ENST00000381513; ENSP00000370924; ENSG00000066117 [Q96GM5-2] ENST00000394963; ENSP00000378414; ENSG00000066117 [Q96GM5-1] |
GeneIDi | 6602 |
KEGGi | hsa:6602 |
UCSCi | uc001rvx.5 human [Q96GM5-1] |
Organism-specific databases
CTDi | 6602 |
DisGeNETi | 6602 |
GeneCardsi | SMARCD1 |
HGNCi | HGNC:11106 SMARCD1 |
HPAi | HPA004101 |
MIMi | 601735 gene |
neXtProti | NX_Q96GM5 |
OpenTargetsi | ENSG00000066117 |
PharmGKBi | PA35956 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2570 Eukaryota COG5531 LUCA |
GeneTreei | ENSGT00940000156629 |
HOGENOMi | HOG000240746 |
InParanoidi | Q96GM5 |
KOi | K11650 |
OMAi | MNITINL |
OrthoDBi | 1027566at2759 |
PhylomeDBi | Q96GM5 |
TreeFami | TF106486 |
Enzyme and pathway databases
Reactomei | R-HSA-3214858 RMTs methylate histone arginines R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known |
SIGNORi | Q96GM5 |
Miscellaneous databases
ChiTaRSi | SMARCD1 human |
GeneWikii | SMARCD1 |
GenomeRNAii | 6602 |
Pharosi | Q96GM5 |
PROi | PR:Q96GM5 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000066117 Expressed in 218 organ(s), highest expression level in left adrenal gland |
ExpressionAtlasi | Q96GM5 baseline and differential |
Genevisiblei | Q96GM5 HS |
Family and domain databases
Gene3Di | 1.10.245.10, 1 hit |
InterProi | View protein in InterPro IPR038041 SMARCD1 IPR019835 SWIB_domain IPR036885 SWIB_MDM2_dom_sf IPR003121 SWIB_MDM2_domain |
PANTHERi | PTHR13844:SF1 PTHR13844:SF1, 1 hit |
Pfami | View protein in Pfam PF02201 SWIB, 1 hit |
SMARTi | View protein in SMART SM00151 SWIB, 1 hit |
SUPFAMi | SSF47592 SSF47592, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SMRD1_HUMAN | |
Accessioni | Q96GM5Primary (citable) accession number: Q96GM5 Secondary accession number(s): A6NN27, Q92924, Q9Y635 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 17, 2003 |
Last sequence update: | May 26, 2009 | |
Last modified: | November 13, 2019 | |
This is version 174 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - SIMILARITY comments
Index of protein domains and families - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot