UniProtKB - Q96GM1 (PLPR2_HUMAN)
Protein
Phospholipid phosphatase-related protein type 2
Gene
PLPPR2
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
- EC:3.1.3.4
GO - Molecular functioni
- lipid phosphatase activity Source: GO_Central
- phosphatidate phosphatase activity Source: GO_Central
GO - Biological processi
- phospholipid dephosphorylation Source: GO_Central
- phospholipid metabolic process Source: GO_Central
- signal transduction Source: GO_Central
Keywordsi
Molecular function | Hydrolase |
Enzyme and pathway databases
BRENDAi | 3.1.3.4, 2681 |
PathwayCommonsi | Q96GM1 |
Reactomei | R-HSA-419408, Lysosphingolipid and LPA receptors |
Names & Taxonomyi
Protein namesi | Recommended name: Phospholipid phosphatase-related protein type 2Curated (EC:3.1.3.4)Alternative name(s): Lipid phosphate phosphatase-related protein type 21 Publication Plasticity-related gene 4 protein1 Publication Short name: PRG-41 Publication |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:29566, PLPPR2 |
neXtProti | NX_Q96GM1 |
VEuPathDBi | HostDB:ENSG00000105520.10 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 12 – 32 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 69 – 89 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 129 – 149 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 210 – 230 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 239 – 259 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 266 – 286 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 64748 |
OpenTargetsi | ENSG00000105520 |
Miscellaneous databases
Pharosi | Q96GM1, Tdark |
Genetic variation databases
BioMutai | PLPPR2 |
DMDMi | 74760839 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000317538 | 1 – 343 | Phospholipid phosphatase-related protein type 2Add BLAST | 343 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 165 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 299 | PhosphoserineBy similarity | 1 | |
Modified residuei | 312 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
MassIVEi | Q96GM1 |
PaxDbi | Q96GM1 |
PeptideAtlasi | Q96GM1 |
PRIDEi | Q96GM1 |
ProteomicsDBi | 76643 [Q96GM1-1] 76644 [Q96GM1-2] |
PTM databases
DEPODi | PLPPR2 |
GlyGeni | Q96GM1, 1 site |
iPTMneti | Q96GM1 |
PhosphoSitePlusi | Q96GM1 |
Expressioni
Gene expression databases
Bgeei | ENSG00000105520, Expressed in blood and 213 other tissues |
ExpressionAtlasi | Q96GM1, baseline and differential |
Genevisiblei | Q96GM1, HS |
Organism-specific databases
HPAi | ENSG00000105520, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ96GM1
Protein-protein interaction databases
BioGRIDi | 122264, 44 interactors |
IntActi | Q96GM1, 38 interactors |
STRINGi | 9606.ENSP00000466898 |
Miscellaneous databases
RNActi | Q96GM1, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the PA-phosphatase related phosphoesterase family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3030, Eukaryota |
GeneTreei | ENSGT00940000158145 |
HOGENOMi | CLU_021458_1_1_1 |
InParanoidi | Q96GM1 |
OMAi | CVINNFK |
OrthoDBi | 1621899at2759 |
PhylomeDBi | Q96GM1 |
Family and domain databases
InterProi | View protein in InterPro IPR028679, LPPR2 IPR036938, P_Acid_Pase_2/haloperoxi_sf IPR000326, P_Acid_Pase_2/haloperoxidase IPR043216, PLPP |
PANTHERi | PTHR10165, PTHR10165, 1 hit PTHR10165:SF15, PTHR10165:SF15, 1 hit |
Pfami | View protein in Pfam PF01569, PAP2, 1 hit |
SMARTi | View protein in SMART SM00014, acidPPc, 1 hit |
SUPFAMi | SSF48317, SSF48317, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q96GM1-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAGGRPHLKR SFSIIPCFVF VESVLLGIVI LLAYRLEFTD TFPVHTQGFF
60 70 80 90 100
CYDSTYAKPY PGPEAASRVP PALVYALVTA GPTLTILLGE LARAFFPAPP
110 120 130 140 150
SAVPVIGEST IVSGACCRFS PPVRRLVRFL GVYSFGLFTT TIFANAGQVV
160 170 180 190 200
TGNPTPHFLS VCRPNYTALG CLPPSPDRPG PDRFVTDQGA CAGSPSLVAA
210 220 230 240 250
ARRAFPCKDA ALCAYAVTYT AMYVTLVFRV KGSRLVKPSL CLALLCPAFL
260 270 280 290 300
VGVVRVAEYR NHWSDVLAGF LTGAAIATFL VTCVVHNFQS RPPSGRRLSP
310 320 330 340
WEDLGQAPTM DSPLEKNPRS AGRIRHRHGS PHPSRRTAPA VAT
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketK7EQF7 | K7EQF7_HUMAN | Phospholipid phosphatase-related pr... | PLPPR2 | 84 | Annotation score: | ||
K7EMX8 | K7EMX8_HUMAN | Phospholipid phosphatase-related pr... | PLPPR2 | 66 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 42 | F → L in BAB14414 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 259 | Y → H in BAC04443 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_038546 | 155 | T → M in a colorectal cancer sample; somatic mutation. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_031010 | 23 – 47 | Missing in isoform 2. 2 PublicationsAdd BLAST | 25 | |
Alternative sequenceiVSP_031011 | 317 – 343 | NPRSA…PAVAT → LSVAQEPEVCRPHSTPARLT PSKSQNCARRGHLIPSCVSS RAPAMCSSPRVPRPRLRSEP TPLPLPLPLPAPTPSQGPSP SSPGPGGPGGGGGRGRKLLL PTPLLRDLYTLSGLYPSPFH RDNFSPYLFASRDHLL in isoform 2. 2 PublicationsAdd BLAST | 27 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY339628 mRNA Translation: AAQ73540.1 AY304516 mRNA Translation: AAP72153.1 AK094869 mRNA Translation: BAC04443.1 AK023117 mRNA Translation: BAB14414.1 CH471106 Genomic DNA Translation: EAW84200.1 BC009378 mRNA Translation: AAH09378.1 CR936652 Transcribed RNA Translation: CAI56790.1 |
CCDSi | CCDS12258.1 [Q96GM1-1] CCDS59352.1 [Q96GM1-2] |
RefSeqi | NP_001164106.1, NM_001170635.1 [Q96GM1-2] NP_073574.2, NM_022737.2 [Q96GM1-1] XP_016882637.1, XM_017027148.1 [Q96GM1-2] |
Genome annotation databases
Ensembli | ENST00000251473; ENSP00000251473; ENSG00000105520 [Q96GM1-1] ENST00000591608; ENSP00000466898; ENSG00000105520 [Q96GM1-2] |
GeneIDi | 64748 |
KEGGi | hsa:64748 |
UCSCi | uc002mre.2, human [Q96GM1-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY339628 mRNA Translation: AAQ73540.1 AY304516 mRNA Translation: AAP72153.1 AK094869 mRNA Translation: BAC04443.1 AK023117 mRNA Translation: BAB14414.1 CH471106 Genomic DNA Translation: EAW84200.1 BC009378 mRNA Translation: AAH09378.1 CR936652 Transcribed RNA Translation: CAI56790.1 |
CCDSi | CCDS12258.1 [Q96GM1-1] CCDS59352.1 [Q96GM1-2] |
RefSeqi | NP_001164106.1, NM_001170635.1 [Q96GM1-2] NP_073574.2, NM_022737.2 [Q96GM1-1] XP_016882637.1, XM_017027148.1 [Q96GM1-2] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 122264, 44 interactors |
IntActi | Q96GM1, 38 interactors |
STRINGi | 9606.ENSP00000466898 |
PTM databases
DEPODi | PLPPR2 |
GlyGeni | Q96GM1, 1 site |
iPTMneti | Q96GM1 |
PhosphoSitePlusi | Q96GM1 |
Genetic variation databases
BioMutai | PLPPR2 |
DMDMi | 74760839 |
Proteomic databases
MassIVEi | Q96GM1 |
PaxDbi | Q96GM1 |
PeptideAtlasi | Q96GM1 |
PRIDEi | Q96GM1 |
ProteomicsDBi | 76643 [Q96GM1-1] 76644 [Q96GM1-2] |
Protocols and materials databases
Antibodypediai | 25796, 93 antibodies |
DNASUi | 64748 |
Genome annotation databases
Ensembli | ENST00000251473; ENSP00000251473; ENSG00000105520 [Q96GM1-1] ENST00000591608; ENSP00000466898; ENSG00000105520 [Q96GM1-2] |
GeneIDi | 64748 |
KEGGi | hsa:64748 |
UCSCi | uc002mre.2, human [Q96GM1-1] |
Organism-specific databases
CTDi | 64748 |
DisGeNETi | 64748 |
GeneCardsi | PLPPR2 |
HGNCi | HGNC:29566, PLPPR2 |
HPAi | ENSG00000105520, Low tissue specificity |
neXtProti | NX_Q96GM1 |
OpenTargetsi | ENSG00000105520 |
VEuPathDBi | HostDB:ENSG00000105520.10 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3030, Eukaryota |
GeneTreei | ENSGT00940000158145 |
HOGENOMi | CLU_021458_1_1_1 |
InParanoidi | Q96GM1 |
OMAi | CVINNFK |
OrthoDBi | 1621899at2759 |
PhylomeDBi | Q96GM1 |
Enzyme and pathway databases
BRENDAi | 3.1.3.4, 2681 |
PathwayCommonsi | Q96GM1 |
Reactomei | R-HSA-419408, Lysosphingolipid and LPA receptors |
Miscellaneous databases
BioGRID-ORCSi | 64748, 3 hits in 887 CRISPR screens |
ChiTaRSi | PLPPR2, human |
GenomeRNAii | 64748 |
Pharosi | Q96GM1, Tdark |
PROi | PR:Q96GM1 |
RNActi | Q96GM1, protein |
Gene expression databases
Bgeei | ENSG00000105520, Expressed in blood and 213 other tissues |
ExpressionAtlasi | Q96GM1, baseline and differential |
Genevisiblei | Q96GM1, HS |
Family and domain databases
InterProi | View protein in InterPro IPR028679, LPPR2 IPR036938, P_Acid_Pase_2/haloperoxi_sf IPR000326, P_Acid_Pase_2/haloperoxidase IPR043216, PLPP |
PANTHERi | PTHR10165, PTHR10165, 1 hit PTHR10165:SF15, PTHR10165:SF15, 1 hit |
Pfami | View protein in Pfam PF01569, PAP2, 1 hit |
SMARTi | View protein in SMART SM00014, acidPPc, 1 hit |
SUPFAMi | SSF48317, SSF48317, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PLPR2_HUMAN | |
Accessioni | Q96GM1Primary (citable) accession number: Q96GM1 Secondary accession number(s): Q5CZ76, Q8N1U4, Q9H929 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 5, 2008 |
Last sequence update: | December 1, 2001 | |
Last modified: | April 7, 2021 | |
This is version 139 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families