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Protein

Phospholipid phosphatase-related protein type 2

Gene

PLPPR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

A 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate.

GO - Molecular functioni

  • lipid phosphatase activity Source: GO_Central
  • phosphatase activity Source: GO_Central
  • phosphatidate phosphatase activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

BRENDAi3.1.3.4 2681
ReactomeiR-HSA-419408 Lysosphingolipid and LPA receptors

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipid phosphatase-related protein type 2Curated (EC:3.1.3.4)
Alternative name(s):
Lipid phosphate phosphatase-related protein type 21 Publication
Plasticity-related gene 4 protein1 Publication
Short name:
PRG-41 Publication
Gene namesi
Name:PLPPR2Imported
Synonyms:LPPR21 Publication, PRG4By similarity
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000105520.10
HGNCiHGNC:29566 PLPPR2
neXtProtiNX_Q96GM1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei12 – 32HelicalSequence analysisAdd BLAST21
Transmembranei69 – 89HelicalSequence analysisAdd BLAST21
Transmembranei129 – 149HelicalSequence analysisAdd BLAST21
Transmembranei210 – 230HelicalSequence analysisAdd BLAST21
Transmembranei239 – 259HelicalSequence analysisAdd BLAST21
Transmembranei266 – 286HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000105520

Polymorphism and mutation databases

BioMutaiLPPR2
DMDMi74760839

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003175381 – 343Phospholipid phosphatase-related protein type 2Add BLAST343

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi165N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei299PhosphoserineBy similarity1
Modified residuei312PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ96GM1
PeptideAtlasiQ96GM1
PRIDEiQ96GM1
ProteomicsDBi76643
76644 [Q96GM1-2]

PTM databases

DEPODiQ96GM1
iPTMnetiQ96GM1
PhosphoSitePlusiQ96GM1

Expressioni

Gene expression databases

BgeeiENSG00000105520 Expressed in 200 organ(s), highest expression level in blood
CleanExiHS_PRG4
ExpressionAtlasiQ96GM1 baseline and differential
GenevisibleiQ96GM1 HS

Organism-specific databases

HPAiHPA048973

Interactioni

Protein-protein interaction databases

BioGridi122264, 23 interactors
IntActiQ96GM1, 19 interactors
STRINGi9606.ENSP00000251473

Structurei

3D structure databases

ProteinModelPortaliQ96GM1
SMRiQ96GM1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3030 Eukaryota
COG0671 LUCA
GeneTreeiENSGT00620000087654
HOGENOMiHOG000286008
HOVERGENiHBG108093
InParanoidiQ96GM1
KOiK19581
OMAiTALGCQP
PhylomeDBiQ96GM1

Family and domain databases

InterProiView protein in InterPro
IPR028679 LPPR2
IPR036938 P_Acid_Pase_2/haloperoxi_sf
IPR000326 P_Acid_Pase_2/haloperoxidase
PANTHERiPTHR10165:SF15 PTHR10165:SF15, 1 hit
PfamiView protein in Pfam
PF01569 PAP2, 1 hit
SMARTiView protein in SMART
SM00014 acidPPc, 1 hit
SUPFAMiSSF48317 SSF48317, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96GM1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGGRPHLKR SFSIIPCFVF VESVLLGIVI LLAYRLEFTD TFPVHTQGFF
60 70 80 90 100
CYDSTYAKPY PGPEAASRVP PALVYALVTA GPTLTILLGE LARAFFPAPP
110 120 130 140 150
SAVPVIGEST IVSGACCRFS PPVRRLVRFL GVYSFGLFTT TIFANAGQVV
160 170 180 190 200
TGNPTPHFLS VCRPNYTALG CLPPSPDRPG PDRFVTDQGA CAGSPSLVAA
210 220 230 240 250
ARRAFPCKDA ALCAYAVTYT AMYVTLVFRV KGSRLVKPSL CLALLCPAFL
260 270 280 290 300
VGVVRVAEYR NHWSDVLAGF LTGAAIATFL VTCVVHNFQS RPPSGRRLSP
310 320 330 340
WEDLGQAPTM DSPLEKNPRS AGRIRHRHGS PHPSRRTAPA VAT
Length:343
Mass (Da):36,880
Last modified:December 1, 2001 - v1
Checksum:iCB46CE2FA8503E4E
GO
Isoform 2 (identifier: Q96GM1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     23-47: Missing.
     317-343: NPRSAGRIRHRHGSPHPSRRTAPAVAT → LSVAQEPEVC...YLFASRDHLL

Show »
Length:427
Mass (Da):45,576
Checksum:i3F8A866AD7A572B4
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EQF7K7EQF7_HUMAN
Phospholipid phosphatase-related pr...
PLPPR2
84Annotation score:
K7EMX8K7EMX8_HUMAN
Phospholipid phosphatase-related pr...
PLPPR2
66Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti42F → L in BAB14414 (PubMed:14702039).Curated1
Sequence conflicti259Y → H in BAC04443 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_038546155T → M in a colorectal cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03101023 – 47Missing in isoform 2. 2 PublicationsAdd BLAST25
Alternative sequenceiVSP_031011317 – 343NPRSA…PAVAT → LSVAQEPEVCRPHSTPARLT PSKSQNCARRGHLIPSCVSS RAPAMCSSPRVPRPRLRSEP TPLPLPLPLPAPTPSQGPSP SSPGPGGPGGGGGRGRKLLL PTPLLRDLYTLSGLYPSPFH RDNFSPYLFASRDHLL in isoform 2. 2 PublicationsAdd BLAST27

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY339628 mRNA Translation: AAQ73540.1
AY304516 mRNA Translation: AAP72153.1
AK094869 mRNA Translation: BAC04443.1
AK023117 mRNA Translation: BAB14414.1
CH471106 Genomic DNA Translation: EAW84200.1
BC009378 mRNA Translation: AAH09378.1
CR936652 Transcribed RNA Translation: CAI56790.1
CCDSiCCDS12258.1 [Q96GM1-1]
CCDS59352.1 [Q96GM1-2]
RefSeqiNP_001164106.1, NM_001170635.1 [Q96GM1-2]
NP_073574.2, NM_022737.2 [Q96GM1-1]
XP_016882637.1, XM_017027148.1 [Q96GM1-2]
UniGeneiHs.6846

Genome annotation databases

EnsembliENST00000251473; ENSP00000251473; ENSG00000105520 [Q96GM1-1]
ENST00000591608; ENSP00000466898; ENSG00000105520 [Q96GM1-2]
GeneIDi64748
KEGGihsa:64748
UCSCiuc002mre.2 human [Q96GM1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY339628 mRNA Translation: AAQ73540.1
AY304516 mRNA Translation: AAP72153.1
AK094869 mRNA Translation: BAC04443.1
AK023117 mRNA Translation: BAB14414.1
CH471106 Genomic DNA Translation: EAW84200.1
BC009378 mRNA Translation: AAH09378.1
CR936652 Transcribed RNA Translation: CAI56790.1
CCDSiCCDS12258.1 [Q96GM1-1]
CCDS59352.1 [Q96GM1-2]
RefSeqiNP_001164106.1, NM_001170635.1 [Q96GM1-2]
NP_073574.2, NM_022737.2 [Q96GM1-1]
XP_016882637.1, XM_017027148.1 [Q96GM1-2]
UniGeneiHs.6846

3D structure databases

ProteinModelPortaliQ96GM1
SMRiQ96GM1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122264, 23 interactors
IntActiQ96GM1, 19 interactors
STRINGi9606.ENSP00000251473

PTM databases

DEPODiQ96GM1
iPTMnetiQ96GM1
PhosphoSitePlusiQ96GM1

Polymorphism and mutation databases

BioMutaiLPPR2
DMDMi74760839

Proteomic databases

PaxDbiQ96GM1
PeptideAtlasiQ96GM1
PRIDEiQ96GM1
ProteomicsDBi76643
76644 [Q96GM1-2]

Protocols and materials databases

DNASUi64748
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000251473; ENSP00000251473; ENSG00000105520 [Q96GM1-1]
ENST00000591608; ENSP00000466898; ENSG00000105520 [Q96GM1-2]
GeneIDi64748
KEGGihsa:64748
UCSCiuc002mre.2 human [Q96GM1-1]

Organism-specific databases

CTDi64748
EuPathDBiHostDB:ENSG00000105520.10
GeneCardsiPLPPR2
HGNCiHGNC:29566 PLPPR2
HPAiHPA048973
neXtProtiNX_Q96GM1
OpenTargetsiENSG00000105520
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3030 Eukaryota
COG0671 LUCA
GeneTreeiENSGT00620000087654
HOGENOMiHOG000286008
HOVERGENiHBG108093
InParanoidiQ96GM1
KOiK19581
OMAiTALGCQP
PhylomeDBiQ96GM1

Enzyme and pathway databases

BRENDAi3.1.3.4 2681
ReactomeiR-HSA-419408 Lysosphingolipid and LPA receptors

Miscellaneous databases

ChiTaRSiPLPPR2 human
GenomeRNAii64748
PROiPR:Q96GM1

Gene expression databases

BgeeiENSG00000105520 Expressed in 200 organ(s), highest expression level in blood
CleanExiHS_PRG4
ExpressionAtlasiQ96GM1 baseline and differential
GenevisibleiQ96GM1 HS

Family and domain databases

InterProiView protein in InterPro
IPR028679 LPPR2
IPR036938 P_Acid_Pase_2/haloperoxi_sf
IPR000326 P_Acid_Pase_2/haloperoxidase
PANTHERiPTHR10165:SF15 PTHR10165:SF15, 1 hit
PfamiView protein in Pfam
PF01569 PAP2, 1 hit
SMARTiView protein in SMART
SM00014 acidPPc, 1 hit
SUPFAMiSSF48317 SSF48317, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPLPR2_HUMAN
AccessioniPrimary (citable) accession number: Q96GM1
Secondary accession number(s): Q5CZ76, Q8N1U4, Q9H929
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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