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UniProtKB - Q96GL9 (F163A_HUMAN)

Entry version 121 (07 Oct 2020)
Sequence version 1 (01 Dec 2001)
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Protein

Protein FAM163A

Gene

FAM163A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q96GL9

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein FAM163A
Alternative name(s):
Cebelin
Neuroblastoma-derived secretory protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FAM163A
Synonyms:C1orf76, NDSP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000143340.6

Human Gene Nomenclature Database

More...HGNCi		HGNC:28274, FAM163A

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		611727, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q96GL9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei6 – 26HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		148753

Open Targets

More...OpenTargetsi		ENSG00000143340

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162386944

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q96GL9, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		FAM163A

Domain mapping of disease mutations (DMDM)

More...DMDMi		74751887

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002802561 – 167Protein FAM163AAdd BLAST167

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q96GL9

PeptideAtlas

More...PeptideAtlasi		Q96GL9

PRoteomics IDEntifications database

More...PRIDEi		Q96GL9

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		76642

Consortium for Top Down Proteomics

More...TopDownProteomicsi		Q96GL9

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q96GL9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q96GL9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in neuroblastoma compared to other tissues, suggesting that it may be used as a marker for metastasis in bone marrow.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000143340, Expressed in sperm and 103 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q96GL9, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000143340, Tissue enhanced (brain, lymphoid tissue, pituitary gland)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		127166, 12 interactors

Protein interaction database and analysis system

More...IntActi		Q96GL9, 10 interactors

Molecular INTeraction database

More...MINTi		Q96GL9

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000354891

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q96GL9, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FAM163 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502S10V, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159228

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_138617_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q96GL9

Identification of Orthologs from Complete Genome Data

More...OMAi		TYMPTHY

Database of Orthologous Groups

More...OrthoDBi		1417278at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q96GL9

TreeFam database of animal gene trees

More...TreeFami		TF333084

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR029379, FAM163
IPR040281, FAM163A

The PANTHER Classification System

More...PANTHERi		PTHR31914, PTHR31914, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF15069, FAM163, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q96GL9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTAGTVVITG GILATVILLC IIAVLCYCRL QYYCCKKSGT EVADEEEERE 
        60         70         80         90        100
HDLPTHPRGP TCNACSSQAL DGRGSLAPLT SEPCSQPCGV AASHCTTCSP 
       110        120        130        140        150
YSSPFYIRTA DMVPNGGGGE RLSFAPTYYK EGGPPSLKLA APQSYPVTWP 
       160 
GSGREAFTNP RAISTDV
Length:167
Mass (Da):17,641
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8BF4D4A6C59046F9
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY902195 mRNA Translation: AAX07133.1
AB299025 mRNA Translation: BAF96730.1
AK292432 mRNA Translation: BAF85121.1
AK313887 mRNA Translation: BAG36612.1
AL359853 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW91055.1
BC009382 mRNA Translation: AAH09382.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS1333.1

NCBI Reference Sequences

More...RefSeqi		NP_001316641.1, NM_001329712.1
NP_001316642.1, NM_001329713.1
NP_001316643.1, NM_001329714.1
NP_001316644.1, NM_001329715.1
NP_001316645.1, NM_001329716.1
NP_001316646.1, NM_001329717.1
NP_001316647.1, NM_001329718.1
NP_001316648.1, NM_001329719.1
NP_775780.1, NM_173509.2
XP_006711237.1, XM_006711174.2
XP_006711238.1, XM_006711175.2
XP_006711240.1, XM_006711177.1
XP_011507519.1, XM_011509217.1
XP_016855875.1, XM_017000386.1
XP_016855876.1, XM_017000387.1
XP_016855877.1, XM_017000388.1
XP_016855878.1, XM_017000389.1
XP_016855879.1, XM_017000390.1
XP_016855880.1, XM_017000391.1
XP_016855881.1, XM_017000392.1
XP_016855882.1, XM_017000393.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000341785; ENSP00000354891; ENSG00000143340

Database of genes from NCBI RefSeq genomes

More...GeneIDi		148753

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:148753

UCSC genome browser

More...UCSCi		uc001gnj.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY902195 mRNA Translation: AAX07133.1
AB299025 mRNA Translation: BAF96730.1
AK292432 mRNA Translation: BAF85121.1
AK313887 mRNA Translation: BAG36612.1
AL359853 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW91055.1
BC009382 mRNA Translation: AAH09382.1
CCDSiCCDS1333.1
RefSeqiNP_001316641.1, NM_001329712.1
NP_001316642.1, NM_001329713.1
NP_001316643.1, NM_001329714.1
NP_001316644.1, NM_001329715.1
NP_001316645.1, NM_001329716.1
NP_001316646.1, NM_001329717.1
NP_001316647.1, NM_001329718.1
NP_001316648.1, NM_001329719.1
NP_775780.1, NM_173509.2
XP_006711237.1, XM_006711174.2
XP_006711238.1, XM_006711175.2
XP_006711240.1, XM_006711177.1
XP_011507519.1, XM_011509217.1
XP_016855875.1, XM_017000386.1
XP_016855876.1, XM_017000387.1
XP_016855877.1, XM_017000388.1
XP_016855878.1, XM_017000389.1
XP_016855879.1, XM_017000390.1
XP_016855880.1, XM_017000391.1
XP_016855881.1, XM_017000392.1
XP_016855882.1, XM_017000393.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi127166, 12 interactors
IntActiQ96GL9, 10 interactors
MINTiQ96GL9
STRINGi9606.ENSP00000354891

PTM databases

iPTMnetiQ96GL9
PhosphoSitePlusiQ96GL9

Polymorphism and mutation databases

BioMutaiFAM163A
DMDMi74751887

Proteomic databases

PaxDbiQ96GL9
PeptideAtlasiQ96GL9
PRIDEiQ96GL9
ProteomicsDBi76642
TopDownProteomicsiQ96GL9

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		2490, 104 antibodies

The DNASU plasmid repository

More...DNASUi		148753

Genome annotation databases

EnsembliENST00000341785; ENSP00000354891; ENSG00000143340
GeneIDi148753
KEGGihsa:148753
UCSCiuc001gnj.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		148753
DisGeNETi148753
EuPathDBiHostDB:ENSG00000143340.6

GeneCards: human genes, protein and diseases

More...GeneCardsi		FAM163A
HGNCiHGNC:28274, FAM163A
HPAiENSG00000143340, Tissue enhanced (brain, lymphoid tissue, pituitary gland)
MIMi611727, gene
neXtProtiNX_Q96GL9
OpenTargetsiENSG00000143340
PharmGKBiPA162386944

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502S10V, Eukaryota
GeneTreeiENSGT00940000159228
HOGENOMiCLU_138617_0_0_1
InParanoidiQ96GL9
OMAiTYMPTHY
OrthoDBi1417278at2759
PhylomeDBiQ96GL9
TreeFamiTF333084

Enzyme and pathway databases

PathwayCommonsiQ96GL9

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		148753, 6 hits in 869 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		FAM163A, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		148753
PharosiQ96GL9, Tdark

Protein Ontology

More...PROi		PR:Q96GL9
RNActiQ96GL9, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000143340, Expressed in sperm and 103 other tissues
GenevisibleiQ96GL9, HS

Family and domain databases

InterProiView protein in InterPro
IPR029379, FAM163
IPR040281, FAM163A
PANTHERiPTHR31914, PTHR31914, 1 hit
PfamiView protein in Pfam
PF15069, FAM163, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF163A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96GL9
Secondary accession number(s): A8K8R7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: December 1, 2001
Last modified: October 7, 2020
This is version 121 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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