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Entry version 119 (12 Aug 2020)
Sequence version 1 (01 Dec 2001)
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Protein

Protein FAM89A

Gene

FAM89A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
Q96GI7

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein FAM89A
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FAM89A
Synonyms:C1orf153
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000182118.5

Human Gene Nomenclature Database

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HGNCi
HGNC:25057, FAM89A

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96GI7

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
375061

Open Targets

More...
OpenTargetsi
ENSG00000182118

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA142671794

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
Q96GI7, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
FAM89A

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002717611 – 184Protein FAM89AAdd BLAST184

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q96GI7

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q96GI7

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q96GI7

MaxQB - The MaxQuant DataBase

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MaxQBi
Q96GI7

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q96GI7

PeptideAtlas

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PeptideAtlasi
Q96GI7

PRoteomics IDEntifications database

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PRIDEi
Q96GI7

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
76636

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q96GI7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q96GI7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000182118, Expressed in placenta and 114 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q96GI7, HS

Organism-specific databases

Human Protein Atlas

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HPAi
ENSG00000182118, Tissue enhanced (adipose tissue, placenta)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
131954, 1 interactor

Protein interaction database and analysis system

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IntActi
Q96GI7, 1 interactor

STRING: functional protein association networks

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STRINGi
9606.ENSP00000355614

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
Q96GI7, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FAM89 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG502S28T, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000153370

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_128818_1_1_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q96GI7

Identification of Orthologs from Complete Genome Data

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OMAi
DSWDSFH

Database of Orthologous Groups

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OrthoDBi
1585340at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q96GI7

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q96GI7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGARAAPGA AGNGAVRGLR VDGLPPLPKS LSGLLHSASG GGASGGWRHL
60 70 80 90 100
ERLYAQKSRI QDELSRGGPG GGGARAAALP AKPPNLDAAL ALLRKEMVGL
110 120 130 140 150
RQLDMSLLCQ LYSLYESIQE YKGACQAASS PDCTYALENG FFDEEEEYFQ
160 170 180
EQNSLHDRRD RGPPRDLSLP VSSLSSSDWI LESI
Length:184
Mass (Da):19,569
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE727C153156C0004
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AL732414 Genomic DNA No translation available.
BC009447 mRNA Translation: AAH09447.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS1590.1

NCBI Reference Sequences

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RefSeqi
NP_940954.1, NM_198552.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000366654; ENSP00000355614; ENSG00000182118

Database of genes from NCBI RefSeq genomes

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GeneIDi
375061

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:375061

UCSC genome browser

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UCSCi
uc001hui.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL732414 Genomic DNA No translation available.
BC009447 mRNA Translation: AAH09447.1
CCDSiCCDS1590.1
RefSeqiNP_940954.1, NM_198552.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi131954, 1 interactor
IntActiQ96GI7, 1 interactor
STRINGi9606.ENSP00000355614

PTM databases

iPTMnetiQ96GI7
PhosphoSitePlusiQ96GI7

Polymorphism and mutation databases

BioMutaiFAM89A

Proteomic databases

EPDiQ96GI7
jPOSTiQ96GI7
MassIVEiQ96GI7
MaxQBiQ96GI7
PaxDbiQ96GI7
PeptideAtlasiQ96GI7
PRIDEiQ96GI7
ProteomicsDBi76636

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
68454, 8 antibodies

Genome annotation databases

EnsembliENST00000366654; ENSP00000355614; ENSG00000182118
GeneIDi375061
KEGGihsa:375061
UCSCiuc001hui.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
375061
DisGeNETi375061
EuPathDBiHostDB:ENSG00000182118.5

GeneCards: human genes, protein and diseases

More...
GeneCardsi
FAM89A
HGNCiHGNC:25057, FAM89A
HPAiENSG00000182118, Tissue enhanced (adipose tissue, placenta)
neXtProtiNX_Q96GI7
OpenTargetsiENSG00000182118
PharmGKBiPA142671794

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502S28T, Eukaryota
GeneTreeiENSGT00940000153370
HOGENOMiCLU_128818_1_1_1
InParanoidiQ96GI7
OMAiDSWDSFH
OrthoDBi1585340at2759
PhylomeDBiQ96GI7

Enzyme and pathway databases

PathwayCommonsiQ96GI7

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
375061, 1 hit in 874 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
FAM89A, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
375061
PharosiQ96GI7, Tdark

Protein Ontology

More...
PROi
PR:Q96GI7
RNActiQ96GI7, protein

Gene expression databases

BgeeiENSG00000182118, Expressed in placenta and 114 other tissues
GenevisibleiQ96GI7, HS

Family and domain databases

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFA89A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96GI7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: December 1, 2001
Last modified: August 12, 2020
This is version 119 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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