UniProtKB - Q96GE4 (CEP95_HUMAN)
Protein
Centrosomal protein of 95 kDa
Gene
CEP95
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Centrosomal protein of 95 kDaShort name: Cep95 Alternative name(s): Coiled-coil domain-containing protein 45 |
Gene namesi | Name:CEP95 Synonyms:CCDC45, CEP45 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000258890.6 |
HGNCi | HGNC:25141, CEP95 |
neXtProti | NX_Q96GE4 |
Subcellular locationi
Cytoskeleton
- centrosome 2 Publications
- spindle pole 1 Publication
Cytoskeleton
- centrosome Source: UniProtKB
- spindle pole Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB-KW
Keywords - Cellular componenti
Cytoplasm, CytoskeletonPathology & Biotechi
Organism-specific databases
DisGeNETi | 90799 |
OpenTargetsi | ENSG00000258890 |
PharmGKBi | PA142672162 |
Miscellaneous databases
Pharosi | Q96GE4, Tdark |
Polymorphism and mutation databases
BioMutai | CEP95 |
DMDMi | 74751882 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000234505 | 1 – 821 | Centrosomal protein of 95 kDaAdd BLAST | 821 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 449 | PhosphoserineCombined sources | 1 | |
Modified residuei | 451 | PhosphoserineCombined sources | 1 | |
Modified residuei | 453 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q96GE4 |
jPOSTi | Q96GE4 |
MassIVEi | Q96GE4 |
MaxQBi | Q96GE4 |
PaxDbi | Q96GE4 |
PeptideAtlasi | Q96GE4 |
PRIDEi | Q96GE4 |
ProteomicsDBi | 4597 76624 [Q96GE4-1] |
PTM databases
iPTMneti | Q96GE4 |
PhosphoSitePlusi | Q96GE4 |
Expressioni
Gene expression databases
Bgeei | ENSG00000258890, Expressed in left lobe of thyroid gland and 208 other tissues |
ExpressionAtlasi | Q96GE4, baseline and differential |
Genevisiblei | Q96GE4, HS |
Organism-specific databases
HPAi | ENSG00000258890, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ96GE4
Protein-protein interaction databases
BioGRIDi | 124762, 35 interactors |
IntActi | Q96GE4, 33 interactors |
STRINGi | 9606.ENSP00000450461 |
Miscellaneous databases
RNActi | Q96GE4, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 585 – 632 | Sequence analysisAdd BLAST | 48 | |
Coiled coili | 700 – 794 | Sequence analysisAdd BLAST | 95 |
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502QTFE, Eukaryota |
GeneTreei | ENSGT00390000005412 |
HOGENOMi | CLU_018428_1_0_1 |
InParanoidi | Q96GE4 |
OMAi | KHSQPWK |
OrthoDBi | 1353802at2759 |
PhylomeDBi | Q96GE4 |
TreeFami | TF333224 |
Family and domain databases
Gene3Di | 1.10.418.10, 1 hit |
InterProi | View protein in InterPro IPR026619, CEP95 IPR036872, CH_dom_sf IPR044039, DUF5745 |
PANTHERi | PTHR22545, PTHR22545, 1 hit |
Pfami | View protein in Pfam PF19016, DUF5745, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q96GE4-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAGSDAEWVT IANNLLFKCH IHLRIHELQD CDANVFIALY QSILGEKVPD
60 70 80 90 100
LIVIPRSQED DAHNVQAVID SLALDYLQVS LSHITGENIV KGDKESIKNL
110 120 130 140 150
LEIFDGLLEY LTERISETSH EKSETEQYFK ESDRGERLEE PESTKESKSS
160 170 180 190 200
WKRVSFGRCS LSSEMLGPSW DGDEAESTGE IIRLGDTAHT FSLRSNGAQC
210 220 230 240 250
PNEMLSKKAL ASPSSKSHED MLYPPSVLSK SRTSFVEDTE TLSVSGIPNA
260 270 280 290 300
RKLGEPIRAA IPLHPPYHPS EPRAPCPIGK EYLHSSHCSP AVNSTGEHTE
310 320 330 340 350
FSGDLDDGLF LISKLPKGSK WEVYPAQVQG PRTRKPPKGK RNENRATASS
360 370 380 390 400
CNSPFPQRPR KRLTEQELHD VSEKLSQRLS ELDWMLKSAL GDRIKEKTDH
410 420 430 440 450
KEENTGNEEV EDGTEETLSQ HSDGIVEYGP KKSRPGLSMR RKPPYRSHSL
460 470 480 490 500
SPSPVNKHKQ FHLERKRQRK PRETDVRQFQ AQAFTEAFER ELRRHKVQEN
510 520 530 540 550
IGPLRIHEKE EETEKIYRGE AVRKGTPECS QPWKIYSRKT TTQSLRGGLP
560 570 580 590 600
KPNKAVPMKV SEHSLLPLML EQFPFLYVSG PTLSKMWKQQ IAQVEQLKKE
610 620 630 640 650
ACRENRSKKK LQDEIEEALR RHDLLTTLVK KEYEHNKRLQ DFKDCIRRQR
660 670 680 690 700
LTQSKIKENR QQIVRARKYY DDYRVQLCAK MMRMRTREEM IFKKLFEEGL
710 720 730 740 750
NIQKQRLRDL RNYAKEKRDE QRRRHQDELD SMENYYKDQF SLLAEAISQE
760 770 780 790 800
HQELKAREKS QAQTLHKVKR ELRSKMEKEI QQLQDMITQN DDDVFFRELE
810 820
AERFRSRLQL ASFQYSKSPS L
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0A0MTQ1 | A0A0A0MTQ1_HUMAN | Centrosomal protein of 95 kDa | CEP95 | 756 | Annotation score: | ||
J3KRW3 | J3KRW3_HUMAN | Centrosomal protein of 95 kDa | CEP95 | 156 | Annotation score: | ||
J3KRC3 | J3KRC3_HUMAN | Centrosomal protein of 95 kDa | CEP95 | 135 | Annotation score: | ||
J3KS50 | J3KS50_HUMAN | Centrosomal protein of 95 kDa | CEP95 | 102 | Annotation score: | ||
K7ENV0 | K7ENV0_HUMAN | Centrosomal protein of 95 kDa | CEP95 | 56 | Annotation score: | ||
B7ZAE2 | B7ZAE2_HUMAN | Centrosomal protein of 95 kDa | CEP95 | 157 | Annotation score: | ||
H0YJW6 | H0YJW6_HUMAN | Centrosomal protein of 95 kDa | CEP95 | 99 | Annotation score: | ||
J3QLG4 | J3QLG4_HUMAN | Centrosomal protein of 95 kDa | CEP95 | 71 | Annotation score: | ||
J3KST6 | J3KST6_HUMAN | Centrosomal protein of 95 kDa | CEP95 | 74 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_033666 | 165 | M → I. Corresponds to variant dbSNP:rs9910506Ensembl. | 1 | |
Natural variantiVAR_050751 | 811 | A → V. Corresponds to variant dbSNP:rs11550922Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056356 | 1 – 164 | Missing in isoform 2. 1 PublicationAdd BLAST | 164 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK057326 mRNA Translation: BAB71428.1 AK297409 mRNA Translation: BAG59844.1 AC009994 Genomic DNA No translation available. BC009518 mRNA Translation: AAH09518.1 |
CCDSi | CCDS45763.1 [Q96GE4-1] |
RefSeqi | NP_001303919.1, NM_001316990.1 [Q96GE4-2] NP_612372.1, NM_138363.2 [Q96GE4-1] |
Genome annotation databases
Ensembli | ENST00000556440; ENSP00000450461; ENSG00000258890 [Q96GE4-1] |
GeneIDi | 90799 |
KEGGi | hsa:90799 |
UCSCi | uc002jem.4, human [Q96GE4-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK057326 mRNA Translation: BAB71428.1 AK297409 mRNA Translation: BAG59844.1 AC009994 Genomic DNA No translation available. BC009518 mRNA Translation: AAH09518.1 |
CCDSi | CCDS45763.1 [Q96GE4-1] |
RefSeqi | NP_001303919.1, NM_001316990.1 [Q96GE4-2] NP_612372.1, NM_138363.2 [Q96GE4-1] |
3D structure databases
SMRi | Q96GE4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 124762, 35 interactors |
IntActi | Q96GE4, 33 interactors |
STRINGi | 9606.ENSP00000450461 |
PTM databases
iPTMneti | Q96GE4 |
PhosphoSitePlusi | Q96GE4 |
Polymorphism and mutation databases
BioMutai | CEP95 |
DMDMi | 74751882 |
Proteomic databases
EPDi | Q96GE4 |
jPOSTi | Q96GE4 |
MassIVEi | Q96GE4 |
MaxQBi | Q96GE4 |
PaxDbi | Q96GE4 |
PeptideAtlasi | Q96GE4 |
PRIDEi | Q96GE4 |
ProteomicsDBi | 4597 76624 [Q96GE4-1] |
Protocols and materials databases
Antibodypediai | 67088, 75 antibodies |
Genome annotation databases
Ensembli | ENST00000556440; ENSP00000450461; ENSG00000258890 [Q96GE4-1] |
GeneIDi | 90799 |
KEGGi | hsa:90799 |
UCSCi | uc002jem.4, human [Q96GE4-1] |
Organism-specific databases
CTDi | 90799 |
DisGeNETi | 90799 |
EuPathDBi | HostDB:ENSG00000258890.6 |
GeneCardsi | CEP95 |
HGNCi | HGNC:25141, CEP95 |
HPAi | ENSG00000258890, Low tissue specificity |
neXtProti | NX_Q96GE4 |
OpenTargetsi | ENSG00000258890 |
PharmGKBi | PA142672162 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QTFE, Eukaryota |
GeneTreei | ENSGT00390000005412 |
HOGENOMi | CLU_018428_1_0_1 |
InParanoidi | Q96GE4 |
OMAi | KHSQPWK |
OrthoDBi | 1353802at2759 |
PhylomeDBi | Q96GE4 |
TreeFami | TF333224 |
Enzyme and pathway databases
PathwayCommonsi | Q96GE4 |
Miscellaneous databases
BioGRID-ORCSi | 90799, 6 hits in 843 CRISPR screens |
ChiTaRSi | CEP95, human |
GenomeRNAii | 90799 |
Pharosi | Q96GE4, Tdark |
PROi | PR:Q96GE4 |
RNActi | Q96GE4, protein |
Gene expression databases
Bgeei | ENSG00000258890, Expressed in left lobe of thyroid gland and 208 other tissues |
ExpressionAtlasi | Q96GE4, baseline and differential |
Genevisiblei | Q96GE4, HS |
Family and domain databases
Gene3Di | 1.10.418.10, 1 hit |
InterProi | View protein in InterPro IPR026619, CEP95 IPR036872, CH_dom_sf IPR044039, DUF5745 |
PANTHERi | PTHR22545, PTHR22545, 1 hit |
Pfami | View protein in Pfam PF19016, DUF5745, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CEP95_HUMAN | |
Accessioni | Q96GE4Primary (citable) accession number: Q96GE4 Secondary accession number(s): B4DMD2, Q96M81 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 16, 2006 |
Last sequence update: | December 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 134 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations