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UniProtKB - Q96GE4 (CEP95_HUMAN)

Entry version 137 (02 Jun 2021)
Sequence version 1 (01 Dec 2001)
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Protein

Centrosomal protein of 95 kDa

Gene

CEP95

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q96GE4

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Centrosomal protein of 95 kDa
Short name:
Cep95
Alternative name(s):
Coiled-coil domain-containing protein 45
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CEP95
Synonyms:CCDC45, CEP45
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:25141, CEP95

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q96GE4

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000258890.6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		90799

Open Targets

More...OpenTargetsi		ENSG00000258890

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA142672162

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q96GE4, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CEP95

Domain mapping of disease mutations (DMDM)

More...DMDMi		74751882

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002345051 – 821Centrosomal protein of 95 kDaAdd BLAST821

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei449PhosphoserineCombined sources1
Modified residuei451PhosphoserineCombined sources1
Modified residuei453PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q96GE4

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q96GE4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q96GE4

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q96GE4

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q96GE4

PeptideAtlas

More...PeptideAtlasi		Q96GE4

PRoteomics IDEntifications database

More...PRIDEi		Q96GE4

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		4597
76624 [Q96GE4-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q96GE4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q96GE4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000258890, Expressed in left lobe of thyroid gland and 208 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q96GE4, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q96GE4, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000258890, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		124762, 38 interactors

Protein interaction database and analysis system

More...IntActi		Q96GE4, 33 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000450461

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q96GE4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q96GE4

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni118 – 149DisorderedSequence analysisAdd BLAST32
Regioni323 – 369DisorderedSequence analysisAdd BLAST47
Regioni395 – 475DisorderedSequence analysisAdd BLAST81

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili585 – 632Sequence analysisAdd BLAST48
Coiled coili700 – 794Sequence analysisAdd BLAST95

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi343 – 359Polar residuesSequence analysisAdd BLAST17

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QTFE, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000005412

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_018428_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q96GE4

Identification of Orthologs from Complete Genome Data

More...OMAi		KHSQPWK

Database of Orthologous Groups

More...OrthoDBi		1353802at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q96GE4

TreeFam database of animal gene trees

More...TreeFami		TF333224

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.418.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR026619, CEP95
IPR036872, CH_dom_sf
IPR044039, DUF5745

The PANTHER Classification System

More...PANTHERi		PTHR22545, PTHR22545, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF19016, DUF5745, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96GE4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGSDAEWVT IANNLLFKCH IHLRIHELQD CDANVFIALY QSILGEKVPD 
        60         70         80         90        100
LIVIPRSQED DAHNVQAVID SLALDYLQVS LSHITGENIV KGDKESIKNL 
       110        120        130        140        150
LEIFDGLLEY LTERISETSH EKSETEQYFK ESDRGERLEE PESTKESKSS 
       160        170        180        190        200
WKRVSFGRCS LSSEMLGPSW DGDEAESTGE IIRLGDTAHT FSLRSNGAQC 
       210        220        230        240        250
PNEMLSKKAL ASPSSKSHED MLYPPSVLSK SRTSFVEDTE TLSVSGIPNA 
       260        270        280        290        300
RKLGEPIRAA IPLHPPYHPS EPRAPCPIGK EYLHSSHCSP AVNSTGEHTE 
       310        320        330        340        350
FSGDLDDGLF LISKLPKGSK WEVYPAQVQG PRTRKPPKGK RNENRATASS 
       360        370        380        390        400
CNSPFPQRPR KRLTEQELHD VSEKLSQRLS ELDWMLKSAL GDRIKEKTDH 
       410        420        430        440        450
KEENTGNEEV EDGTEETLSQ HSDGIVEYGP KKSRPGLSMR RKPPYRSHSL 
       460        470        480        490        500
SPSPVNKHKQ FHLERKRQRK PRETDVRQFQ AQAFTEAFER ELRRHKVQEN 
       510        520        530        540        550
IGPLRIHEKE EETEKIYRGE AVRKGTPECS QPWKIYSRKT TTQSLRGGLP 
       560        570        580        590        600
KPNKAVPMKV SEHSLLPLML EQFPFLYVSG PTLSKMWKQQ IAQVEQLKKE 
       610        620        630        640        650
ACRENRSKKK LQDEIEEALR RHDLLTTLVK KEYEHNKRLQ DFKDCIRRQR 
       660        670        680        690        700
LTQSKIKENR QQIVRARKYY DDYRVQLCAK MMRMRTREEM IFKKLFEEGL 
       710        720        730        740        750
NIQKQRLRDL RNYAKEKRDE QRRRHQDELD SMENYYKDQF SLLAEAISQE 
       760        770        780        790        800
HQELKAREKS QAQTLHKVKR ELRSKMEKEI QQLQDMITQN DDDVFFRELE 
       810        820 
AERFRSRLQL ASFQYSKSPS L
Length:821
Mass (Da):95,297
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i789AB2EF7E057F51
GO
Isoform 2 (identifier: Q96GE4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-164: Missing.

Show »
Length:657
Mass (Da):76,675
Checksum:i34346241437441F0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MTQ1A0A0A0MTQ1_HUMAN
Centrosomal protein of 95 kDa
CEP95
756Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KRW3J3KRW3_HUMAN
Centrosomal protein of 95 kDa
CEP95
156Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KRC3J3KRC3_HUMAN
Centrosomal protein of 95 kDa
CEP95
135Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KS50J3KS50_HUMAN
Centrosomal protein of 95 kDa
CEP95
102Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ENV0K7ENV0_HUMAN
Centrosomal protein of 95 kDa
CEP95
56Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B7ZAE2B7ZAE2_HUMAN
Centrosomal protein of 95 kDa
CEP95
157Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YJW6H0YJW6_HUMAN
Centrosomal protein of 95 kDa
CEP95
99Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QLG4J3QLG4_HUMAN
Centrosomal protein of 95 kDa
CEP95
71Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KST6J3KST6_HUMAN
Centrosomal protein of 95 kDa
CEP95
74Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_033666165M → I. Corresponds to variant dbSNP:rs9910506Ensembl.1
Natural variantiVAR_050751811A → V. Corresponds to variant dbSNP:rs11550922Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0563561 – 164Missing in isoform 2. 1 PublicationAdd BLAST164

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK057326 mRNA Translation: BAB71428.1
AK297409 mRNA Translation: BAG59844.1
AC009994 Genomic DNA No translation available.
BC009518 mRNA Translation: AAH09518.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS45763.1 [Q96GE4-1]

NCBI Reference Sequences

More...RefSeqi		NP_001303919.1, NM_001316990.1 [Q96GE4-2]
NP_612372.1, NM_138363.2 [Q96GE4-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000556440; ENSP00000450461; ENSG00000258890 [Q96GE4-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		90799

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:90799

UCSC genome browser

More...UCSCi		uc002jem.4, human [Q96GE4-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057326 mRNA Translation: BAB71428.1
AK297409 mRNA Translation: BAG59844.1
AC009994 Genomic DNA No translation available.
BC009518 mRNA Translation: AAH09518.1
CCDSiCCDS45763.1 [Q96GE4-1]
RefSeqiNP_001303919.1, NM_001316990.1 [Q96GE4-2]
NP_612372.1, NM_138363.2 [Q96GE4-1]

3D structure databases

SMRiQ96GE4
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi124762, 38 interactors
IntActiQ96GE4, 33 interactors
STRINGi9606.ENSP00000450461

PTM databases

iPTMnetiQ96GE4
PhosphoSitePlusiQ96GE4

Genetic variation databases

BioMutaiCEP95
DMDMi74751882

Proteomic databases

EPDiQ96GE4
jPOSTiQ96GE4
MassIVEiQ96GE4
MaxQBiQ96GE4
PaxDbiQ96GE4
PeptideAtlasiQ96GE4
PRIDEiQ96GE4
ProteomicsDBi4597
76624 [Q96GE4-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		67088, 80 antibodies

The DNASU plasmid repository

More...DNASUi		90799

Genome annotation databases

EnsembliENST00000556440; ENSP00000450461; ENSG00000258890 [Q96GE4-1]
GeneIDi90799
KEGGihsa:90799
UCSCiuc002jem.4, human [Q96GE4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		90799
DisGeNETi90799

GeneCards: human genes, protein and diseases

More...GeneCardsi		CEP95
HGNCiHGNC:25141, CEP95
HPAiENSG00000258890, Low tissue specificity
neXtProtiNX_Q96GE4
OpenTargetsiENSG00000258890
PharmGKBiPA142672162
VEuPathDBiHostDB:ENSG00000258890.6

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QTFE, Eukaryota
GeneTreeiENSGT00390000005412
HOGENOMiCLU_018428_1_0_1
InParanoidiQ96GE4
OMAiKHSQPWK
OrthoDBi1353802at2759
PhylomeDBiQ96GE4
TreeFamiTF333224

Enzyme and pathway databases

PathwayCommonsiQ96GE4

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		90799, 6 hits in 993 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CEP95, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		90799
PharosiQ96GE4, Tdark

Protein Ontology

More...PROi		PR:Q96GE4
RNActiQ96GE4, protein

Gene expression databases

BgeeiENSG00000258890, Expressed in left lobe of thyroid gland and 208 other tissues
ExpressionAtlasiQ96GE4, baseline and differential
GenevisibleiQ96GE4, HS

Family and domain databases

Gene3Di1.10.418.10, 1 hit
InterProiView protein in InterPro
IPR026619, CEP95
IPR036872, CH_dom_sf
IPR044039, DUF5745
PANTHERiPTHR22545, PTHR22545, 1 hit
PfamiView protein in Pfam
PF19016, DUF5745, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCEP95_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96GE4
Secondary accession number(s): B4DMD2, Q96M81
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: December 1, 2001
Last modified: June 2, 2021
This is version 137 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
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