UniProtKB - Q96GD4 (AURKB_HUMAN)
Protein
Aurora kinase B
Gene
AURKB
Organism
Homo sapiens (Human)
Status
Functioni
Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: phosphorylates CHMP4C, leading to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis (PubMed:22422861, PubMed:24814515). AURKB phosphorylates the CPC complex subunits BIRC5/survivin, CDCA8/borealin and INCENP. Phosphorylation of INCENP leads to increased AURKB activity. Other known AURKB substrates involved in centromeric functions and mitosis are CENPA, DES/desmin, GPAF, KIF2C, NSUN2, RACGAP1, SEPT1, VIM/vimentin, HASPIN, and histone H3. A positive feedback loop involving HASPIN and AURKB contributes to localization of CPC to centromeres. Phosphorylation of VIM controls vimentin filament segregation in cytokinetic process, whereas histone H3 is phosphorylated at 'Ser-10' and 'Ser-28' during mitosis (H3S10ph and H3S28ph, respectively). A positive feedback between HASPIN and AURKB contributes to CPC localization. AURKB is also required for kinetochore localization of BUB1 and SGO1. Phosphorylation of p53/TP53 negatively regulates its transcriptional activity. Key regulator of active promoters in resting B- and T-lymphocytes: acts by mediating phosphorylation of H3S28ph at active promoters in resting B-cells, inhibiting RNF2/RING1B-mediated ubiquitination of histone H2A and enhancing binding and activity of the USP16 deubiquitinase at transcribed genes.19 Publications
Catalytic activityi
Cofactori
Activity regulationi
Activity is greatly increased when AURKB is within the CPC complex. In particular, AURKB-phosphorylated INCENP acts as an activator of AURKB. Positive feedback between HASPIN and AURKB contributes to CPC localization.3 Publications
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 106 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 200 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 83 – 91 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- histone serine kinase activity Source: UniProtKB
- kinase binding Source: UniProtKB
- metal ion binding Source: UniProtKB-KW
- protein serine/threonine/tyrosine kinase activity Source: UniProtKB
- protein serine/threonine kinase activity Source: FlyBase
GO - Biological processi
- abscission Source: UniProtKB
- aging Source: Ensembl
- anaphase-promoting complex-dependent catabolic process Source: Reactome
- attachment of spindle microtubules to kinetochore Source: UniProtKB
- cell population proliferation Source: Ensembl
- cellular response to UV Source: UniProtKB
- cleavage furrow formation Source: UniProtKB
- histone H3-S28 phosphorylation Source: UniProtKB
- histone modification Source: UniProtKB
- mitotic cytokinesis checkpoint Source: UniProtKB
- mitotic spindle assembly checkpoint Source: InterPro
- mitotic spindle midzone assembly Source: UniProtKB
- mitotic spindle organization Source: GO_Central
- negative regulation of B cell apoptotic process Source: UniProtKB
- negative regulation of cytokinesis Source: UniProtKB
- negative regulation of protein binding Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: UniProtKB
- positive regulation of cytokinesis Source: UniProtKB
- positive regulation of telomerase activity Source: BHF-UCL
- positive regulation of telomere capping Source: BHF-UCL
- positive regulation of telomere maintenance via telomerase Source: BHF-UCL
- protein autophosphorylation Source: UniProtKB
- protein localization to kinetochore Source: UniProtKB
- protein phosphorylation Source: UniProtKB
- regulation of chromosome segregation Source: UniProtKB
- regulation of cytokinesis Source: GO_Central
- regulation of signal transduction by p53 class mediator Source: Reactome
- spindle organization Source: UniProtKB
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Biological process | Cell cycle, Cell division, Mitosis |
Ligand | ATP-binding, Magnesium, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-2467813 Separation of Sister Chromatids R-HSA-2500257 Resolution of Sister Chromatid Cohesion R-HSA-4615885 SUMOylation of DNA replication proteins R-HSA-5663220 RHO GTPases Activate Formins R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation R-HSA-68877 Mitotic Prometaphase R-HSA-9022692 Regulation of MECP2 expression and activity |
SignaLinki | Q96GD4 |
SIGNORi | Q96GD4 |
Names & Taxonomyi
Protein namesi | Recommended name: Aurora kinase B (EC:2.7.11.1)Alternative name(s): Aurora 1 Aurora- and IPL1-like midbody-associated protein 1 Short name: AIM-1 Aurora/IPL1-related kinase 2 Short name: ARK-2 Short name: Aurora-related kinase 2 STK-1 Serine/threonine-protein kinase 12 Serine/threonine-protein kinase 5 Serine/threonine-protein kinase aurora-B |
Gene namesi | Name:AURKB Synonyms:AIK2, AIM1, AIRK2, ARK2, STK1, STK12, STK5 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000178999.12 |
HGNCi | HGNC:11390 AURKB |
MIMi | 604970 gene |
neXtProti | NX_Q96GD4 |
Subcellular locationi
Cytoskeleton
Nucleus
Other locations
Note: Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis. Colocalized with gamma tubulin in the midbody. Proper localization of the active, Thr-232-phosphorylated form during metaphase may be dependent upon interaction with SPDYC. Colocalized with SIRT2 during cytokinesis with the midbody. Localization (and probably targeting of the CPC) to the inner centromere occurs predominantly in regions with overlapping mitosis-specific histone phosphorylations H3pT3 and H2ApT12.1 Publication
Cytoskeleton
- chromosome passenger complex Source: UniProtKB
- mitotic spindle midzone Source: Ensembl
- spindle Source: UniProtKB
- spindle microtubule Source: GO_Central
- spindle midzone Source: GO_Central
- spindle pole centrosome Source: GO_Central
Cytosol
- cytosol Source: Reactome
Nucleus
- condensed nuclear chromosome, centromeric region Source: BHF-UCL
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Other locations
- chromocenter Source: Ensembl
- condensed chromosome, centromeric region Source: UniProtKB
- kinetochore Source: CACAO
- midbody Source: UniProtKB
Keywords - Cellular componenti
Centromere, Chromosome, Cytoplasm, Cytoskeleton, NucleusPathology & Biotechi
Involvement in diseasei
Disruptive regulation of expression is a possible mechanism of the perturbation of chromosomal integrity in cancer cells through its dominant-negative effect on cytokinesis.
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 106 | K → R: Leads to loss of kinase activity and severely impairs mitotic progression. 4 Publications | 1 |
Organism-specific databases
DisGeNETi | 9212 |
OpenTargetsi | ENSG00000178999 |
PharmGKBi | PA36199 |
Chemistry databases
ChEMBLi | CHEMBL2185 |
DrugBanki | DB05169 AT9283 DB04703 HESPERIDIN |
GuidetoPHARMACOLOGYi | 1937 |
Polymorphism and mutation databases
BioMutai | AURKB |
DMDMi | 317373473 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000085656 | 1 – 344 | Aurora kinase BAdd BLAST | 344 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 35 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 62 | PhosphoserineCombined sources | 1 | |
Modified residuei | 64 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 227 | PhosphoserineCombined sources | 1 | |
Modified residuei | 232 | Phosphothreonine; by autocatalysis1 Publication | 1 |
Post-translational modificationi
The phosphorylation of Thr-232 requires the binding to INCENP and occurs by means of an autophosphorylation mechanism. Thr-232 phosphorylation is indispensable for the AURKB kinase activity.1 Publication
Ubiquitinated by different BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complexes. Ubiquitinated by the BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex, ubiquitination leads to removal from mitotic chromosomes and is required for cytokinesis. During anaphase, the BCR(KLHL21) E3 ubiquitin ligase complex recruits the CPC complex from chromosomes to the spindle midzone and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome.2 Publications
Keywords - PTMi
Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q96GD4 |
jPOSTi | Q96GD4 |
MaxQBi | Q96GD4 |
PaxDbi | Q96GD4 |
PeptideAtlasi | Q96GD4 |
PRIDEi | Q96GD4 |
ProteomicsDBi | 76623 |
PTM databases
iPTMneti | Q96GD4 |
PhosphoSitePlusi | Q96GD4 |
SwissPalmi | Q96GD4 |
Expressioni
Tissue specificityi
High level expression seen in the thymus. It is also expressed in the spleen, lung, testis, colon, placenta and fetal liver. Expressed during S and G2/M phase and expression is up-regulated in cancer cells during M phase.2 Publications
Inductioni
Expression is cell cycle-regulated, with a low in G1/S, an increase during G2 and M. Expression decreases again after M phase.1 Publication
Gene expression databases
Bgeei | ENSG00000178999 Expressed in 135 organ(s), highest expression level in oocyte |
ExpressionAtlasi | Q96GD4 baseline and differential |
Genevisiblei | Q96GD4 HS |
Organism-specific databases
HPAi | CAB005862 HPA037708 |
Interactioni
Subunit structurei
Component of the chromosomal passenger complex (CPC) composed of at least BIRC5/survivin, CDCA8/borealin, INCENP, AURKB or AURKC; predominantly independent AURKB- and AURKC-containing complexes exist. Associates with RACGAP1 during M phase. Interacts with CDCA1, EVI5, JTB, NDC80, PSMA3, SEPT1, SIRT2 and TACC1. Interacts with SPDYC; this interaction may be required for proper localization of active, Thr-232-phosphorylated AURKB form during prometaphase and metaphase. Interacts with p53/TP53. Interacts (via the middle kinase domain) with NOC2L (via the N- and C-terminus domains). Interacts with TTC28. Interacts with RNF2/RING1B.19 Publications
Binary interactionsi
GO - Molecular functioni
- kinase binding Source: UniProtKB
Protein-protein interaction databases
BioGridi | 114646, 170 interactors |
ComplexPortali | CPX-116 Chromosomal passenger complex |
CORUMi | Q96GD4 |
DIPi | DIP-34530N |
ELMi | Q96GD4 |
IntActi | Q96GD4, 90 interactors |
MINTi | Q96GD4 |
STRINGi | 9606.ENSP00000463999 |
Chemistry databases
BindingDBi | Q96GD4 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4AF3 | X-ray | 2.75 | A | 55-344 | [»] | |
ProteinModelPortali | Q96GD4 | |||||
SMRi | Q96GD4 | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 77 – 327 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 251 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.PROSITE-ProRule annotation
Phylogenomic databases
eggNOGi | KOG0580 Eukaryota ENOG410XNRB LUCA |
GeneTreei | ENSGT00940000158980 |
HOVERGENi | HBG108519 |
InParanoidi | Q96GD4 |
KOi | K11479 |
OMAi | PYGRQTT |
OrthoDBi | 954262at2759 |
PhylomeDBi | Q96GD4 |
TreeFami | TF351439 |
Family and domain databases
InterProi | View protein in InterPro IPR030616 Aur IPR028772 AURKB IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS |
PANTHERi | PTHR24350 PTHR24350, 1 hit PTHR24350:SF4 PTHR24350:SF4, 1 hit |
Pfami | View protein in Pfam PF00069 Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220 S_TKc, 1 hit |
SUPFAMi | SSF56112 SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q96GD4-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MAQKENSYPW PYGRQTAPSG LSTLPQRVLR KEPVTPSALV LMSRSNVQPT
60 70 80 90 100
AAPGQKVMEN SSGTPDILTR HFTIDDFEIG RPLGKGKFGN VYLAREKKSH
110 120 130 140 150
FIVALKVLFK SQIEKEGVEH QLRREIEIQA HLHHPNILRL YNYFYDRRRI
160 170 180 190 200
YLILEYAPRG ELYKELQKSC TFDEQRTATI MEELADALMY CHGKKVIHRD
210 220 230 240 250
IKPENLLLGL KGELKIADFG WSVHAPSLRR KTMCGTLDYL PPEMIEGRMH
260 270 280 290 300
NEKVDLWCIG VLCYELLVGN PPFESASHNE TYRRIVKVDL KFPASVPMGA
310 320 330 340
QDLISKLLRH NPSERLPLAQ VSAHPWVRAN SRRVLPPSAL QSVA
Isoform 3 (identifier: Q96GD4-3) [UniParc]FASTAAdd to basket
Also known as: aurkb-sv2
The sequence of this isoform differs from the canonical sequence as follows:
69-69: T → TR
133-141: HHPNILRLY → QSWRSWQML
142-344: Missing.
Note: Not expressed in normal liver, high expression in metastatic liver.
Show »Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketJ3KTD6 | J3KTD6_HUMAN | Aurora kinase B | AURKB | 228 | Annotation score: | ||
J3QR41 | J3QR41_HUMAN | Aurora kinase B | AURKB | 172 | Annotation score: | ||
J3KT86 | J3KT86_HUMAN | Aurora kinase B | AURKB | 242 | Annotation score: | ||
J3QLN8 | J3QLN8_HUMAN | Aurora kinase B | AURKB | 230 | Annotation score: | ||
J3KRJ2 | J3KRJ2_HUMAN | Aurora kinase B | AURKB | 69 | Annotation score: | ||
J3KRF8 | J3KRF8_HUMAN | Aurora kinase B | AURKB | 123 | Annotation score: |
Sequence cautioni
The sequence AAH13300 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 14 – 15 | RQ → DK in AAC98891 (Ref. 5) Curated | 2 | |
Sequence conflicti | 161 | E → M in AAB65786 (PubMed:11471245).Curated | 1 | |
Sequence conflicti | 161 | E → M in AAC98891 (Ref. 5) Curated | 1 | |
Sequence conflicti | 167 – 169 | QKS → HKT in AAB65786 (PubMed:11471245).Curated | 3 | |
Sequence conflicti | 179 | T → TVRR in AAB65786 (PubMed:11471245).Curated | 1 | |
Sequence conflicti | 180 | I → VRAV in AAC98891 (Ref. 5) Curated | 1 | |
Sequence conflicti | 226 | P → T in BAA82709 (PubMed:9858806).Curated | 1 | |
Sequence conflicti | 249 – 250 | MH → ID in BAA82709 (PubMed:9858806).Curated | 2 | |
Sequence conflicti | 271 | Missing in BAA82709 (PubMed:9858806).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_040383 | 52 | A → V1 PublicationCorresponds to variant dbSNP:rs55878091Ensembl. | 1 | |
Natural variantiVAR_027970 | 100 | H → Q. Corresponds to variant dbSNP:rs3027254Ensembl. | 1 | |
Natural variantiVAR_040384 | 179 | T → M1 PublicationCorresponds to variant dbSNP:rs55871613Ensembl. | 1 | |
Natural variantiVAR_027971 | 298 | M → T8 PublicationsCorresponds to variant dbSNP:rs1059476Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_047103 | 1 – 41 | Missing in isoform 4. 1 PublicationAdd BLAST | 41 | |
Alternative sequenceiVSP_044384 | 69 | T → TR in isoform 3 and isoform 5. 2 Publications | 1 | |
Alternative sequenceiVSP_044385 | 86 – 134 | GKFGN…AHLHH → ALLCLWPEASSVSSPSH in isoform 2. 1 PublicationAdd BLAST | 49 | |
Alternative sequenceiVSP_044386 | 133 – 141 | HHPNILRLY → QSWRSWQML in isoform 3. 1 Publication | 9 | |
Alternative sequenceiVSP_044387 | 142 – 344 | Missing in isoform 3. 1 PublicationAdd BLAST | 203 |
Sequence databases
Genome annotation databases
Ensembli | ENST00000316199; ENSP00000313950; ENSG00000178999 [Q96GD4-5] ENST00000534871; ENSP00000443869; ENSG00000178999 [Q96GD4-4] ENST00000578549; ENSP00000462207; ENSG00000178999 [Q96GD4-2] ENST00000585124; ENSP00000463999; ENSG00000178999 [Q96GD4-1] |
GeneIDi | 9212 |
KEGGi | hsa:9212 |
UCSCi | uc002gkm.5 human [Q96GD4-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4AF3 | X-ray | 2.75 | A | 55-344 | [»] | |
ProteinModelPortali | Q96GD4 | |||||
SMRi | Q96GD4 | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Protein-protein interaction databases
BioGridi | 114646, 170 interactors |
ComplexPortali | CPX-116 Chromosomal passenger complex |
CORUMi | Q96GD4 |
DIPi | DIP-34530N |
ELMi | Q96GD4 |
IntActi | Q96GD4, 90 interactors |
MINTi | Q96GD4 |
STRINGi | 9606.ENSP00000463999 |
Chemistry databases
BindingDBi | Q96GD4 |
ChEMBLi | CHEMBL2185 |
DrugBanki | DB05169 AT9283 DB04703 HESPERIDIN |
GuidetoPHARMACOLOGYi | 1937 |
PTM databases
iPTMneti | Q96GD4 |
PhosphoSitePlusi | Q96GD4 |
SwissPalmi | Q96GD4 |
Polymorphism and mutation databases
BioMutai | AURKB |
DMDMi | 317373473 |
Proteomic databases
EPDi | Q96GD4 |
jPOSTi | Q96GD4 |
MaxQBi | Q96GD4 |
PaxDbi | Q96GD4 |
PeptideAtlasi | Q96GD4 |
PRIDEi | Q96GD4 |
ProteomicsDBi | 76623 |
Protocols and materials databases
DNASUi | 9212 |
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENST00000316199; ENSP00000313950; ENSG00000178999 [Q96GD4-5] ENST00000534871; ENSP00000443869; ENSG00000178999 [Q96GD4-4] ENST00000578549; ENSP00000462207; ENSG00000178999 [Q96GD4-2] ENST00000585124; ENSP00000463999; ENSG00000178999 [Q96GD4-1] |
GeneIDi | 9212 |
KEGGi | hsa:9212 |
UCSCi | uc002gkm.5 human [Q96GD4-1] |
Organism-specific databases
CTDi | 9212 |
DisGeNETi | 9212 |
EuPathDBi | HostDB:ENSG00000178999.12 |
GeneCardsi | AURKB |
H-InvDBi | HIX0019005 |
HGNCi | HGNC:11390 AURKB |
HPAi | CAB005862 HPA037708 |
MIMi | 604970 gene |
neXtProti | NX_Q96GD4 |
OpenTargetsi | ENSG00000178999 |
PharmGKBi | PA36199 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0580 Eukaryota ENOG410XNRB LUCA |
GeneTreei | ENSGT00940000158980 |
HOVERGENi | HBG108519 |
InParanoidi | Q96GD4 |
KOi | K11479 |
OMAi | PYGRQTT |
OrthoDBi | 954262at2759 |
PhylomeDBi | Q96GD4 |
TreeFami | TF351439 |
Enzyme and pathway databases
Reactomei | R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-2467813 Separation of Sister Chromatids R-HSA-2500257 Resolution of Sister Chromatid Cohesion R-HSA-4615885 SUMOylation of DNA replication proteins R-HSA-5663220 RHO GTPases Activate Formins R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation R-HSA-68877 Mitotic Prometaphase R-HSA-9022692 Regulation of MECP2 expression and activity |
SignaLinki | Q96GD4 |
SIGNORi | Q96GD4 |
Miscellaneous databases
GeneWikii | Aurora_B_kinase |
GenomeRNAii | 9212 |
PROi | PR:Q96GD4 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000178999 Expressed in 135 organ(s), highest expression level in oocyte |
ExpressionAtlasi | Q96GD4 baseline and differential |
Genevisiblei | Q96GD4 HS |
Family and domain databases
InterProi | View protein in InterPro IPR030616 Aur IPR028772 AURKB IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS |
PANTHERi | PTHR24350 PTHR24350, 1 hit PTHR24350:SF4 PTHR24350:SF4, 1 hit |
Pfami | View protein in Pfam PF00069 Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220 S_TKc, 1 hit |
SUPFAMi | SSF56112 SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | AURKB_HUMAN | |
Accessioni | Q96GD4Primary (citable) accession number: Q96GD4 Secondary accession number(s): B4DNM4 Q9UQ46 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 17, 2003 |
Last sequence update: | January 11, 2011 | |
Last modified: | February 13, 2019 | |
This is version 204 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Complete proteome, Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - SIMILARITY comments
Index of protein domains and families - Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations