UniProtKB - Q96GD4 (AURKB_HUMAN)
Aurora kinase B
AURKB
Functioni
Catalytic activityi
Cofactori
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 106 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 200 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 83 – 91 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- histone serine kinase activity Source: UniProtKB
- kinase binding Source: UniProtKB
- metal ion binding Source: UniProtKB-KW
- protein serine/threonine/tyrosine kinase activity Source: UniProtKB
- protein serine/threonine kinase activity Source: FlyBase
- protein serine kinase activity Source: UniProtKB-EC
- protein threonine kinase activity Source: UniProtKB-EC
GO - Biological processi
- abscission Source: UniProtKB
- aging Source: Ensembl
- anaphase-promoting complex-dependent catabolic process Source: Reactome
- attachment of spindle microtubules to kinetochore Source: UniProtKB
- cell population proliferation Source: Ensembl
- cellular response to UV Source: UniProtKB
- cleavage furrow formation Source: UniProtKB
- histone H3-S28 phosphorylation Source: UniProtKB
- histone modification Source: UniProtKB
- mitotic cytokinesis checkpoint Source: UniProtKB
- mitotic spindle assembly checkpoint Source: InterPro
- mitotic spindle midzone assembly Source: UniProtKB
- mitotic spindle organization Source: GO_Central
- negative regulation of B cell apoptotic process Source: UniProtKB
- negative regulation of cytokinesis Source: UniProtKB
- negative regulation of protein binding Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: UniProtKB
- positive regulation of cytokinesis Source: UniProtKB
- positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore Source: CACAO
- positive regulation of telomerase activity Source: BHF-UCL
- positive regulation of telomere capping Source: BHF-UCL
- positive regulation of telomere maintenance via telomerase Source: BHF-UCL
- protein autophosphorylation Source: UniProtKB
- protein localization to kinetochore Source: UniProtKB
- protein phosphorylation Source: UniProtKB
- regulation of chromosome segregation Source: UniProtKB
- regulation of cytokinesis Source: GO_Central
- regulation of signal transduction by p53 class mediator Source: Reactome
- spindle organization Source: UniProtKB
- ubiquitin-dependent protein catabolic process Source: Reactome
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Biological process | Cell cycle, Cell division, Mitosis |
Ligand | ATP-binding, Magnesium, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q96GD4 |
Reactomei | R-HSA-141444, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-174178, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-2467813, Separation of Sister Chromatids R-HSA-2500257, Resolution of Sister Chromatid Cohesion R-HSA-4615885, SUMOylation of DNA replication proteins R-HSA-5663220, RHO GTPases Activate Formins R-HSA-6804756, Regulation of TP53 Activity through Phosphorylation R-HSA-68877, Mitotic Prometaphase R-HSA-9022692, Regulation of MECP2 expression and activity R-HSA-9648025, EML4 and NUDC in mitotic spindle formation |
SignaLinki | Q96GD4 |
SIGNORi | Q96GD4 |
Names & Taxonomyi
Protein namesi | Recommended name: Aurora kinase B (EC:2.7.11.1)Alternative name(s): Aurora 1 Aurora- and IPL1-like midbody-associated protein 1 Short name: AIM-1 Aurora/IPL1-related kinase 2 Short name: ARK-2 Short name: Aurora-related kinase 2 STK-1 Serine/threonine-protein kinase 12 Serine/threonine-protein kinase 5 Serine/threonine-protein kinase aurora-B |
Gene namesi | Name:AURKB Synonyms:AIK2, AIM1, AIRK2, ARK2, STK1, STK12, STK5 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11390, AURKB |
MIMi | 604970, gene |
neXtProti | NX_Q96GD4 |
VEuPathDBi | HostDB:ENSG00000178999.12 |
Subcellular locationi
Cytoskeleton
Nucleus
Other locations
Note: Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis. Colocalized with gamma tubulin in the midbody. Proper localization of the active, Thr-232-phosphorylated form during metaphase may be dependent upon interaction with SPDYC. Colocalized with SIRT2 during cytokinesis with the midbody. Localization (and probably targeting of the CPC) to the inner centromere occurs predominantly in regions with overlapping mitosis-specific histone phosphorylations H3pT3 and H2ApT12.1 Publication
Cytoskeleton
- chromosome passenger complex Source: UniProtKB
- mitotic spindle midzone Source: Ensembl
- mitotic spindle pole Source: Ensembl
- spindle Source: UniProtKB
- spindle microtubule Source: GO_Central
- spindle midzone Source: GO_Central
- spindle pole centrosome Source: GO_Central
Cytosol
- cytosol Source: Reactome
Nucleus
- condensed nuclear chromosome, centromeric region Source: BHF-UCL
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Other locations
- chromocenter Source: Ensembl
- condensed chromosome, centromeric region Source: UniProtKB
- kinetochore Source: CACAO
- midbody Source: UniProtKB
Keywords - Cellular componenti
Centromere, Chromosome, Cytoplasm, Cytoskeleton, NucleusPathology & Biotechi
Involvement in diseasei
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 106 | K → R: Leads to loss of kinase activity and severely impairs mitotic progression. 4 Publications | 1 |
Organism-specific databases
DisGeNETi | 9212 |
OpenTargetsi | ENSG00000178999 |
PharmGKBi | PA36199 |
Miscellaneous databases
Pharosi | Q96GD4, Tchem |
Chemistry databases
ChEMBLi | CHEMBL2185 |
DrugBanki | DB05169, AT9283 DB06486, Enzastaurin DB12010, Fostamatinib DB04703, Hesperidin DB07340, Reversine |
DrugCentrali | Q96GD4 |
GuidetoPHARMACOLOGYi | 1937 |
Genetic variation databases
BioMutai | AURKB |
DMDMi | 317373473 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000085656 | 1 – 344 | Aurora kinase BAdd BLAST | 344 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 35 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 62 | PhosphoserineCombined sources | 1 | |
Modified residuei | 64 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 227 | PhosphoserineCombined sources | 1 | |
Modified residuei | 232 | Phosphothreonine; by autocatalysis1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Phosphoprotein, Ubl conjugationProteomic databases
CPTACi | CPTAC-1219 CPTAC-1228 CPTAC-1340 |
EPDi | Q96GD4 |
jPOSTi | Q96GD4 |
MassIVEi | Q96GD4 |
MaxQBi | Q96GD4 |
PaxDbi | Q96GD4 |
PeptideAtlasi | Q96GD4 |
PRIDEi | Q96GD4 |
ProteomicsDBi | 4709 7611 76623 [Q96GD4-1] |
PTM databases
iPTMneti | Q96GD4 |
MetOSitei | Q96GD4 |
PhosphoSitePlusi | Q96GD4 |
SwissPalmi | Q96GD4 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000178999, Expressed in ventricular zone and 155 other tissues |
ExpressionAtlasi | Q96GD4, baseline and differential |
Genevisiblei | Q96GD4, HS |
Organism-specific databases
HPAi | ENSG00000178999, Tissue enhanced (bone marrow, lymphoid tissue) |
Interactioni
Subunit structurei
Component of the chromosomal passenger complex (CPC) composed of at least BIRC5/survivin, CDCA8/borealin, INCENP, AURKB or AURKC; predominantly independent AURKB- and AURKC-containing complexes exist. Associates with RACGAP1 during M phase.
Interacts with CDCA1, EVI5, JTB, NDC80, PSMA3, SEPTIN1, SIRT2 and TACC1.
Interacts with SPDYC; this interaction may be required for proper localization of active, Thr-232-phosphorylated AURKB form during prometaphase and metaphase.
Interacts with p53/TP53.
Interacts (via the middle kinase domain) with NOC2L (via the N- and C-terminus domains).
Interacts with TTC28.
Interacts with RNF2/RING1B.
19 PublicationsBinary interactionsi
Hide detailsQ96GD4
GO - Molecular functioni
- kinase binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 114646, 217 interactors |
ComplexPortali | CPX-116, Chromosomal passenger complex |
CORUMi | Q96GD4 |
DIPi | DIP-34530N |
ELMi | Q96GD4 |
IntActi | Q96GD4, 97 interactors |
MINTi | Q96GD4 |
STRINGi | 9606.ENSP00000313950 |
Chemistry databases
BindingDBi | Q96GD4 |
Miscellaneous databases
RNActi | Q96GD4, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q96GD4 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 77 – 327 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 251 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0580, Eukaryota |
GeneTreei | ENSGT00940000158980 |
InParanoidi | Q96GD4 |
OMAi | WPYGRQM |
OrthoDBi | 954262at2759 |
PhylomeDBi | Q96GD4 |
TreeFami | TF351439 |
Family and domain databases
InterProi | View protein in InterPro IPR030616, Aur IPR028772, AURKB IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
PANTHERi | PTHR24350, PTHR24350, 1 hit PTHR24350:SF4, PTHR24350:SF4, 1 hit |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAQKENSYPW PYGRQTAPSG LSTLPQRVLR KEPVTPSALV LMSRSNVQPT
60 70 80 90 100
AAPGQKVMEN SSGTPDILTR HFTIDDFEIG RPLGKGKFGN VYLAREKKSH
110 120 130 140 150
FIVALKVLFK SQIEKEGVEH QLRREIEIQA HLHHPNILRL YNYFYDRRRI
160 170 180 190 200
YLILEYAPRG ELYKELQKSC TFDEQRTATI MEELADALMY CHGKKVIHRD
210 220 230 240 250
IKPENLLLGL KGELKIADFG WSVHAPSLRR KTMCGTLDYL PPEMIEGRMH
260 270 280 290 300
NEKVDLWCIG VLCYELLVGN PPFESASHNE TYRRIVKVDL KFPASVPMGA
310 320 330 340
QDLISKLLRH NPSERLPLAQ VSAHPWVRAN SRRVLPPSAL QSVA
The sequence of this isoform differs from the canonical sequence as follows:
69-69: T → TR
133-141: HHPNILRLY → QSWRSWQML
142-344: Missing.
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketJ3KTD6 | J3KTD6_HUMAN | Aurora kinase | AURKB | 228 | Annotation score: | ||
J3QLN8 | J3QLN8_HUMAN | Aurora kinase | AURKB | 230 | Annotation score: | ||
J3QR41 | J3QR41_HUMAN | Aurora kinase | AURKB | 172 | Annotation score: | ||
J3KT86 | J3KT86_HUMAN | Aurora kinase | AURKB | 242 | Annotation score: | ||
J3KRJ2 | J3KRJ2_HUMAN | Aurora kinase | AURKB | 69 | Annotation score: | ||
J3KRF8 | J3KRF8_HUMAN | Aurora kinase | AURKB | 123 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 14 – 15 | RQ → DK in AAC98891 (Ref. 5) Curated | 2 | |
Sequence conflicti | 161 | E → M in AAB65786 (PubMed:11471245).Curated | 1 | |
Sequence conflicti | 161 | E → M in AAC98891 (Ref. 5) Curated | 1 | |
Sequence conflicti | 167 – 169 | QKS → HKT in AAB65786 (PubMed:11471245).Curated | 3 | |
Sequence conflicti | 179 | T → TVRR in AAB65786 (PubMed:11471245).Curated | 1 | |
Sequence conflicti | 180 | I → VRAV in AAC98891 (Ref. 5) Curated | 1 | |
Sequence conflicti | 226 | P → T in BAA82709 (PubMed:9858806).Curated | 1 | |
Sequence conflicti | 249 – 250 | MH → ID in BAA82709 (PubMed:9858806).Curated | 2 | |
Sequence conflicti | 271 | Missing in BAA82709 (PubMed:9858806).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_040383 | 52 | A → V1 PublicationCorresponds to variant dbSNP:rs55878091Ensembl. | 1 | |
Natural variantiVAR_027970 | 100 | H → Q. Corresponds to variant dbSNP:rs3027254Ensembl. | 1 | |
Natural variantiVAR_040384 | 179 | T → M1 PublicationCorresponds to variant dbSNP:rs55871613Ensembl. | 1 | |
Natural variantiVAR_027971 | 298 | M → T8 PublicationsCorresponds to variant dbSNP:rs1059476Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_047103 | 1 – 41 | Missing in isoform 4. 1 PublicationAdd BLAST | 41 | |
Alternative sequenceiVSP_044384 | 69 | T → TR in isoform 3 and isoform 5. 2 Publications | 1 | |
Alternative sequenceiVSP_044385 | 86 – 134 | GKFGN…AHLHH → ALLCLWPEASSVSSPSH in isoform 2. 1 PublicationAdd BLAST | 49 | |
Alternative sequenceiVSP_044386 | 133 – 141 | HHPNILRLY → QSWRSWQML in isoform 3. 1 Publication | 9 | |
Alternative sequenceiVSP_044387 | 142 – 344 | Missing in isoform 3. 1 PublicationAdd BLAST | 203 |
Sequence databases
Genome annotation databases
Ensembli | ENST00000316199; ENSP00000313950; ENSG00000178999 [Q96GD4-5] ENST00000534871; ENSP00000443869; ENSG00000178999 [Q96GD4-4] ENST00000578549; ENSP00000462207; ENSG00000178999 [Q96GD4-2] ENST00000585124; ENSP00000463999; ENSG00000178999 [Q96GD4-1] |
GeneIDi | 9212 |
KEGGi | hsa:9212 |
UCSCi | uc002gkm.5, human [Q96GD4-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4AF3 | X-ray | 2.75 | A | 55-344 | [»] | |
SMRi | Q96GD4 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 114646, 217 interactors |
ComplexPortali | CPX-116, Chromosomal passenger complex |
CORUMi | Q96GD4 |
DIPi | DIP-34530N |
ELMi | Q96GD4 |
IntActi | Q96GD4, 97 interactors |
MINTi | Q96GD4 |
STRINGi | 9606.ENSP00000313950 |
Chemistry databases
BindingDBi | Q96GD4 |
ChEMBLi | CHEMBL2185 |
DrugBanki | DB05169, AT9283 DB06486, Enzastaurin DB12010, Fostamatinib DB04703, Hesperidin DB07340, Reversine |
DrugCentrali | Q96GD4 |
GuidetoPHARMACOLOGYi | 1937 |
PTM databases
iPTMneti | Q96GD4 |
MetOSitei | Q96GD4 |
PhosphoSitePlusi | Q96GD4 |
SwissPalmi | Q96GD4 |
Genetic variation databases
BioMutai | AURKB |
DMDMi | 317373473 |
Proteomic databases
CPTACi | CPTAC-1219 CPTAC-1228 CPTAC-1340 |
EPDi | Q96GD4 |
jPOSTi | Q96GD4 |
MassIVEi | Q96GD4 |
MaxQBi | Q96GD4 |
PaxDbi | Q96GD4 |
PeptideAtlasi | Q96GD4 |
PRIDEi | Q96GD4 |
ProteomicsDBi | 4709 7611 76623 [Q96GD4-1] |
Protocols and materials databases
Antibodypediai | 3128, 1048 antibodies |
DNASUi | 9212 |
Genome annotation databases
Ensembli | ENST00000316199; ENSP00000313950; ENSG00000178999 [Q96GD4-5] ENST00000534871; ENSP00000443869; ENSG00000178999 [Q96GD4-4] ENST00000578549; ENSP00000462207; ENSG00000178999 [Q96GD4-2] ENST00000585124; ENSP00000463999; ENSG00000178999 [Q96GD4-1] |
GeneIDi | 9212 |
KEGGi | hsa:9212 |
UCSCi | uc002gkm.5, human [Q96GD4-1] |
Organism-specific databases
CTDi | 9212 |
DisGeNETi | 9212 |
GeneCardsi | AURKB |
HGNCi | HGNC:11390, AURKB |
HPAi | ENSG00000178999, Tissue enhanced (bone marrow, lymphoid tissue) |
MIMi | 604970, gene |
neXtProti | NX_Q96GD4 |
OpenTargetsi | ENSG00000178999 |
PharmGKBi | PA36199 |
VEuPathDBi | HostDB:ENSG00000178999.12 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0580, Eukaryota |
GeneTreei | ENSGT00940000158980 |
InParanoidi | Q96GD4 |
OMAi | WPYGRQM |
OrthoDBi | 954262at2759 |
PhylomeDBi | Q96GD4 |
TreeFami | TF351439 |
Enzyme and pathway databases
PathwayCommonsi | Q96GD4 |
Reactomei | R-HSA-141444, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-174178, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-2467813, Separation of Sister Chromatids R-HSA-2500257, Resolution of Sister Chromatid Cohesion R-HSA-4615885, SUMOylation of DNA replication proteins R-HSA-5663220, RHO GTPases Activate Formins R-HSA-6804756, Regulation of TP53 Activity through Phosphorylation R-HSA-68877, Mitotic Prometaphase R-HSA-9022692, Regulation of MECP2 expression and activity R-HSA-9648025, EML4 and NUDC in mitotic spindle formation |
SignaLinki | Q96GD4 |
SIGNORi | Q96GD4 |
Miscellaneous databases
BioGRID-ORCSi | 9212, 784 hits in 920 CRISPR screens |
GeneWikii | Aurora_B_kinase |
GenomeRNAii | 9212 |
Pharosi | Q96GD4, Tchem |
PROi | PR:Q96GD4 |
RNActi | Q96GD4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000178999, Expressed in ventricular zone and 155 other tissues |
ExpressionAtlasi | Q96GD4, baseline and differential |
Genevisiblei | Q96GD4, HS |
Family and domain databases
InterProi | View protein in InterPro IPR030616, Aur IPR028772, AURKB IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
PANTHERi | PTHR24350, PTHR24350, 1 hit PTHR24350:SF4, PTHR24350:SF4, 1 hit |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | AURKB_HUMAN | |
Accessioni | Q96GD4Primary (citable) accession number: Q96GD4 Secondary accession number(s): B4DNM4 Q9UQ46 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 17, 2003 |
Last sequence update: | January 11, 2011 | |
Last modified: | February 10, 2021 | |
This is version 219 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families