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UniProtKB - Q96GD0 (PLPP_HUMAN)

Entry version 170 (23 Feb 2022)
Sequence version 2 (01 Mar 2004)
Previous versions | rss
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Protein

Chronophin

Gene

PDXP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions as a pyridoxal phosphate (PLP) phosphatase, which also catalyzes the dephosphorylation of pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), with order of substrate preference PLP > PNP > PMP and therefore plays a role in vitamin B6 metabolism (PubMed:14522954, PubMed:8132548).

Also functions as a protein serine phosphatase that specifically dephosphorylates 'Ser-3' in proteins of the actin-depolymerizing factor (ADF)/cofilin family like CFL1 and DSTN. Thereby, regulates cofilin-dependent actin cytoskeleton reorganization, being required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phosphothreonines in LIMK1. Does not dephosphorylate peptides containing phosphotyrosine (PubMed:15580268).

3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+2 PublicationsNote: Divalent metal ions. Mg2+ is the most effective.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by NaF, Zn2+, Ca2+, Mn2+ and EDTA.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

kcat is 1.52 sec(-1) for the dephosphorylation of pyridoxal 5'-phosphate (at pH 7.4 and 37 degrees Celsius). kcat is 1.25 sec(-1) for the dephosphorylation of pyridoxine 5'-phosphate (at pH 7.4 and 37 degrees Celsius). kcat is 0.45 sec(-1) for the dephosphorylation of pyridoxamine 5'-phosphate (at pH 7.4 and 37 degrees Celsius).1 Publication
  1. KM=2.5 µM for pyridoxal 5'-phosphate (at pH 7.4 and 37 degrees Celsius)1 Publication
  2. KM=43.4 µM for pyridoxine 5'-phosphate (at pH 7.4 and 37 degrees Celsius)1 Publication
  3. KM=80.6 µM for pyridoxamine 5'-phosphate (at pH 7.4 and 37 degrees Celsius)1 Publication
  1. Vmax=1.42 µmol/min/mg enzyme with pyridoxal 5'-phosphate as substrate1 Publication
  2. Vmax=1.17 µmol/min/mg enzyme with pyridoxine 5'-phosphate as substrate1 Publication
  3. Vmax=0.42 µmol/min/mg enzyme with pyridoxamine 5'-phosphate as substrate1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei25NucleophileCombined sources2 Publications1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi25MagnesiumCombined sources1 Publication1
Active sitei27Proton donorCombined sources2 Publications1
Metal bindingi27Magnesium; via carbonyl oxygenCombined sources1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei182SubstrateCombined sources1 Publication1
Binding sitei213SubstrateCombined sources1 Publication1
Metal bindingi238MagnesiumCombined sources1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
LigandMagnesium, Metal-binding, Pyridoxal phosphate

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		3.1.3.74, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q96GD0

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		Q96GD0

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q96GD0

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q96GD0

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Chronophin1 Publication (EC:3.1.3.161 Publication, EC:3.1.3.742 Publications)
Alternative name(s):
Pyridoxal phosphate phosphatase1 Publication
Short name:
PLP phosphatase1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PDXPImported
Synonyms:CIN1 Publication, PLP1 Publication, PLPP1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:30259, PDXP

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		609246, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q96GD0

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000241360

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi25D → N: Abolishes protein phosphatase activity. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		57026

Open Targets

More...OpenTargetsi		ENSG00000241360

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134882132

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q96GD0, Tbio

Chemistry databases

Drug and drug target database

More...DrugBanki		DB00114, Pyridoxal phosphate
DB00165, Pyridoxine

DrugCentral

More...DrugCentrali		Q96GD0

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PDXP

Domain mapping of disease mutations (DMDM)

More...DMDMi		44888310

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000688371 – 296ChronophinAdd BLAST296

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q96GD0

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q96GD0

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q96GD0

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q96GD0

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q96GD0

PeptideAtlas

More...PeptideAtlasi		Q96GD0

PRoteomics IDEntifications database

More...PRIDEi		Q96GD0

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		76616

2D gel databases

REPRODUCTION-2DPAGE

More...REPRODUCTION-2DPAGEi		IPI00025340

University College Dublin 2-DE Proteome Database

More...UCD-2DPAGEi		Q96GD0

PTM databases

DEPOD human dephosphorylation database

More...DEPODi		PDXP

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q96GD0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q96GD0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed (at protein level) (PubMed:23223568). Highly expressed in all the regions of central nerve system except the spinal cord. Also expressed at high level in liver and testis. In fetus, it is weakly expressed in all organs except brain (PubMed:14522954, PubMed:15580268).3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000241360, Expressed in prefrontal cortex and 116 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q96GD0, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q96GD0, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000241360, Tissue enhanced (brain, choroid plexus)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		121330, 24 interactors

Protein interaction database and analysis system

More...IntActi		Q96GD0, 5 interactors

Molecular INTeraction database

More...MINTi		Q96GD0

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000215904

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q96GD0, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1296
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q96GD0

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q96GD0

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni58 – 60Substrate bindingCombined sources1 Publication3

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the HAD-like hydrolase superfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2882, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000162045

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_043473_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q96GD0

Identification of Orthologs from Complete Genome Data

More...OMAi		MDGVLIH

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q96GD0

TreeFam database of animal gene trees

More...TreeFami		TF314344

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.50.1000, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR036412, HAD-like_sf
IPR006357, HAD-SF_hydro_IIA
IPR023214, HAD_sf
IPR006349, PGP_euk

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13344, Hydrolase_6, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF000915, PGP-type_phosphatase, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF56784, SSF56784, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR01460, HAD-SF-IIA, 1 hit
TIGR01452, PGP_euk, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing and alternative initiation. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform CIN1 Publication (identifier: Q96GD0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MARCERLRGA ALRDVLGRAQ GVLFDCDGVL WNGERAVPGA PELLERLARA 
        60         70         80         90        100
GKAALFVSNN SRRARPELAL RFARLGFGGL RAEQLFSSAL CAARLLRQRL 
       110        120        130        140        150
PGPPDAPGAV FVLGGEGLRA ELRAAGLRLA GDPSAGDGAA PRVRAVLVGY 
       160        170        180        190        200
DEHFSFAKLR EACAHLRDPE CLLVATDRDP WHPLSDGSRT PGTGSLAAAV 
       210        220        230        240        250
ETASGRQALV VGKPSPYMFE CITENFSIDP ARTLMVGDRL ETDILFGHRC 
       260        270        280        290 
GMTTVLTLTG VSRLEEAQAY LAAGQHDLVP HYYVESIADL TEGLED
Length:296
Mass (Da):31,698
Last modified:March 1, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i33466C35A76B458C
GO
Isoform Long BGIN1 Publication (identifier: Q6ZT62-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q6ZT62.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:677
Mass (Da):73,599
GO
Isoform Short BGIN1 Publication (identifier: Q6ZT62-2) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q6ZT62.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:605
Mass (Da):66,180
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1AHD3B1AHD3_HUMAN
Chronophin
PDXP
79Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY125047 mRNA Translation: AAM94358.1
Z83844 Genomic DNA No translation available.
BC000320 mRNA Translation: AAH00320.1
BC009756 mRNA Translation: AAH09756.2
BC064922 mRNA Translation: AAH64922.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS13953.1 [Q96GD0-1]

NCBI Reference Sequences

More...RefSeqi		NP_064711.1, NM_020315.4 [Q96GD0-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000215904; ENSP00000215904; ENSG00000241360

Database of genes from NCBI RefSeq genomes

More...GeneIDi		57026

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:57026

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000215904.7; ENSP00000215904.6; NM_020315.5; NP_064711.1

UCSC genome browser

More...UCSCi		uc003atm.2, human [Q96GD0-1]

Keywords - Coding sequence diversityi

Alternative initiation, Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY125047 mRNA Translation: AAM94358.1
Z83844 Genomic DNA No translation available.
BC000320 mRNA Translation: AAH00320.1
BC009756 mRNA Translation: AAH09756.2
BC064922 mRNA Translation: AAH64922.1
CCDSiCCDS13953.1 [Q96GD0-1]
RefSeqiNP_064711.1, NM_020315.4 [Q96GD0-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CFRX-ray2.40A1-296[»]
2CFSX-ray2.40A1-296[»]
2CFTX-ray1.80A1-296[»]
2OYCX-ray1.72A2-296[»]
2P27X-ray1.90A2-296[»]
2P69X-ray2.25A2-296[»]
5GYNX-ray2.00A1-296[»]
SMRiQ96GD0
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi121330, 24 interactors
IntActiQ96GD0, 5 interactors
MINTiQ96GD0
STRINGi9606.ENSP00000215904

Chemistry databases

DrugBankiDB00114, Pyridoxal phosphate
DB00165, Pyridoxine
DrugCentraliQ96GD0

PTM databases

DEPODiPDXP
iPTMnetiQ96GD0
PhosphoSitePlusiQ96GD0

Genetic variation databases

BioMutaiPDXP
DMDMi44888310

2D gel databases

REPRODUCTION-2DPAGEiIPI00025340
UCD-2DPAGEiQ96GD0

Proteomic databases

EPDiQ96GD0
jPOSTiQ96GD0
MassIVEiQ96GD0
MaxQBiQ96GD0
PaxDbiQ96GD0
PeptideAtlasiQ96GD0
PRIDEiQ96GD0
ProteomicsDBi76616

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		34919, 109 antibodies from 27 providers

The DNASU plasmid repository

More...DNASUi		57026

Genome annotation databases

EnsembliENST00000215904; ENSP00000215904; ENSG00000241360
GeneIDi57026
KEGGihsa:57026
MANE-SelectiENST00000215904.7; ENSP00000215904.6; NM_020315.5; NP_064711.1
UCSCiuc003atm.2, human [Q96GD0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		57026
DisGeNETi57026

GeneCards: human genes, protein and diseases

More...GeneCardsi		PDXP
HGNCiHGNC:30259, PDXP
HPAiENSG00000241360, Tissue enhanced (brain, choroid plexus)
MIMi609246, gene
neXtProtiNX_Q96GD0
OpenTargetsiENSG00000241360
PharmGKBiPA134882132
VEuPathDBiHostDB:ENSG00000241360

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2882, Eukaryota
GeneTreeiENSGT00940000162045
HOGENOMiCLU_043473_0_1_1
InParanoidiQ96GD0
OMAiMDGVLIH
PhylomeDBiQ96GD0
TreeFamiTF314344

Enzyme and pathway databases

BRENDAi3.1.3.74, 2681
PathwayCommonsiQ96GD0
SABIO-RKiQ96GD0
SignaLinkiQ96GD0
SIGNORiQ96GD0

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		57026, 6 hits in 1045 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		PDXP, human
EvolutionaryTraceiQ96GD0

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		57026
PharosiQ96GD0, Tbio

Protein Ontology

More...PROi		PR:Q96GD0
RNActiQ96GD0, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000241360, Expressed in prefrontal cortex and 116 other tissues
ExpressionAtlasiQ96GD0, baseline and differential
GenevisibleiQ96GD0, HS

Family and domain databases

Gene3Di3.40.50.1000, 2 hits
InterProiView protein in InterPro
IPR036412, HAD-like_sf
IPR006357, HAD-SF_hydro_IIA
IPR023214, HAD_sf
IPR006349, PGP_euk
PfamiView protein in Pfam
PF13344, Hydrolase_6, 1 hit
PIRSFiPIRSF000915, PGP-type_phosphatase, 1 hit
SUPFAMiSSF56784, SSF56784, 1 hit
TIGRFAMsiTIGR01460, HAD-SF-IIA, 1 hit
TIGR01452, PGP_euk, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPLPP_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96GD0
Secondary accession number(s): Q9UGY2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: March 1, 2004
Last modified: February 23, 2022
This is version 170 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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