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Protein

Vacuole membrane protein 1

Gene

VMP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Stress-induced protein that, when overexpressed, promotes formation of intracellular vacuoles followed by cell death. May be involved in the cytoplasmic vacuolization of acinar cells during the early stage of acute pancreatitis. Plays a role in the initial stages of the autophagic process through its interaction with BECN1 (By similarity). Involved in cell-cell adhesion. Plays an essential role in formation of cell junctions (PubMed:17724469). Required for autophagosome formation (PubMed:30093494).By similarity2 Publications

GO - Biological processi

  • autophagosome assembly Source: UniProtKB
  • cell-cell adhesion Source: UniProtKB
  • cell junction assembly Source: UniProtKB
  • embryo implantation Source: Ensembl
  • endoplasmic reticulum organization Source: GO_Central
  • exocytosis Source: GO_Central
  • Golgi organization Source: GO_Central
  • macroautophagy Source: GO_Central

Keywordsi

Biological processAutophagy, Cell adhesion

Protein family/group databases

TCDBi8.A.97.1.1 the epg-3/vmp1 (epg/vpm) family

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuole membrane protein 1
Alternative name(s):
Transmembrane protein 49
Gene namesi
Name:VMP1
Synonyms:TDC1, TMEM49
ORF Names:HSPC292
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000062716.10
HGNCiHGNC:29559 VMP1
MIMi611753 gene
neXtProtiNX_Q96GC9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 43CytoplasmicSequence analysisAdd BLAST42
Transmembranei44 – 64HelicalSequence analysisAdd BLAST21
Topological domaini65 – 77ExtracellularSequence analysisAdd BLAST13
Transmembranei78 – 98HelicalSequence analysisAdd BLAST21
Topological domaini99 – 109CytoplasmicSequence analysisAdd BLAST11
Transmembranei110 – 130HelicalSequence analysisAdd BLAST21
Topological domaini131 – 250ExtracellularSequence analysisAdd BLAST120
Transmembranei251 – 271HelicalSequence analysisAdd BLAST21
Topological domaini272 – 273CytoplasmicSequence analysis2
Transmembranei274 – 294HelicalSequence analysisAdd BLAST21
Topological domaini295 – 305ExtracellularSequence analysisAdd BLAST11
Transmembranei306 – 326HelicalSequence analysisAdd BLAST21
Topological domaini327 – 363CytoplasmicSequence analysisAdd BLAST37
Transmembranei364 – 384HelicalSequence analysisAdd BLAST21
Topological domaini385 – 406ExtracellularSequence analysisAdd BLAST22

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane, Vacuole

Pathology & Biotechi

Organism-specific databases

DisGeNETi81671
OpenTargetsiENSG00000062716
PharmGKBiPA142670765

Polymorphism and mutation databases

BioMutaiVMP1
DMDMi74731809

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002845462 – 406Vacuole membrane protein 1Add BLAST405

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ96GC9
MaxQBiQ96GC9
PaxDbiQ96GC9
PeptideAtlasiQ96GC9
PRIDEiQ96GC9
ProteomicsDBi76615
TopDownProteomicsiQ96GC9-1 [Q96GC9-1]

PTM databases

iPTMnetiQ96GC9
PhosphoSitePlusiQ96GC9
SwissPalmiQ96GC9

Expressioni

Gene expression databases

BgeeiENSG00000062716 Expressed in 228 organ(s), highest expression level in left coronary artery
CleanExiHS_TMEM49
ExpressionAtlasiQ96GC9 baseline and differential
GenevisibleiQ96GC9 HS

Organism-specific databases

HPAiHPA030773
HPA064780

Interactioni

Subunit structurei

Interacts with BECN1 (By similarity). Interacts with TJP1 (PubMed:17724469). Interacts with TP53INP2 (PubMed:19056683). Interacts with TMEM41B (PubMed:30093494).By similarity3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
BECN1Q144573EBI-2800296,EBI-949378

Protein-protein interaction databases

BioGridi123567, 35 interactors
IntActiQ96GC9, 16 interactors
MINTiQ96GC9
STRINGi9606.ENSP00000262291

Structurei

3D structure databases

ProteinModelPortaliQ96GC9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni173 – 316VTT domain1 PublicationAdd BLAST144

Domaini

The VTT domain was previously called the SNARE-assoc domain. As there is no evidence that this domain associates with SNARE proteins, it was renamed as VMP1, TMEM41, and TVP38 (VTT) domain.1 Publication

Sequence similaritiesi

Belongs to the VMP1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1109 Eukaryota
ENOG410XQHA LUCA
GeneTreeiENSGT00390000007230
HOVERGENiHBG057290
InParanoidiQ96GC9
KOiK21248
OMAiWVFEKVV
OrthoDBiEOG091G0AKM
PhylomeDBiQ96GC9
TreeFamiTF313699

Family and domain databases

InterProiView protein in InterPro
IPR032816 SNARE_assoc
PfamiView protein in Pfam
PF09335 SNARE_assoc, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96GC9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAENGKNCDQ RRVAMNKEHH NGNFTDPSSV NEKKRREREE RQNIVLWRQP
60 70 80 90 100
LITLQYFSLE ILVILKEWTS KLWHRQSIVV SFLLLLAVLI ATYYVEGVHQ
110 120 130 140 150
QYVQRIEKQF LLYAYWIGLG ILSSVGLGTG LHTFLLYLGP HIASVTLAAY
160 170 180 190 200
ECNSVNFPEP PYPDQIICPD EEGTEGTISL WSIISKVRIE ACMWGIGTAI
210 220 230 240 250
GELPPYFMAR AARLSGAEPD DEEYQEFEEM LEHAESAQDF ASRAKLAVQK
260 270 280 290 300
LVQKVGFFGI LACASIPNPL FDLAGITCGH FLVPFWTFFG ATLIGKAIIK
310 320 330 340 350
MHIQKIFVII TFSKHIVEQM VAFIGAVPGI GPSLQKPFQE YLEAQRQKLH
360 370 380 390 400
HKSEMGTPQG ENWLSWMFEK LVVVMVCYFI LSIINSMAQS YAKRIQQRLN

SEEKTK
Length:406
Mass (Da):46,238
Last modified:December 1, 2001 - v1
Checksum:iE9DDE63F80143091
GO
Isoform 2 (identifier: Q96GC9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-192: Missing.

Note: No experimental confirmation available.
Show »
Length:214
Mass (Da):24,148
Checksum:i12E4B3C1A5594A3E
GO

Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EMI0K7EMI0_HUMAN
Vacuole membrane protein 1
VMP1
138Annotation score:
K7EK01K7EK01_HUMAN
Vacuole membrane protein 1
VMP1
92Annotation score:
K7ELS2K7ELS2_HUMAN
Vacuole membrane protein 1
VMP1
167Annotation score:
K7ENU2K7ENU2_HUMAN
Vacuole membrane protein 1
VMP1
78Annotation score:
K7EPE7K7EPE7_HUMAN
Vacuole membrane protein 1
VMP1
225Annotation score:
K7EL74K7EL74_HUMAN
Vacuole membrane protein 1
VMP1
75Annotation score:
K7EL93K7EL93_HUMAN
Vacuole membrane protein 1
VMP1
74Annotation score:
K7EL46K7EL46_HUMAN
Vacuole membrane protein 1
VMP1
58Annotation score:
K7EM96K7EM96_HUMAN
Vacuole membrane protein 1
VMP1
44Annotation score:
K7EMN6K7EMN6_HUMAN
Vacuole membrane protein 1
VMP1
44Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti179S → F in CAB66646 (PubMed:11230166).Curated1
Sequence conflicti179S → F in CAG38552 (Ref. 5) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0561061 – 192Missing in isoform 2. 1 PublicationAdd BLAST192

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF214006 mRNA Translation: AAL36461.1
AB047551 mRNA Translation: BAF47368.1
AL136711 mRNA Translation: CAB66646.1
AK301254 mRNA Translation: BAG62821.1
CR533521 mRNA Translation: CAG38552.1
AC004686 Genomic DNA No translation available.
AC025858 Genomic DNA No translation available.
AC040904 Genomic DNA No translation available.
AC091271 Genomic DNA No translation available.
BC009758 mRNA Translation: AAH09758.1
AF161410 mRNA Translation: AAF28970.1
CCDSiCCDS11619.1 [Q96GC9-1]
RefSeqiNP_001316323.1, NM_001329394.1 [Q96GC9-1]
NP_001316326.1, NM_001329397.1
NP_001316331.1, NM_001329402.1 [Q96GC9-2]
NP_112200.2, NM_030938.4 [Q96GC9-1]
UniGeneiHs.444569
Hs.708260
Hs.743288

Genome annotation databases

EnsembliENST00000262291; ENSP00000262291; ENSG00000062716 [Q96GC9-1]
GeneIDi81671
KEGGihsa:81671
UCSCiuc002ixu.5 human [Q96GC9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF214006 mRNA Translation: AAL36461.1
AB047551 mRNA Translation: BAF47368.1
AL136711 mRNA Translation: CAB66646.1
AK301254 mRNA Translation: BAG62821.1
CR533521 mRNA Translation: CAG38552.1
AC004686 Genomic DNA No translation available.
AC025858 Genomic DNA No translation available.
AC040904 Genomic DNA No translation available.
AC091271 Genomic DNA No translation available.
BC009758 mRNA Translation: AAH09758.1
AF161410 mRNA Translation: AAF28970.1
CCDSiCCDS11619.1 [Q96GC9-1]
RefSeqiNP_001316323.1, NM_001329394.1 [Q96GC9-1]
NP_001316326.1, NM_001329397.1
NP_001316331.1, NM_001329402.1 [Q96GC9-2]
NP_112200.2, NM_030938.4 [Q96GC9-1]
UniGeneiHs.444569
Hs.708260
Hs.743288

3D structure databases

ProteinModelPortaliQ96GC9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123567, 35 interactors
IntActiQ96GC9, 16 interactors
MINTiQ96GC9
STRINGi9606.ENSP00000262291

Protein family/group databases

TCDBi8.A.97.1.1 the epg-3/vmp1 (epg/vpm) family

PTM databases

iPTMnetiQ96GC9
PhosphoSitePlusiQ96GC9
SwissPalmiQ96GC9

Polymorphism and mutation databases

BioMutaiVMP1
DMDMi74731809

Proteomic databases

EPDiQ96GC9
MaxQBiQ96GC9
PaxDbiQ96GC9
PeptideAtlasiQ96GC9
PRIDEiQ96GC9
ProteomicsDBi76615
TopDownProteomicsiQ96GC9-1 [Q96GC9-1]

Protocols and materials databases

DNASUi81671
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262291; ENSP00000262291; ENSG00000062716 [Q96GC9-1]
GeneIDi81671
KEGGihsa:81671
UCSCiuc002ixu.5 human [Q96GC9-1]

Organism-specific databases

CTDi81671
DisGeNETi81671
EuPathDBiHostDB:ENSG00000062716.10
GeneCardsiVMP1
H-InvDBiHIX0039412
HGNCiHGNC:29559 VMP1
HPAiHPA030773
HPA064780
MIMi611753 gene
neXtProtiNX_Q96GC9
OpenTargetsiENSG00000062716
PharmGKBiPA142670765
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1109 Eukaryota
ENOG410XQHA LUCA
GeneTreeiENSGT00390000007230
HOVERGENiHBG057290
InParanoidiQ96GC9
KOiK21248
OMAiWVFEKVV
OrthoDBiEOG091G0AKM
PhylomeDBiQ96GC9
TreeFamiTF313699

Miscellaneous databases

ChiTaRSiVMP1 human
GeneWikiiTMEM49
GenomeRNAii81671
PROiPR:Q96GC9
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000062716 Expressed in 228 organ(s), highest expression level in left coronary artery
CleanExiHS_TMEM49
ExpressionAtlasiQ96GC9 baseline and differential
GenevisibleiQ96GC9 HS

Family and domain databases

InterProiView protein in InterPro
IPR032816 SNARE_assoc
PfamiView protein in Pfam
PF09335 SNARE_assoc, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiVMP1_HUMAN
AccessioniPrimary (citable) accession number: Q96GC9
Secondary accession number(s): B4DVV9, Q9H0P4, Q9P089
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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