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Protein

Neurotrophin receptor-interacting factor homolog

Gene

ZNF274

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable transcription repressor. Specifically binds to the 3'-end of zinc-finger coding genes and recruiting chromatin-modifying proteins such as SETDB1 and TRIM28/KAP1, leading to transcription repression. The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610).2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri507 – 529C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri535 – 557C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri563 – 585C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri591 – 613C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri619 – 641C2H2-type 5PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

  • regulation of histone H3-K9 trimethylation Source: UniProtKB
  • regulation of transcription, DNA-templated Source: ProtInc

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway
SignaLinkiQ96GC6

Names & Taxonomyi

Protein namesi
Recommended name:
Neurotrophin receptor-interacting factor homolog
Alternative name(s):
Zinc finger protein 274
Zinc finger protein HFB101
Zinc finger protein with KRAB and SCAN domains 19
Zinc finger protein zfp2
Short name:
Zf2
Gene namesi
Name:ZNF274
Synonyms:ZKSCAN19
ORF Names:SP2114
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000171606.17
HGNCiHGNC:13068 ZNF274
MIMi605467 gene
neXtProtiNX_Q96GC6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi10782
OpenTargetsiENSG00000171606
PharmGKBiPA37644

Polymorphism and mutation databases

BioMutaiZNF274
DMDMi327478548

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000475011 – 653Neurotrophin receptor-interacting factor homologAdd BLAST653

Proteomic databases

EPDiQ96GC6
MaxQBiQ96GC6
PaxDbiQ96GC6
PeptideAtlasiQ96GC6
PRIDEiQ96GC6
ProteomicsDBi76611
76612 [Q96GC6-2]
76613 [Q96GC6-3]
76614 [Q96GC6-4]

PTM databases

iPTMnetiQ96GC6
PhosphoSitePlusiQ96GC6

Expressioni

Gene expression databases

BgeeiENSG00000171606 Expressed in 225 organ(s), highest expression level in left lobe of thyroid gland
CleanExiHS_ZNF274
ExpressionAtlasiQ96GC6 baseline and differential
GenevisibleiQ96GC6 HS

Organism-specific databases

HPAiHPA028880

Interactioni

Subunit structurei

Interacts with SETDB1 and TRIM28/KAP1. Interacts with ATRX. Forms a complex with ATRX, SETDB1 and TRIM28 (PubMed:27029610).2 Publications

Protein-protein interaction databases

BioGridi115999, 12 interactors
IntActiQ96GC6, 2 interactors
STRINGi9606.ENSP00000321209

Structurei

3D structure databases

ProteinModelPortaliQ96GC6
SMRiQ96GC6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 85KRAB 1PROSITE-ProRule annotationAdd BLAST72
Domaini161 – 243SCAN boxPROSITE-ProRule annotationAdd BLAST83
Domaini287 – 360KRAB 2PROSITE-ProRule annotationAdd BLAST74

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri507 – 529C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri535 – 557C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri563 – 585C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri591 – 613C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri619 – 641C2H2-type 5PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144197
HOVERGENiHBG054183
InParanoidiQ96GC6
KOiK12458
OMAiTQRTEYH
OrthoDBiEOG091G02MB
PhylomeDBiQ96GC6
TreeFamiTF338018

Family and domain databases

CDDicd07765 KRAB_A-box, 2 hits
cd07936 SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 2 hits
PF02023 SCAN, 1 hit
PF00096 zf-C2H2, 4 hits
SMARTiView protein in SMART
SM00349 KRAB, 2 hits
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF109640 SSF109640, 2 hits
SSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 2 hits
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 5 hits

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket
Note: Experimental confirmation may be lacking for some isoforms.

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96GC6-1) [UniParc]FASTAAdd to basket
Also known as: SP2114a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASRLPTAWS CEPVTFEDVT LGFTPEEWGL LDLKQKSLYR EVMLENYRNL
60 70 80 90 100
VSVEHQLSKP DVVSQLEEAE DFWPVERGIP QDTIPEYPEL QLDPKLDPLP
110 120 130 140 150
AESPLMNIEV VEVLTLNQEV AGPRNAQIQA LYAEDGSLSA DAPSEQVQQQ
160 170 180 190 200
GKHPGDPEAA RQRFRQFRYK DMTGPREALD QLRELCHQWL QPKARSKEQI
210 220 230 240 250
LELLVLEQFL GALPVKLRTW VESQHPENCQ EVVALVEGVT WMSEEEVLPA
260 270 280 290 300
GQPAEGTTCC LEVTAQQEEK QEDAAICPVT VLPEEPVTFQ DVAVDFSREE
310 320 330 340 350
WGLLGPTQRT EYRDVMLETF GHLVSVGWET TLENKELAPN SDIPEEEPAP
360 370 380 390 400
SLKVQESSRD CALSSTLEDT LQGGVQEVQD TVLKQMESAQ EKDLPQKKHF
410 420 430 440 450
DNRESQANSG ALDTNQVSLQ KIDNPESQAN SGALDTNQVL LHKIPPRKRL
460 470 480 490 500
RKRDSQVKSM KHNSRVKIHQ KSCERQKAKE GNGCRKTFSR STKQITFIRI
510 520 530 540 550
HKGSQVCRCS ECGKIFRNPR YFSVHKKIHT GERPYVCQDC GKGFVQSSSL
560 570 580 590 600
TQHQRVHSGE RPFECQECGR TFNDRSAISQ HLRTHTGAKP YKCQDCGKAF
610 620 630 640 650
RQSSHLIRHQ RTHTGERPYA CNKCGKAFTQ SSHLIGHQRT HNRTKRKKKQ

PTS
Length:653
Mass (Da):74,177
Last modified:April 5, 2011 - v2
Checksum:i8B91F51F4BEED925
GO
Isoform 2 (identifier: Q96GC6-2) [UniParc]FASTAAdd to basket
Also known as: ZNF274a

The sequence of this isoform differs from the canonical sequence as follows:
     55-86: Missing.

Show »
Length:621
Mass (Da):70,505
Checksum:i8B3B3F12B341A136
GO
Isoform 3 (identifier: Q96GC6-3) [UniParc]FASTAAdd to basket
Also known as: ZNF274b

The sequence of this isoform differs from the canonical sequence as follows:
     1-105: Missing.

Show »
Length:548
Mass (Da):62,113
Checksum:i1A8C8BFE6FB17B69
GO
Isoform 4 (identifier: Q96GC6-4) [UniParc]FASTAAdd to basket
Also known as: SP2114b

The sequence of this isoform differs from the canonical sequence as follows:
     1-281: Missing.
     282-284: LPE → MLQ

Show »
Length:372
Mass (Da):42,448
Checksum:iF7D35AECFECCF7CD
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MR47A0A0A0MR47_HUMAN
Neurotrophin receptor-interacting f...
ZNF274
611Annotation score:
M0QY30M0QY30_HUMAN
Neurotrophin receptor-interacting f...
ZNF274
79Annotation score:
M0QXW4M0QXW4_HUMAN
Neurotrophin receptor-interacting f...
ZNF274
103Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti14V → E in AAG24390 (PubMed:15498874).Curated1
Sequence conflicti212A → T in AAG24390 (PubMed:15498874).Curated1
Sequence conflicti289F → S in CAE46074 (PubMed:17974005).Curated1
Sequence conflicti636G → W in BAA88522 (PubMed:10777669).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_064920147V → I4 PublicationsCorresponds to variant dbSNP:rs7256349Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0069121 – 281Missing in isoform 4. 2 PublicationsAdd BLAST281
Alternative sequenceiVSP_0069101 – 105Missing in isoform 3. 1 PublicationAdd BLAST105
Alternative sequenceiVSP_00691155 – 86Missing in isoform 2. 1 PublicationAdd BLAST32
Alternative sequenceiVSP_006913282 – 284LPE → MLQ in isoform 4. 2 Publications3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB029149 mRNA Translation: BAA88522.1
AB029150 mRNA Translation: BAA88523.1
AF275680 mRNA Translation: AAG24390.1
AF275681 mRNA Translation: AAG24391.1
BX641169 mRNA Translation: CAE46074.1
BT007304 mRNA Translation: AAP35968.1
AC008751 Genomic DNA No translation available.
AC020915 Genomic DNA No translation available.
BC009763 mRNA Translation: AAH09763.1
U71598 mRNA Translation: AAB16810.1
CCDSiCCDS74473.1 [Q96GC6-1]
CCDS74474.1 [Q96GC6-2]
CCDS74476.1 [Q96GC6-3]
RefSeqiNP_001265663.1, NM_001278734.1
NP_057408.2, NM_016324.3 [Q96GC6-3]
NP_057409.1, NM_016325.3 [Q96GC6-2]
NP_598009.1, NM_133502.2 [Q96GC6-1]
XP_011524629.1, XM_011526327.1 [Q96GC6-3]
XP_016881663.1, XM_017026174.1 [Q96GC6-3]
UniGeneiHs.83761

Genome annotation databases

EnsembliENST00000345813; ENSP00000321187; ENSG00000171606 [Q96GC6-2]
ENST00000424679; ENSP00000409872; ENSG00000171606 [Q96GC6-3]
ENST00000610905; ENSP00000478533; ENSG00000171606 [Q96GC6-1]
ENST00000617501; ENSP00000484810; ENSG00000171606 [Q96GC6-1]
GeneIDi10782
KEGGihsa:10782
UCSCiuc032igq.2 human [Q96GC6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB029149 mRNA Translation: BAA88522.1
AB029150 mRNA Translation: BAA88523.1
AF275680 mRNA Translation: AAG24390.1
AF275681 mRNA Translation: AAG24391.1
BX641169 mRNA Translation: CAE46074.1
BT007304 mRNA Translation: AAP35968.1
AC008751 Genomic DNA No translation available.
AC020915 Genomic DNA No translation available.
BC009763 mRNA Translation: AAH09763.1
U71598 mRNA Translation: AAB16810.1
CCDSiCCDS74473.1 [Q96GC6-1]
CCDS74474.1 [Q96GC6-2]
CCDS74476.1 [Q96GC6-3]
RefSeqiNP_001265663.1, NM_001278734.1
NP_057408.2, NM_016324.3 [Q96GC6-3]
NP_057409.1, NM_016325.3 [Q96GC6-2]
NP_598009.1, NM_133502.2 [Q96GC6-1]
XP_011524629.1, XM_011526327.1 [Q96GC6-3]
XP_016881663.1, XM_017026174.1 [Q96GC6-3]
UniGeneiHs.83761

3D structure databases

ProteinModelPortaliQ96GC6
SMRiQ96GC6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115999, 12 interactors
IntActiQ96GC6, 2 interactors
STRINGi9606.ENSP00000321209

PTM databases

iPTMnetiQ96GC6
PhosphoSitePlusiQ96GC6

Polymorphism and mutation databases

BioMutaiZNF274
DMDMi327478548

Proteomic databases

EPDiQ96GC6
MaxQBiQ96GC6
PaxDbiQ96GC6
PeptideAtlasiQ96GC6
PRIDEiQ96GC6
ProteomicsDBi76611
76612 [Q96GC6-2]
76613 [Q96GC6-3]
76614 [Q96GC6-4]

Protocols and materials databases

DNASUi10782
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000345813; ENSP00000321187; ENSG00000171606 [Q96GC6-2]
ENST00000424679; ENSP00000409872; ENSG00000171606 [Q96GC6-3]
ENST00000610905; ENSP00000478533; ENSG00000171606 [Q96GC6-1]
ENST00000617501; ENSP00000484810; ENSG00000171606 [Q96GC6-1]
GeneIDi10782
KEGGihsa:10782
UCSCiuc032igq.2 human [Q96GC6-1]

Organism-specific databases

CTDi10782
DisGeNETi10782
EuPathDBiHostDB:ENSG00000171606.17
GeneCardsiZNF274
HGNCiHGNC:13068 ZNF274
HPAiHPA028880
MIMi605467 gene
neXtProtiNX_Q96GC6
OpenTargetsiENSG00000171606
PharmGKBiPA37644
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144197
HOVERGENiHBG054183
InParanoidiQ96GC6
KOiK12458
OMAiTQRTEYH
OrthoDBiEOG091G02MB
PhylomeDBiQ96GC6
TreeFamiTF338018

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway
SignaLinkiQ96GC6

Miscellaneous databases

ChiTaRSiZNF274 human
GeneWikiiZNF274
GenomeRNAii10782
PROiPR:Q96GC6
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000171606 Expressed in 225 organ(s), highest expression level in left lobe of thyroid gland
CleanExiHS_ZNF274
ExpressionAtlasiQ96GC6 baseline and differential
GenevisibleiQ96GC6 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 2 hits
cd07936 SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 2 hits
PF02023 SCAN, 1 hit
PF00096 zf-C2H2, 4 hits
SMARTiView protein in SMART
SM00349 KRAB, 2 hits
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF109640 SSF109640, 2 hits
SSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 2 hits
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 5 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZN274_HUMAN
AccessioniPrimary (citable) accession number: Q96GC6
Secondary accession number(s): Q53XU4
, Q6MZG1, Q8WY37, Q8WY38, Q92969, Q9UII0, Q9UII1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: April 5, 2011
Last modified: November 7, 2018
This is version 159 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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