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Entry version 165 (31 Jul 2019)
Sequence version 2 (05 Apr 2011)
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Protein

Neurotrophin receptor-interacting factor homolog

Gene

ZNF274

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable transcription repressor. Specifically binds to the 3'-end of zinc-finger coding genes and recruiting chromatin-modifying proteins such as SETDB1 and TRIM28/KAP1, leading to transcription repression. The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610).2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri507 – 529C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri535 – 557C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri563 – 585C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri591 – 613C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri619 – 641C2H2-type 5PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-212436 Generic Transcription Pathway

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q96GC6

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Neurotrophin receptor-interacting factor homolog
Alternative name(s):
Zinc finger protein 274
Zinc finger protein HFB101
Zinc finger protein with KRAB and SCAN domains 19
Zinc finger protein zfp2
Short name:
Zf2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF274
Synonyms:ZKSCAN19
ORF Names:SP2114
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13068 ZNF274

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605467 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96GC6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
10782

Open Targets

More...
OpenTargetsi
ENSG00000171606

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37644

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF274

Domain mapping of disease mutations (DMDM)

More...
DMDMi
327478548

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000475011 – 653Neurotrophin receptor-interacting factor homologAdd BLAST653

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96GC6

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96GC6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96GC6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96GC6

PeptideAtlas

More...
PeptideAtlasi
Q96GC6

PRoteomics IDEntifications database

More...
PRIDEi
Q96GC6

ProteomicsDB human proteome resource

More...
ProteomicsDBi
76611 [Q96GC6-1]
76612 [Q96GC6-2]
76613 [Q96GC6-3]
76614 [Q96GC6-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96GC6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96GC6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000171606 Expressed in 225 organ(s), highest expression level in left lobe of thyroid gland

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q96GC6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96GC6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA028880

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SETDB1 and TRIM28/KAP1.

Interacts with ATRX.

Forms a complex with ATRX, SETDB1 and TRIM28 (PubMed:27029610).

2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115999, 12 interactors

Protein interaction database and analysis system

More...
IntActi
Q96GC6, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000478533

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q96GC6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini14 – 85KRAB 1PROSITE-ProRule annotationAdd BLAST72
Domaini161 – 243SCAN boxPROSITE-ProRule annotationAdd BLAST83
Domaini287 – 360KRAB 2PROSITE-ProRule annotationAdd BLAST74

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri507 – 529C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri535 – 557C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri563 – 585C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri591 – 613C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri619 – 641C2H2-type 5PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162111

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96GC6

KEGG Orthology (KO)

More...
KOi
K12458

Identification of Orthologs from Complete Genome Data

More...
OMAi
TQRTEYH

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96GC6

TreeFam database of animal gene trees

More...
TreeFami
TF338018

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07765 KRAB_A-box, 2 hits
cd07936 SCAN, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.4020.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01352 KRAB, 2 hits
PF02023 SCAN, 1 hit
PF00096 zf-C2H2, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00349 KRAB, 2 hits
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109640 SSF109640, 2 hits
SSF57667 SSF57667, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50805 KRAB, 2 hits
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Experimental confirmation may be lacking for some isoforms.

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96GC6-1) [UniParc]FASTAAdd to basket
Also known as: SP2114a

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASRLPTAWS CEPVTFEDVT LGFTPEEWGL LDLKQKSLYR EVMLENYRNL
60 70 80 90 100
VSVEHQLSKP DVVSQLEEAE DFWPVERGIP QDTIPEYPEL QLDPKLDPLP
110 120 130 140 150
AESPLMNIEV VEVLTLNQEV AGPRNAQIQA LYAEDGSLSA DAPSEQVQQQ
160 170 180 190 200
GKHPGDPEAA RQRFRQFRYK DMTGPREALD QLRELCHQWL QPKARSKEQI
210 220 230 240 250
LELLVLEQFL GALPVKLRTW VESQHPENCQ EVVALVEGVT WMSEEEVLPA
260 270 280 290 300
GQPAEGTTCC LEVTAQQEEK QEDAAICPVT VLPEEPVTFQ DVAVDFSREE
310 320 330 340 350
WGLLGPTQRT EYRDVMLETF GHLVSVGWET TLENKELAPN SDIPEEEPAP
360 370 380 390 400
SLKVQESSRD CALSSTLEDT LQGGVQEVQD TVLKQMESAQ EKDLPQKKHF
410 420 430 440 450
DNRESQANSG ALDTNQVSLQ KIDNPESQAN SGALDTNQVL LHKIPPRKRL
460 470 480 490 500
RKRDSQVKSM KHNSRVKIHQ KSCERQKAKE GNGCRKTFSR STKQITFIRI
510 520 530 540 550
HKGSQVCRCS ECGKIFRNPR YFSVHKKIHT GERPYVCQDC GKGFVQSSSL
560 570 580 590 600
TQHQRVHSGE RPFECQECGR TFNDRSAISQ HLRTHTGAKP YKCQDCGKAF
610 620 630 640 650
RQSSHLIRHQ RTHTGERPYA CNKCGKAFTQ SSHLIGHQRT HNRTKRKKKQ

PTS
Length:653
Mass (Da):74,177
Last modified:April 5, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8B91F51F4BEED925
GO
Isoform 2 (identifier: Q96GC6-2) [UniParc]FASTAAdd to basket
Also known as: ZNF274a

The sequence of this isoform differs from the canonical sequence as follows:
     55-86: Missing.

Show »
Length:621
Mass (Da):70,505
Checksum:i8B3B3F12B341A136
GO
Isoform 3 (identifier: Q96GC6-3) [UniParc]FASTAAdd to basket
Also known as: ZNF274b

The sequence of this isoform differs from the canonical sequence as follows:
     1-105: Missing.

Show »
Length:548
Mass (Da):62,113
Checksum:i1A8C8BFE6FB17B69
GO
Isoform 4 (identifier: Q96GC6-4) [UniParc]FASTAAdd to basket
Also known as: SP2114b

The sequence of this isoform differs from the canonical sequence as follows:
     1-281: Missing.
     282-284: LPE → MLQ

Show »
Length:372
Mass (Da):42,448
Checksum:iF7D35AECFECCF7CD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MR47A0A0A0MR47_HUMAN
Neurotrophin receptor-interacting f...
ZNF274
611Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QXW4M0QXW4_HUMAN
Neurotrophin receptor-interacting f...
ZNF274
103Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QY30M0QY30_HUMAN
Neurotrophin receptor-interacting f...
ZNF274
79Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti14V → E in AAG24390 (PubMed:15498874).Curated1
Sequence conflicti212A → T in AAG24390 (PubMed:15498874).Curated1
Sequence conflicti289F → S in CAE46074 (PubMed:17974005).Curated1
Sequence conflicti636G → W in BAA88522 (PubMed:10777669).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_064920147V → I4 PublicationsCorresponds to variant dbSNP:rs7256349Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0069121 – 281Missing in isoform 4. 2 PublicationsAdd BLAST281
Alternative sequenceiVSP_0069101 – 105Missing in isoform 3. 1 PublicationAdd BLAST105
Alternative sequenceiVSP_00691155 – 86Missing in isoform 2. 1 PublicationAdd BLAST32
Alternative sequenceiVSP_006913282 – 284LPE → MLQ in isoform 4. 2 Publications3

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB029149 mRNA Translation: BAA88522.1
AB029150 mRNA Translation: BAA88523.1
AF275680 mRNA Translation: AAG24390.1
AF275681 mRNA Translation: AAG24391.1
BX641169 mRNA Translation: CAE46074.1
BT007304 mRNA Translation: AAP35968.1
AC008751 Genomic DNA No translation available.
AC020915 Genomic DNA No translation available.
BC009763 mRNA Translation: AAH09763.1
U71598 mRNA Translation: AAB16810.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS74473.1 [Q96GC6-1]
CCDS74474.1 [Q96GC6-2]
CCDS74476.1 [Q96GC6-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001265663.1, NM_001278734.1
NP_057408.2, NM_016324.3 [Q96GC6-3]
NP_057409.1, NM_016325.3 [Q96GC6-2]
NP_598009.1, NM_133502.2 [Q96GC6-1]
XP_011524629.1, XM_011526327.1 [Q96GC6-3]
XP_016881663.1, XM_017026174.1 [Q96GC6-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000345813; ENSP00000321187; ENSG00000171606 [Q96GC6-2]
ENST00000424679; ENSP00000409872; ENSG00000171606 [Q96GC6-3]
ENST00000610905; ENSP00000478533; ENSG00000171606 [Q96GC6-1]
ENST00000617501; ENSP00000484810; ENSG00000171606 [Q96GC6-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
10782

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:10782

UCSC genome browser

More...
UCSCi
uc032igq.2 human [Q96GC6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB029149 mRNA Translation: BAA88522.1
AB029150 mRNA Translation: BAA88523.1
AF275680 mRNA Translation: AAG24390.1
AF275681 mRNA Translation: AAG24391.1
BX641169 mRNA Translation: CAE46074.1
BT007304 mRNA Translation: AAP35968.1
AC008751 Genomic DNA No translation available.
AC020915 Genomic DNA No translation available.
BC009763 mRNA Translation: AAH09763.1
U71598 mRNA Translation: AAB16810.1
CCDSiCCDS74473.1 [Q96GC6-1]
CCDS74474.1 [Q96GC6-2]
CCDS74476.1 [Q96GC6-3]
RefSeqiNP_001265663.1, NM_001278734.1
NP_057408.2, NM_016324.3 [Q96GC6-3]
NP_057409.1, NM_016325.3 [Q96GC6-2]
NP_598009.1, NM_133502.2 [Q96GC6-1]
XP_011524629.1, XM_011526327.1 [Q96GC6-3]
XP_016881663.1, XM_017026174.1 [Q96GC6-3]

3D structure databases

SMRiQ96GC6
ModBaseiSearch...

Protein-protein interaction databases

BioGridi115999, 12 interactors
IntActiQ96GC6, 2 interactors
STRINGi9606.ENSP00000478533

PTM databases

iPTMnetiQ96GC6
PhosphoSitePlusiQ96GC6

Polymorphism and mutation databases

BioMutaiZNF274
DMDMi327478548

Proteomic databases

EPDiQ96GC6
jPOSTiQ96GC6
MaxQBiQ96GC6
PaxDbiQ96GC6
PeptideAtlasiQ96GC6
PRIDEiQ96GC6
ProteomicsDBi76611 [Q96GC6-1]
76612 [Q96GC6-2]
76613 [Q96GC6-3]
76614 [Q96GC6-4]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
10782
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000345813; ENSP00000321187; ENSG00000171606 [Q96GC6-2]
ENST00000424679; ENSP00000409872; ENSG00000171606 [Q96GC6-3]
ENST00000610905; ENSP00000478533; ENSG00000171606 [Q96GC6-1]
ENST00000617501; ENSP00000484810; ENSG00000171606 [Q96GC6-1]
GeneIDi10782
KEGGihsa:10782
UCSCiuc032igq.2 human [Q96GC6-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
10782
DisGeNETi10782

GeneCards: human genes, protein and diseases

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GeneCardsi
ZNF274
HGNCiHGNC:13068 ZNF274
HPAiHPA028880
MIMi605467 gene
neXtProtiNX_Q96GC6
OpenTargetsiENSG00000171606
PharmGKBiPA37644

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000162111
InParanoidiQ96GC6
KOiK12458
OMAiTQRTEYH
OrthoDBi1318335at2759
PhylomeDBiQ96GC6
TreeFamiTF338018

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway
SignaLinkiQ96GC6

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZNF274 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
ZNF274

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
10782

Protein Ontology

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PROi
PR:Q96GC6

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000171606 Expressed in 225 organ(s), highest expression level in left lobe of thyroid gland
ExpressionAtlasiQ96GC6 baseline and differential
GenevisibleiQ96GC6 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 2 hits
cd07936 SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 2 hits
PF02023 SCAN, 1 hit
PF00096 zf-C2H2, 4 hits
SMARTiView protein in SMART
SM00349 KRAB, 2 hits
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF109640 SSF109640, 2 hits
SSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 2 hits
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN274_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96GC6
Secondary accession number(s): Q53XU4
, Q6MZG1, Q8WY37, Q8WY38, Q92969, Q9UII0, Q9UII1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: April 5, 2011
Last modified: July 31, 2019
This is version 165 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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