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Entry version 151 (23 Feb 2022)
Sequence version 1 (01 Dec 2001)
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Protein

Serine dehydratase-like

Gene

SDSL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Has low serine dehydratase and threonine dehydratase activity.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

pyridoxal 5'-phosphate

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=30 mM for serine
  2. KM=7 mM for threonine

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLyase
Biological processLipid metabolism
LigandPyridoxal phosphate

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
4.3.1.17, 2681

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q96GA7

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8849175, Threonine catabolism

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
Q96GA7

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q96GA7

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine dehydratase-like
Alternative name(s):
L-serine deaminase
L-serine dehydratase/L-threonine deaminase
L-threonine dehydratase (EC:4.3.1.19)
Short name:
TDH
Serine dehydratase 2 (EC:4.3.1.17)
Short name:
SDH 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SDSL
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30404, SDSL

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96GA7

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000139410

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi72G → A: Strongly increased enzyme activity towards threonine. 1 Publication1
Mutagenesisi309C → A: Loss of enzyme activity. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
113675

Open Targets

More...
OpenTargetsi
ENSG00000139410

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134862016

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96GA7, Tbio

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB00114, Pyridoxal phosphate

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SDSL

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74731799

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002646241 – 329Serine dehydratase-likeAdd BLAST329

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei48N6-(pyridoxal phosphate)lysine1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96GA7

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96GA7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q96GA7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96GA7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96GA7

PeptideAtlas

More...
PeptideAtlasi
Q96GA7

PRoteomics IDEntifications database

More...
PRIDEi
Q96GA7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
76609

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96GA7

MetOSite database of methionine sulfoxide sites

More...
MetOSitei
Q96GA7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96GA7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000139410, Expressed in right lobe of liver and 142 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96GA7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96GA7, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000139410, Tissue enhanced (liver)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q96GA7
With#Exp.IntAct
itself6EBI-744440,EBI-744440

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
125255, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q96GA7, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000385790

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q96GA7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1329
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q96GA7

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q96GA7

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1250, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160713

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_021152_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96GA7

Identification of Orthologs from Complete Genome Data

More...
OMAi
IWEGNAS

Database of Orthologous Groups

More...
OrthoDBi
1199679at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96GA7

TreeFam database of animal gene trees

More...
TreeFami
TF329014

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.1100, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001926, PLP-dep
IPR000634, Ser/Thr_deHydtase_PyrdxlP-BS
IPR036052, Trypto_synt_PLP_dependent

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00291, PALP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53686, SSF53686, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00165, DEHYDRATASE_SER_THR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q96GA7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDGPVAEHAK QEPFHVVTPL LESWALSQVA GMPVFLKCEN VQPSGSFKIR
60 70 80 90 100
GIGHFCQEMA KKGCRHLVCS SGGNAGIAAA YAARKLGIPA TIVLPESTSL
110 120 130 140 150
QVVQRLQGEG AEVQLTGKVW DEANLRAQEL AKRDGWENVP PFDHPLIWKG
160 170 180 190 200
HASLVQELKA VLRTPPGALV LAVGGGGLLA GVVAGLLEVG WQHVPIIAME
210 220 230 240 250
THGAHCFNAA ITAGKLVTLP DITSVAKSLG AKTVAARALE CMQVCKIHSE
260 270 280 290 300
VVEDTEAVSA VQQLLDDERM LVEPACGAAL AAIYSGLLRR LQAEGCLPPS
310 320
LTSVVVIVCG GNNINSRELQ ALKTHLGQV
Length:329
Mass (Da):34,674
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCEAD30E570A43B7E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VYZ3F8VYZ3_HUMAN
Serine dehydratase-like
SDSL
172Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YID3H0YID3_HUMAN
Serine dehydratase-like
SDSL
225Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YIA2H0YIA2_HUMAN
Serine dehydratase-like
SDSL
60Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VZ97F8VZ97_HUMAN
Serine dehydratase-like
SDSL
29Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF134473 mRNA Translation: AAP97250.1
BC009849 mRNA Translation: AAH09849.1
BC091479 mRNA Translation: AAH91479.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS9170.1

NCBI Reference Sequences

More...
RefSeqi
NP_001291922.1, NM_001304993.1
NP_612441.1, NM_138432.3
XP_005253888.1, XM_005253831.4
XP_011536148.1, XM_011537846.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000345635; ENSP00000341117; ENSG00000139410
ENST00000403593; ENSP00000385790; ENSG00000139410

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
113675

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:113675

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...
MANE-Selecti
ENST00000403593.9; ENSP00000385790.4; NM_001304993.2; NP_001291922.1

UCSC genome browser

More...
UCSCi
uc009zwh.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF134473 mRNA Translation: AAP97250.1
BC009849 mRNA Translation: AAH09849.1
BC091479 mRNA Translation: AAH91479.1
CCDSiCCDS9170.1
RefSeqiNP_001291922.1, NM_001304993.1
NP_612441.1, NM_138432.3
XP_005253888.1, XM_005253831.4
XP_011536148.1, XM_011537846.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2RKBX-ray2.80A/B/C/D/E11-328[»]
SMRiQ96GA7
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi125255, 2 interactors
IntActiQ96GA7, 2 interactors
STRINGi9606.ENSP00000385790

Chemistry databases

DrugBankiDB00114, Pyridoxal phosphate

PTM databases

iPTMnetiQ96GA7
MetOSiteiQ96GA7
PhosphoSitePlusiQ96GA7

Genetic variation databases

BioMutaiSDSL
DMDMi74731799

Proteomic databases

EPDiQ96GA7
jPOSTiQ96GA7
MassIVEiQ96GA7
MaxQBiQ96GA7
PaxDbiQ96GA7
PeptideAtlasiQ96GA7
PRIDEiQ96GA7
ProteomicsDBi76609

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
31274, 294 antibodies from 26 providers

The DNASU plasmid repository

More...
DNASUi
113675

Genome annotation databases

EnsembliENST00000345635; ENSP00000341117; ENSG00000139410
ENST00000403593; ENSP00000385790; ENSG00000139410
GeneIDi113675
KEGGihsa:113675
MANE-SelectiENST00000403593.9; ENSP00000385790.4; NM_001304993.2; NP_001291922.1
UCSCiuc009zwh.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
113675
DisGeNETi113675

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SDSL
HGNCiHGNC:30404, SDSL
HPAiENSG00000139410, Tissue enhanced (liver)
neXtProtiNX_Q96GA7
OpenTargetsiENSG00000139410
PharmGKBiPA134862016
VEuPathDBiHostDB:ENSG00000139410

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1250, Eukaryota
GeneTreeiENSGT00940000160713
HOGENOMiCLU_021152_3_0_1
InParanoidiQ96GA7
OMAiIWEGNAS
OrthoDBi1199679at2759
PhylomeDBiQ96GA7
TreeFamiTF329014

Enzyme and pathway databases

BRENDAi4.3.1.17, 2681
PathwayCommonsiQ96GA7
ReactomeiR-HSA-8849175, Threonine catabolism
SABIO-RKiQ96GA7
SignaLinkiQ96GA7

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
113675, 4 hits in 1047 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SDSL, human
EvolutionaryTraceiQ96GA7

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
113675
PharosiQ96GA7, Tbio

Protein Ontology

More...
PROi
PR:Q96GA7
RNActiQ96GA7, protein

Gene expression databases

BgeeiENSG00000139410, Expressed in right lobe of liver and 142 other tissues
ExpressionAtlasiQ96GA7, baseline and differential
GenevisibleiQ96GA7, HS

Family and domain databases

Gene3Di3.40.50.1100, 2 hits
InterProiView protein in InterPro
IPR001926, PLP-dep
IPR000634, Ser/Thr_deHydtase_PyrdxlP-BS
IPR036052, Trypto_synt_PLP_dependent
PfamiView protein in Pfam
PF00291, PALP, 1 hit
SUPFAMiSSF53686, SSF53686, 1 hit
PROSITEiView protein in PROSITE
PS00165, DEHYDRATASE_SER_THR, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSDSL_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96GA7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: December 1, 2001
Last modified: February 23, 2022
This is version 151 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
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