UniProtKB - Q96GA3 (LTV1_HUMAN)

BLAST

>sp|Q96GA3|LTV1_HUMAN Protein LTV1 homolog OS=Homo sapiens OX=9606 GN=LTV1 PE=1 SV=1
MPHRKKKPFIEKKKAVSFHLVHRSQRDPLAADESAPQRVLLPTQKIDNEERRAEQRKYGV
FFDDDYDYLQHLKEPSGPSELIPSSTFSAHNRREEKEETLVIPSTGIKLPSSVFASEFEE
DVGLLNKAAPVSGPRLDFDPDIVAALDDDFDFDDPDNLLEDDFILQANKATGEEEGMDIQ
KSENEDDSEWEDVDDEKGDSNDDYDSAGLLSDEDCMSVPGKTHRAIADHLFWSEETKSRF
TEYSMTSSVMRRNEQLTLHDERFEKFYEQYDDDEIGALDNAELEGSIQVDSNRLQEVLND
YYKEKAENCVKLNTLEPLEDQDLPMNELDESEEEEMITVVLEEAKEKWDCESICSTYSNL
YNHPQLIKYQPKPKQIRISSKTGIPLNVLPKKGLTAKQTERIQMINGSDLPKVSTQPRSK
NESKEDKRARKQAIKEERKERRVEKKANKLAFKLEKRRQEKELLNLKKNVEGLKL

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History
Entry version 133 (07 Nov 2018)
Sequence version 1 (01 Dec 2001)
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Protein

Protein LTV1 homolog

Gene

LTV1

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

GO - Biological processⁱ

ribosomal small subunit biogenesis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
ribosomal small subunit export from nucleus
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Reactomeⁱ

R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein LTV1 homolog
Gene namesⁱ	Name:LTV1 Synonyms:C6orf93
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000135521.8
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:21173 LTV1
neXtProtⁱ	NX_Q96GA3

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000135521
PharmGKBⁱ	PA134893631

Polymorphism and mutation databases

BioMutaⁱ	LTV1
DMDMⁱ	74751878

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000302813	1 – 475	Protein LTV1 homologAdd BLAST		475

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	17	PhosphoserineCombined sources	1
Modified residueⁱ	24	PhosphoserineCombined sources	1
Modified residueⁱ	248	PhosphoserineBy similarity	1
Modified residueⁱ	331	PhosphoserineCombined sources	1
Modified residueⁱ	408	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q96GA3
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q96GA3
PaxDbⁱ	Q96GA3
PeptideAtlas More...PeptideAtlasⁱ	Q96GA3
PRIDEⁱ	Q96GA3
ProteomicsDBⁱ	76608

PTM databases

iPTMnetⁱ	Q96GA3
PhosphoSitePlusⁱ	Q96GA3

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000135521 Expressed in 195 organ(s), highest expression level in quadriceps femoris
CleanExⁱ	HS_LTV1
Genevisibleⁱ	Q96GA3 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA030159 HPA030160 HPA030161

HPAⁱ

HPA030159
HPA030160
HPA030161

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
BYSL	Q13895	7	EBI-2558389,EBI-358049

With

Entry

#Exp.

IntAct

Notes

BYSL

Q13895

EBI-2558389,EBI-358049

Protein-protein interaction databases

BioGridⁱ	124379, 45 interactors
IntActⁱ	Q96GA3, 27 interactors
STRINGⁱ	9606.ENSP00000356548

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q96GA3
SMRⁱ	Q96GA3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	418 – 475	Sequence analysisAdd BLAST		58

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	137 – 214	Asp-richAdd BLAST		78
Compositional biasⁱ	330 – 335	Poly-Glu		6

Sequence similaritiesⁱ

Belongs to the LTV1 family.Curated

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	KOG2637 Eukaryota ENOG410XP9T LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000002789
HOGENOMⁱ	HOG000047205
HOVERGENⁱ	HBG104438
InParanoidⁱ	Q96GA3
KEGG Orthology (KO) More...KOⁱ	K14798
OMAⁱ	KKWDCES
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0DLW
PhylomeDBⁱ	Q96GA3
TreeFamⁱ	TF314845

Family and domain databases

InterProⁱ	View protein in InterPro IPR007307 LTV
PANTHERⁱ	PTHR21531 PTHR21531, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04180 LTV, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q96GA3-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPHRKKKPFI EKKKAVSFHL VHRSQRDPLA ADESAPQRVL LPTQKIDNEE 
        60         70         80         90        100
RRAEQRKYGV FFDDDYDYLQ HLKEPSGPSE LIPSSTFSAH NRREEKEETL 
       110        120        130        140        150
VIPSTGIKLP SSVFASEFEE DVGLLNKAAP VSGPRLDFDP DIVAALDDDF 
       160        170        180        190        200
DFDDPDNLLE DDFILQANKA TGEEEGMDIQ KSENEDDSEW EDVDDEKGDS 
       210        220        230        240        250
NDDYDSAGLL SDEDCMSVPG KTHRAIADHL FWSEETKSRF TEYSMTSSVM 
       260        270        280        290        300
RRNEQLTLHD ERFEKFYEQY DDDEIGALDN AELEGSIQVD SNRLQEVLND 
       310        320        330        340        350
YYKEKAENCV KLNTLEPLED QDLPMNELDE SEEEEMITVV LEEAKEKWDC 
       360        370        380        390        400
ESICSTYSNL YNHPQLIKYQ PKPKQIRISS KTGIPLNVLP KKGLTAKQTE 
       410        420        430        440        450
RIQMINGSDL PKVSTQPRSK NESKEDKRAR KQAIKEERKE RRVEKKANKL 
       460        470 
AFKLEKRRQE KELLNLKKNV EGLKL

Length:475

Mass (Da):54,855

Last modified:December 1, 2001 - v1

Checksum:ⁱ76AB95901C5BF239

Sequence cautionⁱ

The sequence BAB55388 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL049844 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW47859.1 BC009855 mRNA Translation: AAH09855.1 AK027815 mRNA Translation: BAB55388.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS5201.1
NCBI Reference Sequences More...RefSeqⁱ	NP_116249.2, NM_032860.4
UniGeneⁱ	Hs.185675

Genome annotation databases

Ensemblⁱ	ENST00000367576; ENSP00000356548; ENSG00000135521
GeneIDⁱ	84946
KEGGⁱ	hsa:84946
UCSC genome browser More...UCSCⁱ	uc003qjs.4 human

Protein	Similar proteins		Species	Score	Length	Source
Q96GA3	Protein LTV1 homolog		PONAB		475	UniRef100_Q96GA3

Protein	Similar proteins		Species	Score	Length	Source
Q96GA3	Protein LTV1 homolog		PONAB		475	UniRef90_Q96GA3
Uncharacterized protein		PAPAN		499
Uncharacterized protein		GORGO		481
Protein LTV1 homolog		CALJA		478
Uncharacterized protein		NOMLE		476
+64

Protein	Similar proteins		Species	Score	Length	Source
Q96GA3	Protein LTV1 homolog		PONAB		475	UniRef50_Q96GA3
Protein LTV1 homolog		BOVIN		475
Protein LTV1 homolog		DANRE		469
Protein LTV1 homolog		XENLA		469
Protein LTV1 homolog		RAT		470
+337

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL049844 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW47859.1 BC009855 mRNA Translation: AAH09855.1 AK027815 mRNA Translation: BAB55388.1 Different initiation.
CCDSⁱ	CCDS5201.1
RefSeqⁱ	NP_116249.2, NM_032860.4
UniGeneⁱ	Hs.185675

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	6G18	electron microscopy	3.60	t	1-475	[»]
	6G4S	electron microscopy	4.00	t	1-475	[»]
	6G4W	electron microscopy	4.50	t	352-369	[»]
	6G51	electron microscopy	4.10	t	1-475	[»]
	6G53	electron microscopy	4.50	t	1-475	[»]
ProteinModelPortalⁱ	Q96GA3
SMRⁱ	Q96GA3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	124379, 45 interactors
IntActⁱ	Q96GA3, 27 interactors
STRINGⁱ	9606.ENSP00000356548

PTM databases

iPTMnetⁱ	Q96GA3
PhosphoSitePlusⁱ	Q96GA3

Polymorphism and mutation databases

BioMutaⁱ	LTV1
DMDMⁱ	74751878

Proteomic databases

EPDⁱ	Q96GA3
MaxQBⁱ	Q96GA3
PaxDbⁱ	Q96GA3
PeptideAtlasⁱ	Q96GA3
PRIDEⁱ	Q96GA3
ProteomicsDBⁱ	76608

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	84946
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000367576; ENSP00000356548; ENSG00000135521
GeneIDⁱ	84946
KEGGⁱ	hsa:84946
UCSCⁱ	uc003qjs.4 human

Organism-specific databases

CTDⁱ	84946
EuPathDBⁱ	HostDB:ENSG00000135521.8
GeneCardsⁱ	LTV1
H-InvDBⁱ	HIX0200846
HGNCⁱ	HGNC:21173 LTV1
HPAⁱ	HPA030159 HPA030160 HPA030161
neXtProtⁱ	NX_Q96GA3
OpenTargetsⁱ	ENSG00000135521
PharmGKBⁱ	PA134893631
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2637 Eukaryota ENOG410XP9T LUCA
GeneTreeⁱ	ENSGT00390000002789
HOGENOMⁱ	HOG000047205
HOVERGENⁱ	HBG104438
InParanoidⁱ	Q96GA3
KOⁱ	K14798
OMAⁱ	KKWDCES
OrthoDBⁱ	EOG091G0DLW
PhylomeDBⁱ	Q96GA3
TreeFamⁱ	TF314845

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Reactomeⁱ

R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Miscellaneous databases

ChiTaRSⁱ	LTV1 human
GenomeRNAiⁱ	84946
Protein Ontology More...PROⁱ	PR:Q96GA3

Gene expression databases

Bgeeⁱ	ENSG00000135521 Expressed in 195 organ(s), highest expression level in quadriceps femoris
CleanExⁱ	HS_LTV1
Genevisibleⁱ	Q96GA3 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR007307 LTV
PANTHERⁱ	PTHR21531 PTHR21531, 1 hit
Pfamⁱ	View protein in Pfam PF04180 LTV, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	LTV1_HUMAN
Accessionⁱ	Q96GA3Primary (citable) accession number: Q96GA3 Secondary accession number(s): Q96JX8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
	Last sequence update:	December 1, 2001
	Last modified:	November 7, 2018
	This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q96GA3 (LTV1_HUMAN)

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Protein LTV1 homolog

LTV1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

Endosome

Nucleus

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ