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Protein

Protein LTV1 homolog

Gene

LTV1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • ribosomal small subunit biogenesis Source: GO_Central
  • ribosomal small subunit export from nucleus Source: GO_Central

Enzyme and pathway databases

ReactomeiR-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Names & Taxonomyi

Protein namesi
Recommended name:
Protein LTV1 homolog
Gene namesi
Name:LTV1
Synonyms:C6orf93
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000135521.8
HGNCiHGNC:21173 LTV1
neXtProtiNX_Q96GA3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000135521
PharmGKBiPA134893631

Polymorphism and mutation databases

BioMutaiLTV1
DMDMi74751878

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003028131 – 475Protein LTV1 homologAdd BLAST475

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei17PhosphoserineCombined sources1
Modified residuei24PhosphoserineCombined sources1
Modified residuei248PhosphoserineBy similarity1
Modified residuei331PhosphoserineCombined sources1
Modified residuei408PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96GA3
MaxQBiQ96GA3
PaxDbiQ96GA3
PeptideAtlasiQ96GA3
PRIDEiQ96GA3
ProteomicsDBi76608

PTM databases

iPTMnetiQ96GA3
PhosphoSitePlusiQ96GA3

Expressioni

Gene expression databases

BgeeiENSG00000135521 Expressed in 195 organ(s), highest expression level in quadriceps femoris
CleanExiHS_LTV1
GenevisibleiQ96GA3 HS

Organism-specific databases

HPAiHPA030159
HPA030160
HPA030161

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
BYSLQ138957EBI-2558389,EBI-358049

Protein-protein interaction databases

BioGridi124379, 45 interactors
IntActiQ96GA3, 27 interactors
STRINGi9606.ENSP00000356548

Structurei

3D structure databases

ProteinModelPortaliQ96GA3
SMRiQ96GA3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili418 – 475Sequence analysisAdd BLAST58

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi137 – 214Asp-richAdd BLAST78
Compositional biasi330 – 335Poly-Glu6

Sequence similaritiesi

Belongs to the LTV1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2637 Eukaryota
ENOG410XP9T LUCA
GeneTreeiENSGT00390000002789
HOGENOMiHOG000047205
HOVERGENiHBG104438
InParanoidiQ96GA3
KOiK14798
OMAiKKWDCES
OrthoDBiEOG091G0DLW
PhylomeDBiQ96GA3
TreeFamiTF314845

Family and domain databases

InterProiView protein in InterPro
IPR007307 LTV
PANTHERiPTHR21531 PTHR21531, 1 hit
PfamiView protein in Pfam
PF04180 LTV, 1 hit

Sequencei

Sequence statusi: Complete.

Q96GA3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPHRKKKPFI EKKKAVSFHL VHRSQRDPLA ADESAPQRVL LPTQKIDNEE
60 70 80 90 100
RRAEQRKYGV FFDDDYDYLQ HLKEPSGPSE LIPSSTFSAH NRREEKEETL
110 120 130 140 150
VIPSTGIKLP SSVFASEFEE DVGLLNKAAP VSGPRLDFDP DIVAALDDDF
160 170 180 190 200
DFDDPDNLLE DDFILQANKA TGEEEGMDIQ KSENEDDSEW EDVDDEKGDS
210 220 230 240 250
NDDYDSAGLL SDEDCMSVPG KTHRAIADHL FWSEETKSRF TEYSMTSSVM
260 270 280 290 300
RRNEQLTLHD ERFEKFYEQY DDDEIGALDN AELEGSIQVD SNRLQEVLND
310 320 330 340 350
YYKEKAENCV KLNTLEPLED QDLPMNELDE SEEEEMITVV LEEAKEKWDC
360 370 380 390 400
ESICSTYSNL YNHPQLIKYQ PKPKQIRISS KTGIPLNVLP KKGLTAKQTE
410 420 430 440 450
RIQMINGSDL PKVSTQPRSK NESKEDKRAR KQAIKEERKE RRVEKKANKL
460 470
AFKLEKRRQE KELLNLKKNV EGLKL
Length:475
Mass (Da):54,855
Last modified:December 1, 2001 - v1
Checksum:i76AB95901C5BF239
GO

Sequence cautioni

The sequence BAB55388 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL049844 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47859.1
BC009855 mRNA Translation: AAH09855.1
AK027815 mRNA Translation: BAB55388.1 Different initiation.
CCDSiCCDS5201.1
RefSeqiNP_116249.2, NM_032860.4
UniGeneiHs.185675

Genome annotation databases

EnsembliENST00000367576; ENSP00000356548; ENSG00000135521
GeneIDi84946
KEGGihsa:84946
UCSCiuc003qjs.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL049844 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47859.1
BC009855 mRNA Translation: AAH09855.1
AK027815 mRNA Translation: BAB55388.1 Different initiation.
CCDSiCCDS5201.1
RefSeqiNP_116249.2, NM_032860.4
UniGeneiHs.185675

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6G18electron microscopy3.60t1-475[»]
6G4Selectron microscopy4.00t1-475[»]
6G4Welectron microscopy4.50t352-369[»]
6G51electron microscopy4.10t1-475[»]
6G53electron microscopy4.50t1-475[»]
ProteinModelPortaliQ96GA3
SMRiQ96GA3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124379, 45 interactors
IntActiQ96GA3, 27 interactors
STRINGi9606.ENSP00000356548

PTM databases

iPTMnetiQ96GA3
PhosphoSitePlusiQ96GA3

Polymorphism and mutation databases

BioMutaiLTV1
DMDMi74751878

Proteomic databases

EPDiQ96GA3
MaxQBiQ96GA3
PaxDbiQ96GA3
PeptideAtlasiQ96GA3
PRIDEiQ96GA3
ProteomicsDBi76608

Protocols and materials databases

DNASUi84946
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367576; ENSP00000356548; ENSG00000135521
GeneIDi84946
KEGGihsa:84946
UCSCiuc003qjs.4 human

Organism-specific databases

CTDi84946
EuPathDBiHostDB:ENSG00000135521.8
GeneCardsiLTV1
H-InvDBiHIX0200846
HGNCiHGNC:21173 LTV1
HPAiHPA030159
HPA030160
HPA030161
neXtProtiNX_Q96GA3
OpenTargetsiENSG00000135521
PharmGKBiPA134893631
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2637 Eukaryota
ENOG410XP9T LUCA
GeneTreeiENSGT00390000002789
HOGENOMiHOG000047205
HOVERGENiHBG104438
InParanoidiQ96GA3
KOiK14798
OMAiKKWDCES
OrthoDBiEOG091G0DLW
PhylomeDBiQ96GA3
TreeFamiTF314845

Enzyme and pathway databases

ReactomeiR-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Miscellaneous databases

ChiTaRSiLTV1 human
GenomeRNAii84946
PROiPR:Q96GA3

Gene expression databases

BgeeiENSG00000135521 Expressed in 195 organ(s), highest expression level in quadriceps femoris
CleanExiHS_LTV1
GenevisibleiQ96GA3 HS

Family and domain databases

InterProiView protein in InterPro
IPR007307 LTV
PANTHERiPTHR21531 PTHR21531, 1 hit
PfamiView protein in Pfam
PF04180 LTV, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLTV1_HUMAN
AccessioniPrimary (citable) accession number: Q96GA3
Secondary accession number(s): Q96JX8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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