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Entry version 150 (02 Dec 2020)
Sequence version 1 (01 Dec 2001)
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Protein

Protein LTV1 homolog

Gene

LTV1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q96GA3

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein LTV1 homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LTV1
Synonyms:C6orf93
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...
EuPathDBi
HostDB:ENSG00000135521.8

Human Gene Nomenclature Database

More...
HGNCi
HGNC:21173, LTV1

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96GA3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000135521

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134893631

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96GA3, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LTV1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74751878

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003028131 – 475Protein LTV1 homologAdd BLAST475

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei17PhosphoserineCombined sources1
Modified residuei24PhosphoserineCombined sources1
Modified residuei248PhosphoserineBy similarity1
Modified residuei331PhosphoserineCombined sources1
Modified residuei408PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96GA3

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96GA3

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q96GA3

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96GA3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96GA3

PeptideAtlas

More...
PeptideAtlasi
Q96GA3

PRoteomics IDEntifications database

More...
PRIDEi
Q96GA3

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
76608

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96GA3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96GA3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000135521, Expressed in quadriceps femoris and 209 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96GA3, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000135521, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
124379, 79 interactors

Protein interaction database and analysis system

More...
IntActi
Q96GA3, 41 interactors

Molecular INTeraction database

More...
MINTi
Q96GA3

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000356548

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q96GA3, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96GA3

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili418 – 475Sequence analysisAdd BLAST58

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi137 – 214Asp-richAdd BLAST78
Compositional biasi330 – 335Poly-Glu6

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the LTV1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2637, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000002789

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_035718_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96GA3

Identification of Orthologs from Complete Genome Data

More...
OMAi
KKWDCES

Database of Orthologous Groups

More...
OrthoDBi
917248at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96GA3

TreeFam database of animal gene trees

More...
TreeFami
TF314845

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007307, Ltv1

The PANTHER Classification System

More...
PANTHERi
PTHR21531, PTHR21531, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04180, LTV, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q96GA3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPHRKKKPFI EKKKAVSFHL VHRSQRDPLA ADESAPQRVL LPTQKIDNEE
60 70 80 90 100
RRAEQRKYGV FFDDDYDYLQ HLKEPSGPSE LIPSSTFSAH NRREEKEETL
110 120 130 140 150
VIPSTGIKLP SSVFASEFEE DVGLLNKAAP VSGPRLDFDP DIVAALDDDF
160 170 180 190 200
DFDDPDNLLE DDFILQANKA TGEEEGMDIQ KSENEDDSEW EDVDDEKGDS
210 220 230 240 250
NDDYDSAGLL SDEDCMSVPG KTHRAIADHL FWSEETKSRF TEYSMTSSVM
260 270 280 290 300
RRNEQLTLHD ERFEKFYEQY DDDEIGALDN AELEGSIQVD SNRLQEVLND
310 320 330 340 350
YYKEKAENCV KLNTLEPLED QDLPMNELDE SEEEEMITVV LEEAKEKWDC
360 370 380 390 400
ESICSTYSNL YNHPQLIKYQ PKPKQIRISS KTGIPLNVLP KKGLTAKQTE
410 420 430 440 450
RIQMINGSDL PKVSTQPRSK NESKEDKRAR KQAIKEERKE RRVEKKANKL
460 470
AFKLEKRRQE KELLNLKKNV EGLKL
Length:475
Mass (Da):54,855
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i76AB95901C5BF239
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB55388 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL049844 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47859.1
BC009855 mRNA Translation: AAH09855.1
AK027815 mRNA Translation: BAB55388.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS5201.1

NCBI Reference Sequences

More...
RefSeqi
NP_116249.2, NM_032860.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000367576; ENSP00000356548; ENSG00000135521

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
84946

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:84946

UCSC genome browser

More...
UCSCi
uc003qjs.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL049844 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47859.1
BC009855 mRNA Translation: AAH09855.1
AK027815 mRNA Translation: BAB55388.1 Different initiation.
CCDSiCCDS5201.1
RefSeqiNP_116249.2, NM_032860.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6G18electron microscopy3.60t1-475[»]
6G4Selectron microscopy4.00t1-475[»]
6G4Welectron microscopy4.50t352-369[»]
6G51electron microscopy4.10t1-475[»]
6G53electron microscopy4.50t1-475[»]
SMRiQ96GA3
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi124379, 79 interactors
IntActiQ96GA3, 41 interactors
MINTiQ96GA3
STRINGi9606.ENSP00000356548

PTM databases

iPTMnetiQ96GA3
PhosphoSitePlusiQ96GA3

Polymorphism and mutation databases

BioMutaiLTV1
DMDMi74751878

Proteomic databases

EPDiQ96GA3
jPOSTiQ96GA3
MassIVEiQ96GA3
MaxQBiQ96GA3
PaxDbiQ96GA3
PeptideAtlasiQ96GA3
PRIDEiQ96GA3
ProteomicsDBi76608

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
33167, 69 antibodies

The DNASU plasmid repository

More...
DNASUi
84946

Genome annotation databases

EnsembliENST00000367576; ENSP00000356548; ENSG00000135521
GeneIDi84946
KEGGihsa:84946
UCSCiuc003qjs.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
84946
EuPathDBiHostDB:ENSG00000135521.8

GeneCards: human genes, protein and diseases

More...
GeneCardsi
LTV1
HGNCiHGNC:21173, LTV1
HPAiENSG00000135521, Low tissue specificity
neXtProtiNX_Q96GA3
OpenTargetsiENSG00000135521
PharmGKBiPA134893631

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2637, Eukaryota
GeneTreeiENSGT00390000002789
HOGENOMiCLU_035718_0_0_1
InParanoidiQ96GA3
OMAiKKWDCES
OrthoDBi917248at2759
PhylomeDBiQ96GA3
TreeFamiTF314845

Enzyme and pathway databases

PathwayCommonsiQ96GA3
ReactomeiR-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
84946, 684 hits in 851 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
LTV1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
84946
PharosiQ96GA3, Tdark

Protein Ontology

More...
PROi
PR:Q96GA3
RNActiQ96GA3, protein

Gene expression databases

BgeeiENSG00000135521, Expressed in quadriceps femoris and 209 other tissues
GenevisibleiQ96GA3, HS

Family and domain databases

InterProiView protein in InterPro
IPR007307, Ltv1
PANTHERiPTHR21531, PTHR21531, 1 hit
PfamiView protein in Pfam
PF04180, LTV, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLTV1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96GA3
Secondary accession number(s): Q96JX8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: December 1, 2001
Last modified: December 2, 2020
This is version 150 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
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