UniProtKB - Q96GA3 (LTV1_HUMAN)
Protein
Protein LTV1 homolog
Gene
LTV1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Biological processi
- ribosomal small subunit biogenesis Source: GO_Central
- ribosomal small subunit export from nucleus Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | Q96GA3 |
Reactomei | R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol |
Names & Taxonomyi
Protein namesi | Recommended name: Protein LTV1 homolog |
Gene namesi | Name:LTV1 Synonyms:C6orf93 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:21173, LTV1 |
neXtProti | NX_Q96GA3 |
VEuPathDBi | HostDB:ENSG00000135521.8 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: GO_Central
Other locations
- preribosome, small subunit precursor Source: GO_Central
Pathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000135521 |
PharmGKBi | PA134893631 |
Miscellaneous databases
Pharosi | Q96GA3, Tdark |
Genetic variation databases
BioMutai | LTV1 |
DMDMi | 74751878 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000302813 | 1 – 475 | Protein LTV1 homologAdd BLAST | 475 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 17 | PhosphoserineCombined sources | 1 | |
Modified residuei | 24 | PhosphoserineCombined sources | 1 | |
Modified residuei | 248 | PhosphoserineBy similarity | 1 | |
Modified residuei | 331 | PhosphoserineCombined sources | 1 | |
Modified residuei | 408 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q96GA3 |
jPOSTi | Q96GA3 |
MassIVEi | Q96GA3 |
MaxQBi | Q96GA3 |
PaxDbi | Q96GA3 |
PeptideAtlasi | Q96GA3 |
PRIDEi | Q96GA3 |
ProteomicsDBi | 76608 |
PTM databases
iPTMneti | Q96GA3 |
PhosphoSitePlusi | Q96GA3 |
Expressioni
Gene expression databases
Bgeei | ENSG00000135521, Expressed in quadriceps femoris and 209 other tissues |
Genevisiblei | Q96GA3, HS |
Organism-specific databases
HPAi | ENSG00000135521, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ96GA3
With | #Exp. | IntAct |
---|---|---|
BYSL [Q13895] | 11 | EBI-2558389,EBI-358049 |
GAS2L2 [Q8NHY3] | 3 | EBI-2558389,EBI-7960826 |
RPS3 [P23396] | 3 | EBI-2558389,EBI-351193 |
Protein-protein interaction databases
BioGRIDi | 124379, 80 interactors |
IntActi | Q96GA3, 41 interactors |
MINTi | Q96GA3 |
STRINGi | 9606.ENSP00000356548 |
Miscellaneous databases
RNActi | Q96GA3, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 418 – 475 | Sequence analysisAdd BLAST | 58 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 137 – 214 | Asp-richAdd BLAST | 78 | |
Compositional biasi | 330 – 335 | Poly-Glu | 6 |
Sequence similaritiesi
Belongs to the LTV1 family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG2637, Eukaryota |
GeneTreei | ENSGT00390000002789 |
HOGENOMi | CLU_035718_0_0_1 |
InParanoidi | Q96GA3 |
OMAi | KKWDCES |
OrthoDBi | 917248at2759 |
PhylomeDBi | Q96GA3 |
TreeFami | TF314845 |
Family and domain databases
InterProi | View protein in InterPro IPR007307, Ltv1 |
PANTHERi | PTHR21531, PTHR21531, 1 hit |
Pfami | View protein in Pfam PF04180, LTV, 1 hit |
i Sequence
Sequence statusi: Complete.
Q96GA3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPHRKKKPFI EKKKAVSFHL VHRSQRDPLA ADESAPQRVL LPTQKIDNEE
60 70 80 90 100
RRAEQRKYGV FFDDDYDYLQ HLKEPSGPSE LIPSSTFSAH NRREEKEETL
110 120 130 140 150
VIPSTGIKLP SSVFASEFEE DVGLLNKAAP VSGPRLDFDP DIVAALDDDF
160 170 180 190 200
DFDDPDNLLE DDFILQANKA TGEEEGMDIQ KSENEDDSEW EDVDDEKGDS
210 220 230 240 250
NDDYDSAGLL SDEDCMSVPG KTHRAIADHL FWSEETKSRF TEYSMTSSVM
260 270 280 290 300
RRNEQLTLHD ERFEKFYEQY DDDEIGALDN AELEGSIQVD SNRLQEVLND
310 320 330 340 350
YYKEKAENCV KLNTLEPLED QDLPMNELDE SEEEEMITVV LEEAKEKWDC
360 370 380 390 400
ESICSTYSNL YNHPQLIKYQ PKPKQIRISS KTGIPLNVLP KKGLTAKQTE
410 420 430 440 450
RIQMINGSDL PKVSTQPRSK NESKEDKRAR KQAIKEERKE RRVEKKANKL
460 470
AFKLEKRRQE KELLNLKKNV EGLKL
Sequence cautioni
The sequence BAB55388 differs from that shown. Reason: Erroneous initiation.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL049844 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW47859.1 BC009855 mRNA Translation: AAH09855.1 AK027815 mRNA Translation: BAB55388.1 Different initiation. |
CCDSi | CCDS5201.1 |
RefSeqi | NP_116249.2, NM_032860.4 |
Genome annotation databases
Ensembli | ENST00000367576; ENSP00000356548; ENSG00000135521 |
GeneIDi | 84946 |
KEGGi | hsa:84946 |
UCSCi | uc003qjs.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL049844 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW47859.1 BC009855 mRNA Translation: AAH09855.1 AK027815 mRNA Translation: BAB55388.1 Different initiation. |
CCDSi | CCDS5201.1 |
RefSeqi | NP_116249.2, NM_032860.4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6G18 | electron microscopy | 3.60 | t | 1-475 | [»] | |
6G4S | electron microscopy | 4.00 | t | 1-475 | [»] | |
6G4W | electron microscopy | 4.50 | t | 352-369 | [»] | |
6G51 | electron microscopy | 4.10 | t | 1-475 | [»] | |
6G53 | electron microscopy | 4.50 | t | 1-475 | [»] | |
SMRi | Q96GA3 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 124379, 80 interactors |
IntActi | Q96GA3, 41 interactors |
MINTi | Q96GA3 |
STRINGi | 9606.ENSP00000356548 |
PTM databases
iPTMneti | Q96GA3 |
PhosphoSitePlusi | Q96GA3 |
Genetic variation databases
BioMutai | LTV1 |
DMDMi | 74751878 |
Proteomic databases
EPDi | Q96GA3 |
jPOSTi | Q96GA3 |
MassIVEi | Q96GA3 |
MaxQBi | Q96GA3 |
PaxDbi | Q96GA3 |
PeptideAtlasi | Q96GA3 |
PRIDEi | Q96GA3 |
ProteomicsDBi | 76608 |
Protocols and materials databases
Antibodypediai | 33167, 70 antibodies |
DNASUi | 84946 |
Genome annotation databases
Ensembli | ENST00000367576; ENSP00000356548; ENSG00000135521 |
GeneIDi | 84946 |
KEGGi | hsa:84946 |
UCSCi | uc003qjs.4, human |
Organism-specific databases
CTDi | 84946 |
GeneCardsi | LTV1 |
HGNCi | HGNC:21173, LTV1 |
HPAi | ENSG00000135521, Low tissue specificity |
neXtProti | NX_Q96GA3 |
OpenTargetsi | ENSG00000135521 |
PharmGKBi | PA134893631 |
VEuPathDBi | HostDB:ENSG00000135521.8 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2637, Eukaryota |
GeneTreei | ENSGT00390000002789 |
HOGENOMi | CLU_035718_0_0_1 |
InParanoidi | Q96GA3 |
OMAi | KKWDCES |
OrthoDBi | 917248at2759 |
PhylomeDBi | Q96GA3 |
TreeFami | TF314845 |
Enzyme and pathway databases
PathwayCommonsi | Q96GA3 |
Reactomei | R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol |
Miscellaneous databases
BioGRID-ORCSi | 84946, 684 hits in 882 CRISPR screens |
ChiTaRSi | LTV1, human |
GenomeRNAii | 84946 |
Pharosi | Q96GA3, Tdark |
PROi | PR:Q96GA3 |
RNActi | Q96GA3, protein |
Gene expression databases
Bgeei | ENSG00000135521, Expressed in quadriceps femoris and 209 other tissues |
Genevisiblei | Q96GA3, HS |
Family and domain databases
InterProi | View protein in InterPro IPR007307, Ltv1 |
PANTHERi | PTHR21531, PTHR21531, 1 hit |
Pfami | View protein in Pfam PF04180, LTV, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LTV1_HUMAN | |
Accessioni | Q96GA3Primary (citable) accession number: Q96GA3 Secondary accession number(s): Q96JX8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 11, 2007 |
Last sequence update: | December 1, 2001 | |
Last modified: | February 10, 2021 | |
This is version 151 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM