BSCL2

Functionⁱ

Is a regulator of lipid catabolism essential for adipocyte differentiation. May also be involved in the central regulation of energy homeostasis (By similarity). Necessary for correct lipid storage and lipid droplets maintenance; may play a tissue-autonomous role in controlling lipid storage in adipocytes and in preventing ectopic lipid droplet formation in non-adipose tissues.By similarity2 Publications

GO - Biological processⁱ

fat cell differentiation Source: UniProtKB
lipid catabolic process Source: UniProtKB-KW
lipid particle organization
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 19278620
lipid storage
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 19278620
negative regulation of lipid catabolic process Source: UniProtKB
positive regulation of cold-induced thermogenesis
Source: YuBioLab
Inferred from sequence or structural similarityⁱ
- 27748422

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Lipid degradation, Lipid metabolism

Biological process

Lipid degradation, Lipid metabolism

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Seipin Alternative name(s): Bernardinelli-Seip congenital lipodystrophy type 2 protein
Gene namesⁱ	Name:BSCL2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000168000.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:15832 BSCL2
MIMⁱ	606158 gene
neXtProtⁱ	NX_Q96G97

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 26	CytoplasmicSequence analysisAdd BLAST	26
Transmembraneⁱ	27 – 47	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	48 – 242	LumenalSequence analysisAdd BLAST	195
Transmembraneⁱ	243 – 263	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	264 – 398	CytoplasmicSequence analysisAdd BLAST	135

Keywords - Cellular componentⁱ

Endoplasmic reticulum, Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Congenital generalized lipodystrophy 2 (CGL2)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAn autosomal recessive disorder characterized by a near complete absence of adipose tissue, extreme insulin resistance, hypertriglyceridemia, hepatic steatosis and early onset of diabetes.

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_022377	212	A → P in CGL2; increases localization to nuclear envelope. 2 PublicationsCorresponds to variant dbSNP:rs137852971EnsemblClinVar.		1

Spastic paraplegia 17, autosomal dominant (SPG17)4 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. SPG17 is characterized by prominent amyotrophy of the hand muscles, the presence of mild to severe pyramidal tract signs and spastic paraplegia. SPG17 is a motor neuron disease overlapping with distal spinal muscular atrophy type 5.

Neuronopathy, distal hereditary motor, 5A (HMN5A)2 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA disorder characterized by distal muscular atrophy mainly affecting the upper extremities, in contrast to other distal motor neuronopathies. These constitute a heterogeneous group of neuromuscular diseases caused by selective degeneration of motor neurons in the anterior horn of the spinal cord, without sensory deficit in the posterior horn. The overall clinical picture consists of a classical distal muscular atrophy syndrome in the legs without clinical sensory loss. The disease starts with weakness and wasting of distal muscles of the anterior tibial and peroneal compartments of the legs. Later on, weakness and atrophy may expand to the proximal muscles of the lower limbs and/or to the distal upper limbs.

Encephalopathy, progressive, with or without lipodystrophy (PELD)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA neurodegenerative disease characterized by developmental regression of motor and cognitive skills in the first years of life, often leading to death in the first decade, hyperactive behavior, seizures, tremor and ataxic gait. Patients may show a mild or typical lipodystrophic appearance.

Keywords - Diseaseⁱ

Congenital generalized lipodystrophy, Diabetes mellitus, Disease mutation, Hereditary spastic paraplegia, Neurodegeneration, Neuropathy

Organism-specific databases

DisGeNET More...DisGeNETⁱ	26580
GeneReviewsⁱ	BSCL2
MalaCards human disease database More...MalaCardsⁱ	BSCL2
MIMⁱ	269700 phenotype 270685 phenotype 600794 phenotype 615924 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000168000
Orphanetⁱ	100998 Autosomal dominant spastic paraplegia type 17 528 Berardinelli-Seip congenital lipodystrophy 139536 Distal hereditary motor neuropathy type 5 363400 Severe neurodegenerative syndrome with lipodystrophy
PharmGKBⁱ	PA25432

Polymorphism and mutation databases

BioMutaⁱ	BSCL2
DMDMⁱ	269849705

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000191679	1 – 398	SeipinAdd BLAST		398

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	88	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	242	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	289	PhosphoserineCombined sources	1
Modified residueⁱ	346	PhosphoserineBy similarity	1
Modified residueⁱ	351	PhosphoserineBy similarity	1
Modified residueⁱ	372	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Glycoprotein, Phosphoprotein

Proteomic databases

EPDⁱ	Q96G97
PaxDbⁱ	Q96G97
PeptideAtlas More...PeptideAtlasⁱ	Q96G97
PRIDEⁱ	Q96G97
ProteomicsDBⁱ	76606 76607 [Q96G97-3]

PTM databases

CarbonylDBⁱ	Q96G97
iPTMnetⁱ	Q96G97
PhosphoSitePlusⁱ	Q96G97

Expressionⁱ

Tissue specificityⁱ

Expressed in motor neurons in the spinal cord and cortical neurons in the frontal lobe (at protein level). Highly expressed in brain, testis and adipose tissue.3 Publications

Gene expression databases

Bgeeⁱ	ENSG00000168000 Expressed in 96 organ(s), highest expression level in testis
CleanExⁱ	HS_BSCL2
ExpressionAtlasⁱ	Q96G97 baseline and differential
Genevisibleⁱ	Q96G97 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA042394

HPAⁱ

HPA042394

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
NSG1	P42857	3	EBI-10178113,EBI-6380741
PLEKHF2	Q9H8W4	3	EBI-10178113,EBI-742388
SMIM3	Q9BZL3	4	EBI-741806,EBI-741850
SMLR1	H3BR10	3	EBI-10178113,EBI-10178109
TMEM19	Q96HH6	4	EBI-741806,EBI-741829

Protein-protein interaction databases

BioGridⁱ	117749, 43 interactors
CORUMⁱ	Q96G97
IntActⁱ	Q96G97, 11 interactors
Molecular INTeraction database More...MINTⁱ	Q96G97
STRINGⁱ	9606.ENSP00000354032

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q96G97
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the seipin family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG4200 Eukaryota ENOG4111GRP LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000011639
HOGENOMⁱ	HOG000220875
HOVERGENⁱ	HBG050736
InParanoidⁱ	Q96G97
KEGG Orthology (KO) More...KOⁱ	K19365
PhylomeDBⁱ	Q96G97
TreeFamⁱ	TF314000

Family and domain databases

InterProⁱ	View protein in InterPro IPR009617 Seipin
PANTHERⁱ	PTHR21212 PTHR21212, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF06775 Seipin, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 14 potential isoforms that are computationally mapped.ⁱShow all

Isoform 1 (identifier: Q96G97-2) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVNDPPVPAL LWAQEVGQVL AGRARRLLLQ FGVLFCTILL LLWVSVFLYG 
        60         70         80         90        100
SFYYSYMPTV SHLSPVHFYY RTDCDSSTTS LCSFPVANVS LTKGGRDRVL 
       110        120        130        140        150
MYGQPYRVTL ELELPESPVN QDLGMFLVTI SCYTRGGRII STSSRSVMLH 
       160        170        180        190        200
YRSDLLQMLD TLVFSSLLLF GFAEQKQLLE VELYADYREN SYVPTTGAII 
       210        220        230        240        250
EIHSKRIQLY GAYLRIHAHF TGLRYLLYNF PMTCAFIGVA SNFTFLSVIV 
       260        270        280        290        300
LFSYMQWVWG GIWPRHRFSL QVNIRKRDNS RKEVQRRISA HQPGPEGQEE 
       310        320        330        340        350
STPQSDVTED GESPEDPSGT EGQLSEEEKP DQQPLSGEEE LEPEASDGSG 
       360        370        380        390 
SWEDAALLTE ANLPAPAPAS ASAPVLETLG SSEPAGGALR QRPTCSSS

Length:398

Mass (Da):44,392

Last modified:November 24, 2009 - v3

Checksum:ⁱ9FB1B37E72493DB9

GO

Isoform 2 (identifier: Q96G97-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
225-287: YLLYNFPMTC...DNSRKEVQRR → LTSEKETIPG...PRRRNQISSP
288-398: Missing.

« Hide

        10         20         30         40         50
MVNDPPVPAL LWAQEVGQVL AGRARRLLLQ FGVLFCTILL LLWVSVFLYG 
        60         70         80         90        100
SFYYSYMPTV SHLSPVHFYY RTDCDSSTTS LCSFPVANVS LTKGGRDRVL 
       110        120        130        140        150
MYGQPYRVTL ELELPESPVN QDLGMFLVTI SCYTRGGRII STSSRSVMLH 
       160        170        180        190        200
YRSDLLQMLD TLVFSSLLLF GFAEQKQLLE VELYADYREN SYVPTTGAII 
       210        220        230        240        250
EIHSKRIQLY GAYLRIHAHF TGLRLTSEKE TIPGRKSNEG SLLISQGLKA 
       260        270        280 
RRSQLRNQML QRMVRALKIP QGQRVSCPRR RNQISSP

Note: No experimental confirmation available.Curated

Show »

Length:287

Mass (Da):32,654

Checksum:ⁱ674512CF110B8382

GO

Isoform 3 (identifier: Q96G97-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MSTEKVDQKEEAGEKEVCGDQIKGPDKEEEPPAAASHGQGWRPGGRAARNARPEPGARHPALPAM

« Hide

        10         20         30         40         50
MSTEKVDQKE EAGEKEVCGD QIKGPDKEEE PPAAASHGQG WRPGGRAARN 
        60         70         80         90        100
ARPEPGARHP ALPAMVNDPP VPALLWAQEV GQVLAGRARR LLLQFGVLFC 
       110        120        130        140        150
TILLLLWVSV FLYGSFYYSY MPTVSHLSPV HFYYRTDCDS STTSLCSFPV 
       160        170        180        190        200
ANVSLTKGGR DRVLMYGQPY RVTLELELPE SPVNQDLGMF LVTISCYTRG 
       210        220        230        240        250
GRIISTSSRS VMLHYRSDLL QMLDTLVFSS LLLFGFAEQK QLLEVELYAD 
       260        270        280        290        300
YRENSYVPTT GAIIEIHSKR IQLYGAYLRI HAHFTGLRYL LYNFPMTCAF 
       310        320        330        340        350
IGVASNFTFL SVIVLFSYMQ WVWGGIWPRH RFSLQVNIRK RDNSRKEVQR 
       360        370        380        390        400
RISAHQPGPE GQEESTPQSD VTEDGESPED PSGTEGQLSE EEKPDQQPLS 
       410        420        430        440        450
GEEELEPEAS DGSGSWEDAA LLTEANLPAP APASASAPVL ETLGSSEPAG 
       460 
GALRQRPTCS SS

Note: No experimental confirmation available.Curated

Show »

Length:462

Mass (Da):51,159

Checksum:ⁱ2DBDD5A48366AF48

GO

Computationally mapped potential isoform sequencesⁱ

There are 14 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name	Protein names	Gene names	Length	Annotation
	J3KQ12	J3KQ12_HUMAN	HCG2020143, isoform CRA_b HCG2020143, isoform CRA_b (Seipin)	BSCL2 hCG_2020143	464	Annotation score:
	F8W7Q8	F8W7Q8_HUMAN	Seipin Seipin	BSCL2	223	Annotation score:
	H7BXM1	H7BXM1_HUMAN	Seipin Seipin	BSCL2	277	Annotation score:
	E9PIU3	E9PIU3_HUMAN	Seipin Seipin	BSCL2	226	Annotation score:
	E9PRU2	E9PRU2_HUMAN	Seipin Seipin	BSCL2	99	Annotation score:
	E9PSB5	E9PSB5_HUMAN	Seipin Seipin	BSCL2	123	Annotation score:
	E9PR78	E9PR78_HUMAN	Seipin Seipin	BSCL2	111	Annotation score:
	H7BYY0	H7BYY0_HUMAN	Seipin Seipin	BSCL2	79	Annotation score:
	H0YF20	H0YF20_HUMAN	Seipin Seipin	BSCL2	52	Annotation score:
	H7C2D5	H7C2D5_HUMAN	Seipin Seipin	BSCL2	150	Annotation score:
There are more potential isoformsShow all

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_022375	88	N → S in SPG17 and HMN5A; does not affect protein subcellular location. 3 PublicationsCorresponds to variant dbSNP:rs137852972EnsemblClinVar.	1
Natural variantⁱVAR_022376	90	S → L in SPG17 and HMN5A; also found in patients with hereditary motor and sensory neuropathy type 2; does not affect the function in lipid storage. 4 PublicationsCorresponds to variant dbSNP:rs137852973EnsemblClinVar.	1
Natural variantⁱVAR_022377	212	A → P in CGL2; increases localization to nuclear envelope. 2 PublicationsCorresponds to variant dbSNP:rs137852971EnsemblClinVar.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_044545	1	M → MSTEKVDQKEEAGEKEVCGD QIKGPDKEEEPPAAASHGQG WRPGGRAARNARPEPGARHP ALPAM in isoform 3. Curated	1
Alternative sequenceⁱVSP_051726	225 – 287	YLLYN…EVQRR → LTSEKETIPGRKSNEGSLLI SQGLKARRSQLRNQMLQRMV RALKIPQGQRVSCPRRRNQI SSP in isoform 2. 1 PublicationAdd BLAST	63
Alternative sequenceⁱVSP_051727	288 – 398	Missing in isoform 2. 1 PublicationAdd BLAST	111

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK027524 mRNA Translation: BAB55175.1 AK075317 mRNA Translation: BAC11543.1 AF052149 mRNA No translation available. CH471076 Genomic DNA Translation: EAW74070.1 CH471076 Genomic DNA Translation: EAW74074.1 AP001458 Genomic DNA No translation available. BC004911 mRNA Translation: AAH04911.1 BC012140 mRNA Translation: AAH12140.1 BC041640 mRNA Translation: AAH41640.1 BC093048 mRNA Translation: AAH93048.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS44627.1 [Q96G97-4] CCDS55769.1 [Q96G97-3] CCDS8031.1 [Q96G97-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001116427.1, NM_001122955.3 [Q96G97-4] NP_001124174.2, NM_001130702.2 [Q96G97-3] NP_116056.3, NM_032667.6 [Q96G97-2]
UniGeneⁱ	Hs.533709

Genome annotation databases

Ensemblⁱ	ENST00000278893; ENSP00000278893; ENSG00000168000 [Q96G97-3] ENST00000360796; ENSP00000354032; ENSG00000168000 [Q96G97-4] ENST00000403550; ENSP00000385561; ENSG00000168000 [Q96G97-2] ENST00000407022; ENSP00000384080; ENSG00000168000 [Q96G97-2] ENST00000421906; ENSP00000413209; ENSG00000168000 [Q96G97-2]
GeneIDⁱ	26580
KEGGⁱ	hsa:26580
UCSC genome browser More...UCSCⁱ	uc001nup.4 human [Q96G97-2]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q96G97	HCG2020143, isoform CRA_d		HUMAN		462	UniRef100_Q96G97
BSCL2, seipin lipid droplet biogenesis associated		GORGO		462
Isoform 3 of Seipin		HUMAN		462
Berardinelli-Seip congenital lipodystrophy 2 isoform 1		HUMAN		398

Protein	Similar proteins		Species	Score	Length	Source
Q96G97	HCG2020143, isoform CRA_d		HUMAN		462	UniRef90_Q96G97
BSCL2, seipin lipid droplet biogenesis associated		GORGO		462
BSCL2 isoform 3		PANTR		464
BSCL2, seipin lipid droplet biogenesis associated		COLAP		464
BSCL2, seipin lipid droplet biogenesis associated		CERAT		464
+39
Q96G97-3	BSCL2, seipin lipid droplet biogenesis associated		MACMU		287	UniRef90_F7CSP2
Seipin		MACFA		287
BSCL2, seipin lipid droplet biogenesis associated		Cebus capucinus imitator		287
BSCL2, seipin lipid droplet biogenesis associated		RHIRO		287
BSCL2, seipin lipid droplet biogenesis associated		RHIBE		287
+13

Protein	Similar proteins		Species	Score	Length	Source
Q96G97	Seipin		BOVIN		394	UniRef50_Q96G97
Seipin		MOUSE		383
Seipin		RAT		377
HCG2020143, isoform CRA_d		HUMAN		462
BSCL2, seipin lipid droplet biogenesis associated		GORGO		462
+313
Q96G97-3	Uncharacterized protein		FELCA		330	UniRef50_M3WPC1
Uncharacterized protein DKFZp469D236		PONAB		342
BSCL2, seipin lipid droplet biogenesis associated		CERAT		287
BSCL2, seipin lipid droplet biogenesis associated		MACNE		287
BSCL2, seipin lipid droplet biogenesis associated		MANLE		287
+20

Entry informationⁱ

Entry nameⁱ	BSCL2_HUMAN
Accessionⁱ	Q96G97Primary (citable) accession number: Q96G97 Secondary accession number(s): G3XAE4 , Q567S1, Q96SV1, Q9BSQ0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 26, 2005
	Last sequence update:	November 24, 2009
	Last modified:	September 12, 2018
	This is version 144 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

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Annotation systems

Supporting data

UniProtKB - Q96G97 (BSCL2_HUMAN)

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Seipin

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endoplasmic reticulum

Endoplasmic reticulum

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Computationally mapped potential isoform sequencesi

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Computationally mapped potential isoform sequencesⁱ

Keywords - Coding sequence diversityⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ