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Protein

P2Y purinoceptor 11

Gene

P2RY11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for ATP and ADP coupled to G-proteins that activate both phosphatidylinositol-calcium and adenylyl cyclase second messenger systems. Not activated by UTP or UDP.

Miscellaneous

A chimeric transcript, characterized by the first third of PPAN exon 12 joined to P2RY11 exon 2, has been detected. It is possibly produced by trans-splicing. The chimeric transcript is widely expressed and can be induced by retinoic acid during the granulocytic differentiation of the HL-60 cell line. The resulting chimeric protein shows a much lower activity than the non-chimeric P2RY11 gene product, but qualitatively indistinguishable (PubMed:11278528).1 Publication

GO - Molecular functioni

  • ATP-activated adenosine receptor activity Source: BHF-UCL
  • G-protein coupled purinergic nucleotide receptor activity Source: InterPro
  • neurotransmitter receptor activity Source: BHF-UCL
  • signaling receptor activity Source: ProtInc

GO - Biological processi

  • activation of adenylate cyclase activity Source: ProtInc
  • calcium-mediated signaling Source: BHF-UCL
  • cellular response to ATP Source: BHF-UCL
  • defense response Source: ProtInc
  • G-protein coupled receptor signaling pathway Source: BHF-UCL
  • neuronal signal transduction Source: BHF-UCL
  • phospholipase C-activating G-protein coupled receptor signaling pathway Source: ProtInc

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-416476 G alpha (q) signalling events
R-HSA-417957 P2Y receptors
R-HSA-418555 G alpha (s) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
P2Y purinoceptor 11
Short name:
P2Y11
Gene namesi
Name:P2RY11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000244165.1
HGNCiHGNC:8540 P2RY11
MIMi602697 gene
neXtProtiNX_Q96G91

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 29ExtracellularSequence analysisAdd BLAST29
Transmembranei30 – 50Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini51 – 64CytoplasmicSequence analysisAdd BLAST14
Transmembranei65 – 85Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini86 – 116ExtracellularSequence analysisAdd BLAST31
Transmembranei117 – 137Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini138 – 146CytoplasmicSequence analysis9
Transmembranei147 – 167Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini168 – 206ExtracellularSequence analysisAdd BLAST39
Transmembranei207 – 227Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini228 – 245CytoplasmicSequence analysisAdd BLAST18
Transmembranei246 – 266Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini267 – 308ExtracellularSequence analysisAdd BLAST42
Transmembranei309 – 329Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini330 – 374CytoplasmicSequence analysisAdd BLAST45

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi5032
MalaCardsiP2RY11
OpenTargetsiENSG00000244165
Orphaneti2073 Narcolepsy-cataplexy
PharmGKBiPA32869

Chemistry databases

ChEMBLiCHEMBL4867
GuidetoPHARMACOLOGYi327

Polymorphism and mutation databases

BioMutaiP2RY11
DMDMi21263830

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000700351 – 374P2Y purinoceptor 11Add BLAST374

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi102 ↔ 180PROSITE-ProRule annotation
Glycosylationi179N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ96G91
PeptideAtlasiQ96G91
PRIDEiQ96G91
ProteomicsDBi76604

PTM databases

iPTMnetiQ96G91
PhosphoSitePlusiQ96G91

Expressioni

Tissue specificityi

Highest expression in liver and spleen.1 Publication

Inductioni

Increased by DMSO and retinoic acid.

Gene expression databases

BgeeiENSG00000244165
GenevisibleiQ96G91 HS

Organism-specific databases

HPAiHPA014232

Interactioni

Protein-protein interaction databases

BioGridi111071, 1 interactor
IntActiQ96G91, 1 interactor
STRINGi9606.ENSP00000323872

Chemistry databases

BindingDBiQ96G91

Structurei

3D structure databases

ProteinModelPortaliQ96G91
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IW3D Eukaryota
ENOG4111H44 LUCA
GeneTreeiENSGT00920000148939
HOGENOMiHOG000059583
HOVERGENiHBG105351
InParanoidiQ96G91
KOiK08387
OrthoDBiEOG091G079K
PhylomeDBiQ96G91
TreeFamiTF330775

Family and domain databases

CDDicd15376 7tmA_P2Y11, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR027677 P2Y11_rcpt
PANTHERiPTHR45260 PTHR45260, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q96G91-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAANVSGAKS CPANFLAAAD DKLSGFQGDF LWPILVVEFL VAVASNGLAL
60 70 80 90 100
YRFSIRKQRP WHPAVVFSVQ LAVSDLLCAL TLPPLAAYLY PPKHWRYGEA
110 120 130 140 150
ACRLERFLFT CNLLGSVIFI TCISLNRYLG IVHPFFARSH LRPKHAWAVS
160 170 180 190 200
AAGWVLAALL AMPTLSFSHL KRPQQGAGNC SVARPEACIK CLGTADHGLA
210 220 230 240 250
AYRAYSLVLA GLGCGLPLLL TLAAYGALGR AVLRSPGMTV AEKLRVAALV
260 270 280 290 300
ASGVALYASS YVPYHIMRVL NVDARRRWST RCPSFADIAQ ATAALELGPY
310 320 330 340 350
VGYQVMRGLM PLAFCVHPLL YMAAVPSLGC CCRHCPGYRD SWNPEDAKST
360 370
GQALPLNATA APKPSEPQSR ELSQ
Length:374
Mass (Da):40,345
Last modified:May 27, 2002 - v2
Checksum:iC02DF9B3B381D25E
GO

Sequence cautioni

The sequence AAB88674 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAC18877 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02007487A → T. Corresponds to variant dbSNP:rs3745601Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030335 mRNA Translation: AAB88674.1 Different initiation.
AJ298334 mRNA Translation: CAC29362.1
AJ300588 mRNA Translation: CAC18877.1 Different initiation.
AY449733 mRNA Translation: AAR18077.1
AK313550 mRNA Translation: BAG36326.1
CH471106 Genomic DNA Translation: EAW84077.1
BC073827 mRNA Translation: AAH73827.1
AF498921 mRNA Translation: AAM18130.1
CCDSiCCDS12226.1
RefSeqiNP_002557.2, NM_002566.4
UniGeneiHs.14468

Genome annotation databases

EnsembliENST00000321826; ENSP00000323872; ENSG00000244165
GeneIDi5032
KEGGihsa:5032
UCSCiuc002mnc.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiP2Y11_HUMAN
AccessioniPrimary (citable) accession number: Q96G91
Secondary accession number(s): B2R8X9
, O43190, Q9BYU4, Q9H170
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: May 27, 2002
Last modified: June 20, 2018
This is version 154 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

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