UniProtKB - Q96G75 (RMD5B_HUMAN)
E3 ubiquitin-protein transferase RMND5B
RMND5B
Functioni
Catalytic activityi
- S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.1 Publication EC:2.3.2.27
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 338 – 379 | RING-Gid-typePROSITE-ProRule annotationAdd BLAST | 42 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- ubiquitin-protein transferase activity Source: InterPro
GO - Biological processi
- proteasome-mediated ubiquitin-dependent protein catabolic process Source: GO_Central
- ubiquitin-dependent protein catabolic process Source: GO_Central
Keywordsi
Molecular function | Transferase |
Biological process | Ubl conjugation pathway |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q96G75 |
Names & Taxonomyi
Protein namesi | Recommended name: E3 ubiquitin-protein transferase RMND5B (EC:2.3.2.271 Publication)Alternative name(s): Protein RMD5 homolog B |
Gene namesi | Name:RMND5B ORF Names:UNQ2508/PRO5996 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:26181, RMND5B |
neXtProti | NX_Q96G75 |
VEuPathDBi | HostDB:ENSG00000145916.18 |
Subcellular locationi
Cytosol
- cytosol 1 Publication
Cytosol
- cytosol Source: UniProtKB
Nucleus
- nucleus Source: GO_Central
Other locations
- cytoplasm Source: GO_Central
- GID complex Source: GO_Central
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
DisGeNETi | 64777 |
OpenTargetsi | ENSG00000145916 |
PharmGKBi | PA144596389 |
Miscellaneous databases
Pharosi | Q96G75, Tdark |
Genetic variation databases
BioMutai | RMND5B |
DMDMi | 29840869 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000065709 | 1 – 393 | E3 ubiquitin-protein transferase RMND5BAdd BLAST | 393 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | Q96G75 |
jPOSTi | Q96G75 |
MassIVEi | Q96G75 |
MaxQBi | Q96G75 |
PaxDbi | Q96G75 |
PeptideAtlasi | Q96G75 |
PRIDEi | Q96G75 |
ProteomicsDBi | 76601 [Q96G75-1] 76602 [Q96G75-2] |
PTM databases
iPTMneti | Q96G75 |
PhosphoSitePlusi | Q96G75 |
Expressioni
Gene expression databases
Bgeei | ENSG00000145916, Expressed in testis and 231 other tissues |
ExpressionAtlasi | Q96G75, baseline and differential |
Genevisiblei | Q96G75, HS |
Organism-specific databases
HPAi | ENSG00000145916, Low tissue specificity |
Interactioni
Subunit structurei
Identified in the CTLH complex that contains GID4, RANBP9 and/or RANBP10, MKLN1, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, ARMC8, WDR26 and YPEL5 (PubMed:29911972). Within this complex, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, WDR26, and RANBP9 and/or RANBP10 form the catalytic core, while GID4, MKLN1, ARMC8 and YPEL5 have ancillary roles (PubMed:29911972).
1 PublicationBinary interactionsi
Hide detailsProtein-protein interaction databases
BioGRIDi | 122287, 36 interactors |
IntActi | Q96G75, 28 interactors |
MINTi | Q96G75 |
STRINGi | 9606.ENSP00000420875 |
Miscellaneous databases
RNActi | Q96G75, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 116 – 148 | LisHPROSITE-ProRule annotationAdd BLAST | 33 | |
Domaini | 155 – 212 | CTLHPROSITE-ProRule annotationAdd BLAST | 58 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 338 – 379 | RING-Gid-typePROSITE-ProRule annotationAdd BLAST | 42 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG2817, Eukaryota |
GeneTreei | ENSGT00940000153203 |
HOGENOMi | CLU_020227_3_1_1 |
InParanoidi | Q96G75 |
OMAi | CQESTLS |
OrthoDBi | 987270at2759 |
PhylomeDBi | Q96G75 |
TreeFami | TF315176 |
Family and domain databases
CDDi | cd16795, dRING_RMD5B, 1 hit |
InterProi | View protein in InterPro IPR013144, CRA_dom IPR024964, CTLH/CRA IPR006595, CTLH_C IPR006594, LisH IPR037681, RMD5B_dRING IPR044063, ZF_RING_GID |
Pfami | View protein in Pfam PF10607, CLTH, 1 hit |
SMARTi | View protein in SMART SM00757, CRA, 1 hit SM00668, CTLH, 1 hit SM00667, LisH, 1 hit |
PROSITEi | View protein in PROSITE PS50897, CTLH, 1 hit PS50896, LISH, 1 hit PS51867, ZF_RING_GID, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEQCACVERE LDKVLQKFLT YGQHCERSLE ELLHYVGQLR AELASAALQG
60 70 80 90 100
TPLSATLSLV MSQCCRKIKD TVQKLASDHK DIHSSVSRVG KAIDRNFDSE
110 120 130 140 150
ICGVVSDAVW DAREQQQQIL QMAIVEHLYQ QGMLSVAEEL CQESTLNVDL
160 170 180 190 200
DFKQPFLELN RILEALHEQD LGPALEWAVS HRQRLLELNS SLEFKLHRLH
210 220 230 240 250
FIRLLAGGPA KQLEALSYAR HFQPFARLHQ REIQVMMGSL VYLRLGLEKS
260 270 280 290 300
PYCHLLDSSH WAEICETFTR DACSLLGLSV ESPLSVSFAS GCVALPVLMN
310 320 330 340 350
IKAVIEQRQC TGVWNHKDEL PIEIELGMKC WYHSVFACPI LRQQTSDSNP
360 370 380 390
PIKLICGHVI SRDALNKLIN GGKLKCPYCP MEQNPADGKR IIF
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF5H6G4 | F5H6G4_HUMAN | RING-type E3 ubiquitin transferase | RMND5B | 380 | Annotation score: | ||
D6RFE6 | D6RFE6_HUMAN | E3 ubiquitin-protein transferase RM... | RMND5B | 77 | Annotation score: | ||
D6RIF9 | D6RIF9_HUMAN | E3 ubiquitin-protein transferase RM... | RMND5B | 148 | Annotation score: | ||
D6RER3 | D6RER3_HUMAN | E3 ubiquitin-protein transferase RM... | RMND5B | 114 | Annotation score: | ||
D6R9A2 | D6R9A2_HUMAN | E3 ubiquitin-protein transferase RM... | RMND5B | 62 | Annotation score: | ||
D6RFK1 | D6RFK1_HUMAN | E3 ubiquitin-protein transferase RM... | RMND5B | 56 | Annotation score: |
Sequence cautioni
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_013174 | 1 – 60 | Missing in isoform 2. 1 PublicationAdd BLAST | 60 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ494789 mRNA Translation: ABF50942.1 AY359092 mRNA Translation: AAQ89450.1 AK025971 mRNA Translation: BAB15303.1 Different initiation. AK125337 mRNA Translation: BAG54186.1 AL713670 mRNA Translation: CAD28476.1 CH471165 Genomic DNA Translation: EAW53849.1 CH471165 Genomic DNA Translation: EAW53850.1 BC009911 mRNA Translation: AAH09911.1 |
CCDSi | CCDS4431.1 [Q96G75-1] |
RefSeqi | NP_001275723.1, NM_001288794.1 [Q96G75-1] NP_001275724.1, NM_001288795.1 NP_073599.2, NM_022762.4 [Q96G75-1] XP_005266026.1, XM_005265969.3 [Q96G75-1] XP_005266028.1, XM_005265971.4 [Q96G75-2] XP_005266029.1, XM_005265972.3 [Q96G75-2] XP_016865216.1, XM_017009727.1 XP_016865217.1, XM_017009728.1 [Q96G75-2] |
Genome annotation databases
Ensembli | ENST00000313386; ENSP00000320623; ENSG00000145916 [Q96G75-1] ENST00000515098; ENSP00000420875; ENSG00000145916 [Q96G75-1] |
GeneIDi | 64777 |
KEGGi | hsa:64777 |
UCSCi | uc003mim.5, human [Q96G75-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ494789 mRNA Translation: ABF50942.1 AY359092 mRNA Translation: AAQ89450.1 AK025971 mRNA Translation: BAB15303.1 Different initiation. AK125337 mRNA Translation: BAG54186.1 AL713670 mRNA Translation: CAD28476.1 CH471165 Genomic DNA Translation: EAW53849.1 CH471165 Genomic DNA Translation: EAW53850.1 BC009911 mRNA Translation: AAH09911.1 |
CCDSi | CCDS4431.1 [Q96G75-1] |
RefSeqi | NP_001275723.1, NM_001288794.1 [Q96G75-1] NP_001275724.1, NM_001288795.1 NP_073599.2, NM_022762.4 [Q96G75-1] XP_005266026.1, XM_005265969.3 [Q96G75-1] XP_005266028.1, XM_005265971.4 [Q96G75-2] XP_005266029.1, XM_005265972.3 [Q96G75-2] XP_016865216.1, XM_017009727.1 XP_016865217.1, XM_017009728.1 [Q96G75-2] |
3D structure databases
SMRi | Q96G75 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 122287, 36 interactors |
IntActi | Q96G75, 28 interactors |
MINTi | Q96G75 |
STRINGi | 9606.ENSP00000420875 |
PTM databases
iPTMneti | Q96G75 |
PhosphoSitePlusi | Q96G75 |
Genetic variation databases
BioMutai | RMND5B |
DMDMi | 29840869 |
Proteomic databases
EPDi | Q96G75 |
jPOSTi | Q96G75 |
MassIVEi | Q96G75 |
MaxQBi | Q96G75 |
PaxDbi | Q96G75 |
PeptideAtlasi | Q96G75 |
PRIDEi | Q96G75 |
ProteomicsDBi | 76601 [Q96G75-1] 76602 [Q96G75-2] |
Protocols and materials databases
Antibodypediai | 46079, 93 antibodies |
DNASUi | 64777 |
Genome annotation databases
Ensembli | ENST00000313386; ENSP00000320623; ENSG00000145916 [Q96G75-1] ENST00000515098; ENSP00000420875; ENSG00000145916 [Q96G75-1] |
GeneIDi | 64777 |
KEGGi | hsa:64777 |
UCSCi | uc003mim.5, human [Q96G75-1] |
Organism-specific databases
CTDi | 64777 |
DisGeNETi | 64777 |
GeneCardsi | RMND5B |
HGNCi | HGNC:26181, RMND5B |
HPAi | ENSG00000145916, Low tissue specificity |
neXtProti | NX_Q96G75 |
OpenTargetsi | ENSG00000145916 |
PharmGKBi | PA144596389 |
VEuPathDBi | HostDB:ENSG00000145916.18 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2817, Eukaryota |
GeneTreei | ENSGT00940000153203 |
HOGENOMi | CLU_020227_3_1_1 |
InParanoidi | Q96G75 |
OMAi | CQESTLS |
OrthoDBi | 987270at2759 |
PhylomeDBi | Q96G75 |
TreeFami | TF315176 |
Enzyme and pathway databases
PathwayCommonsi | Q96G75 |
Miscellaneous databases
BioGRID-ORCSi | 64777, 4 hits in 870 CRISPR screens |
ChiTaRSi | RMND5B, human |
GeneWikii | RMND5B |
GenomeRNAii | 64777 |
Pharosi | Q96G75, Tdark |
PROi | PR:Q96G75 |
RNActi | Q96G75, protein |
Gene expression databases
Bgeei | ENSG00000145916, Expressed in testis and 231 other tissues |
ExpressionAtlasi | Q96G75, baseline and differential |
Genevisiblei | Q96G75, HS |
Family and domain databases
CDDi | cd16795, dRING_RMD5B, 1 hit |
InterProi | View protein in InterPro IPR013144, CRA_dom IPR024964, CTLH/CRA IPR006595, CTLH_C IPR006594, LisH IPR037681, RMD5B_dRING IPR044063, ZF_RING_GID |
Pfami | View protein in Pfam PF10607, CLTH, 1 hit |
SMARTi | View protein in SMART SM00757, CRA, 1 hit SM00668, CTLH, 1 hit SM00667, LisH, 1 hit |
PROSITEi | View protein in PROSITE PS50897, CTLH, 1 hit PS50896, LISH, 1 hit PS51867, ZF_RING_GID, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RMD5B_HUMAN | |
Accessioni | Q96G75Primary (citable) accession number: Q96G75 Secondary accession number(s): Q1HE27, Q6UVY7, Q9H6F6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 28, 2003 |
Last sequence update: | December 1, 2001 | |
Last modified: | February 10, 2021 | |
This is version 145 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM