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UniProtKB - Q96G74 (OTUD5_HUMAN)

Entry version 154 (25 May 2022)
Sequence version 1 (01 Dec 2001)
Previous versions | rss
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Protein

OTU domain-containing protein 5

Gene

OTUD5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Deubiquitinating enzyme that functions as negative regulator of the innate immune system. Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production. Has peptidase activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Can also cleave 'Lys-11'-linked ubiquitin chains (in vitro). Controls neuroectodermal differentiation through cleaving 'Lys-48'-linked ubiquitin chains to counteract degradation of select chromatin regulators such as ARID1A, HDAC2 and HCF1 (PubMed:33523931).

4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by N-ethyl-maleimide (NEM).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei221Sequence analysis1
Active sitei224Nucleophile1 Publication1
Active sitei3341 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processUbl conjugation pathway

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q96G74

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-5689896, Ovarian tumor domain proteases
R-HSA-936440, Negative regulators of DDX58/IFIH1 signaling

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q96G74

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q96G74

Protein family/group databases

MEROPS protease database

More...MEROPSi		C85.001

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
OTU domain-containing protein 5Curated (EC:3.4.19.121 Publication)
Alternative name(s):
Deubiquitinating enzyme A
Short name:
DUBA
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:OTUD5Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:25402, OTUD5

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		300713, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q96G74

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000068308

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Multiple congenital anomalies-neurodevelopmental syndrome, X-linked (MCAND)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn X-linked recessive, congenital disorder characterized by central nervous system, craniofacial, cardiac, skeletal, and genitourinary anomalies. Clinical features include poor growth, short stature, global developmental delay, impaired intellectual development, microcephaly, hydrocephalus, hypotonia, congenital heart defects, hypospadias, and other variable abnormalities. Brain imaging typically shows ventriculomegaly and thin corpus callosum. The severity of the disorder is highly variable, ranging from death in early infancy to survival into the second or third decade.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_085336161 – 163Missing in MCAND; reduced cleavage activity towards 'K-48'-chains but not 'K-63'-chains; no effect on phosphorylation. 1 Publication3
Natural variantiVAR_085337256D → N in MCAND; reduced cleavage activity towards 'K-63'- and 'K-48'-chains; no effect on phosphorylation. 1 Publication1
Natural variantiVAR_085338274R → W in MCAND; partial mislocation at the cytoplasm; reduced cleavage activity towards 'K-63'- and 'K-48'-chains; no effect on phosphorylation. 1 Publication1
Natural variantiVAR_085339352L → P in MCAND; in mice embryo the mutation is lethal; reduced cleavage activity towards 'K-48'-chains but not 'K-63'-chains; no effect on nuclear location; no effect on phosphorylation. 1 Publication1
Natural variantiVAR_085340404R → W in MCAND; unknown pathological significance. 1 Publication1
Natural variantiVAR_085341494G → S in MCAND; decreased mRNA and protein levels; no effect on cleavage activity towards 'K-48'-chains but not 'K-63'-chains; in mice embryo the mutation is lethal; no effect on phosphorylation. 1 Publication1
Natural variantiVAR_085342520R → W in MCAND; unknown pathological significance. 1 Publication1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi177S → D or E: Loss of deubiquitinase activity. Abolishes activation by protein kinases. 1 Publication1
Mutagenesisi224C → S: Loss of deubiquitinase activity. Loss of suppression of IFN production. No effect on nuclear location. 3 Publications1
Mutagenesisi542L → A: Loss of 'K-48'- and 'K-63'-linked polyubiquitin chain binding. Partial loss of TRAF3 deubiquitination; when associated with A-549. 1 Publication1
Mutagenesisi549S → A: Loss of 'K-48'- and 'K-63'-linked polyubiquitin chain binding. Partial loss of TRAF3 deubiquitination; when associated with A-542. 1 Publication1

Keywords - Diseasei

Disease variant, Mental retardation

Organism-specific databases

DisGeNET

More...DisGeNETi		55593

MalaCards human disease database

More...MalaCardsi		OTUD5
MIMi301056, phenotype

Open Targets

More...OpenTargetsi		ENSG00000068308

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA142671217

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q96G74, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		OTUD5

Domain mapping of disease mutations (DMDM)

More...DMDMi		74731791

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002782231 – 571OTU domain-containing protein 5Add BLAST571

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei64PhosphoserineCombined sources1 Publication1
Modified residuei165PhosphoserineCombined sources1 Publication1
Modified residuei175Phosphotyrosine1 Publication1
Modified residuei177PhosphoserineCombined sources1 Publication1
Modified residuei452PhosphoserineCombined sources1
Modified residuei507Phosphothreonine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation at Ser-177 is required for deubiquitinating activity.2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q96G74

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q96G74

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q96G74

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q96G74

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q96G74

PeptideAtlas

More...PeptideAtlasi		Q96G74

PRoteomics IDEntifications database

More...PRIDEi		Q96G74

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		33910
4133
76598 [Q96G74-1]
76599 [Q96G74-2]
76600 [Q96G74-3]

Consortium for Top Down Proteomics

More...TopDownProteomicsi		Q96G74-2 [Q96G74-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q96G74, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q96G74

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q96G74

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in various tissues, including the liver and placenta, as well as in peripheral blood leukocytes.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by bacterial lipopolysaccharide (LPS) in bone marrow-derived macrophages.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000068308, Expressed in quadriceps femoris and 217 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q96G74, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q96G74, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000068308, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with TRAF3.

2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		120738, 47 interactors

Database of interacting proteins

More...DIPi		DIP-53541N

Protein interaction database and analysis system

More...IntActi		Q96G74, 23 interactors

Molecular INTeraction database

More...MINTi		Q96G74

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000156084

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q96G74, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1571
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q96G74

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q96G74

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini213 – 341OTUPROSITE-ProRule annotationAdd BLAST129

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 111DisorderedSequence analysisAdd BLAST111
Regioni146 – 175DisorderedSequence analysisAdd BLAST30
Regioni218 – 224Cys-loopBy similarity7
Regioni273 – 283Variable-loopBy similarityAdd BLAST11
Regioni329 – 334His-loopBy similarity6
Regioni418 – 502DisorderedSequence analysisAdd BLAST85

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 30Pro residuesSequence analysisAdd BLAST30
Compositional biasi93 – 108Pro residuesSequence analysisAdd BLAST16
Compositional biasi420 – 460Polar residuesSequence analysisAdd BLAST41

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase C85 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2605, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158963

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_021938_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q96G74

Identification of Orthologs from Complete Genome Data

More...OMAi		REDKHFE

Database of Orthologous Groups

More...OrthoDBi		1448656at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q96G74

TreeFam database of animal gene trees

More...TreeFami		TF326812

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR031084, OTU5
IPR003323, OTU_dom
IPR038765, Papain-like_cys_pep_sf

The PANTHER Classification System

More...PANTHERi		PTHR12419:SF4, PTHR12419:SF4, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02338, OTU, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54001, SSF54001, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50802, OTU, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96G74-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTILPKKKPP PPDADPANEP PPPGPMPPAP RRGGGVGVGG GGTGVGGGDR 
        60         70         80         90        100
DRDSGVVGAR PRASPPPQGP LPGPPGALHR WALAVPPGAV AGPRPQQASP 
       110        120        130        140        150
PPCGGPGGPG GGPGDALGAA AAGVGAAGVV VGVGGAVGVG GCCSGPGHSK 
       160        170        180        190        200
RRRQAPGVGA VGGGSPEREE VGAGYNSEDE YEAAAARIEA MDPATVEQQE 
       210        220        230        240        250
HWFEKALRDK KGFIIKQMKE DGACLFRAVA DQVYGDQDMH EVVRKHCMDY 
       260        270        280        290        300
LMKNADYFSN YVTEDFTTYI NRKRKNNCHG NHIEMQAMAE MYNRPVEVYQ 
       310        320        330        340        350
YSTGTSAVEP INTFHGIHQN EDEPIRVSYH RNIHYNSVVN PNKATIGVGL 
       360        370        380        390        400
GLPSFKPGFA EQSLMKNAIK TSEESWIEQQ MLEDKKRATD WEATNEAIEE 
       410        420        430        440        450
QVARESYLQW LRDQEKQARQ VRGPSQPRKA SATCSSATAA ASSGLEEWTS 
       460        470        480        490        500
RSPRQRSSAS SPEHPELHAE LGMKPPSPGT VLALAKPPSP CAPGTSSQFS 
       510        520        530        540        550
AGADRATSPL VSLYPALECR ALIQQMSPSA FGLNDWDDDE ILASVLAVSQ 
       560        570 
QEYLDSMKKN KVHRDPPPDK S
Length:571
Mass (Da):60,626
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF4B2B385B84ABC46
GO
Isoform 2 (identifier: Q96G74-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     17-40: Missing.
     304-308: Missing.

Note: Dubious isoform produced through aberrant splice sites.Curated
Show »
Length:542
Mass (Da):58,007
Checksum:iFB641E44937EC3F2
GO
Isoform 3 (identifier: Q96G74-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     304-308: Missing.
     563-566: HRDP → PCRC
     567-571: Missing.

Note: Dubious isoform produced through aberrant splice sites.Curated
Show »
Length:561
Mass (Da):59,640
Checksum:i9C931880385CF8CB
GO
Isoform 4 (identifier: Q96G74-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-217: Missing.
     304-308: Missing.

Show »
Length:349
Mass (Da):39,185
Checksum:i555902ECCA9C52E4
GO
Isoform 5 (identifier: Q96G74-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     304-308: Missing.

Show »
Length:566
Mass (Da):60,210
Checksum:i46EBC6634CD55DA2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7BZQ3H7BZQ3_HUMAN
Ubiquitinyl hydrolase 1
OTUD5
444Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB14131 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAB15416 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_085336161 – 163Missing in MCAND; reduced cleavage activity towards 'K-48'-chains but not 'K-63'-chains; no effect on phosphorylation. 1 Publication3
Natural variantiVAR_085337256D → N in MCAND; reduced cleavage activity towards 'K-63'- and 'K-48'-chains; no effect on phosphorylation. 1 Publication1
Natural variantiVAR_085338274R → W in MCAND; partial mislocation at the cytoplasm; reduced cleavage activity towards 'K-63'- and 'K-48'-chains; no effect on phosphorylation. 1 Publication1
Natural variantiVAR_085339352L → P in MCAND; in mice embryo the mutation is lethal; reduced cleavage activity towards 'K-48'-chains but not 'K-63'-chains; no effect on nuclear location; no effect on phosphorylation. 1 Publication1
Natural variantiVAR_085340404R → W in MCAND; unknown pathological significance. 1 Publication1
Natural variantiVAR_085341494G → S in MCAND; decreased mRNA and protein levels; no effect on cleavage activity towards 'K-48'-chains but not 'K-63'-chains; in mice embryo the mutation is lethal; no effect on phosphorylation. 1 Publication1
Natural variantiVAR_085342520R → W in MCAND; unknown pathological significance. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0451851 – 217Missing in isoform 4. 1 PublicationAdd BLAST217
Alternative sequenceiVSP_02319517 – 40Missing in isoform 2. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_023192304 – 308Missing in isoform 2, isoform 3, isoform 4 and isoform 5. 3 Publications5
Alternative sequenceiVSP_023193563 – 566HRDP → PCRC in isoform 3. 1 Publication4
Alternative sequenceiVSP_023194567 – 571Missing in isoform 3. 1 Publication5

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK022612 mRNA Translation: BAB14131.1 Different initiation.
AK026260 mRNA Translation: BAB15416.1 Different initiation.
AK294590 mRNA Translation: BAG57778.1
AF207550 Genomic DNA No translation available.
CH471224 Genomic DNA Translation: EAW50724.1
BC009917 mRNA Translation: AAH09917.1
BC028225 mRNA Translation: AAH28225.1
BC098440 mRNA Translation: AAH98440.1
AL137509 mRNA Translation: CAB70778.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS14313.1 [Q96G74-1]
CCDS48104.1 [Q96G74-5]
CCDS48105.1 [Q96G74-4]

Protein sequence database of the Protein Information Resource

More...PIRi		T46265

NCBI Reference Sequences

More...RefSeqi		NP_001129629.1, NM_001136157.1 [Q96G74-5]
NP_001129630.1, NM_001136158.1 [Q96G74-5]
NP_001129631.1, NM_001136159.1 [Q96G74-4]
NP_060072.1, NM_017602.3 [Q96G74-1]
XP_006724600.1, XM_006724537.2 [Q96G74-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000156084.8; ENSP00000156084.4; ENSG00000068308.15
ENST00000376488.8; ENSP00000365671.3; ENSG00000068308.15 [Q96G74-5]
ENST00000396743.7; ENSP00000379969.3; ENSG00000068308.15 [Q96G74-5]
ENST00000428668.2; ENSP00000401629.2; ENSG00000068308.15 [Q96G74-4]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		55593

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:55593

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000376488.8; ENSP00000365671.3; NM_001136157.2; NP_001129629.1 [Q96G74-5]

UCSC genome browser

More...UCSCi		uc004dlt.5, human [Q96G74-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022612 mRNA Translation: BAB14131.1 Different initiation.
AK026260 mRNA Translation: BAB15416.1 Different initiation.
AK294590 mRNA Translation: BAG57778.1
AF207550 Genomic DNA No translation available.
CH471224 Genomic DNA Translation: EAW50724.1
BC009917 mRNA Translation: AAH09917.1
BC028225 mRNA Translation: AAH28225.1
BC098440 mRNA Translation: AAH98440.1
AL137509 mRNA Translation: CAB70778.1
CCDSiCCDS14313.1 [Q96G74-1]
CCDS48104.1 [Q96G74-5]
CCDS48105.1 [Q96G74-4]
PIRiT46265
RefSeqiNP_001129629.1, NM_001136157.1 [Q96G74-5]
NP_001129630.1, NM_001136158.1 [Q96G74-5]
NP_001129631.1, NM_001136159.1 [Q96G74-4]
NP_060072.1, NM_017602.3 [Q96G74-1]
XP_006724600.1, XM_006724537.2 [Q96G74-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3PFYX-ray1.70A172-344[»]
3TMOX-ray2.20A172-351[»]
3TMPX-ray1.91A/C/E/G172-351[»]
AlphaFoldDBiQ96G74
SMRiQ96G74
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi120738, 47 interactors
DIPiDIP-53541N
IntActiQ96G74, 23 interactors
MINTiQ96G74
STRINGi9606.ENSP00000156084

Protein family/group databases

MEROPSiC85.001

PTM databases

GlyGeniQ96G74, 1 site, 1 O-linked glycan (1 site)
iPTMnetiQ96G74
PhosphoSitePlusiQ96G74

Genetic variation databases

BioMutaiOTUD5
DMDMi74731791

Proteomic databases

EPDiQ96G74
jPOSTiQ96G74
MassIVEiQ96G74
MaxQBiQ96G74
PaxDbiQ96G74
PeptideAtlasiQ96G74
PRIDEiQ96G74
ProteomicsDBi33910
4133
76598 [Q96G74-1]
76599 [Q96G74-2]
76600 [Q96G74-3]
TopDownProteomicsiQ96G74-2 [Q96G74-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		409, 169 antibodies from 33 providers

The DNASU plasmid repository

More...DNASUi		55593

Genome annotation databases

EnsembliENST00000156084.8; ENSP00000156084.4; ENSG00000068308.15
ENST00000376488.8; ENSP00000365671.3; ENSG00000068308.15 [Q96G74-5]
ENST00000396743.7; ENSP00000379969.3; ENSG00000068308.15 [Q96G74-5]
ENST00000428668.2; ENSP00000401629.2; ENSG00000068308.15 [Q96G74-4]
GeneIDi55593
KEGGihsa:55593
MANE-SelectiENST00000376488.8; ENSP00000365671.3; NM_001136157.2; NP_001129629.1 [Q96G74-5]
UCSCiuc004dlt.5, human [Q96G74-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		55593
DisGeNETi55593

GeneCards: human genes, protein and diseases

More...GeneCardsi		OTUD5
HGNCiHGNC:25402, OTUD5
HPAiENSG00000068308, Low tissue specificity
MalaCardsiOTUD5
MIMi300713, gene
301056, phenotype
neXtProtiNX_Q96G74
OpenTargetsiENSG00000068308
PharmGKBiPA142671217
VEuPathDBiHostDB:ENSG00000068308

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2605, Eukaryota
GeneTreeiENSGT00940000158963
HOGENOMiCLU_021938_0_1_1
InParanoidiQ96G74
OMAiREDKHFE
OrthoDBi1448656at2759
PhylomeDBiQ96G74
TreeFamiTF326812

Enzyme and pathway databases

PathwayCommonsiQ96G74
ReactomeiR-HSA-5689896, Ovarian tumor domain proteases
R-HSA-936440, Negative regulators of DDX58/IFIH1 signaling
SignaLinkiQ96G74
SIGNORiQ96G74

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		55593, 105 hits in 721 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		OTUD5, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		55593
PharosiQ96G74, Tbio

Protein Ontology

More...PROi		PR:Q96G74
RNActiQ96G74, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000068308, Expressed in quadriceps femoris and 217 other tissues
ExpressionAtlasiQ96G74, baseline and differential
GenevisibleiQ96G74, HS

Family and domain databases

InterProiView protein in InterPro
IPR031084, OTU5
IPR003323, OTU_dom
IPR038765, Papain-like_cys_pep_sf
PANTHERiPTHR12419:SF4, PTHR12419:SF4, 1 hit
PfamiView protein in Pfam
PF02338, OTU, 1 hit
SUPFAMiSSF54001, SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS50802, OTU, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiOTUD5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96G74
Secondary accession number(s): B4DGG7
, G5E9D7, Q4KMN9, Q8N6T5, Q9H650, Q9H9U0, Q9NT65
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: December 1, 2001
Last modified: May 25, 2022
This is version 154 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families
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