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Protein

Cilia- and flagella-associated protein 36

Gene

CFAP36

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May act as an effector for ARL3.

GO - Molecular functioni

  • protein N-terminus binding Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Cilia- and flagella-associated protein 36Imported
Alternative name(s):
Coiled-coil domain-containing protein 104Imported
Gene namesi
Name:CFAP36
Synonyms:CCDC104
ORF Names:UNQ163/PRO189
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000163001.11
HGNCiHGNC:30540 CFAP36
neXtProtiNX_Q96G28

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Flagellum, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000163001
PharmGKBiPA145008608

Polymorphism and mutation databases

BioMutaiCCDC104
DMDMi126215682

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002786381 – 342Cilia- and flagella-associated protein 36Add BLAST342

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei85PhosphoserineBy similarity1
Modified residuei147PhosphoserineBy similarity1
Modified residuei201PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96G28
MaxQBiQ96G28
PaxDbiQ96G28
PeptideAtlasiQ96G28
PRIDEiQ96G28
ProteomicsDBi76589
76590 [Q96G28-2]

PTM databases

iPTMnetiQ96G28
PhosphoSitePlusiQ96G28

Miscellaneous databases

PMAP-CutDBiQ96G28

Expressioni

Tissue specificityi

Expressed in several human tissues including brain, testis, heart, lung, pancreas and spleen (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000163001 Expressed in 197 organ(s), highest expression level in testis
CleanExiHS_CCDC104
ExpressionAtlasiQ96G28 baseline and differential
GenevisibleiQ96G28 HS

Organism-specific databases

HPAiHPA008994
HPA017061

Interactioni

Subunit structurei

Interacts with ARL3.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Arl3Q9WUL72EBI-2654750,EBI-6860857From Mus musculus.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi125218, 9 interactors
DIPiDIP-57013N
IntActiQ96G28, 7 interactors
STRINGi9606.ENSP00000295117

Structurei

3D structure databases

ProteinModelPortaliQ96G28
SMRiQ96G28
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili150 – 187Sequence analysisAdd BLAST38

Sequence similaritiesi

Belongs to the CFAP36 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4511 Eukaryota
ENOG41116YE LUCA
GeneTreeiENSGT00390000012785
HOGENOMiHOG000007745
HOVERGENiHBG062543
InParanoidiQ96G28
OMAiIWAANEY
OrthoDBiEOG091G09GK
PhylomeDBiQ96G28
TreeFamiTF315143

Family and domain databases

InterProiView protein in InterPro
IPR023379 BART_dom
IPR038888 CFAP36
PANTHERiPTHR21532 PTHR21532, 1 hit
PfamiView protein in Pfam
PF11527 ARL2_Bind_BART, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96G28-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAEEEDEVE WVVESIAGFL RGPDWSIPIL DFVEQKCEVF DDEEESKLTY
60 70 80 90 100
TEIHQEYKEL VEKLLEGYLK EIGINEDQFQ EACTSPLAKT HTSQAILQPV
110 120 130 140 150
LAAEDFTIFK AMMVQKNIEM QLQAIRIIQE RNGVLPDCLT DGSDVVSDLE
160 170 180 190 200
HEEMKILREV LRKSKEEYDQ EEERKRKKQL SEAKTEEPTV HSSEAAIMNN
210 220 230 240 250
SQGDGEHFAH PPSEVKMHFA NQSIEPLGRK VERSETSSLP QKDLKIPGLE
260 270 280 290 300
HASIEGPIAN LSVLGTEELR QREHYLKQKR DKLMSMRKDM RTKQIQNMEQ
310 320 330 340
KGKPTGEVEE MTEKPEMTAE EKQTLLKRRL LAEKLKEEVI NK
Length:342
Mass (Da):39,447
Last modified:February 20, 2007 - v2
Checksum:iC8ACF26FC57DFBD6
GO
Isoform 2 (identifier: Q96G28-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     39-39: V → VNCKGGHVITPGSPEPVILVACVPLV

Show »
Length:367
Mass (Da):41,929
Checksum:i2E0F8C275213CE05
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B5MC35B5MC35_HUMAN
Cilia- and flagella-associated prot...
CFAP36
218Annotation score:
B5MCA1B5MCA1_HUMAN
Cilia- and flagella-associated prot...
CFAP36
313Annotation score:
B5MD16B5MD16_HUMAN
Cilia- and flagella-associated prot...
CFAP36
223Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0507256E → D. Corresponds to variant dbSNP:rs34891804Ensembl.1
Natural variantiVAR_030795243D → G2 PublicationsCorresponds to variant dbSNP:rs1045910Ensembl.1
Natural variantiVAR_030796246I → F1 PublicationCorresponds to variant dbSNP:rs1045920Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02333839V → VNCKGGHVITPGSPEPVILV ACVPLV in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358097 mRNA Translation: AAQ88464.1
BC010011 mRNA Translation: AAH10011.1
AC019198 Genomic DNA Translation: AAY14933.1
AC015982 Genomic DNA Translation: AAY24269.1
CCDSiCCDS1854.2 [Q96G28-1]
CCDS62911.1 [Q96G28-2]
RefSeqiNP_001269690.1, NM_001282761.1 [Q96G28-2]
NP_542398.3, NM_080667.6 [Q96G28-1]
UniGeneiHs.264208

Genome annotation databases

EnsembliENST00000339012; ENSP00000342699; ENSG00000163001 [Q96G28-2]
ENST00000349456; ENSP00000295117; ENSG00000163001 [Q96G28-1]
GeneIDi112942
KEGGihsa:112942
UCSCiuc002ryx.4 human [Q96G28-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358097 mRNA Translation: AAQ88464.1
BC010011 mRNA Translation: AAH10011.1
AC019198 Genomic DNA Translation: AAY14933.1
AC015982 Genomic DNA Translation: AAY24269.1
CCDSiCCDS1854.2 [Q96G28-1]
CCDS62911.1 [Q96G28-2]
RefSeqiNP_001269690.1, NM_001282761.1 [Q96G28-2]
NP_542398.3, NM_080667.6 [Q96G28-1]
UniGeneiHs.264208

3D structure databases

ProteinModelPortaliQ96G28
SMRiQ96G28
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125218, 9 interactors
DIPiDIP-57013N
IntActiQ96G28, 7 interactors
STRINGi9606.ENSP00000295117

PTM databases

iPTMnetiQ96G28
PhosphoSitePlusiQ96G28

Polymorphism and mutation databases

BioMutaiCCDC104
DMDMi126215682

Proteomic databases

EPDiQ96G28
MaxQBiQ96G28
PaxDbiQ96G28
PeptideAtlasiQ96G28
PRIDEiQ96G28
ProteomicsDBi76589
76590 [Q96G28-2]

Protocols and materials databases

DNASUi112942
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000339012; ENSP00000342699; ENSG00000163001 [Q96G28-2]
ENST00000349456; ENSP00000295117; ENSG00000163001 [Q96G28-1]
GeneIDi112942
KEGGihsa:112942
UCSCiuc002ryx.4 human [Q96G28-1]

Organism-specific databases

CTDi112942
EuPathDBiHostDB:ENSG00000163001.11
GeneCardsiCFAP36
H-InvDBiHIX0002064
HGNCiHGNC:30540 CFAP36
HPAiHPA008994
HPA017061
neXtProtiNX_Q96G28
OpenTargetsiENSG00000163001
PharmGKBiPA145008608
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4511 Eukaryota
ENOG41116YE LUCA
GeneTreeiENSGT00390000012785
HOGENOMiHOG000007745
HOVERGENiHBG062543
InParanoidiQ96G28
OMAiIWAANEY
OrthoDBiEOG091G09GK
PhylomeDBiQ96G28
TreeFamiTF315143

Miscellaneous databases

ChiTaRSiCFAP36 human
GenomeRNAii112942
PMAP-CutDBiQ96G28
PROiPR:Q96G28

Gene expression databases

BgeeiENSG00000163001 Expressed in 197 organ(s), highest expression level in testis
CleanExiHS_CCDC104
ExpressionAtlasiQ96G28 baseline and differential
GenevisibleiQ96G28 HS

Family and domain databases

InterProiView protein in InterPro
IPR023379 BART_dom
IPR038888 CFAP36
PANTHERiPTHR21532 PTHR21532, 1 hit
PfamiView protein in Pfam
PF11527 ARL2_Bind_BART, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCFA36_HUMAN
AccessioniPrimary (citable) accession number: Q96G28
Secondary accession number(s): Q53SF0, Q53ST9, Q6UY34
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: February 20, 2007
Last modified: November 7, 2018
This is version 115 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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Main funding by: National Institutes of Health

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