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Protein

WW domain-binding protein 1

Gene

WBP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • WW domain binding Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
WW domain-binding protein 1
Short name:
WBP-1
Gene namesi
Name:WBP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000239779.6
HGNCiHGNC:12737 WBP1
MIMi606961 gene
neXtProtiNX_Q96G27

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi141Y → A: Abolishes interaction with WWOX. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000239779
PharmGKBiPA37348

Polymorphism and mutation databases

BioMutaiWBP1
DMDMi25091540

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000659481 – 269WW domain-binding protein 1Add BLAST269

Proteomic databases

MaxQBiQ96G27
PaxDbiQ96G27
PeptideAtlasiQ96G27
PRIDEiQ96G27
ProteomicsDBi76588

PTM databases

iPTMnetiQ96G27
PhosphoSitePlusiQ96G27

Expressioni

Tissue specificityi

Expressed in most tissues but at significantly lower levels in placenta, lung, liver, and kidney.

Gene expression databases

BgeeiENSG00000239779
CleanExiHS_WBP1
ExpressionAtlasiQ96G27 baseline and differential
GenevisibleiQ96G27 HS

Organism-specific databases

HPAiHPA057067

Interactioni

Subunit structurei

Interacts with NEDD4 (By similarity). Binds to the WW domain of YAP1, WWP1 and WWP2. Interacts with WWOX.By similarity3 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • WW domain binding Source: UniProtKB

Protein-protein interaction databases

BioGridi117103, 38 interactors
IntActiQ96G27, 6 interactors
MINTiQ96G27
STRINGi9606.ENSP00000233615

Structurei

3D structure databases

ProteinModelPortaliQ96G27
SMRiQ96G27
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi124 – 127PPxY motif 14
Motifi137 – 141PPxY motif 25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi85 – 90Poly-Gln6
Compositional biasi159 – 163Poly-Ser5

Domaini

The PPxY motif 2 mediates interaction with WWOX. Both PPxY motifs mediate interaction with NEDD4 (By similarity).By similarity

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IWXA Eukaryota
ENOG41104IZ LUCA
GeneTreeiENSGT00530000063663
HOGENOMiHOG000231948
HOVERGENiHBG029355
InParanoidiQ96G27
PhylomeDBiQ96G27
TreeFamiTF330726

Family and domain databases

InterProiView protein in InterPro
IPR021684 WBP1-like
PfamiView protein in Pfam
PF11669 WBP-1, 1 hit

Sequencei

Sequence statusi: Complete.

Q96G27-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARASSGNGS EEAWGALRAP QQQLRELCPG VNNQPYLCES GHCCGETGCC
60 70 80 90 100
TYYYELWWFW LLWTVLILFS CCCAFRHRRA KLRLQQQQRQ REINLLAYHG
110 120 130 140 150
ACHGAGPFPT GSLLDLRFLS TFKPPAYEDV VHRPGTPPPP YTVAPGRPLT
160 170 180 190 200
ASSEQTCCSS SSSCPAHFEG TNVEGVSSHQ SAPPHQEGEP GAGVTPASTP
210 220 230 240 250
PSCRYRRLTG DSGIELCPCP ASGEGEPVKE VRVSATLPDL EDYSPCALPP
260
ESVPQIFPMG LSSSEGDIP
Length:269
Mass (Da):29,140
Last modified:December 1, 2001 - v1
Checksum:i009CF5A444E62AC0
GO

Sequence cautioni

The sequence AAD10950 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U79457 mRNA Translation: AAD10950.1 Different initiation.
AK315745 mRNA Translation: BAG38099.1
CH471053 Genomic DNA Translation: EAW99656.1
BC010012 mRNA Translation: AAH10012.1
BC064482 mRNA Translation: AAH64482.1
BC071626 mRNA Translation: AAH71626.1
BC071850 mRNA Translation: AAH71850.1
CCDSiCCDS1943.1
RefSeqiNP_036609.1, NM_012477.3
UniGeneiHs.516114

Genome annotation databases

EnsembliENST00000233615; ENSP00000233615; ENSG00000239779
GeneIDi23559
KEGGihsa:23559
UCSCiuc002slj.3 human

Similar proteinsi

Entry informationi

Entry nameiWBP1_HUMAN
AccessioniPrimary (citable) accession number: Q96G27
Secondary accession number(s): B2RE02, O95637
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: December 1, 2001
Last modified: July 18, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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