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Protein

U3 small nucleolar ribonucleoprotein protein IMP4

Gene

IMP4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.1 Publication

GO - Molecular functioni

  • rRNA primary transcript binding Source: GO_Central
  • snoRNA binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein
Biological processRibosome biogenesis, rRNA processing

Enzyme and pathway databases

ReactomeiR-HSA-6790901 rRNA modification in the nucleus and cytosol
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Names & Taxonomyi

Protein namesi
Recommended name:
U3 small nucleolar ribonucleoprotein protein IMP4
Short name:
U3 snoRNP protein IMP4
Alternative name(s):
Brix domain-containing protein 4
Gene namesi
Name:IMP4
Synonyms:BXDC4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000136718.9
HGNCiHGNC:30856 IMP4
MIMi612981 gene
neXtProtiNX_Q96G21

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000136718
PharmGKBiPA142671656

Polymorphism and mutation databases

BioMutaiIMP4
DMDMi73621060

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001202361 – 291U3 small nucleolar ribonucleoprotein protein IMP4Add BLAST291

Proteomic databases

EPDiQ96G21
MaxQBiQ96G21
PaxDbiQ96G21
PeptideAtlasiQ96G21
PRIDEiQ96G21
ProteomicsDBi76583

PTM databases

iPTMnetiQ96G21
PhosphoSitePlusiQ96G21

Expressioni

Gene expression databases

BgeeiENSG00000136718 Expressed in 222 organ(s), highest expression level in body of pancreas
CleanExiHS_IMP4
ExpressionAtlasiQ96G21 baseline and differential
GenevisibleiQ96G21 HS

Organism-specific databases

HPAiHPA066222
HPA066673

Interactioni

Subunit structurei

Component of a heterotrimeric complex containing IMP3, IMP4 and MPHOSPH10. Interacts with MPHOSPH10.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ZBTB7BO151564EBI-8641721,EBI-740434

Protein-protein interaction databases

BioGridi124984, 35 interactors
CORUMiQ96G21
IntActiQ96G21, 4 interactors
MINTiQ96G21
STRINGi9606.ENSP00000259239

Structurei

3D structure databases

ProteinModelPortaliQ96G21
SMRiQ96G21
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini83 – 264BrixPROSITE-ProRule annotationAdd BLAST182

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi3 – 48Arg-richAdd BLAST46

Phylogenomic databases

eggNOGiKOG2781 Eukaryota
COG2136 LUCA
GeneTreeiENSGT00550000074987
HOGENOMiHOG000172063
HOVERGENiHBG056795
InParanoidiQ96G21
KOiK14561
OMAiFFNISDV
OrthoDBiEOG091G0GP1
PhylomeDBiQ96G21
TreeFamiTF300016

Family and domain databases

InterProiView protein in InterPro
IPR007109 Brix
PfamiView protein in Pfam
PF04427 Brix, 1 hit
SMARTiView protein in SMART
SM00879 Brix, 1 hit
PROSITEiView protein in PROSITE
PS50833 BRIX, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q96G21-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLRREARLRR EYLYRKAREE AQRSAQERKE RLRRALEENR LIPTELRREA
60 70 80 90 100
LALQGSLEFD DAGGEGVTSH VDDEYRWAGV EDPKVMITTS RDPSSRLKMF
110 120 130 140 150
AKELKLVFPG AQRMNRGRHE VGALVRACKA NGVTDLLVVH EHRGTPVGLI
160 170 180 190 200
VSHLPFGPTA YFTLCNVVMR HDIPDLGTMS EAKPHLITHG FSSRLGKRVS
210 220 230 240 250
DILRYLFPVP KDDSHRVITF ANQDDYISFR HHVYKKTDHR NVELTEVGPR
260 270 280 290
FELKLYMIRL GTLEQEATAD VEWRWHPYTN TARKRVFLST E
Length:291
Mass (Da):33,757
Last modified:December 1, 2001 - v1
Checksum:i460A05DFFE70C580
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y714H0Y714_HUMAN
U3 small nucleolar ribonucleoprotei...
IMP4
280Annotation score:
B8ZZ47B8ZZ47_HUMAN
U3 small nucleolar ribonucleoprotei...
IMP4
248Annotation score:
E7ENR5E7ENR5_HUMAN
U3 small nucleolar ribonucleoprotei...
IMP4
236Annotation score:
B9A008B9A008_HUMAN
U3 small nucleolar ribonucleoprotei...
IMP4
172Annotation score:
F8WCN0F8WCN0_HUMAN
U3 small nucleolar ribonucleoprotei...
IMP4
76Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY364245 mRNA Translation: AAQ76804.1
AK289878 mRNA Translation: BAF82567.1
AK292345 mRNA Translation: BAF85034.1
AK312808 mRNA Translation: BAG35666.1
AC132479 Genomic DNA Translation: AAY24076.1
BC010042 mRNA Translation: AAH10042.1
CCDSiCCDS2160.1
RefSeqiNP_001307233.1, NM_001320304.1
NP_001307234.1, NM_001320305.1
NP_001307235.1, NM_001320306.1
NP_001307236.1, NM_001320307.1
NP_001307238.1, NM_001320309.1
NP_001307239.1, NM_001320310.1
NP_001307240.1, NM_001320311.1
NP_219484.1, NM_033416.2
UniGeneiHs.91579

Genome annotation databases

EnsembliENST00000259239; ENSP00000259239; ENSG00000136718
GeneIDi92856
KEGGihsa:92856
UCSCiuc002tra.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY364245 mRNA Translation: AAQ76804.1
AK289878 mRNA Translation: BAF82567.1
AK292345 mRNA Translation: BAF85034.1
AK312808 mRNA Translation: BAG35666.1
AC132479 Genomic DNA Translation: AAY24076.1
BC010042 mRNA Translation: AAH10042.1
CCDSiCCDS2160.1
RefSeqiNP_001307233.1, NM_001320304.1
NP_001307234.1, NM_001320305.1
NP_001307235.1, NM_001320306.1
NP_001307236.1, NM_001320307.1
NP_001307238.1, NM_001320309.1
NP_001307239.1, NM_001320310.1
NP_001307240.1, NM_001320311.1
NP_219484.1, NM_033416.2
UniGeneiHs.91579

3D structure databases

ProteinModelPortaliQ96G21
SMRiQ96G21
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124984, 35 interactors
CORUMiQ96G21
IntActiQ96G21, 4 interactors
MINTiQ96G21
STRINGi9606.ENSP00000259239

PTM databases

iPTMnetiQ96G21
PhosphoSitePlusiQ96G21

Polymorphism and mutation databases

BioMutaiIMP4
DMDMi73621060

Proteomic databases

EPDiQ96G21
MaxQBiQ96G21
PaxDbiQ96G21
PeptideAtlasiQ96G21
PRIDEiQ96G21
ProteomicsDBi76583

Protocols and materials databases

DNASUi92856
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000259239; ENSP00000259239; ENSG00000136718
GeneIDi92856
KEGGihsa:92856
UCSCiuc002tra.2 human

Organism-specific databases

CTDi92856
EuPathDBiHostDB:ENSG00000136718.9
GeneCardsiIMP4
HGNCiHGNC:30856 IMP4
HPAiHPA066222
HPA066673
MIMi612981 gene
neXtProtiNX_Q96G21
OpenTargetsiENSG00000136718
PharmGKBiPA142671656
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2781 Eukaryota
COG2136 LUCA
GeneTreeiENSGT00550000074987
HOGENOMiHOG000172063
HOVERGENiHBG056795
InParanoidiQ96G21
KOiK14561
OMAiFFNISDV
OrthoDBiEOG091G0GP1
PhylomeDBiQ96G21
TreeFamiTF300016

Enzyme and pathway databases

ReactomeiR-HSA-6790901 rRNA modification in the nucleus and cytosol
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Miscellaneous databases

ChiTaRSiIMP4 human
GeneWikiiIMP4
GenomeRNAii92856
PROiPR:Q96G21
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000136718 Expressed in 222 organ(s), highest expression level in body of pancreas
CleanExiHS_IMP4
ExpressionAtlasiQ96G21 baseline and differential
GenevisibleiQ96G21 HS

Family and domain databases

InterProiView protein in InterPro
IPR007109 Brix
PfamiView protein in Pfam
PF04427 Brix, 1 hit
SMARTiView protein in SMART
SM00879 Brix, 1 hit
PROSITEiView protein in PROSITE
PS50833 BRIX, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIMP4_HUMAN
AccessioniPrimary (citable) accession number: Q96G21
Secondary accession number(s): Q3ZTT3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: December 1, 2001
Last modified: October 10, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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