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Protein

Phosphoglucomutase-2

Gene

PGM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the conversion of the nucleoside breakdown products ribose-1-phosphate and deoxyribose-1-phosphate to the corresponding 5-phosphopentoses. May also catalyze the interconversion of glucose-1-phosphate and glucose-6-phosphate. Has low glucose 1,6-bisphosphate synthase activity.1 Publication

Catalytic activityi

Alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate.
Alpha-D-ribose 1-phosphate = D-ribose 5-phosphate.
2-deoxy-alpha-D-ribose 1-phosphate = 2-deoxy-alpha-D-ribose 5-phosphate.

Cofactori

Mg2+By similarityNote: Binds 1 Mg2+ ion per subunit.By similarity

Kineticsi

  1. KM=45.7 µM for alpha-D-ribose 1-phosphate1 Publication
  2. KM=4.1 µM for 2-deoxy-alpha-D-ribose 1-phosphate1 Publication
  3. KM=114 µM for alpha-D-glucose 1-phosphate1 Publication
  1. Vmax=104.3 µmol/min/mg enzyme with alpha-D-ribose 1-phosphate as substrate1 Publication
  2. Vmax=20.8 µmol/min/mg enzyme with 2-deoxy-alpha-D-ribose 1-phosphate as substrate1 Publication
  3. Vmax=22.8 µmol/min/mg enzyme with alpha-D-glucose 1-phosphate as substrate1 Publication

Pathwayi: 2-deoxy-D-ribose 1-phosphate degradation

This protein is involved in step 1 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Phosphoglucomutase-2 (PGM2)
  2. Deoxyribose-phosphate aldolase (DERA)
This subpathway is part of the pathway 2-deoxy-D-ribose 1-phosphate degradation, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate, the pathway 2-deoxy-D-ribose 1-phosphate degradation and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei59SubstrateBy similarity1
Binding sitei63SubstrateBy similarity1
Active sitei165Phosphoserine intermediateBy similarity1
Metal bindingi165Magnesium; via phosphate groupBy similarity1
Metal bindingi322MagnesiumBy similarity1
Metal bindingi324MagnesiumBy similarity1
Metal bindingi326MagnesiumBy similarity1
Binding sitei400SubstrateBy similarity1
Binding sitei438SubstrateBy similarity1

GO - Molecular functioni

  • magnesium ion binding Source: InterPro
  • phosphoglucomutase activity Source: Reactome
  • phosphopentomutase activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processCarbohydrate metabolism, Glucose metabolism
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciMetaCyc:HS09924-MONOMER
ReactomeiR-HSA-3322077 Glycogen synthesis
R-HSA-6798695 Neutrophil degranulation
R-HSA-70221 Glycogen breakdown (glycogenolysis)
R-HSA-70370 Galactose catabolism
R-HSA-71336 Pentose phosphate pathway
SABIO-RKiQ96G03
UniPathwayi
UPA00002;UER00467

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglucomutase-2 (EC:5.4.2.2)
Short name:
PGM 2
Alternative name(s):
Glucose phosphomutase 2
Phosphodeoxyribomutase
Phosphopentomutase (EC:5.4.2.7)
Gene namesi
Name:PGM2
ORF Names:MSTP006
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000169299.13
HGNCiHGNC:8906 PGM2
MIMi172000 gene
neXtProtiNX_Q96G03

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000169299
PharmGKBiPA33243

Polymorphism and mutation databases

BioMutaiPGM2
DMDMi116242708

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00001477812 – 612Phosphoglucomutase-2Add BLAST611

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei165PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ96G03
MaxQBiQ96G03
PaxDbiQ96G03
PeptideAtlasiQ96G03
PRIDEiQ96G03
ProteomicsDBi76580

PTM databases

iPTMnetiQ96G03
PhosphoSitePlusiQ96G03
SwissPalmiQ96G03

Expressioni

Gene expression databases

BgeeiENSG00000169299 Expressed in 198 organ(s), highest expression level in epithelial cell of pancreas
CleanExiHS_PGM2
ExpressionAtlasiQ96G03 baseline and differential
GenevisibleiQ96G03 HS

Organism-specific databases

HPAiHPA040676

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi120564, 14 interactors
IntActiQ96G03, 5 interactors
STRINGi9606.ENSP00000371393

Structurei

3D structure databases

ProteinModelPortaliQ96G03
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni165 – 166Substrate bindingBy similarity2
Regioni326 – 327Substrate bindingBy similarity2
Regioni424 – 426Substrate bindingBy similarity3

Sequence similaritiesi

Belongs to the phosphohexose mutase family.Curated

Phylogenomic databases

eggNOGiKOG1220 Eukaryota
COG1109 LUCA
GeneTreeiENSGT00390000017247
HOGENOMiHOG000268676
HOVERGENiHBG056917
InParanoidiQ96G03
KOiK15779
OMAiEEPGAMD
OrthoDBiEOG091G040C
PhylomeDBiQ96G03
TreeFamiTF300692

Family and domain databases

InterProiView protein in InterPro
IPR005844 A-D-PHexomutase_a/b/a-I
IPR016055 A-D-PHexomutase_a/b/a-I/II/III
IPR005845 A-D-PHexomutase_a/b/a-II
IPR005846 A-D-PHexomutase_a/b/a-III
IPR005843 A-D-PHexomutase_C
IPR036900 A-D-PHexomutase_C_sf
IPR016066 A-D-PHexomutase_CS
IPR005841 Alpha-D-phosphohexomutase_SF
PfamiView protein in Pfam
PF02878 PGM_PMM_I, 1 hit
PF02879 PGM_PMM_II, 1 hit
PF02880 PGM_PMM_III, 1 hit
PF00408 PGM_PMM_IV, 1 hit
PRINTSiPR00509 PGMPMM
SUPFAMiSSF53738 SSF53738, 3 hits
SSF55957 SSF55957, 1 hit
PROSITEiView protein in PROSITE
PS00710 PGM_PMM, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96G03-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAPEGSGLG EDARLDQETA QWLRWDKNSL TLEAVKRLIA EGNKEELRKC
60 70 80 90 100
FGARMEFGTA GLRAAMGPGI SRMNDLTIIQ TTQGFCRYLE KQFSDLKQKG
110 120 130 140 150
IVISFDARAH PSSGGSSRRF ARLAATTFIS QGIPVYLFSD ITPTPFVPFT
160 170 180 190 200
VSHLKLCAGI MITASHNPKQ DNGYKVYWDN GAQIISPHDK GISQAIEENL
210 220 230 240 250
EPWPQAWDDS LIDSSPLLHN PSASINNDYF EDLKKYCFHR SVNRETKVKF
260 270 280 290 300
VHTSVHGVGH SFVQSAFKAF DLVPPEAVPE QKDPDPEFPT VKYPNPEEGK
310 320 330 340 350
GVLTLSFALA DKTKARIVLA NDPDADRLAV AEKQDSGEWR VFSGNELGAL
360 370 380 390 400
LGWWLFTSWK EKNQDRSALK DTYMLSSTVS SKILRAIALK EGFHFEETLT
410 420 430 440 450
GFKWMGNRAK QLIDQGKTVL FAFEEAIGYM CCPFVLDKDG VSAAVISAEL
460 470 480 490 500
ASFLATKNLS LSQQLKAIYV EYGYHITKAS YFICHDQETI KKLFENLRNY
510 520 530 540 550
DGKNNYPKAC GKFEISAIRD LTTGYDDSQP DKKAVLPTSK SSQMITFTFA
560 570 580 590 600
NGGVATMRTS GTEPKIKYYA ELCAPPGNSD PEQLKKELNE LVSAIEEHFF
610
QPQKYNLQPK AD
Length:612
Mass (Da):68,283
Last modified:January 23, 2007 - v4
Checksum:i82234DDE810D1F52
GO
Isoform 2 (identifier: Q96G03-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-8: MAAPEGSG → MSSQLILR
     9-147: Missing.
     429-430: YM → KK
     431-612: Missing.

Note: No experimental confirmation available.
Show »
Length:291
Mass (Da):32,724
Checksum:i743821357CF0B3A4
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7ENQ8E7ENQ8_HUMAN
Phosphoglucomutase-2
PGM2
195Annotation score:
H0Y921H0Y921_HUMAN
Phosphoglucomutase-2
PGM2
59Annotation score:
E9PD70E9PD70_HUMAN
Phosphoglucomutase-2
PGM2
86Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti114G → A in BAD96957 (Ref. 5) Curated1
Sequence conflicti162I → V in BAA91938 (Ref. 2) Curated1
Sequence conflicti282K → R in CAB66640 (PubMed:11230166).Curated1
Sequence conflicti495E → G in BAD96957 (Ref. 5) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02796810G → D2 PublicationsCorresponds to variant dbSNP:rs17856324Ensembl.1
Natural variantiVAR_027969488E → D. Corresponds to variant dbSNP:rs10001580Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0562211 – 8MAAPEGSG → MSSQLILR in isoform 2. 1 Publication8
Alternative sequenceiVSP_0562229 – 147Missing in isoform 2. 1 PublicationAdd BLAST139
Alternative sequenceiVSP_056223429 – 430YM → KK in isoform 2. 1 Publication2
Alternative sequenceiVSP_056224431 – 612Missing in isoform 2. 1 PublicationAdd BLAST182

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136705 mRNA Translation: CAB66640.1
AF109360 mRNA Translation: AAQ13508.1
AK001845 mRNA Translation: BAA91938.1
AK303374 mRNA Translation: BAG64430.1
CR457274 mRNA Translation: CAG33555.1
AK223237 mRNA Translation: BAD96957.1
AC021106 Genomic DNA No translation available.
AC108022 Genomic DNA No translation available.
BC010087 mRNA Translation: AAH10087.1
CCDSiCCDS3443.1 [Q96G03-1]
RefSeqiNP_060760.2, NM_018290.3 [Q96G03-1]
UniGeneiHs.23363
Hs.607816

Genome annotation databases

EnsembliENST00000381967; ENSP00000371393; ENSG00000169299 [Q96G03-1]
GeneIDi55276
KEGGihsa:55276
UCSCiuc011byb.2 human [Q96G03-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136705 mRNA Translation: CAB66640.1
AF109360 mRNA Translation: AAQ13508.1
AK001845 mRNA Translation: BAA91938.1
AK303374 mRNA Translation: BAG64430.1
CR457274 mRNA Translation: CAG33555.1
AK223237 mRNA Translation: BAD96957.1
AC021106 Genomic DNA No translation available.
AC108022 Genomic DNA No translation available.
BC010087 mRNA Translation: AAH10087.1
CCDSiCCDS3443.1 [Q96G03-1]
RefSeqiNP_060760.2, NM_018290.3 [Q96G03-1]
UniGeneiHs.23363
Hs.607816

3D structure databases

ProteinModelPortaliQ96G03
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120564, 14 interactors
IntActiQ96G03, 5 interactors
STRINGi9606.ENSP00000371393

PTM databases

iPTMnetiQ96G03
PhosphoSitePlusiQ96G03
SwissPalmiQ96G03

Polymorphism and mutation databases

BioMutaiPGM2
DMDMi116242708

Proteomic databases

EPDiQ96G03
MaxQBiQ96G03
PaxDbiQ96G03
PeptideAtlasiQ96G03
PRIDEiQ96G03
ProteomicsDBi76580

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000381967; ENSP00000371393; ENSG00000169299 [Q96G03-1]
GeneIDi55276
KEGGihsa:55276
UCSCiuc011byb.2 human [Q96G03-1]

Organism-specific databases

CTDi55276
EuPathDBiHostDB:ENSG00000169299.13
GeneCardsiPGM2
HGNCiHGNC:8906 PGM2
HPAiHPA040676
MIMi172000 gene
neXtProtiNX_Q96G03
OpenTargetsiENSG00000169299
PharmGKBiPA33243
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1220 Eukaryota
COG1109 LUCA
GeneTreeiENSGT00390000017247
HOGENOMiHOG000268676
HOVERGENiHBG056917
InParanoidiQ96G03
KOiK15779
OMAiEEPGAMD
OrthoDBiEOG091G040C
PhylomeDBiQ96G03
TreeFamiTF300692

Enzyme and pathway databases

UniPathwayi
UPA00002;UER00467

BioCyciMetaCyc:HS09924-MONOMER
ReactomeiR-HSA-3322077 Glycogen synthesis
R-HSA-6798695 Neutrophil degranulation
R-HSA-70221 Glycogen breakdown (glycogenolysis)
R-HSA-70370 Galactose catabolism
R-HSA-71336 Pentose phosphate pathway
SABIO-RKiQ96G03

Miscellaneous databases

ChiTaRSiPGM2 human
GeneWikiiPGM2
GenomeRNAii55276
PROiPR:Q96G03
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000169299 Expressed in 198 organ(s), highest expression level in epithelial cell of pancreas
CleanExiHS_PGM2
ExpressionAtlasiQ96G03 baseline and differential
GenevisibleiQ96G03 HS

Family and domain databases

InterProiView protein in InterPro
IPR005844 A-D-PHexomutase_a/b/a-I
IPR016055 A-D-PHexomutase_a/b/a-I/II/III
IPR005845 A-D-PHexomutase_a/b/a-II
IPR005846 A-D-PHexomutase_a/b/a-III
IPR005843 A-D-PHexomutase_C
IPR036900 A-D-PHexomutase_C_sf
IPR016066 A-D-PHexomutase_CS
IPR005841 Alpha-D-phosphohexomutase_SF
PfamiView protein in Pfam
PF02878 PGM_PMM_I, 1 hit
PF02879 PGM_PMM_II, 1 hit
PF02880 PGM_PMM_III, 1 hit
PF00408 PGM_PMM_IV, 1 hit
PRINTSiPR00509 PGMPMM
SUPFAMiSSF53738 SSF53738, 3 hits
SSF55957 SSF55957, 1 hit
PROSITEiView protein in PROSITE
PS00710 PGM_PMM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPGM2_HUMAN
AccessioniPrimary (citable) accession number: Q96G03
Secondary accession number(s): B4E0G8
, Q53FP5, Q5QTR0, Q9H0P9, Q9NV22
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 155 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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