UniProtKB - Q96G01 (BICD1_HUMAN)
Protein
Protein bicaudal D homolog 1
Gene
BICD1
Organism
Homo sapiens (Human)
Status
Functioni
Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport by recruiting the dynein-dynactin motor complex.
GO - Molecular functioni
- cytoskeletal anchor activity Source: BHF-UCL
- dynactin binding Source: BHF-UCL
- dynein complex binding Source: BHF-UCL
- dynein intermediate chain binding Source: ARUK-UCL
- proteinase activated receptor binding Source: BHF-UCL
- protein kinase binding Source: ARUK-UCL
- Rab GTPase binding Source: BHF-UCL
- structural constituent of cytoskeleton Source: ProtInc
GO - Biological processi
- anatomical structure morphogenesis Source: ProtInc
- intracellular mRNA localization Source: UniProtKB
- microtubule anchoring at microtubule organizing center Source: BHF-UCL
- minus-end-directed organelle transport along microtubule Source: BHF-UCL
- negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway Source: BHF-UCL
- negative regulation of phospholipase C activity Source: BHF-UCL
- positive regulation of protein localization to centrosome Source: ARUK-UCL
- positive regulation of receptor-mediated endocytosis Source: BHF-UCL
- protein localization to organelle Source: BHF-UCL
- regulation of microtubule cytoskeleton organization Source: ARUK-UCL
- regulation of proteinase activated receptor activity Source: BHF-UCL
- RNA processing Source: ProtInc
- stress granule assembly Source: BHF-UCL
- viral process Source: BHF-UCL
Keywordsi
Biological process | Host-virus interaction |
Enzyme and pathway databases
PathwayCommonsi | Q96G01 |
Reactomei | R-HSA-6811436, COPI-independent Golgi-to-ER retrograde traffic |
Names & Taxonomyi
Protein namesi | Recommended name: Protein bicaudal D homolog 1Short name: Bic-D 1 |
Gene namesi | Name:BICD1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000151746.13 |
HGNCi | HGNC:1049, BICD1 |
MIMi | 602204, gene |
neXtProti | NX_Q96G01 |
Subcellular locationi
Golgi apparatus
Cytoskeleton
- centrosome Source: ARUK-UCL
- cytoskeleton Source: UniProtKB
Cytosol
- cytosol Source: BHF-UCL
Golgi apparatus
- Golgi apparatus Source: UniProtKB
- trans-Golgi network Source: BHF-UCL
Other locations
- cytoplasmic vesicle Source: BHF-UCL
- membrane Source: BHF-UCL
- perinuclear region of cytoplasm Source: BHF-UCL
- secretory vesicle Source: BHF-UCL
Keywords - Cellular componenti
Golgi apparatusPathology & Biotechi
Organism-specific databases
DisGeNETi | 636 |
OpenTargetsi | ENSG00000151746 |
PharmGKBi | PA25352 |
Miscellaneous databases
Pharosi | Q96G01, Tbio |
Polymorphism and mutation databases
BioMutai | BICD1 |
DMDMi | 209572759 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000205357 | 1 – 975 | Protein bicaudal D homolog 1Add BLAST | 975 |
Proteomic databases
EPDi | Q96G01 |
jPOSTi | Q96G01 |
MassIVEi | Q96G01 |
MaxQBi | Q96G01 |
PaxDbi | Q96G01 |
PeptideAtlasi | Q96G01 |
PRIDEi | Q96G01 |
ProteomicsDBi | 29543 76577 [Q96G01-1] 76578 [Q96G01-2] 76579 [Q96G01-3] |
PTM databases
iPTMneti | Q96G01 |
PhosphoSitePlusi | Q96G01 |
Expressioni
Tissue specificityi
Expressed in the brain, heart and skeletal muscle.
Gene expression databases
Bgeei | ENSG00000151746, Expressed in sural nerve and 226 other tissues |
ExpressionAtlasi | Q96G01, baseline and differential |
Genevisiblei | Q96G01, HS |
Organism-specific databases
HPAi | ENSG00000151746, Tissue enhanced (brain) |
Interactioni
Subunit structurei
Interacts with RAB6A.
Interacts (via C-terminus) with RAB6B (GTP-bound); the interaction is direct.
Interacts with CLIP-115 and KIFC2 (By similarity).
By similarity1 Publication(Microbial infection) Interacts with human cytomegalovirus/HHV-5 protein UL32.
1 PublicationBinary interactionsi
Hide detailsGO - Molecular functioni
- dynactin binding Source: BHF-UCL
- dynein intermediate chain binding Source: ARUK-UCL
- proteinase activated receptor binding Source: BHF-UCL
- protein kinase binding Source: ARUK-UCL
- Rab GTPase binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 107105, 212 interactors |
IntActi | Q96G01, 21 interactors |
MINTi | Q96G01 |
STRINGi | 9606.ENSP00000281474 |
Miscellaneous databases
RNActi | Q96G01, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 663 – 803 | Interaction with RAB6AAdd BLAST | 141 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 1 – 265 | Sequence analysisAdd BLAST | 265 | |
Coiled coili | 319 – 496 | Sequence analysisAdd BLAST | 178 | |
Coiled coili | 663 – 803 | Sequence analysisAdd BLAST | 141 |
Sequence similaritiesi
Belongs to the BicD family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG0999, Eukaryota |
GeneTreei | ENSGT00940000154471 |
HOGENOMi | CLU_2399043_0_0_1 |
InParanoidi | Q96G01 |
OMAi | SGATYLQ |
OrthoDBi | 542877at2759 |
PhylomeDBi | Q96G01 |
TreeFami | TF323833 |
Family and domain databases
InterProi | View protein in InterPro IPR018477, BICD |
PANTHERi | PTHR31233, PTHR31233, 1 hit |
Pfami | View protein in Pfam PF09730, BicD, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q96G01-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAAEEVLQTV DHYKTEIERL TKELTETTHE KIQAAEYGLV VLEEKLTLKQ
60 70 80 90 100
QYDELEAEYD SLKQELEQLK EAFGQSFSIH RKVAEDGETR EETLLQESAS
110 120 130 140 150
KEAYYLGKIL EMQNELKQSR AVVTNVQAEN ERLTAVVQDL KENNEMVELQ
160 170 180 190 200
RIRMKDEIRE YKFREARLLQ DYTELEEENI TLQKLVSTLK QNQVEYEGLK
210 220 230 240 250
HEIKRFEEET VLLNSQLEDA IRLKEIAEHQ LEEALETLKN EREQKNNLRK
260 270 280 290 300
ELSQYISLND NHISISVDGL KFAEDGSEPN NDDKMNGHIH GPLVKLNGDY
310 320 330 340 350
RTPTLRKGES LNPVSDLFSE LNISEIQKLK QQLMQVEREK AILLANLQES
360 370 380 390 400
QTQLEHTKGA LTEQHERVHR LTEHVNAMRG LQSSKELKAE LDGEKGRDSG
410 420 430 440 450
EEAHDYEVDI NGLEILECKY RVAVTEVIDL KAEIKALKEK YNKSVENYTD
460 470 480 490 500
EKAKYESKIQ MYDEQVTSLE KTTKESGEKM AHMEKELQKM TSIANENHST
510 520 530 540 550
LNTAQDELVT FSEELAQLYH HVCLCNNETP NRVMLDYYRQ SRVTRSGSLK
560 570 580 590 600
GPDDPRGLLS PRLARRGVSS PVETRTSSEP VAKESTEASK EPSPTKTPTI
610 620 630 640 650
SPVITAPPSS PVLDTSDIRK EPMNIYNLNA IIRDQIKHLQ KAVDRSLQLS
660 670 680 690 700
RQRAAARELA PMIDKDKEAL MEEILKLKSL LSTKREQIAT LRAVLKANKQ
710 720 730 740 750
TAEVALANLK NKYENEKAMV TETMTKLRNE LKALKEDAAT FSSLRAMFAT
760 770 780 790 800
RCDEYVTQLD EMQRQLAAAE DEKKTLNTLL RMAIQQKLAL TQRLEDLEFD
810 820 830 840 850
HEQSRRSKGK LGKSKIGSPK VSGEASVTVP TIDTYLLHSQ GPQTPNIRVS
860 870 880 890 900
SGTQRKRQFS PSLCDQSRPR TSGASYLQNL LRVPPDPTST ESFLLKGPPS
910 920 930 940 950
MSEFIQGHRL SKEKRLTVAP PDCQQPAASV PPQCSQLAGR QDCPTVSPDT
960 970
ALPEEQPHSS SQCAPLHCLS KPPHP
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA8MVZ6 | A8MVZ6_HUMAN | BICD1 protein | BICD1 | 827 | Annotation score: | ||
F8W056 | F8W056_HUMAN | Protein bicaudal D homolog 1 | BICD1 | 93 | Annotation score: | ||
U3KQF7 | U3KQF7_HUMAN | Protein bicaudal D homolog 1 | BICD1 | 69 | Annotation score: | ||
F8VZX7 | F8VZX7_HUMAN | Protein bicaudal D homolog 1 | BICD1 | 79 | Annotation score: | ||
A0A087WYJ7 | A0A087WYJ7_HUMAN | Protein bicaudal D homolog 1 | BICD1 | 173 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 588 | A → P in AAB94805 (PubMed:9367685).Curated | 1 | |
Sequence conflicti | 746 | A → T in AAB94805 (PubMed:9367685).Curated | 1 | |
Sequence conflicti | 796 | D → G in AAB94806 (PubMed:9367685).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_069060 | 778 | T → A1 PublicationCorresponds to variant dbSNP:rs200845476Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_007961 | 72 – 93 | AFGQS…TREET → VSCLSPLPFLALTPPTRKAH SS in isoform 2. 1 PublicationAdd BLAST | 22 | |
Alternative sequenceiVSP_007962 | 94 – 975 | Missing in isoform 2. 1 PublicationAdd BLAST | 882 | |
Alternative sequenceiVSP_045637 | 821 – 835 | VSGEA…TIDTY → IVSSLLPPYRHSAHN in isoform 4. 1 PublicationAdd BLAST | 15 | |
Alternative sequenceiVSP_045638 | 836 – 975 | Missing in isoform 4. 1 PublicationAdd BLAST | 140 | |
Alternative sequenceiVSP_007963 | 858 – 873 | QFSPS…PRTSG → YACSDLHSTVQWPDFS in isoform 3. 1 PublicationAdd BLAST | 16 | |
Alternative sequenceiVSP_007964 | 874 – 975 | Missing in isoform 3. 1 PublicationAdd BLAST | 102 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U90028 mRNA Translation: AAB94805.1 U90030 mRNA Translation: AAB94806.1 AK290188 mRNA Translation: BAF82877.1 AK313430 mRNA No translation available. AC016954 Genomic DNA No translation available. AC026356 Genomic DNA No translation available. AC048344 Genomic DNA No translation available. AC087245 Genomic DNA No translation available. AC087316 Genomic DNA No translation available. CH471116 Genomic DNA Translation: EAW88534.1 BC010091 mRNA No translation available. |
CCDSi | CCDS44859.1 [Q96G01-4] CCDS8726.1 [Q96G01-1] |
RefSeqi | NP_001003398.1, NM_001003398.1 [Q96G01-4] NP_001705.2, NM_001714.2 [Q96G01-1] |
Genome annotation databases
Ensembli | ENST00000548411; ENSP00000446793; ENSG00000151746 [Q96G01-4] ENST00000551848; ENSP00000448933; ENSG00000151746 [Q96G01-2] ENST00000652176; ENSP00000498700; ENSG00000151746 [Q96G01-1] |
GeneIDi | 636 |
KEGGi | hsa:636 |
UCSCi | uc001rku.4, human [Q96G01-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U90028 mRNA Translation: AAB94805.1 U90030 mRNA Translation: AAB94806.1 AK290188 mRNA Translation: BAF82877.1 AK313430 mRNA No translation available. AC016954 Genomic DNA No translation available. AC026356 Genomic DNA No translation available. AC048344 Genomic DNA No translation available. AC087245 Genomic DNA No translation available. AC087316 Genomic DNA No translation available. CH471116 Genomic DNA Translation: EAW88534.1 BC010091 mRNA No translation available. |
CCDSi | CCDS44859.1 [Q96G01-4] CCDS8726.1 [Q96G01-1] |
RefSeqi | NP_001003398.1, NM_001003398.1 [Q96G01-4] NP_001705.2, NM_001714.2 [Q96G01-1] |
3D structure databases
SMRi | Q96G01 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 107105, 212 interactors |
IntActi | Q96G01, 21 interactors |
MINTi | Q96G01 |
STRINGi | 9606.ENSP00000281474 |
PTM databases
iPTMneti | Q96G01 |
PhosphoSitePlusi | Q96G01 |
Polymorphism and mutation databases
BioMutai | BICD1 |
DMDMi | 209572759 |
Proteomic databases
EPDi | Q96G01 |
jPOSTi | Q96G01 |
MassIVEi | Q96G01 |
MaxQBi | Q96G01 |
PaxDbi | Q96G01 |
PeptideAtlasi | Q96G01 |
PRIDEi | Q96G01 |
ProteomicsDBi | 29543 76577 [Q96G01-1] 76578 [Q96G01-2] 76579 [Q96G01-3] |
Protocols and materials databases
Antibodypediai | 24706, 58 antibodies |
Genome annotation databases
Ensembli | ENST00000548411; ENSP00000446793; ENSG00000151746 [Q96G01-4] ENST00000551848; ENSP00000448933; ENSG00000151746 [Q96G01-2] ENST00000652176; ENSP00000498700; ENSG00000151746 [Q96G01-1] |
GeneIDi | 636 |
KEGGi | hsa:636 |
UCSCi | uc001rku.4, human [Q96G01-1] |
Organism-specific databases
CTDi | 636 |
DisGeNETi | 636 |
EuPathDBi | HostDB:ENSG00000151746.13 |
GeneCardsi | BICD1 |
HGNCi | HGNC:1049, BICD1 |
HPAi | ENSG00000151746, Tissue enhanced (brain) |
MIMi | 602204, gene |
neXtProti | NX_Q96G01 |
OpenTargetsi | ENSG00000151746 |
PharmGKBi | PA25352 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0999, Eukaryota |
GeneTreei | ENSGT00940000154471 |
HOGENOMi | CLU_2399043_0_0_1 |
InParanoidi | Q96G01 |
OMAi | SGATYLQ |
OrthoDBi | 542877at2759 |
PhylomeDBi | Q96G01 |
TreeFami | TF323833 |
Enzyme and pathway databases
PathwayCommonsi | Q96G01 |
Reactomei | R-HSA-6811436, COPI-independent Golgi-to-ER retrograde traffic |
Miscellaneous databases
BioGRID-ORCSi | 636, 1 hit in 840 CRISPR screens |
ChiTaRSi | BICD1, human |
GeneWikii | BICD1 |
GenomeRNAii | 636 |
Pharosi | Q96G01, Tbio |
PROi | PR:Q96G01 |
RNActi | Q96G01, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000151746, Expressed in sural nerve and 226 other tissues |
ExpressionAtlasi | Q96G01, baseline and differential |
Genevisiblei | Q96G01, HS |
Family and domain databases
InterProi | View protein in InterPro IPR018477, BICD |
PANTHERi | PTHR31233, PTHR31233, 1 hit |
Pfami | View protein in Pfam PF09730, BicD, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BICD1_HUMAN | |
Accessioni | Q96G01Primary (citable) accession number: Q96G01 Secondary accession number(s): A8K2C3 O43893 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 15, 2003 |
Last sequence update: | October 14, 2008 | |
Last modified: | December 2, 2020 | |
This is version 152 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations