Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein bicaudal D homolog 1

Gene

BICD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport by recruiting the dynein-dynactin motor complex.

GO - Molecular functioni

  • cytoskeletal adaptor activity Source: BHF-UCL
  • dynactin binding Source: BHF-UCL
  • dynein complex binding Source: BHF-UCL
  • dynein intermediate chain binding Source: ARUK-UCL
  • proteinase activated receptor binding Source: BHF-UCL
  • protein kinase binding Source: ARUK-UCL
  • Rab GTPase binding Source: BHF-UCL
  • structural constituent of cytoskeleton Source: ProtInc

GO - Biological processi

Keywordsi

Biological processHost-virus interaction

Enzyme and pathway databases

ReactomeiR-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic

Names & Taxonomyi

Protein namesi
Recommended name:
Protein bicaudal D homolog 1
Short name:
Bic-D 1
Gene namesi
Name:BICD1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000151746.13
HGNCiHGNC:1049 BICD1
MIMi602204 gene
neXtProtiNX_Q96G01

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Golgi apparatus

Pathology & Biotechi

Organism-specific databases

DisGeNETi636
OpenTargetsiENSG00000151746
PharmGKBiPA25352

Polymorphism and mutation databases

BioMutaiBICD1
DMDMi209572759

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002053571 – 975Protein bicaudal D homolog 1Add BLAST975

Proteomic databases

EPDiQ96G01
MaxQBiQ96G01
PaxDbiQ96G01
PeptideAtlasiQ96G01
PRIDEiQ96G01
ProteomicsDBi76577
76578 [Q96G01-2]
76579 [Q96G01-3]

PTM databases

iPTMnetiQ96G01
PhosphoSitePlusiQ96G01

Expressioni

Tissue specificityi

Expressed in the brain, heart and skeletal muscle.

Gene expression databases

BgeeiENSG00000151746 Expressed in 212 organ(s), highest expression level in cerebral cortex
CleanExiHS_BICD1
ExpressionAtlasiQ96G01 baseline and differential
GenevisibleiQ96G01 HS

Organism-specific databases

HPAiHPA041309

Interactioni

Subunit structurei

Interacts with RAB6A. Interacts (via C-terminus) with RAB6B (GTP-bound); the interaction is direct. Interacts with CLIP-115 and KIFC2 (By similarity).By similarity1 Publication
(Microbial infection) Interacts with human cytomegalovirus/HHV-5 protein UL32.1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi107105, 14 interactors
IntActiQ96G01, 16 interactors
MINTiQ96G01
STRINGi9606.ENSP00000281474

Structurei

3D structure databases

ProteinModelPortaliQ96G01
SMRiQ96G01
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni663 – 803Interaction with RAB6AAdd BLAST141

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1 – 265Sequence analysisAdd BLAST265
Coiled coili319 – 496Sequence analysisAdd BLAST178
Coiled coili663 – 803Sequence analysisAdd BLAST141

Sequence similaritiesi

Belongs to the BicD family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0999 Eukaryota
ENOG410XR47 LUCA
GeneTreeiENSGT00390000004114
HOGENOMiHOG000261658
HOVERGENiHBG050686
InParanoidiQ96G01
KOiK18739
OMAiVHMEKEL
OrthoDBiEOG091G01P4
PhylomeDBiQ96G01
TreeFamiTF323833

Family and domain databases

InterProiView protein in InterPro
IPR018477 BICD
PANTHERiPTHR31233 PTHR31233, 1 hit
PfamiView protein in Pfam
PF09730 BicD, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 5 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: Q96G01-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAEEVLQTV DHYKTEIERL TKELTETTHE KIQAAEYGLV VLEEKLTLKQ
60 70 80 90 100
QYDELEAEYD SLKQELEQLK EAFGQSFSIH RKVAEDGETR EETLLQESAS
110 120 130 140 150
KEAYYLGKIL EMQNELKQSR AVVTNVQAEN ERLTAVVQDL KENNEMVELQ
160 170 180 190 200
RIRMKDEIRE YKFREARLLQ DYTELEEENI TLQKLVSTLK QNQVEYEGLK
210 220 230 240 250
HEIKRFEEET VLLNSQLEDA IRLKEIAEHQ LEEALETLKN EREQKNNLRK
260 270 280 290 300
ELSQYISLND NHISISVDGL KFAEDGSEPN NDDKMNGHIH GPLVKLNGDY
310 320 330 340 350
RTPTLRKGES LNPVSDLFSE LNISEIQKLK QQLMQVEREK AILLANLQES
360 370 380 390 400
QTQLEHTKGA LTEQHERVHR LTEHVNAMRG LQSSKELKAE LDGEKGRDSG
410 420 430 440 450
EEAHDYEVDI NGLEILECKY RVAVTEVIDL KAEIKALKEK YNKSVENYTD
460 470 480 490 500
EKAKYESKIQ MYDEQVTSLE KTTKESGEKM AHMEKELQKM TSIANENHST
510 520 530 540 550
LNTAQDELVT FSEELAQLYH HVCLCNNETP NRVMLDYYRQ SRVTRSGSLK
560 570 580 590 600
GPDDPRGLLS PRLARRGVSS PVETRTSSEP VAKESTEASK EPSPTKTPTI
610 620 630 640 650
SPVITAPPSS PVLDTSDIRK EPMNIYNLNA IIRDQIKHLQ KAVDRSLQLS
660 670 680 690 700
RQRAAARELA PMIDKDKEAL MEEILKLKSL LSTKREQIAT LRAVLKANKQ
710 720 730 740 750
TAEVALANLK NKYENEKAMV TETMTKLRNE LKALKEDAAT FSSLRAMFAT
760 770 780 790 800
RCDEYVTQLD EMQRQLAAAE DEKKTLNTLL RMAIQQKLAL TQRLEDLEFD
810 820 830 840 850
HEQSRRSKGK LGKSKIGSPK VSGEASVTVP TIDTYLLHSQ GPQTPNIRVS
860 870 880 890 900
SGTQRKRQFS PSLCDQSRPR TSGASYLQNL LRVPPDPTST ESFLLKGPPS
910 920 930 940 950
MSEFIQGHRL SKEKRLTVAP PDCQQPAASV PPQCSQLAGR QDCPTVSPDT
960 970
ALPEEQPHSS SQCAPLHCLS KPPHP
Length:975
Mass (Da):110,750
Last modified:October 14, 2008 - v3
Checksum:iCCF0FB12013AA294
GO
Isoform 2 (identifier: Q96G01-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     72-93: AFGQSFSIHRKVAEDGETREET → VSCLSPLPFLALTPPTRKAHSS
     94-975: Missing.

Note: Due to intron retention. No experimental confirmation available.
Show »
Length:93
Mass (Da):10,689
Checksum:i2D3BAD41EA5BF9F1
GO
Isoform 3 (identifier: Q96G01-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     858-873: QFSPSLCDQSRPRTSG → YACSDLHSTVQWPDFS
     874-975: Missing.

Note: Due to intron retention.
Show »
Length:873
Mass (Da):99,868
Checksum:i71F286342CB246F9
GO
Isoform 4 (identifier: Q96G01-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     821-835: VSGEASVTVPTIDTY → IVSSLLPPYRHSAHN
     836-975: Missing.

Note: No experimental confirmation available.
Show »
Length:835
Mass (Da):95,739
Checksum:i81A4A7FCCB1D7613
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A8MVZ6A8MVZ6_HUMAN
BICD1 protein
BICD1
827Annotation score:
U3KQF7U3KQF7_HUMAN
Protein bicaudal D homolog 1
BICD1
69Annotation score:
F8W056F8W056_HUMAN
Protein bicaudal D homolog 1
BICD1
93Annotation score:
A0A087WYJ7A0A087WYJ7_HUMAN
Protein bicaudal D homolog 1
BICD1
173Annotation score:
F8VZX7F8VZX7_HUMAN
Protein bicaudal D homolog 1
BICD1
79Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti588A → P in AAB94805 (PubMed:9367685).Curated1
Sequence conflicti746A → T in AAB94805 (PubMed:9367685).Curated1
Sequence conflicti796D → G in AAB94806 (PubMed:9367685).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_069060778T → A1 PublicationCorresponds to variant dbSNP:rs200845476Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00796172 – 93AFGQS…TREET → VSCLSPLPFLALTPPTRKAH SS in isoform 2. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_00796294 – 975Missing in isoform 2. 1 PublicationAdd BLAST882
Alternative sequenceiVSP_045637821 – 835VSGEA…TIDTY → IVSSLLPPYRHSAHN in isoform 4. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_045638836 – 975Missing in isoform 4. 1 PublicationAdd BLAST140
Alternative sequenceiVSP_007963858 – 873QFSPS…PRTSG → YACSDLHSTVQWPDFS in isoform 3. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_007964874 – 975Missing in isoform 3. 1 PublicationAdd BLAST102

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90028 mRNA Translation: AAB94805.1
U90030 mRNA Translation: AAB94806.1
AK290188 mRNA Translation: BAF82877.1
AK313430 mRNA No translation available.
AC016954 Genomic DNA No translation available.
AC026356 Genomic DNA No translation available.
AC048344 Genomic DNA No translation available.
AC087245 Genomic DNA No translation available.
AC087316 Genomic DNA No translation available.
CH471116 Genomic DNA Translation: EAW88534.1
BC010091 mRNA No translation available.
CCDSiCCDS44859.1 [Q96G01-4]
CCDS8726.1 [Q96G01-1]
RefSeqiNP_001003398.1, NM_001003398.1 [Q96G01-4]
NP_001705.2, NM_001714.2 [Q96G01-1]
UniGeneiHs.505202
Hs.633204

Genome annotation databases

EnsembliENST00000281474; ENSP00000281474; ENSG00000151746 [Q96G01-1]
ENST00000548411; ENSP00000446793; ENSG00000151746 [Q96G01-4]
ENST00000551848; ENSP00000448933; ENSG00000151746 [Q96G01-2]
GeneIDi636
KEGGihsa:636
UCSCiuc001rku.4 human [Q96G01-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90028 mRNA Translation: AAB94805.1
U90030 mRNA Translation: AAB94806.1
AK290188 mRNA Translation: BAF82877.1
AK313430 mRNA No translation available.
AC016954 Genomic DNA No translation available.
AC026356 Genomic DNA No translation available.
AC048344 Genomic DNA No translation available.
AC087245 Genomic DNA No translation available.
AC087316 Genomic DNA No translation available.
CH471116 Genomic DNA Translation: EAW88534.1
BC010091 mRNA No translation available.
CCDSiCCDS44859.1 [Q96G01-4]
CCDS8726.1 [Q96G01-1]
RefSeqiNP_001003398.1, NM_001003398.1 [Q96G01-4]
NP_001705.2, NM_001714.2 [Q96G01-1]
UniGeneiHs.505202
Hs.633204

3D structure databases

ProteinModelPortaliQ96G01
SMRiQ96G01
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107105, 14 interactors
IntActiQ96G01, 16 interactors
MINTiQ96G01
STRINGi9606.ENSP00000281474

PTM databases

iPTMnetiQ96G01
PhosphoSitePlusiQ96G01

Polymorphism and mutation databases

BioMutaiBICD1
DMDMi209572759

Proteomic databases

EPDiQ96G01
MaxQBiQ96G01
PaxDbiQ96G01
PeptideAtlasiQ96G01
PRIDEiQ96G01
ProteomicsDBi76577
76578 [Q96G01-2]
76579 [Q96G01-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000281474; ENSP00000281474; ENSG00000151746 [Q96G01-1]
ENST00000548411; ENSP00000446793; ENSG00000151746 [Q96G01-4]
ENST00000551848; ENSP00000448933; ENSG00000151746 [Q96G01-2]
GeneIDi636
KEGGihsa:636
UCSCiuc001rku.4 human [Q96G01-1]

Organism-specific databases

CTDi636
DisGeNETi636
EuPathDBiHostDB:ENSG00000151746.13
GeneCardsiBICD1
H-InvDBiHIX0010532
HGNCiHGNC:1049 BICD1
HPAiHPA041309
MIMi602204 gene
neXtProtiNX_Q96G01
OpenTargetsiENSG00000151746
PharmGKBiPA25352
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0999 Eukaryota
ENOG410XR47 LUCA
GeneTreeiENSGT00390000004114
HOGENOMiHOG000261658
HOVERGENiHBG050686
InParanoidiQ96G01
KOiK18739
OMAiVHMEKEL
OrthoDBiEOG091G01P4
PhylomeDBiQ96G01
TreeFamiTF323833

Enzyme and pathway databases

ReactomeiR-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic

Miscellaneous databases

ChiTaRSiBICD1 human
GeneWikiiBICD1
GenomeRNAii636
PROiPR:Q96G01
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000151746 Expressed in 212 organ(s), highest expression level in cerebral cortex
CleanExiHS_BICD1
ExpressionAtlasiQ96G01 baseline and differential
GenevisibleiQ96G01 HS

Family and domain databases

InterProiView protein in InterPro
IPR018477 BICD
PANTHERiPTHR31233 PTHR31233, 1 hit
PfamiView protein in Pfam
PF09730 BicD, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBICD1_HUMAN
AccessioniPrimary (citable) accession number: Q96G01
Secondary accession number(s): A8K2C3
, F8W113, O43892, O43893
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: October 14, 2008
Last modified: September 12, 2018
This is version 136 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again