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Protein

Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein

Gene

HMCES

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Specifically binds 5-hydroxymethylcytosine (5hmC)-containing DNA in stem cells, suggesting that it acts as a specific reader of 5hmC in stem cells (By similarity). May act as a peptidase; experimental evidences are however required to confirm this prediction (PubMed:23945014).By similarity1 Publication

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding, Hydrolase, Protease

Names & Taxonomyi

Protein namesi
Recommended name:
Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein
Short name:
ES cell-specific 5hmC-binding protein
Alternative name(s):
Putative peptidase SRAPD1 (EC:3.4.-.-)
SRAP domain-containing protein 1
Gene namesi
Name:HMCES
Synonyms:C3orf37, DC12, SRAPD1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000183624.13
HGNCiHGNC:24446 HMCES
neXtProtiNX_Q96FZ2

Pathology & Biotechi

Organism-specific databases

DisGeNETi56941
OpenTargetsiENSG00000183624
PharmGKBiPA142672398

Polymorphism and mutation databases

BioMutaiC3orf37
DMDMi74731769

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001643941 – 354Embryonic stem cell-specific 5-hydroxymethylcytosine-binding proteinAdd BLAST354

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki148Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki151Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei160PhosphoserineCombined sources1
Cross-linki275Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki276Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei295PhosphoserineCombined sources1
Cross-linki306Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei322PhosphoserineCombined sources1
Cross-linki339Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki342Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ96FZ2
MaxQBiQ96FZ2
PaxDbiQ96FZ2
PeptideAtlasiQ96FZ2
PRIDEiQ96FZ2
ProteomicsDBi76573

PTM databases

iPTMnetiQ96FZ2
PhosphoSitePlusiQ96FZ2
SwissPalmiQ96FZ2

Expressioni

Gene expression databases

BgeeiENSG00000183624 Expressed in 223 organ(s), highest expression level in testis
CleanExiHS_C3orf37
ExpressionAtlasiQ96FZ2 baseline and differential
GenevisibleiQ96FZ2 HS

Organism-specific databases

HPAiHPA044968

Interactioni

Protein-protein interaction databases

BioGridi121265, 26 interactors
IntActiQ96FZ2, 13 interactors
STRINGi9606.ENSP00000372955

Structurei

Secondary structure

1354
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ96FZ2
SMRiQ96FZ2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2618 Eukaryota
COG2135 LUCA
GeneTreeiENSGT00390000018439
HOGENOMiHOG000104694
HOVERGENiHBG081414
InParanoidiQ96FZ2
OMAiEQQMNDW
OrthoDBiEOG091G09R0
PhylomeDBiQ96FZ2
TreeFamiTF324343

Family and domain databases

Gene3Di3.90.1680.10, 1 hit
InterProiView protein in InterPro
IPR003738 SRAP
IPR036590 SRAP-like
PANTHERiPTHR13604 PTHR13604, 1 hit
PfamiView protein in Pfam
PF02586 SRAP, 1 hit
SUPFAMiSSF143081 SSF143081, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.iShow all

Q96FZ2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCGRTSCHLP RDVLTRACAY QDRRGQQRLP EWRDPDKYCP SYNKSPQSNS
60 70 80 90 100
PVLLSRLHFE KDADSSERII APMRWGLVPS WFKESDPSKL QFNTTNCRSD
110 120 130 140 150
TVMEKRSFKV PLGKGRRCVV LADGFYEWQR CQGTNQRQPY FIYFPQIKTE
160 170 180 190 200
KSGSIGAADS PENWEKVWDN WRLLTMAGIF DCWEPPEGGD VLYSYTIITV
210 220 230 240 250
DSCKGLSDIH HRMPAILDGE EAVSKWLDFG EVSTQEALKL IHPTENITFH
260 270 280 290 300
AVSSVVNNSR NNTPECLAPV DLVVKKELRA SGSSQRMLQW LATKSPKKED
310 320 330 340 350
SKTPQKEESD VPQWSSQFLQ KSPLPTKRGT AGLLEQWLKR EKEEEPVAKR

PYSQ
Length:354
Mass (Da):40,575
Last modified:December 1, 2001 - v1
Checksum:i209496BB7E331785
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EMP6E7EMP6_HUMAN
Embryonic stem cell-specific 5-hydr...
HMCES
312Annotation score:
D6RAZ3D6RAZ3_HUMAN
Embryonic stem cell-specific 5-hydr...
HMCES
233Annotation score:
D6RGK7D6RGK7_HUMAN
Embryonic stem cell-specific 5-hydr...
HMCES
183Annotation score:
D6RAI0D6RAI0_HUMAN
Embryonic stem cell-specific 5-hydr...
HMCES
140Annotation score:
D6R9T3D6R9T3_HUMAN
Embryonic stem cell-specific 5-hydr...
HMCES
282Annotation score:

Sequence cautioni

The sequence AAF86870 differs from that shown. Reason: Frameshift at positions 285, 326 and 344.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti60E → D in AAH09993 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF201934 mRNA Translation: AAF86870.1 Frameshift.
AC137695 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79266.1
BC009993 mRNA Translation: AAH09993.1
BC010125 mRNA Translation: AAH10125.1
BC050686 mRNA Translation: AAH50686.1
BC088363 mRNA Translation: AAH88363.1
CCDSiCCDS33852.1
RefSeqiNP_001006109.1, NM_001006109.1
NP_064572.2, NM_020187.2
XP_005247693.1, XM_005247636.3
XP_016862366.1, XM_017006877.1
UniGeneiHs.458320

Genome annotation databases

EnsembliENST00000383463; ENSP00000372955; ENSG00000183624
ENST00000389735; ENSP00000374385; ENSG00000183624
ENST00000502878; ENSP00000426215; ENSG00000183624
GeneIDi56941
KEGGihsa:56941
UCSCiuc003elt.4 human

Entry informationi

Entry nameiHMCES_HUMAN
AccessioniPrimary (citable) accession number: Q96FZ2
Secondary accession number(s): A6NJR9, Q96G34, Q9NRP3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: December 1, 2001
Last modified: September 12, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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