UniProtKB - Q96FZ2 (HMCES_HUMAN)

BLAST

>sp|Q96FZ2|HMCES_HUMAN Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein OS=Homo sapiens OX=9606 GN=HMCES PE=1 SV=1
MCGRTSCHLPRDVLTRACAYQDRRGQQRLPEWRDPDKYCPSYNKSPQSNSPVLLSRLHFE
KDADSSERIIAPMRWGLVPSWFKESDPSKLQFNTTNCRSDTVMEKRSFKVPLGKGRRCVV
LADGFYEWQRCQGTNQRQPYFIYFPQIKTEKSGSIGAADSPENWEKVWDNWRLLTMAGIF
DCWEPPEGGDVLYSYTIITVDSCKGLSDIHHRMPAILDGEEAVSKWLDFGEVSTQEALKL
IHPTENITFHAVSSVVNNSRNNTPECLAPVDLVVKKELRASGSSQRMLQWLATKSPKKED
SKTPQKEESDVPQWSSQFLQKSPLPTKRGTAGLLEQWLKREKEEEPVAKRPYSQ

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History
Entry version 115 (12 Sep 2018)
Sequence version 1 (01 Dec 2001)
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Protein

Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein

Gene

HMCES

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Specifically binds 5-hydroxymethylcytosine (5hmC)-containing DNA in stem cells, suggesting that it acts as a specific reader of 5hmC in stem cells (By similarity). May act as a peptidase; experimental evidences are however required to confirm this prediction (PubMed:23945014).By similarity1 Publication

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
peptidase activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding, Hydrolase, Protease

Molecular function

DNA-binding, Hydrolase, Protease

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein Short name: ES cell-specific 5hmC-binding protein Alternative name(s): Putative peptidase SRAPD1 (EC:3.4.-.-) SRAP domain-containing protein 1
Gene namesⁱ	Name:HMCES Synonyms:C3orf37, DC12, SRAPD1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 3

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000183624.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:24446 HMCES
neXtProtⁱ	NX_Q96FZ2

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	56941
Open Targets More...OpenTargetsⁱ	ENSG00000183624
PharmGKBⁱ	PA142672398

Polymorphism and mutation databases

BioMutaⁱ	C3orf37
DMDMⁱ	74731769

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000164394	1 – 354	Embryonic stem cell-specific 5-hydroxymethylcytosine-binding proteinAdd BLAST		354

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Cross-linkⁱ	148	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	151	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	160	PhosphoserineCombined sources	1
Cross-linkⁱ	275	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	276	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	295	PhosphoserineCombined sources	1
Cross-linkⁱ	306	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	322	PhosphoserineCombined sources	1
Cross-linkⁱ	339	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	342	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q96FZ2
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q96FZ2
PaxDbⁱ	Q96FZ2
PeptideAtlas More...PeptideAtlasⁱ	Q96FZ2
PRIDEⁱ	Q96FZ2
ProteomicsDBⁱ	76573

PTM databases

iPTMnetⁱ	Q96FZ2
PhosphoSitePlusⁱ	Q96FZ2
SwissPalmⁱ	Q96FZ2

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000183624 Expressed in 223 organ(s), highest expression level in testis
CleanExⁱ	HS_C3orf37
ExpressionAtlasⁱ	Q96FZ2 baseline and differential
Genevisibleⁱ	Q96FZ2 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA044968

HPAⁱ

HPA044968

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	121265, 26 interactors
IntActⁱ	Q96FZ2, 13 interactors
STRINGⁱ	9606.ENSP00000372955

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	5 – 7	Combined sources	3
Helixⁱ	11 – 16	Combined sources	6
Beta strandⁱ	31 – 34	Combined sources	4
Helixⁱ	35 – 37	Combined sources	3
Beta strandⁱ	41 – 44	Combined sources	4
Beta strandⁱ	48 – 55	Combined sources	8
Helixⁱ	56 – 58	Combined sources	3
Beta strandⁱ	67 – 76	Combined sources	10
Helixⁱ	87 – 89	Combined sources	3
Beta strandⁱ	96 – 98	Combined sources	3
Helixⁱ	99 – 101	Combined sources	3
Turnⁱ	102 – 104	Combined sources	3
Helixⁱ	106 – 113	Combined sources	8
Beta strandⁱ	117 – 130	Combined sources	14
Beta strandⁱ	137 – 143	Combined sources	7
Helixⁱ	166 – 168	Combined sources	3
Beta strandⁱ	174 – 183	Combined sources	10
Beta strandⁱ	192 – 201	Combined sources	10
Helixⁱ	204 – 206	Combined sources	3
Turnⁱ	207 – 209	Combined sources	3
Beta strandⁱ	211 – 214	Combined sources	4
Helixⁱ	220 – 227	Combined sources	8
Turnⁱ	229 – 231	Combined sources	3
Helixⁱ	234 – 238	Combined sources	5
Beta strandⁱ	248 – 252	Combined sources	5
Helixⁱ	254 – 257	Combined sources	4
Helixⁱ	264 – 267	Combined sources	4

Show more details

3D structure databases

ProteinModelPortalⁱ	Q96FZ2
SMRⁱ	Q96FZ2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the SOS response-associated peptidase family.Curated

Phylogenomic databases

eggNOGⁱ	KOG2618 Eukaryota COG2135 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000018439
HOGENOMⁱ	HOG000104694
HOVERGENⁱ	HBG081414
InParanoidⁱ	Q96FZ2
OMAⁱ	EQQMNDW
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G09R0
PhylomeDBⁱ	Q96FZ2
TreeFamⁱ	TF324343

Family and domain databases

Gene3Dⁱ	3.90.1680.10, 1 hit
InterProⁱ	View protein in InterPro IPR003738 SRAP IPR036590 SRAP-like
PANTHERⁱ	PTHR13604 PTHR13604, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02586 SRAP, 1 hit
SUPFAMⁱ	SSF143081 SSF143081, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.ⁱShow all

Q96FZ2-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MCGRTSCHLP RDVLTRACAY QDRRGQQRLP EWRDPDKYCP SYNKSPQSNS 
        60         70         80         90        100
PVLLSRLHFE KDADSSERII APMRWGLVPS WFKESDPSKL QFNTTNCRSD 
       110        120        130        140        150
TVMEKRSFKV PLGKGRRCVV LADGFYEWQR CQGTNQRQPY FIYFPQIKTE 
       160        170        180        190        200
KSGSIGAADS PENWEKVWDN WRLLTMAGIF DCWEPPEGGD VLYSYTIITV 
       210        220        230        240        250
DSCKGLSDIH HRMPAILDGE EAVSKWLDFG EVSTQEALKL IHPTENITFH 
       260        270        280        290        300
AVSSVVNNSR NNTPECLAPV DLVVKKELRA SGSSQRMLQW LATKSPKKED 
       310        320        330        340        350
SKTPQKEESD VPQWSSQFLQ KSPLPTKRGT AGLLEQWLKR EKEEEPVAKR 

PYSQ

Length:354

Mass (Da):40,575

Last modified:December 1, 2001 - v1

Checksum:ⁱ209496BB7E331785

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation
E7EMP6	E7EMP6_HUMAN	Embryonic stem cell-specific 5-hydr... Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein, ES cell-specific 5hmC-binding protein, EC 3.4.-.- (Putative peptidase SRAPD1) (SRAP domain-containing protein 1)	HMCES	312	Annotation score:
D6RAZ3	D6RAZ3_HUMAN	Embryonic stem cell-specific 5-hydr... Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein, ES cell-specific 5hmC-binding protein, EC 3.4.-.- (Putative peptidase SRAPD1) (SRAP domain-containing protein 1)	HMCES	233	Annotation score:
D6RGK7	D6RGK7_HUMAN	Embryonic stem cell-specific 5-hydr... Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein, ES cell-specific 5hmC-binding protein, EC 3.4.-.- (Putative peptidase SRAPD1) (SRAP domain-containing protein 1)	HMCES	183	Annotation score:
D6RAI0	D6RAI0_HUMAN	Embryonic stem cell-specific 5-hydr... Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein, ES cell-specific 5hmC-binding protein, EC 3.4.-.- (Putative peptidase SRAPD1) (SRAP domain-containing protein 1)	HMCES	140	Annotation score:
D6R9T3	D6R9T3_HUMAN	Embryonic stem cell-specific 5-hydr... Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein, ES cell-specific 5hmC-binding protein, EC 3.4.-.- (Putative peptidase SRAPD1) (SRAP domain-containing protein 1)	HMCES	282	Annotation score:

Sequence cautionⁱ

The sequence AAF86870 differs from that shown. Reason: Frameshift at positions 285, 326 and 344.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	60	E → D in AAH09993 (PubMed:15489334).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF201934 mRNA Translation: AAF86870.1 Frameshift. AC137695 Genomic DNA No translation available. CH471052 Genomic DNA Translation: EAW79266.1 BC009993 mRNA Translation: AAH09993.1 BC010125 mRNA Translation: AAH10125.1 BC050686 mRNA Translation: AAH50686.1 BC088363 mRNA Translation: AAH88363.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS33852.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001006109.1, NM_001006109.1 NP_064572.2, NM_020187.2 XP_005247693.1, XM_005247636.3 XP_016862366.1, XM_017006877.1
UniGeneⁱ	Hs.458320

Genome annotation databases

Ensemblⁱ	ENST00000383463; ENSP00000372955; ENSG00000183624 ENST00000389735; ENSP00000374385; ENSG00000183624 ENST00000502878; ENSP00000426215; ENSG00000183624
GeneIDⁱ	56941
KEGGⁱ	hsa:56941
UCSC genome browser More...UCSCⁱ	uc003elt.4 human

Protein	Similar proteins		Species	Score	Length	Source
Q96FZ2	Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein (Fragment)		HUMAN		233	UniRef90_Q96FZ2
embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein isoform X1		Florida manatee		366
Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein		PANTR		354
Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein		PANPA		354
Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein		LOXAF		350
+6

Protein	Similar proteins		Species	Score	Length	Source
Q96FZ2	Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein (Fragment)		HUMAN		233	UniRef50_Q96FZ2
embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein isoform X1		Florida manatee		366
Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein		PANTR		354
Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein		PANPA		354
Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein		LOXAF		350
+34

Entry informationⁱ

Entry nameⁱ	HMCES_HUMAN
Accessionⁱ	Q96FZ2Primary (citable) accession number: Q96FZ2 Secondary accession number(s): A6NJR9, Q96G34, Q9NRP3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 24, 2006
	Last sequence update:	December 1, 2001
	Last modified:	September 12, 2018
	This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

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Annotation systems

Supporting data

UniProtKB - Q96FZ2 (HMCES_HUMAN)

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Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein

HMCES

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Computationally mapped potential isoform sequencesi

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Computationally mapped potential isoform sequencesⁱ

Sequence cautionⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ