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UniProtKB - Q96FX2 (DPH3_HUMAN)

Protein

DPH3 homolog

Gene

DPH3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Essential for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in elongation factor 2 (EEF2) and which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta).By similarity
Down-regulation increases extracellular release of proteoglycans, indicating a possible role in the secretion process. Stimulates binding of GNEFR to SEC5.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: peptidyl-diphthamide biosynthesis

This protein is involved in the pathway peptidyl-diphthamide biosynthesis, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway peptidyl-diphthamide biosynthesis and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri4 – 60DPH-typePROSITE-ProRule annotationAdd BLAST57

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-5358493 Synthesis of diphthamide-EEF2

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi
UPA00559

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DPH3 homolog
Alternative name(s):
CSL-type zinc finger-containing protein 2
DelGEF-interacting protein 1
Short name:
DelGIP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DPH3
Synonyms:DESR1, ZCSL2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000154813.9

Human Gene Nomenclature Database

More...HGNCi		HGNC:27717 DPH3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		608959 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q96FX2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		285381

Open Targets

More...OpenTargetsi		ENSG00000154813

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162384061

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		DPH3

Domain mapping of disease mutations (DMDM)

More...DMDMi		29611922

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000826201 – 82DPH3 homologAdd BLAST82

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q96FX2

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q96FX2

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q96FX2

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q96FX2

PeptideAtlas

More...PeptideAtlasi		Q96FX2

PRoteomics IDEntifications database

More...PRIDEi		Q96FX2

ProteomicsDB human proteome resource

More...ProteomicsDBi		76568
76569 [Q96FX2-2]

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q96FX2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed with highest levels in small intestine, spleen, thymus, heart, liver and lung.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000154813 Expressed in 202 organ(s), highest expression level in quadriceps femoris

CleanEx database of gene expression profiles

More...CleanExi		HS_DPH3

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q96FX2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q96FX2 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA035287

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		130097, 8 interactors

Protein interaction database and analysis system

More...IntActi		Q96FX2, 6 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000419599

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

182
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JR7NMR-A1-81[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		Q96FX2

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q96FX2

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q96FX2

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DPH3 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri4 – 60DPH-typePROSITE-ProRule annotationAdd BLAST57

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2923 Eukaryota
COG5216 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00390000007225

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000190740

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG056007

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q96FX2

KEGG Orthology (KO)

More...KOi		K15455

Identification of Orthologs from Complete Genome Data

More...OMAi		YSYPCPC

Database of Orthologous Groups

More...OrthoDBi		1634836at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q96FX2

TreeFam database of animal gene trees

More...TreeFami		TF315102

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.10.660.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR007872 Znf_DHP
IPR036671 Znf_DHP_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF05207 zf-CSL, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF144217 SSF144217, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51074 ZF_DPH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q96FX2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAVFHDEVEI EDFQYDEDSE TYFYPCPCGD NFSITKEDLE NGEDVATCPS 
        60         70         80 
CSLIIKVIYD KDQFVCGETV PAPSANKELV KC
Length:82
Mass (Da):9,240
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7AC8F3FFF8CE766C
GO
Isoform 2 (identifier: Q96FX2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     36-60: Missing.

Note: No experimental confirmation available.
Show »
Length:57
Mass (Da):6,503
Checksum:iB26EFCD8DA36D558
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_01241136 – 60Missing in isoform 2. 1 PublicationAdd BLAST25

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK022970 mRNA No translation available.
BC010181 mRNA Translation: AAH10181.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS2629.1 [Q96FX2-1]
CCDS43058.1 [Q96FX2-2]

NCBI Reference Sequences

More...RefSeqi		NP_001040899.1, NM_001047434.2 [Q96FX2-2]
NP_996662.1, NM_206831.2 [Q96FX2-1]

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.388087

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000383775; ENSP00000373285; ENSG00000154813 [Q96FX2-2]
ENST00000488423; ENSP00000419599; ENSG00000154813 [Q96FX2-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		285381

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:285381

UCSC genome browser

More...UCSCi		uc003cau.4 human [Q96FX2-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022970 mRNA No translation available.
BC010181 mRNA Translation: AAH10181.1
CCDSiCCDS2629.1 [Q96FX2-1]
CCDS43058.1 [Q96FX2-2]
RefSeqiNP_001040899.1, NM_001047434.2 [Q96FX2-2]
NP_996662.1, NM_206831.2 [Q96FX2-1]
UniGeneiHs.388087

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JR7NMR-A1-81[»]
ProteinModelPortaliQ96FX2
SMRiQ96FX2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130097, 8 interactors
IntActiQ96FX2, 6 interactors
STRINGi9606.ENSP00000419599

PTM databases

PhosphoSitePlusiQ96FX2

Polymorphism and mutation databases

BioMutaiDPH3
DMDMi29611922

Proteomic databases

EPDiQ96FX2
jPOSTiQ96FX2
MaxQBiQ96FX2
PaxDbiQ96FX2
PeptideAtlasiQ96FX2
PRIDEiQ96FX2
ProteomicsDBi76568
76569 [Q96FX2-2]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		285381
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000383775; ENSP00000373285; ENSG00000154813 [Q96FX2-2]
ENST00000488423; ENSP00000419599; ENSG00000154813 [Q96FX2-1]
GeneIDi285381
KEGGihsa:285381
UCSCiuc003cau.4 human [Q96FX2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		285381
DisGeNETi285381
EuPathDBiHostDB:ENSG00000154813.9

GeneCards: human genes, protein and diseases

More...GeneCardsi		DPH3
HGNCiHGNC:27717 DPH3
HPAiHPA035287
MIMi608959 gene
neXtProtiNX_Q96FX2
OpenTargetsiENSG00000154813
PharmGKBiPA162384061

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2923 Eukaryota
COG5216 LUCA
GeneTreeiENSGT00390000007225
HOGENOMiHOG000190740
HOVERGENiHBG056007
InParanoidiQ96FX2
KOiK15455
OMAiYSYPCPC
OrthoDBi1634836at2759
PhylomeDBiQ96FX2
TreeFamiTF315102

Enzyme and pathway databases

UniPathwayi
UPA00559

ReactomeiR-HSA-5358493 Synthesis of diphthamide-EEF2

Miscellaneous databases

EvolutionaryTraceiQ96FX2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		285381

Protein Ontology

More...PROi		PR:Q96FX2

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000154813 Expressed in 202 organ(s), highest expression level in quadriceps femoris
CleanExiHS_DPH3
ExpressionAtlasiQ96FX2 baseline and differential
GenevisibleiQ96FX2 HS

Family and domain databases

Gene3Di3.10.660.10, 1 hit
InterProiView protein in InterPro
IPR007872 Znf_DHP
IPR036671 Znf_DHP_sf
PfamiView protein in Pfam
PF05207 zf-CSL, 1 hit
SUPFAMiSSF144217 SSF144217, 1 hit
PROSITEiView protein in PROSITE
PS51074 ZF_DPH, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDPH3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96FX2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2003
Last sequence update: December 1, 2001
Last modified: January 16, 2019
This is version 133 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. UniProtKB entry view manual
    User manual for the UniProtKB entry view
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
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