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Protein

Leucine-rich repeat-containing protein 46

Gene

LRRC46

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 46
Gene namesi
Name:LRRC46
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000141294.9
HGNCiHGNC:25047 LRRC46
neXtProtiNX_Q96FV0

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000141294
PharmGKBiPA142671506

Polymorphism and mutation databases

BioMutaiLRRC46
DMDMi74760826

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002239191 – 321Leucine-rich repeat-containing protein 46Add BLAST321

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei175PhosphoserineBy similarity1
Modified residuei182PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ96FV0
PeptideAtlasiQ96FV0
PRIDEiQ96FV0
ProteomicsDBi76558

PTM databases

iPTMnetiQ96FV0
PhosphoSitePlusiQ96FV0

Expressioni

Gene expression databases

BgeeiENSG00000141294
CleanExiHS_LRRC46
ExpressionAtlasiQ96FV0 baseline and differential
GenevisibleiQ96FV0 HS

Organism-specific databases

HPAiHPA021882
HPA074893

Interactioni

Protein-protein interaction databases

BioGridi124725, 21 interactors
IntActiQ96FV0, 1 interactor
STRINGi9606.ENSP00000269025

Structurei

3D structure databases

ProteinModelPortaliQ96FV0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati45 – 66LRR 1Add BLAST22
Repeati67 – 88LRR 2Add BLAST22
Repeati89 – 110LRR 3Add BLAST22
Repeati111 – 132LRR 4Add BLAST22
Domaini142 – 184LRRCTAdd BLAST43

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili201 – 221Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coil, Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG0531 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00860000133819
HOGENOMiHOG000231068
HOVERGENiHBG080094
InParanoidiQ96FV0
OMAiELSGPFC
OrthoDBiEOG091G0ZR0
PhylomeDBiQ96FV0
TreeFamiTF324815

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
SMARTiView protein in SMART
SM00369 LRR_TYP, 2 hits
PROSITEiView protein in PROSITE
PS51450 LRR, 5 hits

Sequencei

Sequence statusi: Complete.

Q96FV0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGGKSAQGP EEGGVCITEA LITKRNLTFP EDGELSEKMF HTLDELQTVR
60 70 80 90 100
LDREGITTIR NLEGLQNLHS LYLQGNKIQQ IENLACIPSL RFLSLAGNQI
110 120 130 140 150
RQVENLLDLP CLQFLDLSEN LIETLKLDEF PQSLLILNLS GNSCTNQDGY
160 170 180 190 200
RELVTEALPL LLDLDGQPVV ERWISDEEDE ASSDEEFPEL SGPFCSERGF
210 220 230 240 250
LKELEQELSR HREHRQQTAL TEHLLRMEMQ PTLTDLPLLP GVPMAGDSSP
260 270 280 290 300
SATPAQGEET VPEAVSSPQA SSPTKKPCSL IPRGHQSSFW GRKGARAATA
310 320
PKASVAEAPS TTKTTAKRSK K
Length:321
Mass (Da):35,340
Last modified:December 1, 2001 - v1
Checksum:i04788DD11D410BB5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK292765 mRNA Translation: BAF85454.1
AK315665 mRNA Translation: BAG38031.1
CH471109 Genomic DNA Translation: EAW94793.1
BC010412 mRNA Translation: AAH10412.1
CCDSiCCDS11518.1
RefSeqiNP_219481.1, NM_033413.3
UniGeneiHs.130767

Genome annotation databases

EnsembliENST00000269025; ENSP00000269025; ENSG00000141294
GeneIDi90506
KEGGihsa:90506
UCSCiuc002ima.3 human

Similar proteinsi

Entry informationi

Entry nameiLRC46_HUMAN
AccessioniPrimary (citable) accession number: Q96FV0
Secondary accession number(s): A8K9Q0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: December 1, 2001
Last modified: June 20, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM

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