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UniProtKB - Q96FT7 (ASIC4_HUMAN)

Entry version 149 (02 Jun 2021)
Sequence version 2 (18 May 2010)
Previous versions | rss
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Protein

Acid-sensing ion channel 4

Gene

ASIC4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable cation channel with high affinity for sodium. In vitro, has no proton-gated channel activity.

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel, Sodium channel
Biological processIon transport, Sodium transport, Transport
LigandSodium

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q96FT7

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-2672351, Stimuli-sensing channels

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Acid-sensing ion channel 4
Short name:
ASIC4
Alternative name(s):
Amiloride-sensitive cation channel 4
Amiloride-sensitive cation channel 4, pituitary
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ASIC4
Synonyms:ACCN4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:21263, ASIC4

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		606715, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q96FT7

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000072182.12

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini128 – 195CytoplasmicSequence analysisAdd BLAST68
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei196 – 216HelicalSequence analysisAdd BLAST21
Topological domaini217 – 546ExtracellularSequence analysisAdd BLAST330
Transmembranei547 – 567HelicalSequence analysisAdd BLAST21
Topological domaini568 – 647CytoplasmicSequence analysisAdd BLAST80

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi549G → A: No effect on channel function. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		55515

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134956731

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q96FT7, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ASIC4

Domain mapping of disease mutations (DMDM)

More...DMDMi		296434387

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001813041 – 647Acid-sensing ion channel 4Add BLAST647

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi245 ↔ 329By similarity
Disulfide bondi307 ↔ 314By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi318N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi370N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi423 ↔ 483By similarity
Disulfide bondi445 ↔ 479By similarity
Disulfide bondi449 ↔ 477By similarity
Glycosylationi484N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q96FT7

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q96FT7

PeptideAtlas

More...PeptideAtlasi		Q96FT7

PRoteomics IDEntifications database

More...PRIDEi		Q96FT7

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		76552 [Q96FT7-1]
76553 [Q96FT7-2]
76554 [Q96FT7-4]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q96FT7, 3 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q96FT7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q96FT7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in pituitary gland. Weakly expressed in brain, vestibular system and organ of Corti.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000072182, Expressed in pituitary gland and 111 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q96FT7, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000072182, Tissue enhanced (brain, pituitary gland)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotrimer or heterotrimer with other ASIC proteins.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		120693, 46 interactors

Protein interaction database and analysis system

More...IntActi		Q96FT7, 74 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000326627

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q96FT7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q96FT7

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni25 – 82DisorderedSequence analysisAdd BLAST58
Regioni609 – 639DisorderedSequence analysisAdd BLAST31

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi37 – 57Basic and acidic residuesSequence analysisAdd BLAST21
Compositional biasi59 – 77Polar residuesSequence analysisAdd BLAST19

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC4 subfamily. [View classification]Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4294, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_020415_1_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q96FT7

Identification of Orthologs from Complete Genome Data

More...OMAi		AIIHEYC

Database of Orthologous Groups

More...OrthoDBi		686369at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q96FT7

TreeFam database of animal gene trees

More...TreeFami		TF330663

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001873, ENaC
IPR020903, ENaC_CS

The PANTHER Classification System

More...PANTHERi		PTHR11690, PTHR11690, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00858, ASC, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01078, AMINACHANNEL

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01206, ASC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q96FT7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLSGAAGAAR RGGAALAPSL TRSLAGTHAG ADSCAGADKG SHKETIEERD 
        60         70         80         90        100
KRQQRQQRQR QHQGCGAAGS GSDSPTSGPH PVPVLFPLAL SLEEQPLPPL 
       110        120        130        140        150
PLGRAPGLLA REGQGREALA SPSSRGQMPI EIVCKIKFAE EDAKPKEKEA 
       160        170        180        190        200
GDEQSLLGAV APGAAPRDLA TFASTSTLHG LGRACGPGPH GLRRTLWALA 
       210        220        230        240        250
LLTSLAAFLY QAAGLARGYL TRPHLVAMDP AAPAPVAGFP AVTLCNINRF 
       260        270        280        290        300
RHSALSDADI FHLANLTGLP PKDRDGHRAA GLRYPEPDMV DILNRTGHQL 
       310        320        330        340        350
ADMLKSCNFS GHHCSASNFS VVYTRYGKCY TFNADPRSSL PSRAGGMGSG 
       360        370        380        390        400
LEIMLDIQQE EYLPIWRETN ETSFEAGIRV QIHSQEEPPY IHQLGFGVSP 
       410        420        430        440        450
GFQTFVSCQE QRLTYLPQPW GNCRAESELR EPELQGYSAY SVSACRLRCE 
       460        470        480        490        500
KEAVLQRCHC RMVHMPDSLG GGPEGPCFCP TPCNLTRYGK EISMVRIPNR 
       510        520        530        540        550
GSARYLARKY NRNETYIREN FLVLDVFFEA LTSEAMEQRA AYGLSALLGD 
       560        570        580        590        600
LGGQMGLFIG ASILTLLEIL DYIYEVSWDR LKRVWRRPKT PLRTSTGGIS 
       610        620        630        640 
TLGLQELKEQ SPCPSRGRVE GGGVSSLLPN HHHPHGPPGG LFEDFAC
Length:647
Mass (Da):70,105
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i041217169E5A15CF
GO
Isoform 2 (identifier: Q96FT7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     413-417: LTYLP → VSISC
     418-647: Missing.

Show »
Length:417
Mass (Da):44,361
Checksum:iF21C8D9D13ED714C
GO
Isoform 3 (identifier: Q96FT7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     466-466: P → PGNETICPPNIYIECADHTL

Show »
Length:666
Mass (Da):72,190
Checksum:iE9740F1E300D40BA
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAB93980 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence CAC51338 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_052038614P → Q. Corresponds to variant dbSNP:rs6436153Ensembl.1
Natural variantiVAR_052039616R → L3 PublicationsCorresponds to variant dbSNP:rs11689281Ensembl.1
Natural variantiVAR_059806619V → A3 PublicationsCorresponds to variant dbSNP:rs11695248Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_015609413 – 417LTYLP → VSISC in isoform 2. 1 Publication5
Alternative sequenceiVSP_015610418 – 647Missing in isoform 2. 1 PublicationAdd BLAST230
Alternative sequenceiVSP_015611466P → PGNETICPPNIYIECADHTL in isoform 3. Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AJ271643 Genomic DNA Translation: CAB93980.1 Different initiation.
AC009955 Genomic DNA No translation available.
AC053503 Genomic DNA Translation: AAY15054.1
AC139723 Genomic DNA No translation available.
BC010439 mRNA Translation: AAH10439.1
BC031812 mRNA Translation: AAH31812.1
AJ408881 AJ408884 Genomic DNA Translation: CAC51338.1 Different initiation.

NCBI Reference Sequences

More...RefSeqi		NP_061144.3, NM_018674.5
NP_878267.2, NM_182847.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000347842; ENSP00000326627; ENSG00000072182
ENST00000358078; ENSP00000350786; ENSG00000072182

Database of genes from NCBI RefSeq genomes

More...GeneIDi		55515

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:55515

UCSC genome browser

More...UCSCi		uc002vma.4, human [Q96FT7-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ271643 Genomic DNA Translation: CAB93980.1 Different initiation.
AC009955 Genomic DNA No translation available.
AC053503 Genomic DNA Translation: AAY15054.1
AC139723 Genomic DNA No translation available.
BC010439 mRNA Translation: AAH10439.1
BC031812 mRNA Translation: AAH31812.1
AJ408881 AJ408884 Genomic DNA Translation: CAC51338.1 Different initiation.
RefSeqiNP_061144.3, NM_018674.5
NP_878267.2, NM_182847.2

3D structure databases

SMRiQ96FT7
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi120693, 46 interactors
IntActiQ96FT7, 74 interactors
STRINGi9606.ENSP00000326627

PTM databases

GlyGeniQ96FT7, 3 sites
iPTMnetiQ96FT7
PhosphoSitePlusiQ96FT7

Genetic variation databases

BioMutaiASIC4
DMDMi296434387

Proteomic databases

MassIVEiQ96FT7
PaxDbiQ96FT7
PeptideAtlasiQ96FT7
PRIDEiQ96FT7
ProteomicsDBi76552 [Q96FT7-1]
76553 [Q96FT7-2]
76554 [Q96FT7-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		20142, 136 antibodies

The DNASU plasmid repository

More...DNASUi		55515

Genome annotation databases

EnsembliENST00000347842; ENSP00000326627; ENSG00000072182
ENST00000358078; ENSP00000350786; ENSG00000072182
GeneIDi55515
KEGGihsa:55515
UCSCiuc002vma.4, human [Q96FT7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		55515
DisGeNETi55515

GeneCards: human genes, protein and diseases

More...GeneCardsi		ASIC4
HGNCiHGNC:21263, ASIC4
HPAiENSG00000072182, Tissue enhanced (brain, pituitary gland)
MIMi606715, gene
neXtProtiNX_Q96FT7
PharmGKBiPA134956731
VEuPathDBiHostDB:ENSG00000072182.12

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4294, Eukaryota
HOGENOMiCLU_020415_1_2_1
InParanoidiQ96FT7
OMAiAIIHEYC
OrthoDBi686369at2759
PhylomeDBiQ96FT7
TreeFamiTF330663

Enzyme and pathway databases

PathwayCommonsiQ96FT7
ReactomeiR-HSA-2672351, Stimuli-sensing channels

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		55515, 3 hits in 988 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ASIC4, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		ACCN4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		55515
PharosiQ96FT7, Tbio

Protein Ontology

More...PROi		PR:Q96FT7
RNActiQ96FT7, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000072182, Expressed in pituitary gland and 111 other tissues
GenevisibleiQ96FT7, HS

Family and domain databases

InterProiView protein in InterPro
IPR001873, ENaC
IPR020903, ENaC_CS
PANTHERiPTHR11690, PTHR11690, 1 hit
PfamiView protein in Pfam
PF00858, ASC, 1 hit
PRINTSiPR01078, AMINACHANNEL
PROSITEiView protein in PROSITE
PS01206, ASC, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiASIC4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96FT7
Secondary accession number(s): Q53SB7
, Q6GMS1, Q6PIN9, Q9NQA4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: May 18, 2010
Last modified: June 2, 2021
This is version 149 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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