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Entry version 177 (02 Jun 2021)
Sequence version 1 (01 Dec 2001)
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Protein

Signal-induced proliferation-associated protein 1

Gene

SIPA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting them to the putatively inactive GDP-bound state (PubMed:9346962).

Affects cell cycle progression (By similarity).

By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q96FS4

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-392517, Rap1 signalling

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Signal-induced proliferation-associated protein 1
Short name:
Sipa-1
Alternative name(s):
GTPase-activating protein Spa-1
p130 SPA-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SIPA1
Synonyms:SPA1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10885, SIPA1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602180, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96FS4

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000213445.8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
6494

Open Targets

More...
OpenTargetsi
ENSG00000213445

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA35785

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96FS4, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SIPA1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
20455286

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000567441 – 1042Signal-induced proliferation-associated protein 1Add BLAST1042

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei64PhosphothreonineCombined sources1
Modified residuei67PhosphoserineCombined sources1
Modified residuei182PhosphoserineCombined sources1
Modified residuei304PhosphoserineCombined sources1
Modified residuei314PhosphoserineCombined sources1
Modified residuei817PhosphoserineCombined sources1
Modified residuei839PhosphoserineCombined sources1
Modified residuei912PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96FS4

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96FS4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q96FS4

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96FS4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96FS4

PeptideAtlas

More...
PeptideAtlasi
Q96FS4

PRoteomics IDEntifications database

More...
PRIDEi
Q96FS4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
76551

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96FS4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96FS4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in fetal as well as in adult tissues. Expressed abundantly in the lymphoid tissues such as thymus, spleen and peripheral blood lymphocytes and also shows a significant expression in the spinal cord.

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Repressed by 12-O-tetradecanoylphorbol-13-acetate (TPA) in promyelocytic HL-60 cells.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000213445, Expressed in spleen and 164 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96FS4, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96FS4, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000213445, Tissue enhanced (lymphoid)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RRP1B; the interaction leads to inhibition of SIPA1 GTPase activity.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
112385, 24 interactors

Protein interaction database and analysis system

More...
IntActi
Q96FS4, 25 interactors

Molecular INTeraction database

More...
MINTi
Q96FS4

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000377771

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q96FS4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96FS4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini321 – 539Rap-GAPPROSITE-ProRule annotationAdd BLAST219
Domaini687 – 763PDZPROSITE-ProRule annotationAdd BLAST77

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 87DisorderedSequence analysisAdd BLAST87
Regioni132 – 153DisorderedSequence analysisAdd BLAST22
Regioni830 – 903DisorderedSequence analysisAdd BLAST74
Regioni946 – 980DisorderedSequence analysisAdd BLAST35

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili972 – 1034Sequence analysisAdd BLAST63

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi135 – 152Polar residuesSequence analysisAdd BLAST18
Compositional biasi831 – 886Polar residuesSequence analysisAdd BLAST56
Compositional biasi961 – 980Basic and acidic residuesSequence analysisAdd BLAST20

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3686, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160644

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96FS4

Identification of Orthologs from Complete Genome Data

More...
OMAi
PGFLMNE

Database of Orthologous Groups

More...
OrthoDBi
28453at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96FS4

TreeFam database of animal gene trees

More...
TreeFami
TF318626

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.42.10, 1 hit
3.40.50.11210, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001478, PDZ
IPR036034, PDZ_sf
IPR035974, Rap/Ran-GAP_sf
IPR000331, Rap_GAP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00595, PDZ, 1 hit
PF02145, Rap_GAP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00228, PDZ, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF111347, SSF111347, 1 hit
SSF50156, SSF50156, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50106, PDZ, 1 hit
PS50085, RAPGAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q96FS4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPMWAGGVGS PRRGMAPAST DDLFARKLRQ PARPPLTPHT FEPRPVRGPL
60 70 80 90 100
LRSGSDAGEA RPPTPASPRA RAHSHEEASR PAATSTRLFT DPLALLGLPA
110 120 130 140 150
EEPEPAFPPV LEPRWFAHYD VQSLLFDWAP RSQGMGSHSE ASSGTLASAE
160 170 180 190 200
DQAASSDLLH GAPGFVCELG GEGELGLGGP ASPPVPPALP NAAVSILEEP
210 220 230 240 250
QNRTSAYSLE HADLGAGYYR KYFYGKEHQN FFGMDESLGP VAVSLRREEK
260 270 280 290 300
EGSGGGTLHS YRVIVRTTQL RTLRGTISED ALPPGPPRGL SPRKLLEHVA
310 320 330 340 350
PQLSPSCLRL GSASPKVPRT LLTLDEQVLS FQRKVGILYC RAGQGSEEEM
360 370 380 390 400
YNNQEAGPAF MQFLTLLGDV VRLKGFESYR AQLDTKTDST GTHSLYTTYQ
410 420 430 440 450
DHEIMFHVST MLPYTPNNQQ QLLRKRHIGN DIVTIVFQEP GSKPFCPTTI
460 470 480 490 500
RSHFQHVFLV VRAHTPCTPH TTYRVAVSRT QDTPAFGPAL PAGGGPFAAN
510 520 530 540 550
ADFRAFLLAK ALNGEQAAGH ARQFHAMATR TRQQYLQDLA TNEVTTTSLD
560 570 580 590 600
SASRFGLPSL GGRRRAAPRG PGAELQAAGS LVWGVRAAPG ARVAAGAQAS
610 620 630 640 650
GPEGIEVPCL LGISAEALVL VAPRDGRVVF NCACRDVLAW TFSEQQLDLY
660 670 680 690 700
HGRGEAITLR FDGSPGQAVG EVVARLQLVS RGCETRELAL PRDGQGRLGF
710 720 730 740 750
EVDAEGFVTH VERFTFAETA GLRPGARLLR VCGQTLPSLR PEAAAQLLRS
760 770 780 790 800
APKVCVTVLP PDESGRPRRS FSELYTLSLQ EPSRRGAPDP VQDEVQGVTL
810 820 830 840 850
LPTTKQLLHL CLQDGGSPPG PGDLAEERTE FLHSQNSLSP RSSLSDEAPV
860 870 880 890 900
LPNTTPDLLL ATTAKPSVPS ADSETPLTQD RPGSPSGSED KGNPAPELRA
910 920 930 940 950
SFLPRTLSLR NSISRIMSEA GSGTLEDEWQ AISEIASTCN TILESLSREG
960 970 980 990 1000
QPIPESGDPK GTPKSDAEPE PGNLSEKVSH LESMLRKLQE DLQKEKADRA
1010 1020 1030 1040
ALEEEVRSLR HNNRRLQAES ESAATRLLLA SKQLGSPTAD LA
Length:1,042
Mass (Da):112,149
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFB52C7231EA3B6B9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6RY50F6RY50_HUMAN
Signal-induced proliferation-associ...
SIPA1
940Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PIB3E9PIB3_HUMAN
Signal-induced proliferation-associ...
SIPA1
102Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti30Q → H in AAC32559 (PubMed:9651531).Curated1
Sequence conflicti30Q → H in AAC32547 (PubMed:9651531).Curated1
Sequence conflicti53 – 56SGSD → RAAN in AAC32559 (PubMed:9651531).Curated4
Sequence conflicti53 – 56SGSD → RAAN in AAC32547 (PubMed:9651531).Curated4
Sequence conflicti93L → Q in AAC32559 (PubMed:9651531).Curated1
Sequence conflicti93L → Q in AAC32547 (PubMed:9651531).Curated1
Sequence conflicti468T → R in AAC32559 (PubMed:9651531).Curated1
Sequence conflicti658T → P in AAC32547 (PubMed:9651531).Curated1
Sequence conflicti721 – 724GLRP → AAA in AAC32559 (PubMed:9651531).Curated4
Sequence conflicti721 – 724GLRP → AAA in AAC32547 (PubMed:9651531).Curated4
Sequence conflicti781 – 782EP → DA in AAC32559 (PubMed:9651531).Curated2
Sequence conflicti796Q → H in BAA22197 (PubMed:9346962).Curated1
Sequence conflicti888S → C in BAA22197 (PubMed:9346962).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04914880R → Q. Corresponds to variant dbSNP:rs35045265Ensembl.1
Natural variantiVAR_049149106A → S. Corresponds to variant dbSNP:rs3741379EnsemblClinVar.1
Natural variantiVAR_049150174E → D. Corresponds to variant dbSNP:rs34912782Ensembl.1
Natural variantiVAR_049151182S → F1 PublicationCorresponds to variant dbSNP:rs3741378Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB005666 mRNA Translation: BAA22197.1
AF052238 AF052237 Genomic DNA Translation: AAC32559.1
AF029789 mRNA Translation: AAC32547.1
BC010492 mRNA Translation: AAH10492.1
BC110353 mRNA Translation: AAI10354.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS8108.1

NCBI Reference Sequences

More...
RefSeqi
NP_006738.3, NM_006747.3
NP_694985.29, NM_153253.29
XP_005274246.1, XM_005274189.2
XP_011543516.1, XM_011545214.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000394224; ENSP00000377771; ENSG00000213445
ENST00000534313; ENSP00000436269; ENSG00000213445

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
6494

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:6494

UCSC genome browser

More...
UCSCi
uc001ofb.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB005666 mRNA Translation: BAA22197.1
AF052238 AF052237 Genomic DNA Translation: AAC32559.1
AF029789 mRNA Translation: AAC32547.1
BC010492 mRNA Translation: AAH10492.1
BC110353 mRNA Translation: AAI10354.1
CCDSiCCDS8108.1
RefSeqiNP_006738.3, NM_006747.3
NP_694985.29, NM_153253.29
XP_005274246.1, XM_005274189.2
XP_011543516.1, XM_011545214.1

3D structure databases

SMRiQ96FS4
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi112385, 24 interactors
IntActiQ96FS4, 25 interactors
MINTiQ96FS4
STRINGi9606.ENSP00000377771

PTM databases

iPTMnetiQ96FS4
PhosphoSitePlusiQ96FS4

Genetic variation databases

BioMutaiSIPA1
DMDMi20455286

Proteomic databases

EPDiQ96FS4
jPOSTiQ96FS4
MassIVEiQ96FS4
MaxQBiQ96FS4
PaxDbiQ96FS4
PeptideAtlasiQ96FS4
PRIDEiQ96FS4
ProteomicsDBi76551

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
29889, 311 antibodies

The DNASU plasmid repository

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DNASUi
6494

Genome annotation databases

EnsembliENST00000394224; ENSP00000377771; ENSG00000213445
ENST00000534313; ENSP00000436269; ENSG00000213445
GeneIDi6494
KEGGihsa:6494
UCSCiuc001ofb.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6494
DisGeNETi6494

GeneCards: human genes, protein and diseases

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GeneCardsi
SIPA1
HGNCiHGNC:10885, SIPA1
HPAiENSG00000213445, Tissue enhanced (lymphoid)
MIMi602180, gene
neXtProtiNX_Q96FS4
OpenTargetsiENSG00000213445
PharmGKBiPA35785
VEuPathDBiHostDB:ENSG00000213445.8

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3686, Eukaryota
GeneTreeiENSGT00940000160644
InParanoidiQ96FS4
OMAiPGFLMNE
OrthoDBi28453at2759
PhylomeDBiQ96FS4
TreeFamiTF318626

Enzyme and pathway databases

PathwayCommonsiQ96FS4
ReactomeiR-HSA-392517, Rap1 signalling

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
6494, 37 hits in 1000 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SIPA1, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SIPA1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
6494
PharosiQ96FS4, Tbio

Protein Ontology

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PROi
PR:Q96FS4
RNActiQ96FS4, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000213445, Expressed in spleen and 164 other tissues
ExpressionAtlasiQ96FS4, baseline and differential
GenevisibleiQ96FS4, HS

Family and domain databases

Gene3Di2.30.42.10, 1 hit
3.40.50.11210, 1 hit
InterProiView protein in InterPro
IPR001478, PDZ
IPR036034, PDZ_sf
IPR035974, Rap/Ran-GAP_sf
IPR000331, Rap_GAP_dom
PfamiView protein in Pfam
PF00595, PDZ, 1 hit
PF02145, Rap_GAP, 1 hit
SMARTiView protein in SMART
SM00228, PDZ, 1 hit
SUPFAMiSSF111347, SSF111347, 1 hit
SSF50156, SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50106, PDZ, 1 hit
PS50085, RAPGAP, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSIPA1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96FS4
Secondary accession number(s): O14518
, O60484, O60618, Q2YD83
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: December 1, 2001
Last modified: June 2, 2021
This is version 177 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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