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Protein

Signal-induced proliferation-associated protein 1

Gene

SIPA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting them to the putatively inactive GDP-bound state (PubMed:9346962). Affects cell cycle progression (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

  • cell proliferation Source: ProtInc
  • cellular response to water deprivation Source: Ensembl
  • cytoskeleton organization Source: UniProtKB
  • intracellular signal transduction Source: UniProtKB
  • negative regulation of cell adhesion Source: UniProtKB
  • negative regulation of cell cycle Source: UniProtKB
  • negative regulation of cell growth Source: UniProtKB
  • regulation of small GTPase mediated signal transduction Source: InterPro
  • signal transduction Source: ProtInc

Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

ReactomeiR-HSA-392517 Rap1 signalling

Names & Taxonomyi

Protein namesi
Recommended name:
Signal-induced proliferation-associated protein 1
Short name:
Sipa-1
Alternative name(s):
GTPase-activating protein Spa-1
p130 SPA-1
Gene namesi
Name:SIPA1
Synonyms:SPA1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000213445.8
HGNCiHGNC:10885 SIPA1
MIMi602180 gene
neXtProtiNX_Q96FS4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi6494
OpenTargetsiENSG00000213445
PharmGKBiPA35785

Polymorphism and mutation databases

BioMutaiSIPA1
DMDMi20455286

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000567441 – 1042Signal-induced proliferation-associated protein 1Add BLAST1042

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei64PhosphothreonineCombined sources1
Modified residuei67PhosphoserineCombined sources1
Modified residuei182PhosphoserineCombined sources1
Modified residuei304PhosphoserineCombined sources1
Modified residuei314PhosphoserineCombined sources1
Modified residuei817PhosphoserineCombined sources1
Modified residuei839PhosphoserineCombined sources1
Modified residuei912PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96FS4
MaxQBiQ96FS4
PaxDbiQ96FS4
PeptideAtlasiQ96FS4
PRIDEiQ96FS4
ProteomicsDBi76551

PTM databases

iPTMnetiQ96FS4
PhosphoSitePlusiQ96FS4

Expressioni

Tissue specificityi

Expressed in fetal as well as in adult tissues. Expressed abundantly in the lymphoid tissues such as thymus, spleen and peripheral blood lymphocytes and also shows a significant expression in the spinal cord.

Inductioni

Repressed by 12-O-tetradecanoylphorbol-13-acetate (TPA) in promyelocytic HL-60 cells.

Gene expression databases

BgeeiENSG00000213445
CleanExiHS_SIPA1
ExpressionAtlasiQ96FS4 baseline and differential
GenevisibleiQ96FS4 HS

Organism-specific databases

HPAiCAB020833
HPA039867

Interactioni

Subunit structurei

Interacts with RRP1B; the interaction leads to inhibition of SIPA1 GTPase activity.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
CDKN1AP389362EBI-1054981,EBI-375077

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112385, 20 interactors
IntActiQ96FS4, 17 interactors
STRINGi9606.ENSP00000377771

Structurei

3D structure databases

ProteinModelPortaliQ96FS4
SMRiQ96FS4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini321 – 539Rap-GAPPROSITE-ProRule annotationAdd BLAST219
Domaini687 – 763PDZPROSITE-ProRule annotationAdd BLAST77

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili972 – 1034Sequence analysisAdd BLAST63

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3686 Eukaryota
ENOG410XTIX LUCA
GeneTreeiENSGT00760000119182
HOGENOMiHOG000154327
HOVERGENiHBG061666
InParanoidiQ96FS4
KOiK08013
OMAiRSAPKVC
OrthoDBiEOG091G016P
PhylomeDBiQ96FS4
TreeFamiTF318626

Family and domain databases

Gene3Di3.40.50.11210, 1 hit
InterProiView protein in InterPro
IPR001478 PDZ
IPR036034 PDZ_sf
IPR035974 Rap/Ran-GAP_sf
IPR000331 Rap_GAP_dom
PfamiView protein in Pfam
PF00595 PDZ, 1 hit
PF02145 Rap_GAP, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 1 hit
SUPFAMiSSF111347 SSF111347, 1 hit
SSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50106 PDZ, 1 hit
PS50085 RAPGAP, 1 hit

Sequencei

Sequence statusi: Complete.

Q96FS4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPMWAGGVGS PRRGMAPAST DDLFARKLRQ PARPPLTPHT FEPRPVRGPL
60 70 80 90 100
LRSGSDAGEA RPPTPASPRA RAHSHEEASR PAATSTRLFT DPLALLGLPA
110 120 130 140 150
EEPEPAFPPV LEPRWFAHYD VQSLLFDWAP RSQGMGSHSE ASSGTLASAE
160 170 180 190 200
DQAASSDLLH GAPGFVCELG GEGELGLGGP ASPPVPPALP NAAVSILEEP
210 220 230 240 250
QNRTSAYSLE HADLGAGYYR KYFYGKEHQN FFGMDESLGP VAVSLRREEK
260 270 280 290 300
EGSGGGTLHS YRVIVRTTQL RTLRGTISED ALPPGPPRGL SPRKLLEHVA
310 320 330 340 350
PQLSPSCLRL GSASPKVPRT LLTLDEQVLS FQRKVGILYC RAGQGSEEEM
360 370 380 390 400
YNNQEAGPAF MQFLTLLGDV VRLKGFESYR AQLDTKTDST GTHSLYTTYQ
410 420 430 440 450
DHEIMFHVST MLPYTPNNQQ QLLRKRHIGN DIVTIVFQEP GSKPFCPTTI
460 470 480 490 500
RSHFQHVFLV VRAHTPCTPH TTYRVAVSRT QDTPAFGPAL PAGGGPFAAN
510 520 530 540 550
ADFRAFLLAK ALNGEQAAGH ARQFHAMATR TRQQYLQDLA TNEVTTTSLD
560 570 580 590 600
SASRFGLPSL GGRRRAAPRG PGAELQAAGS LVWGVRAAPG ARVAAGAQAS
610 620 630 640 650
GPEGIEVPCL LGISAEALVL VAPRDGRVVF NCACRDVLAW TFSEQQLDLY
660 670 680 690 700
HGRGEAITLR FDGSPGQAVG EVVARLQLVS RGCETRELAL PRDGQGRLGF
710 720 730 740 750
EVDAEGFVTH VERFTFAETA GLRPGARLLR VCGQTLPSLR PEAAAQLLRS
760 770 780 790 800
APKVCVTVLP PDESGRPRRS FSELYTLSLQ EPSRRGAPDP VQDEVQGVTL
810 820 830 840 850
LPTTKQLLHL CLQDGGSPPG PGDLAEERTE FLHSQNSLSP RSSLSDEAPV
860 870 880 890 900
LPNTTPDLLL ATTAKPSVPS ADSETPLTQD RPGSPSGSED KGNPAPELRA
910 920 930 940 950
SFLPRTLSLR NSISRIMSEA GSGTLEDEWQ AISEIASTCN TILESLSREG
960 970 980 990 1000
QPIPESGDPK GTPKSDAEPE PGNLSEKVSH LESMLRKLQE DLQKEKADRA
1010 1020 1030 1040
ALEEEVRSLR HNNRRLQAES ESAATRLLLA SKQLGSPTAD LA
Length:1,042
Mass (Da):112,149
Last modified:December 1, 2001 - v1
Checksum:iFB52C7231EA3B6B9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti30Q → H in AAC32559 (PubMed:9651531).Curated1
Sequence conflicti30Q → H in AAC32547 (PubMed:9651531).Curated1
Sequence conflicti53 – 56SGSD → RAAN in AAC32559 (PubMed:9651531).Curated4
Sequence conflicti53 – 56SGSD → RAAN in AAC32547 (PubMed:9651531).Curated4
Sequence conflicti93L → Q in AAC32559 (PubMed:9651531).Curated1
Sequence conflicti93L → Q in AAC32547 (PubMed:9651531).Curated1
Sequence conflicti468T → R in AAC32559 (PubMed:9651531).Curated1
Sequence conflicti658T → P in AAC32547 (PubMed:9651531).Curated1
Sequence conflicti721 – 724GLRP → AAA in AAC32559 (PubMed:9651531).Curated4
Sequence conflicti721 – 724GLRP → AAA in AAC32547 (PubMed:9651531).Curated4
Sequence conflicti781 – 782EP → DA in AAC32559 (PubMed:9651531).Curated2
Sequence conflicti796Q → H in BAA22197 (PubMed:9346962).Curated1
Sequence conflicti888S → C in BAA22197 (PubMed:9346962).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04914880R → Q. Corresponds to variant dbSNP:rs35045265Ensembl.1
Natural variantiVAR_049149106A → S. Corresponds to variant dbSNP:rs3741379Ensembl.1
Natural variantiVAR_049150174E → D. Corresponds to variant dbSNP:rs34912782Ensembl.1
Natural variantiVAR_049151182S → F1 PublicationCorresponds to variant dbSNP:rs3741378Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB005666 mRNA Translation: BAA22197.1
AF052238
, AF052233, AF052234, AF052235, AF052236, AF052237 Genomic DNA Translation: AAC32559.1
AF029789 mRNA Translation: AAC32547.1
BC010492 mRNA Translation: AAH10492.1
BC110353 mRNA Translation: AAI10354.1
CCDSiCCDS8108.1
RefSeqiNP_006738.3, NM_006747.3
NP_694985.29, NM_153253.29
XP_005274246.1, XM_005274189.2
XP_011543516.1, XM_011545214.1
UniGeneiHs.530477

Genome annotation databases

EnsembliENST00000394224; ENSP00000377771; ENSG00000213445
ENST00000534313; ENSP00000436269; ENSG00000213445
GeneIDi6494
KEGGihsa:6494
UCSCiuc001ofb.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSIPA1_HUMAN
AccessioniPrimary (citable) accession number: Q96FS4
Secondary accession number(s): O14518
, O60484, O60618, Q2YD83
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: December 1, 2001
Last modified: June 20, 2018
This is version 159 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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