Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein S100-A16

Gene

S100A16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Calcium-binding protein. Binds one calcium ion per monomer (PubMed:17030513). Can promote differentiation of adipocytes (in vitro) (By similarity). Overexpression in preadipocytes increases their proliferation, enhances adipogenesis and reduces insulin-stimulated glucose uptake (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi67 – 78High affinity1 PublicationPROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

  • calcium ion binding Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
  • RNA binding Source: UniProtKB

GO - Biological processi

Keywordsi

LigandCalcium, Metal-binding, Zinc

Protein family/group databases

TCDBi8.A.81.1.3 the s100 calcium-binding protein (s100) family

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-A16
Alternative name(s):
Aging-associated gene 13 protein
Protein S100-F
S100 calcium-binding protein A16
Gene namesi
Name:S100A16Imported
Synonyms:S100F
ORF Names:AAG13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000188643.10
HGNCiHGNC:20441 S100A16
MIMi617437 gene
neXtProtiNX_Q96FQ6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi140576
OpenTargetsiENSG00000188643
PharmGKBiPA134931606

Polymorphism and mutation databases

BioMutaiS100A16
DMDMi20178113

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001440231 – 103Protein S100-A16Add BLAST103

Proteomic databases

EPDiQ96FQ6
MaxQBiQ96FQ6
PaxDbiQ96FQ6
PeptideAtlasiQ96FQ6
PRIDEiQ96FQ6
ProteomicsDBi76549
TopDownProteomicsiQ96FQ6

2D gel databases

SWISS-2DPAGEiQ96FQ6

PTM databases

iPTMnetiQ96FQ6
PhosphoSitePlusiQ96FQ6
SwissPalmiQ96FQ6

Expressioni

Tissue specificityi

Ubiquitous (PubMed:14684152). Highly expressed in esophagus, adipose tissues and colon. Expressed at lower level in lung, brain, pancreas and skeletal muscle. Expression is up-regulated in tumors of bladder, lung, thyroid gland, pancreas and ovary (PubMed:14684152). Expressed in astrocytes (PubMed:17030513).2 Publications

Gene expression databases

BgeeiENSG00000188643
CleanExiHS_S100A16
GenevisibleiQ96FQ6 HS

Organism-specific databases

HPAiHPA045841

Interactioni

Subunit structurei

Homodimer (PubMed:17030513, PubMed:21046186). Interacts with TP53 (By similarity).By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
S100A14Q9HCY88EBI-751850,EBI-751842

GO - Molecular functioni

  • protein homodimerization activity Source: UniProtKB

Protein-protein interaction databases

BioGridi126627, 40 interactors
IntActiQ96FQ6, 8 interactors
MINTiQ96FQ6
STRINGi9606.ENSP00000357692

Structurei

Secondary structure

1103
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi7 – 21Combined sources15
Turni28 – 30Combined sources3
Helixi35 – 45Combined sources11
Turni47 – 50Combined sources4
Beta strandi51 – 53Combined sources3
Helixi54 – 65Combined sources12
Helixi66 – 68Combined sources3
Helixi76 – 87Combined sources12
Helixi88 – 90Combined sources3
Helixi91 – 100Combined sources10

3D structure databases

ProteinModelPortaliQ96FQ6
SMRiQ96FQ6
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96FQ6

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 47EF-hand 1; degenerate1 PublicationAdd BLAST36
Domaini54 – 89EF-hand 2PROSITE-ProRule annotationAdd BLAST36

Domaini

S100A16 proteins, but not other S100 proteins, have only one functional Ca2+ binding site per monomer. Upon Ca2+ binding, undergoes conformational changes leading to the exposure of hydrophobic patches which could be implicated in the Ca2+ -dependent nuclear export. Binds Zn2+. Ca2+ and Zn2+ do not bind to the same site. Does not bind Cu2+.1 Publication

Sequence similaritiesi

Belongs to the S-100 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IXNY Eukaryota
ENOG41115R5 LUCA
GeneTreeiENSGT00390000000920
HOGENOMiHOG000013071
HOVERGENiHBG001479
InParanoidiQ96FQ6
OMAiMADCYTE
OrthoDBiEOG091G0YU7
PhylomeDBiQ96FQ6
TreeFamiTF332727

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR001751 S100/CaBP-9k_CS
IPR013787 S100_Ca-bd_sub
PfamiView protein in Pfam
PF01023 S_100, 1 hit
SMARTiView protein in SMART
SM01394 S_100, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 1 hit
PS00303 S100_CABP, 1 hit

Sequencei

Sequence statusi: Complete.

Q96FQ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDCYTELEK AVIVLVENFY KYVSKYSLVK NKISKSSFRE MLQKELNHML
60 70 80 90 100
SDTGNRKAAD KLIQNLDANH DGRISFDEYW TLIGGITGPI AKLIHEQEQQ

SSS
Length:103
Mass (Da):11,801
Last modified:December 1, 2001 - v1
Checksum:i7D00C08F85697A6C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ585980 Genomic DNA Translation: CAE51865.1
AY221961 mRNA Translation: AAP46152.1
AY762098 mRNA Translation: AAW88319.1
AK290804 mRNA Translation: BAF83493.1
BX470102 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53303.1
CH471121 Genomic DNA Translation: EAW53304.1
BC010541 mRNA Translation: AAH10541.1
BC019099 mRNA Translation: AAH19099.1
BC095462 mRNA Translation: AAH95462.1
CCDSiCCDS1045.1
RefSeqiNP_001303936.1, NM_001317007.1
NP_001303937.1, NM_001317008.1
NP_525127.1, NM_080388.2
UniGeneiHs.515714

Genome annotation databases

EnsembliENST00000368703; ENSP00000357692; ENSG00000188643
ENST00000368704; ENSP00000357693; ENSG00000188643
ENST00000368705; ENSP00000357694; ENSG00000188643
ENST00000368706; ENSP00000357695; ENSG00000188643
GeneIDi140576
KEGGihsa:140576
UCSCiuc001fcc.5 human

Similar proteinsi

Entry informationi

Entry nameiS10AG_HUMAN
AccessioniPrimary (citable) accession number: Q96FQ6
Secondary accession number(s): A8K439, D3DV52, Q5RHS6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: December 1, 2001
Last modified: June 20, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health