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Protein

Kinesin-like protein KIF12

Gene

KIF12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi104 – 111ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • ATPase activity Source: GO_Central
  • ATP binding Source: UniProtKB-KW
  • microtubule binding Source: GO_Central
  • microtubule motor activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionMotor protein
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-983189 Kinesins

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF12
Gene namesi
Name:KIF12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:21495 KIF12
MIMi611278 gene
neXtProtiNX_Q96FN5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

DisGeNETi113220
OpenTargetsiENSG00000136883
PharmGKBiPA134931618

Polymorphism and mutation databases

DMDMi85541032

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001254441 – 646Kinesin-like protein KIF12Add BLAST646

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei6PhosphoserineCombined sources1
Modified residuei14PhosphoserineCombined sources1
Modified residuei369PhosphoserineBy similarity1
Modified residuei638PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ96FN5
PeptideAtlasiQ96FN5
PRIDEiQ96FN5
ProteomicsDBi76547

PTM databases

iPTMnetiQ96FN5
PhosphoSitePlusiQ96FN5

Expressioni

Tissue specificityi

Expressed in fetal liver, adult brain and pancreatic islet as well as in kidney tumors, uterus cancer and pancreatic cancer.1 Publication

Gene expression databases

CleanExiHS_KIF12
ExpressionAtlasiQ96FN5 baseline and differential

Organism-specific databases

HPAiHPA020192
HPA024127

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi125234, 3 interactors
IntActiQ96FN5, 2 interactors
STRINGi9606.ENSP00000363232

Structurei

3D structure databases

ProteinModelPortaliQ96FN5
SMRiQ96FN5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 360Kinesin motorPROSITE-ProRule annotationAdd BLAST336

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili372 – 467Sequence analysisAdd BLAST96

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi475 – 597Pro-richAdd BLAST123

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4280 Eukaryota
COG5059 LUCA
HOGENOMiHOG000049053
HOVERGENiHBG052248
InParanoidiQ96FN5
KOiK10399
PhylomeDBiQ96FN5

Family and domain databases

Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR028763 Kif12
IPR027640 Kinesin-like_fam
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase
PANTHERiPTHR24115 PTHR24115, 1 hit
PTHR24115:SF418 PTHR24115:SF418, 1 hit
PfamiView protein in Pfam
PF00225 Kinesin, 1 hit
PRINTSiPR00380 KINESINHEAVY
SMARTiView protein in SMART
SM00129 KISc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

Q96FN5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEERGSPDGD LARSLEQGPE GPETPIQVVL RVRPMSAAEL RRGQQSVLHC
60 70 80 90 100
SGTRTLQGGP EVAFRFGAVL DAARTQEDVF RACGVRRLGE LALRGFSCTV
110 120 130 140 150
FTFGQTGSGK TYTLTGPPPQ GEGVPVPPSL AGIMQRTFAW LLDRVQHLGA
160 170 180 190 200
PVTLRASYLE IYNEQVRDLL SLGSPRPLPV RWNKTRGFYV EQLRVVEFGS
210 220 230 240 250
LEALMELLQT GLSRRRNSAH TLNQASSRSH ALLTLYISRQ TAQQMPSVDP
260 270 280 290 300
GEPPVGGKLC FVDLAGSEKV AATGSRGELM LEANSINRSL LALGHCISLL
310 320 330 340 350
LDPQRKQSHI PFRDSKLTKL LADSLGGRGV TLMVACVSPS AQCLPETLST
360 370 380 390 400
LRYASRAQRV TTRPQAPKSP VAKQPQRLET EMLQLQEENR RLQFQLDQMD
410 420 430 440 450
CKASGLSGAR VAWAQRNLYG MLQEFMLENE RLRKEKSQLQ NSRDLAQNEQ
460 470 480 490 500
RILAQQVHAL ERRLLSACYH HQQGPGLTPP CPCLMAPAPP CHALPPLYSC
510 520 530 540 550
PCCHICPLCR VPLAHWACLP GEHHLPQVLD PEASGGRPPS ARPPPWAPPC
560 570 580 590 600
SPGSAKCPRE RSHSDWTQTR VLAEMLTEEE VVPSAPPLPV RPPKTSPGLR
610 620 630 640
GGAGVPNLAQ RLEALRDQIG SSLRRGRSQP PCSEGARSPG QVLPPH
Length:646
Mass (Da):70,660
Last modified:January 10, 2006 - v3
Checksum:i0DC0A9732D7BB15A
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1ALC3B1ALC3_HUMAN
Kinesin-like protein
KIF12 hCG_32518
513Annotation score:
R4GN27R4GN27_HUMAN
Kinesin-like protein
KIF12
646Annotation score:
A0A1W2PPS5A0A1W2PPS5_HUMAN
Kinesin-like protein
KIF12 hCG_32518
651Annotation score:
A0A1W2PP63A0A1W2PP63_HUMAN
Kinesin-like protein KIF12
KIF12
48Annotation score:
A0A1W2PNV5A0A1W2PNV5_HUMAN
Kinesin-like protein KIF12
KIF12
122Annotation score:
A0A2R8Y6R2A0A2R8Y6R2_HUMAN
Kinesin-like protein KIF12
KIF12
104Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL137850 Genomic DNA No translation available.
BC010626 mRNA Translation: AAH10626.1
RefSeqiNP_612433.1, NM_138424.1
UniGeneiHs.28149

Genome annotation databases

EnsembliENST00000468460; ENSP00000473459; ENSG00000136883
GeneIDi113220
KEGGihsa:113220

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL137850 Genomic DNA No translation available.
BC010626 mRNA Translation: AAH10626.1
RefSeqiNP_612433.1, NM_138424.1
UniGeneiHs.28149

3D structure databases

ProteinModelPortaliQ96FN5
SMRiQ96FN5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125234, 3 interactors
IntActiQ96FN5, 2 interactors
STRINGi9606.ENSP00000363232

PTM databases

iPTMnetiQ96FN5
PhosphoSitePlusiQ96FN5

Polymorphism and mutation databases

DMDMi85541032

Proteomic databases

PaxDbiQ96FN5
PeptideAtlasiQ96FN5
PRIDEiQ96FN5
ProteomicsDBi76547

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000468460; ENSP00000473459; ENSG00000136883
GeneIDi113220
KEGGihsa:113220

Organism-specific databases

CTDi113220
DisGeNETi113220
GeneCardsiKIF12
HGNCiHGNC:21495 KIF12
HPAiHPA020192
HPA024127
MIMi611278 gene
neXtProtiNX_Q96FN5
OpenTargetsiENSG00000136883
PharmGKBiPA134931618
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4280 Eukaryota
COG5059 LUCA
HOGENOMiHOG000049053
HOVERGENiHBG052248
InParanoidiQ96FN5
KOiK10399
PhylomeDBiQ96FN5

Enzyme and pathway databases

ReactomeiR-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-983189 Kinesins

Miscellaneous databases

ChiTaRSiKIF12 human
GenomeRNAii113220
PROiPR:Q96FN5
SOURCEiSearch...

Gene expression databases

CleanExiHS_KIF12
ExpressionAtlasiQ96FN5 baseline and differential

Family and domain databases

Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR028763 Kif12
IPR027640 Kinesin-like_fam
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase
PANTHERiPTHR24115 PTHR24115, 1 hit
PTHR24115:SF418 PTHR24115:SF418, 1 hit
PfamiView protein in Pfam
PF00225 Kinesin, 1 hit
PRINTSiPR00380 KINESINHEAVY
SMARTiView protein in SMART
SM00129 KISc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKIF12_HUMAN
AccessioniPrimary (citable) accession number: Q96FN5
Secondary accession number(s): Q5TBE0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: January 10, 2006
Last modified: November 7, 2018
This is version 134 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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