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Protein

Multidrug and toxin extrusion protein 1

Gene

SLC47A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Solute transporter for tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide (NMN), metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, ganciclovir and also the zwitterionic cephalosporin, cephalexin and cephradin. Seems to also play a role in the uptake of oxaliplatin (a new platinum anticancer agent). Able to transport paraquat (PQ or N,N-dimethyl-4-4'-bipiridinium); a widely used herbicid. Responsible for the secretion of cationic drugs across the brush border membranes.5 Publications

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=0.38 mM for TEA2 Publications
  2. KM=0.10 mM for MPP2 Publications
  3. KM=0.17 mM for cimetidine2 Publications
  4. KM=0.78 mM for metformin2 Publications
  5. KM=2.1 mM for guanidine2 Publications
  6. KM=1.23 mM for procainamide2 Publications
  7. KM=0.07 mM for topotecan2 Publications
  8. KM=0.47 mM for estrone sulfate2 Publications
  9. KM=2.64 mM for acyclovir2 Publications
  10. KM=5.12 mM for ganciclovir2 Publications
  1. Vmax=1.185 nmol/min/mg enzyme toward TEA2 Publications
  2. Vmax=0.735 nmol/min/mg enzyme toward MPP2 Publications
  3. Vmax=0.135 nmol/min/mg enzyme toward cimetidine2 Publications
  4. Vmax=2.23 nmol/min/mg enzyme toward metformin2 Publications
  5. Vmax=0.89 nmol/min/mg enzyme toward guanidine2 Publications
  6. Vmax=3.78 nmol/min/mg enzyme toward procainamide2 Publications
  7. Vmax=0.21 nmol/min/mg enzyme toward topotecan2 Publications
  8. Vmax=0.265 nmol/min/mg enzyme toward estrone sulfate2 Publications
  9. Vmax=0.62 nmol/min/mg enzyme toward acyclovir2 Publications
  10. Vmax=1.08 nmol/min/mg enzyme toward ganciclovir2 Publications

pH dependencei

Optimum pH is 8.5. Active from pH 6 to 8.5.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • drug:proton antiporter activity Source: Reactome
  • drug transmembrane transporter activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-425366 Transport of bile salts and organic acids, metal ions and amine compounds

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.66.1.14 the multidrug/oligosaccharidyl-lipid/polysaccharide (mop) flippase superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Multidrug and toxin extrusion protein 1
Short name:
MATE-1
Short name:
hMATE-1
Alternative name(s):
Solute carrier family 47 member 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC47A1
Synonyms:MATE1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000142494.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25588 SLC47A1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
609832 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96FL8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 37CytoplasmicSequence analysisAdd BLAST37
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei38 – 58HelicalSequence analysisAdd BLAST21
Topological domaini59 – 72ExtracellularSequence analysisAdd BLAST14
Transmembranei73 – 93HelicalSequence analysisAdd BLAST21
Topological domaini94 – 123CytoplasmicSequence analysisAdd BLAST30
Transmembranei124 – 144HelicalSequence analysisAdd BLAST21
Topological domaini145 – 152ExtracellularSequence analysis8
Transmembranei153 – 173HelicalSequence analysisAdd BLAST21
Topological domaini174 – 176CytoplasmicSequence analysis3
Transmembranei177 – 197HelicalSequence analysisAdd BLAST21
Topological domaini198 – 216ExtracellularSequence analysisAdd BLAST19
Transmembranei217 – 237HelicalSequence analysisAdd BLAST21
Topological domaini238 – 256CytoplasmicSequence analysisAdd BLAST19
Transmembranei257 – 276HelicalSequence analysisAdd BLAST20
Topological domaini277 – 295ExtracellularSequence analysisAdd BLAST19
Transmembranei296 – 316HelicalSequence analysisAdd BLAST21
Topological domaini317 – 336CytoplasmicSequence analysisAdd BLAST20
Transmembranei337 – 357HelicalSequence analysisAdd BLAST21
Topological domaini358 – 370ExtracellularSequence analysisAdd BLAST13
Transmembranei371 – 391HelicalSequence analysisAdd BLAST21
Topological domaini392 – 408CytoplasmicSequence analysisAdd BLAST17
Transmembranei409 – 429HelicalSequence analysisAdd BLAST21
Topological domaini430 – 437ExtracellularSequence analysis8
Transmembranei438 – 458HelicalSequence analysisAdd BLAST21
Topological domaini459 – 546CytoplasmicSequence analysisAdd BLAST88
Transmembranei547 – 567HelicalSequence analysisAdd BLAST21
Topological domaini568 – 570ExtracellularSequence analysis3

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi273E → Q: No change in subcellular location and abolition of MATE1-dependent TEA transport activity. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
55244

Open Targets

More...
OpenTargetsi
ENSG00000142494

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162403808

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1743126

Drug and drug target database

More...
DrugBanki
DB00787 Aciclovir
DB01237 Bromodiphenhydramine
DB00567 Cephalexin
DB00501 Cimetidine
DB00331 Metformin
DB00877 Sirolimus

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
1216

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLC47A1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74731723

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003128451 – 570Multidrug and toxin extrusion protein 1Add BLAST570

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96FL8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96FL8

PeptideAtlas

More...
PeptideAtlasi
Q96FL8

PRoteomics IDEntifications database

More...
PRIDEi
Q96FL8

ProteomicsDB human proteome resource

More...
ProteomicsDBi
76538
76539 [Q96FL8-2]
76540 [Q96FL8-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96FL8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96FL8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in adrenal gland, and to a lower extent in liver, skeletal muscle and kidney (especially found in luminal membranes of the urinary tubules, bile caniculi and brush border membranes).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000142494 Expressed in 175 organ(s), highest expression level in adrenal gland

CleanEx database of gene expression profiles

More...
CleanExi
HS_SLC47A1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96FL8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96FL8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA021987

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120535, 42 interactors

Protein interaction database and analysis system

More...
IntActi
Q96FL8, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000270570

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q96FL8

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q96FL8

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1347 Eukaryota
COG0534 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161644

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000060313

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG056043

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96FL8

KEGG Orthology (KO)

More...
KOi
K03327

Identification of Orthologs from Complete Genome Data

More...
OMAi
TTMTGQY

Database of Orthologous Groups

More...
OrthoDBi
EOG091G06X2

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96FL8

TreeFam database of animal gene trees

More...
TreeFami
TF324441

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002528 MATE_fam

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01554 MatE, 2 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00797 matE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96FL8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEAPEEPAPV RGGPEATLEV RGSRCLRLSA FREELRALLV LAGPAFLVQL
60 70 80 90 100
MVFLISFISS VFCGHLGKLE LDAVTLAIAV INVTGVSVGF GLSSACDTLI
110 120 130 140 150
SQTYGSQNLK HVGVILQRSA LVLLLCCFPC WALFLNTQHI LLLFRQDPDV
160 170 180 190 200
SRLTQTYVTI FIPALPATFL YMLQVKYLLN QGIVLPQIVT GVAANLVNAL
210 220 230 240 250
ANYLFLHQLH LGVIGSALAN LISQYTLALL LFLYILGKKL HQATWGGWSL
260 270 280 290 300
ECLQDWASFL RLAIPSMLML CMEWWAYEVG SFLSGILGMV ELGAQSIVYE
310 320 330 340 350
LAIIVYMVPA GFSVAASVRV GNALGAGDME QARKSSTVSL LITVLFAVAF
360 370 380 390 400
SVLLLSCKDH VGYIFTTDRD IINLVAQVVP IYAVSHLFEA LACTSGGVLR
410 420 430 440 450
GSGNQKVGAI VNTIGYYVVG LPIGIALMFA TTLGVMGLWS GIIICTVFQA
460 470 480 490 500
VCFLGFIIQL NWKKACQQAQ VHANLKVNNV PRSGNSALPQ DPLHPGCPEN
510 520 530 540 550
LEGILTNDVG KTGEPQSDQQ MRQEEPLPEH PQDGAKLSRK QLVLRRGLLL
560 570
LGVFLILLVG ILVRFYVRIQ
Length:570
Mass (Da):61,922
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCA940CBC2F6F5CC4
GO
Isoform 2 (identifier: Q96FL8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     286-290: ILGMV → LYEDG
     291-570: Missing.

Note: No experimental confirmation available.
Show »
Length:290
Mass (Da):31,907
Checksum:i662AE04699124D14
GO
Isoform 3 (identifier: Q96FL8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     559-570: VGILVRFYVRIQ → AGVRWCDHSSLQPRTLGLQAILLCQPPE

Note: No experimental confirmation available.
Show »
Length:586
Mass (Da):63,549
Checksum:iA1BF0F64D815E7A8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EX57E7EX57_HUMAN
Multidrug and toxin extrusion prote...
SLC47A1
443Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L345I3L345_HUMAN
Multidrug and toxin extrusion prote...
SLC47A1
268Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KSS8J3KSS8_HUMAN
Multidrug and toxin extrusion prote...
SLC47A1
316Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KRZ3J3KRZ3_HUMAN
Multidrug and toxin extrusion prote...
SLC47A1
99Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH50592 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti50L → R in BAD96345 (Ref. 2) Curated1
Sequence conflicti309P → L in BAA91852 (PubMed:14702039).Curated1
Sequence conflicti448F → L in BAD96345 (Ref. 2) Curated1
Sequence conflicti507N → D in BAD96345 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_037587338V → I. Corresponds to variant dbSNP:rs35790011Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_029903286 – 290ILGMV → LYEDG in isoform 2. 1 Publication5
Alternative sequenceiVSP_029904291 – 570Missing in isoform 2. 1 PublicationAdd BLAST280
Alternative sequenceiVSP_029905559 – 570VGILV…YVRIQ → AGVRWCDHSSLQPRTLGLQA ILLCQPPE in isoform 3. 1 PublicationAdd BLAST12

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK001709 mRNA Translation: BAA91852.1
AK222625 mRNA Translation: BAD96345.1
CH471212 Genomic DNA Translation: EAW50893.1
CH471212 Genomic DNA Translation: EAW50894.1
BC010661 mRNA Translation: AAH10661.1
BC050592 mRNA Translation: AAH50592.1 Different initiation.
BC058882 mRNA Translation: AAH58882.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS11209.1 [Q96FL8-1]

NCBI Reference Sequences

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RefSeqi
NP_060712.2, NM_018242.2 [Q96FL8-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.232054

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000270570; ENSP00000270570; ENSG00000142494 [Q96FL8-1]
ENST00000395585; ENSP00000378951; ENSG00000142494 [Q96FL8-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
55244

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:55244

UCSC genome browser

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UCSCi
uc002gvx.4 human [Q96FL8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001709 mRNA Translation: BAA91852.1
AK222625 mRNA Translation: BAD96345.1
CH471212 Genomic DNA Translation: EAW50893.1
CH471212 Genomic DNA Translation: EAW50894.1
BC010661 mRNA Translation: AAH10661.1
BC050592 mRNA Translation: AAH50592.1 Different initiation.
BC058882 mRNA Translation: AAH58882.1
CCDSiCCDS11209.1 [Q96FL8-1]
RefSeqiNP_060712.2, NM_018242.2 [Q96FL8-1]
UniGeneiHs.232054

3D structure databases

ProteinModelPortaliQ96FL8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120535, 42 interactors
IntActiQ96FL8, 1 interactor
STRINGi9606.ENSP00000270570

Chemistry databases

BindingDBiQ96FL8
ChEMBLiCHEMBL1743126
DrugBankiDB00787 Aciclovir
DB01237 Bromodiphenhydramine
DB00567 Cephalexin
DB00501 Cimetidine
DB00331 Metformin
DB00877 Sirolimus
GuidetoPHARMACOLOGYi1216

Protein family/group databases

TCDBi2.A.66.1.14 the multidrug/oligosaccharidyl-lipid/polysaccharide (mop) flippase superfamily

PTM databases

iPTMnetiQ96FL8
PhosphoSitePlusiQ96FL8

Polymorphism and mutation databases

BioMutaiSLC47A1
DMDMi74731723

Proteomic databases

MaxQBiQ96FL8
PaxDbiQ96FL8
PeptideAtlasiQ96FL8
PRIDEiQ96FL8
ProteomicsDBi76538
76539 [Q96FL8-2]
76540 [Q96FL8-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000270570; ENSP00000270570; ENSG00000142494 [Q96FL8-1]
ENST00000395585; ENSP00000378951; ENSG00000142494 [Q96FL8-3]
GeneIDi55244
KEGGihsa:55244
UCSCiuc002gvx.4 human [Q96FL8-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
55244
DisGeNETi55244
EuPathDBiHostDB:ENSG00000142494.13

GeneCards: human genes, protein and diseases

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GeneCardsi
SLC47A1

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0013619
HGNCiHGNC:25588 SLC47A1
HPAiHPA021987
MIMi609832 gene
neXtProtiNX_Q96FL8
OpenTargetsiENSG00000142494
PharmGKBiPA162403808

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1347 Eukaryota
COG0534 LUCA
GeneTreeiENSGT00940000161644
HOGENOMiHOG000060313
HOVERGENiHBG056043
InParanoidiQ96FL8
KOiK03327
OMAiTTMTGQY
OrthoDBiEOG091G06X2
PhylomeDBiQ96FL8
TreeFamiTF324441

Enzyme and pathway databases

ReactomeiR-HSA-425366 Transport of bile salts and organic acids, metal ions and amine compounds

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SLC47A1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SLC47A1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
55244

Protein Ontology

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PROi
PR:Q96FL8

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000142494 Expressed in 175 organ(s), highest expression level in adrenal gland
CleanExiHS_SLC47A1
ExpressionAtlasiQ96FL8 baseline and differential
GenevisibleiQ96FL8 HS

Family and domain databases

InterProiView protein in InterPro
IPR002528 MATE_fam
PfamiView protein in Pfam
PF01554 MatE, 2 hits
TIGRFAMsiTIGR00797 matE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS47A1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96FL8
Secondary accession number(s): Q53HF5
, Q6PD77, Q86VL4, Q9NVA3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 1, 2001
Last modified: December 5, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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