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Entry version 147 (07 Oct 2020)
Sequence version 1 (01 Dec 2001)
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Protein

WD repeat-containing protein 89

Gene

WDR89

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q96FK6

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q96FK6

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
WD repeat-containing protein 89
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:WDR89
Synonyms:C14orf150
ORF Names:MSTP050
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000140006.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20489, WDR89

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96FK6

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000140006

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134871067

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96FK6, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
WDR89

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74762654

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002540361 – 387WD repeat-containing protein 89Add BLAST387

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96FK6

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96FK6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q96FK6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96FK6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96FK6

PeptideAtlas

More...
PeptideAtlasi
Q96FK6

PRoteomics IDEntifications database

More...
PRIDEi
Q96FK6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
76537

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96FK6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96FK6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000140006, Expressed in placenta and 217 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96FK6, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96FK6, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000140006, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
125208, 19 interactors

Protein interaction database and analysis system

More...
IntActi
Q96FK6, 10 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000378399

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q96FK6, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati21 – 65WD 1Add BLAST45
Repeati68 – 107WD 2Add BLAST40
Repeati112 – 156WD 3Add BLAST45
Repeati168 – 208WD 4Add BLAST41
Repeati214 – 254WD 5Add BLAST41
Repeati319 – 358WD 6Add BLAST40

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1188, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000006996

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_037323_4_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96FK6

Identification of Orthologs from Complete Genome Data

More...
OMAi
WNVQDDS

Database of Orthologous Groups

More...
OrthoDBi
1546666at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96FK6

TreeFam database of animal gene trees

More...
TreeFami
TF324390

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR017986, WD40_repeat_dom
IPR036322, WD40_repeat_dom_sf
IPR039328, WDR89

The PANTHER Classification System

More...
PANTHERi
PTHR22889, PTHR22889, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00400, WD40, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00320, WD40, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978, SSF50978, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50082, WD_REPEATS_2, 3 hits
PS50294, WD_REPEATS_REGION, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q96FK6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEKIEEQFAN LHIVKCSLGT KEPTYLLGID TSKTVQAGKE NLVAVLCSNG
60 70 80 90 100
SIRIYDKERL NVLREFSGYP GLLNGVRFAN SCDSVYSACT DGTVKCWDAR
110 120 130 140 150
VAREKPVQLF KGYPSNIFIS FDINCNDHII CAGTEKVDDD ALLVFWDARM
160 170 180 190 200
NSQNLSTTKD SLGAYSETHS DDVTQVRFHP SNPNMVVSGS SDGLVNVFDI
210 220 230 240 250
NIDNEEDALV TTCNSISSVS CIGWSGKGYK QIYCMTHDEG FYWWDLNHLD
260 270 280 290 300
TDEPVTRLNI QDVREVVNMK EDALDYLIGG LYHEKTDTLH VIGGTNKGRI
310 320 330 340 350
HLMNCSMSGL THVTSLQGGH AATVRSFCWN VQDDSLLTGG EDAQLLLWKP
360 370 380
GAIEKTFTKK ESMKIASSVH QRVRVHSNDS YKRRKKQ
Length:387
Mass (Da):43,215
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC0F35E0066643800
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V4B8G3V4B8_HUMAN
WD repeat-containing protein 89
WDR89
226Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF115513 mRNA Translation: AAO06950.1
BX248008 mRNA Translation: CAD62336.1
AK095324 mRNA Translation: BAC04530.1
BC010698 mRNA Translation: AAH10698.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS9759.1

NCBI Reference Sequences

More...
RefSeqi
NP_001008726.1, NM_001008726.2
NP_001245201.1, NM_001258272.1
NP_542397.1, NM_080666.3
XP_011534687.1, XM_011536385.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000267522; ENSP00000267522; ENSG00000140006
ENST00000394942; ENSP00000378399; ENSG00000140006
ENST00000620954; ENSP00000480112; ENSG00000140006

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
112840

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:112840

UCSC genome browser

More...
UCSCi
uc031qox.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF115513 mRNA Translation: AAO06950.1
BX248008 mRNA Translation: CAD62336.1
AK095324 mRNA Translation: BAC04530.1
BC010698 mRNA Translation: AAH10698.1
CCDSiCCDS9759.1
RefSeqiNP_001008726.1, NM_001008726.2
NP_001245201.1, NM_001258272.1
NP_542397.1, NM_080666.3
XP_011534687.1, XM_011536385.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi125208, 19 interactors
IntActiQ96FK6, 10 interactors
STRINGi9606.ENSP00000378399

PTM databases

iPTMnetiQ96FK6
PhosphoSitePlusiQ96FK6

Polymorphism and mutation databases

BioMutaiWDR89
DMDMi74762654

Proteomic databases

EPDiQ96FK6
jPOSTiQ96FK6
MassIVEiQ96FK6
MaxQBiQ96FK6
PaxDbiQ96FK6
PeptideAtlasiQ96FK6
PRIDEiQ96FK6
ProteomicsDBi76537

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
38, 101 antibodies

The DNASU plasmid repository

More...
DNASUi
112840

Genome annotation databases

EnsembliENST00000267522; ENSP00000267522; ENSG00000140006
ENST00000394942; ENSP00000378399; ENSG00000140006
ENST00000620954; ENSP00000480112; ENSG00000140006
GeneIDi112840
KEGGihsa:112840
UCSCiuc031qox.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
112840
EuPathDBiHostDB:ENSG00000140006.11

GeneCards: human genes, protein and diseases

More...
GeneCardsi
WDR89
HGNCiHGNC:20489, WDR89
HPAiENSG00000140006, Low tissue specificity
neXtProtiNX_Q96FK6
OpenTargetsiENSG00000140006
PharmGKBiPA134871067

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1188, Eukaryota
GeneTreeiENSGT00390000006996
HOGENOMiCLU_037323_4_0_1
InParanoidiQ96FK6
OMAiWNVQDDS
OrthoDBi1546666at2759
PhylomeDBiQ96FK6
TreeFamiTF324390

Enzyme and pathway databases

PathwayCommonsiQ96FK6
SignaLinkiQ96FK6

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
112840, 26 hits in 875 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
WDR89, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
112840
PharosiQ96FK6, Tdark

Protein Ontology

More...
PROi
PR:Q96FK6
RNActiQ96FK6, protein

Gene expression databases

BgeeiENSG00000140006, Expressed in placenta and 217 other tissues
ExpressionAtlasiQ96FK6, baseline and differential
GenevisibleiQ96FK6, HS

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR017986, WD40_repeat_dom
IPR036322, WD40_repeat_dom_sf
IPR039328, WDR89
PANTHERiPTHR22889, PTHR22889, 1 hit
PfamiView protein in Pfam
PF00400, WD40, 3 hits
SMARTiView protein in SMART
SM00320, WD40, 5 hits
SUPFAMiSSF50978, SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50082, WD_REPEATS_2, 3 hits
PS50294, WD_REPEATS_REGION, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiWDR89_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96FK6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: December 1, 2001
Last modified: October 7, 2020
This is version 147 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
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