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Protein

Endonuclease 8-like 1

Gene

NEIL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.PROSITE-ProRule annotation EC:4.2.99.18

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei2Schiff-base intermediate with DNACurated1
Active sitei3Proton donorCurated1
Active sitei54Proton donor; for beta-elimination activityCurated1
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei176DNABy similarity1
Active sitei339Proton donor; for delta-elimination activityCurated1
Binding sitei339DNABy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • class I DNA-(apurinic or apyrimidinic site) endonuclease activity Source: UniProtKB-EC
  • damaged DNA binding Source: InterPro
  • DNA-(apurinic or apyrimidinic site) endonuclease activity Source: GO_Central
  • DNA N-glycosylase activity Source: GO_Central
  • hydrolase activity, acting on glycosyl bonds Source: UniProtKB
  • protein C-terminus binding Source: UniProtKB
  • zinc ion binding Source: InterPro

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Glycosidase, Hydrolase, Lyase, Multifunctional enzyme
Biological processDNA damage, DNA repair

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-110328 Recognition and association of DNA glycosylase with site containing an affected pyrimidine
R-HSA-110329 Cleavage of the damaged pyrimidine
R-HSA-5649702 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q96FI4

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Endonuclease 8-like 1 (EC:3.2.2.-, EC:4.2.99.18)
Alternative name(s):
DNA glycosylase/AP lyase Neil1
DNA-(apurinic or apyrimidinic site) lyase Neil1
Endonuclease VIII-like 1
FPG1
Nei homolog 1
Short name:
NEH1
Nei-like protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NEIL1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000140398.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18448 NEIL1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608844 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96FI4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Cytoplasm, Cytoskeleton, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi2P → T: Loss of glycosylase and AP lyase activity. 2 Publications1
Mutagenesisi2Missing : Loss of glycosylase activity. 2 Publications1
Mutagenesisi3E → Q: Loss of glycosylase and AP lyase activity. 1 Publication1
Mutagenesisi54K → L: Loss of glycosylase activity. 1 Publication1
Mutagenesisi277R → A: Strongly reduced glycosylase activity. Has little effect on AP lyase activity. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
79661

Open Targets

More...
OpenTargetsi
ENSG00000140398

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38334

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB03754 Tris

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NEIL1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
56404654

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001709052 – 390Endonuclease 8-like 1Add BLAST389

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96FI4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96FI4

PeptideAtlas

More...
PeptideAtlasi
Q96FI4

PRoteomics IDEntifications database

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PRIDEi
Q96FI4

ProteomicsDB human proteome resource

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ProteomicsDBi
76532

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96FI4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q96FI4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated during S-phase.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000140398 Expressed in 193 organ(s), highest expression level in right uterine tube

CleanEx database of gene expression profiles

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CleanExi
HS_NEIL1

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q96FI4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q96FI4 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA054084

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
122787, 6 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q96FI4

STRING: functional protein association networks

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STRINGi
9606.ENSP00000347170

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1390
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q96FI4

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q96FI4

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
Q96FI4

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FPG family.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IEAW Eukaryota
ENOG410ZTEH LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000153230

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000067872

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG052592

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q96FI4

KEGG Orthology (KO)

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KOi
K10567

Identification of Orthologs from Complete Genome Data

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OMAi
DKPICEA

Database of Orthologous Groups

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OrthoDBi
EOG091G07LM

Database for complete collections of gene phylogenies

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PhylomeDBi
Q96FI4

TreeFam database of animal gene trees

More...
TreeFami
TF333272

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.20.190.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR015886 DNA_glyclase/AP_lyase_DNA-bd
IPR015371 Endonuclease-VIII_DNA-bd
IPR012319 FPG_cat
IPR035937 MutM-like_N-ter
IPR010979 Ribosomal_S13-like_H2TH

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01149 Fapy_DNA_glyco, 1 hit
PF09292 Neil1-DNA_bind, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00898 Fapy_DNA_glyco, 1 hit
SM01232 H2TH, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF46946 SSF46946, 1 hit
SSF81624 SSF81624, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS51068 FPG_CAT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 11 potential isoforms that are computationally mapped.Show allAlign All

Q96FI4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPEGPELHLA SQFVNEACRA LVFGGCVEKS SVSRNPEVPF ESSAYRISAS
60 70 80 90 100
ARGKELRLIL SPLPGAQPQQ EPLALVFRFG MSGSFQLVPR EELPRHAHLR
110 120 130 140 150
FYTAPPGPRL ALCFVDIRRF GRWDLGGKWQ PGRGPCVLQE YQQFRENVLR
160 170 180 190 200
NLADKAFDRP ICEALLDQRF FNGIGNYLRA EILYRLKIPP FEKARSVLEA
210 220 230 240 250
LQQHRPSPEL TLSQKIRTKL QNPDLLELCH SVPKEVVQLG GKGYGSESGE
260 270 280 290 300
EDFAAFRAWL RCYGMPGMSS LQDRHGRTIW FQGDPGPLAP KGRKSRKKKS
310 320 330 340 350
KATQLSPEDR VEDALPPSKA PSRTRRAKRD LPKRTATQRP EGTSLQQDPE
360 370 380 390
APTVPKKGRR KGRQAASGHC RPRKVKADIP SLEPEGTSAS
Length:390
Mass (Da):43,684
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB2B058486C4EF835
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BQU8H3BQU8_HUMAN
Endonuclease 8-like 1
NEIL1
184Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BM98H3BM98_HUMAN
Endonuclease 8-like 1
NEIL1
154Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BT75H3BT75_HUMAN
Endonuclease 8-like 1
NEIL1
199Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BSZ5H3BSZ5_HUMAN
Endonuclease 8-like 1
NEIL1
152Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BST2H3BST2_HUMAN
Endonuclease 8-like 1
NEIL1
132Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BQE8H3BQE8_HUMAN
Endonuclease 8-like 1
NEIL1
88Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BTX5H3BTX5_HUMAN
Endonuclease 8-like 1
NEIL1
82Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BU98H3BU98_HUMAN
Endonuclease 8-like 1
NEIL1
64Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BN83H3BN83_HUMAN
Endonuclease 8-like 1
NEIL1
39Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BT94H3BT94_HUMAN
Endonuclease 8-like 1
NEIL1
50Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There is more potential isoformShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AK128372 differs from that shown. Erroneous CDS prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti147N → S in BAB15337 (PubMed:14702039).Curated1

<p>This subsection of the ‘Sequence’ section provides information relevant to all types of RNA editing events (conversion, insertion, deletion of nucleotides) that lead to one or more amino acid changes compared to the translation of the non-edited RNA version.<p><a href='/help/rna_editing' target='_top'>More...</a></p>RNA editingi

Edited at position 242.1 Publication
The edited form removes thymine glycol from duplex DNA 30 times more slowly than the form encoded in the genome, whereas editing enhances repair of the guanidinohydantoin lesion by NEIL1. The recoding site is a preferred editing site for the RNA editing adenosine deaminase ADAR1.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02058082S → C1 PublicationCorresponds to variant dbSNP:rs5745905Ensembl.1
Natural variantiVAR_02058183G → D1 PublicationCorresponds to variant dbSNP:rs5745906Ensembl.1
Natural variantiVAR_020582136C → R1 PublicationCorresponds to variant dbSNP:rs5745907Ensembl.1
Natural variantiVAR_065963159R → Q1 PublicationCorresponds to variant dbSNP:rs769880000Ensembl.1
Natural variantiVAR_065964181E → K Found in a patient with nephrotic syndrome also carrying mutation P-159 in MYO1E. 1 PublicationCorresponds to variant dbSNP:rs749636951Ensembl.1
Natural variantiVAR_020583182I → M. Corresponds to variant dbSNP:rs7183491Ensembl.1
Natural variantiVAR_065018242K → R in RNA edited version. 1
Natural variantiVAR_020584252D → N1 PublicationCorresponds to variant dbSNP:rs5745926Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB079068 mRNA Translation: BAC06476.1
AK026055 mRNA Translation: BAB15337.1
AK128372 mRNA No translation available.
AY257544 Genomic DNA Translation: AAO74826.1
AC068338 Genomic DNA No translation available.
CH471136 Genomic DNA Translation: EAW99255.1
CH471136 Genomic DNA Translation: EAW99260.1
BC010876 mRNA Translation: AAH10876.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS10278.1

NCBI Reference Sequences

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RefSeqi
NP_001243481.1, NM_001256552.1
NP_078884.2, NM_024608.3
XP_005254716.1, XM_005254659.4
XP_006720743.1, XM_006720680.1
XP_006720744.1, XM_006720681.1
XP_011520304.1, XM_011522002.1
XP_011520305.1, XM_011522003.2
XP_011520306.1, XM_011522004.2

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.512732

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000355059; ENSP00000347170; ENSG00000140398
ENST00000564784; ENSP00000457352; ENSG00000140398
ENST00000569035; ENSP00000455730; ENSG00000140398

Database of genes from NCBI RefSeq genomes

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GeneIDi
79661

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:79661

UCSC genome browser

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UCSCi
uc002bad.5 human

Keywords - Coding sequence diversityi

Polymorphism, RNA editing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB079068 mRNA Translation: BAC06476.1
AK026055 mRNA Translation: BAB15337.1
AK128372 mRNA No translation available.
AY257544 Genomic DNA Translation: AAO74826.1
AC068338 Genomic DNA No translation available.
CH471136 Genomic DNA Translation: EAW99255.1
CH471136 Genomic DNA Translation: EAW99260.1
BC010876 mRNA Translation: AAH10876.1
CCDSiCCDS10278.1
RefSeqiNP_001243481.1, NM_001256552.1
NP_078884.2, NM_024608.3
XP_005254716.1, XM_005254659.4
XP_006720743.1, XM_006720680.1
XP_006720744.1, XM_006720681.1
XP_011520304.1, XM_011522002.1
XP_011520305.1, XM_011522003.2
XP_011520306.1, XM_011522004.2
UniGeneiHs.512732

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1TDHX-ray2.10A1-390[»]
4NRVX-ray2.60A2-290[»]
5ITQX-ray1.48A1-290[»]
5ITRX-ray2.46A/B/C1-390[»]
5ITTX-ray2.53A/B/C1-390[»]
5ITUX-ray2.41A/B/C1-390[»]
5ITXX-ray2.65A/B/E1-390[»]
5ITYX-ray2.48A/B/C1-390[»]
ProteinModelPortaliQ96FI4
SMRiQ96FI4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122787, 6 interactors
CORUMiQ96FI4
STRINGi9606.ENSP00000347170

Chemistry databases

DrugBankiDB03754 Tris

PTM databases

iPTMnetiQ96FI4
PhosphoSitePlusiQ96FI4

Polymorphism and mutation databases

BioMutaiNEIL1
DMDMi56404654

Proteomic databases

EPDiQ96FI4
PaxDbiQ96FI4
PeptideAtlasiQ96FI4
PRIDEiQ96FI4
ProteomicsDBi76532

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
79661
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355059; ENSP00000347170; ENSG00000140398
ENST00000564784; ENSP00000457352; ENSG00000140398
ENST00000569035; ENSP00000455730; ENSG00000140398
GeneIDi79661
KEGGihsa:79661
UCSCiuc002bad.5 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
79661
DisGeNETi79661
EuPathDBiHostDB:ENSG00000140398.13

GeneCards: human genes, protein and diseases

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GeneCardsi
NEIL1

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0202149
HGNCiHGNC:18448 NEIL1
HPAiHPA054084
MIMi608844 gene
neXtProtiNX_Q96FI4
OpenTargetsiENSG00000140398
PharmGKBiPA38334

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IEAW Eukaryota
ENOG410ZTEH LUCA
GeneTreeiENSGT00940000153230
HOGENOMiHOG000067872
HOVERGENiHBG052592
InParanoidiQ96FI4
KOiK10567
OMAiDKPICEA
OrthoDBiEOG091G07LM
PhylomeDBiQ96FI4
TreeFamiTF333272

Enzyme and pathway databases

ReactomeiR-HSA-110328 Recognition and association of DNA glycosylase with site containing an affected pyrimidine
R-HSA-110329 Cleavage of the damaged pyrimidine
R-HSA-5649702 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
SIGNORiQ96FI4

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
NEIL1 human
EvolutionaryTraceiQ96FI4

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
NEIL1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
79661

Protein Ontology

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PROi
PR:Q96FI4

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000140398 Expressed in 193 organ(s), highest expression level in right uterine tube
CleanExiHS_NEIL1
ExpressionAtlasiQ96FI4 baseline and differential
GenevisibleiQ96FI4 HS

Family and domain databases

Gene3Di3.20.190.10, 1 hit
InterProiView protein in InterPro
IPR015886 DNA_glyclase/AP_lyase_DNA-bd
IPR015371 Endonuclease-VIII_DNA-bd
IPR012319 FPG_cat
IPR035937 MutM-like_N-ter
IPR010979 Ribosomal_S13-like_H2TH
PfamiView protein in Pfam
PF01149 Fapy_DNA_glyco, 1 hit
PF09292 Neil1-DNA_bind, 1 hit
SMARTiView protein in SMART
SM00898 Fapy_DNA_glyco, 1 hit
SM01232 H2TH, 1 hit
SUPFAMiSSF46946 SSF46946, 1 hit
SSF81624 SSF81624, 1 hit
PROSITEiView protein in PROSITE
PS51068 FPG_CAT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNEIL1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96FI4
Secondary accession number(s): D3DW75
, Q6ZRA7, Q86XW7, Q9H6C3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: January 23, 2007
Last modified: December 5, 2018
This is version 158 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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