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Entry version 145 (11 Dec 2019)
Sequence version 2 (20 Mar 2007)
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Protein

Phosphoinositide-3-kinase-interacting protein 1

Gene

PIK3IP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Negative regulator of hepatic phosphatidylinositol 3-kinase (PI3K) activity.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phosphoinositide-3-kinase-interacting protein 1
Alternative name(s):
Kringle domain-containing protein HGFL
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PIK3IP1
Synonyms:HGFL
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000100100.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24942 PIK3IP1

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96FE7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini22 – 168ExtracellularSequence analysisAdd BLAST147
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei169 – 189HelicalSequence analysisAdd BLAST21
Topological domaini190 – 261CytoplasmicSequence analysisAdd BLAST72

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
113791

Open Targets

More...
OpenTargetsi
ENSG00000100100

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162399553

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96FE7 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PIK3IP1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
134034149

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 211 PublicationAdd BLAST21
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000028034722 – 263Phosphoinositide-3-kinase-interacting protein 1Add BLAST242

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi25 ↔ 101PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi39O-linked (GalNAc...) serine1 Publication1
Disulfide bondi46 ↔ 82PROSITE-ProRule annotation
Glycosylationi66N-linked (GlcNAc...) (complex) asparagine1 Publication1
Disulfide bondi70 ↔ 96PROSITE-ProRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans. N-glycan heterogeneity at Asn-66: dHex1Hex5HexNAc4 (major) and dHex1Hex6HexNAc5 (minor).1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96FE7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q96FE7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96FE7

PeptideAtlas

More...
PeptideAtlasi
Q96FE7

PRoteomics IDEntifications database

More...
PRIDEi
Q96FE7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
12726
76518 [Q96FE7-1]
76519 [Q96FE7-2]
76520 [Q96FE7-3]
76521 [Q96FE7-4]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1999
686

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96FE7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96FE7

UniCarbKB; an annotated and curated database of glycan structures

More...
UniCarbKBi
Q96FE7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000100100 Expressed in 216 organ(s), highest expression level in small intestine Peyer's patch

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96FE7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96FE7 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
125260, 9 interactors

Protein interaction database and analysis system

More...
IntActi
Q96FE7, 7 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000215912

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q96FE7 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96FE7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini24 – 101KringlePROSITE-ProRule annotationAdd BLAST78

Keywords - Domaini

Kringle, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IIHU Eukaryota
ENOG4112B5B LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000017774

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000070070

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96FE7

Identification of Orthologs from Complete Genome Data

More...
OMAi
DQKVCER

Database of Orthologous Groups

More...
OrthoDBi
1027586at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96FE7

TreeFam database of animal gene trees

More...
TreeFami
TF331319

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00108 KR, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.20.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000001 Kringle
IPR013806 Kringle-like
IPR018056 Kringle_CS
IPR038178 Kringle_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00051 Kringle, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00130 KR, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57440 SSF57440, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00021 KRINGLE_1, 1 hit
PS50070 KRINGLE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96FE7-1) [UniParc]FASTAAdd to basket
Also known as: HGFL(L)

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLLAWVQAFL VSNMLLAEAY GSGGCFWDNG HLYREDQTSP APGLRCLNWL
60 70 80 90 100
DAQSGLASAP VSGAGNHSYC RNPDEDPRGP WCYVSGEAGV PEKRPCEDLR
110 120 130 140 150
CPETTSQALP AFTTEIQEAS EGPGADEVQV FAPANALPAR SEAAAVQPVI
160 170 180 190 200
GISQRVRMNS KEKKDLGTLG YVLGITMMVI IIAIGAGIIL GYSYKRGKDL
210 220 230 240 250
KEQHDQKVCE REMQRITLPL SAFTNPTCEI VDEKTVVVHT SQTPVDPQEG
260
TTPLMGQAGT PGA
Length:263
Mass (Da):28,248
Last modified:March 20, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i197C3EEE8E54A242
GO
Isoform 2 (identifier: Q96FE7-2) [UniParc]FASTAAdd to basket
Also known as: HGFL(S)

The sequence of this isoform differs from the canonical sequence as follows:
     197-234: GKDLKEQHDQ...NPTCEIVDEK → SVASLLGPLR...KQDVENQLKM
     235-263: Missing.

Show »
Length:234
Mass (Da):25,320
Checksum:iC78F64DBD1B8DC0D
GO
Isoform 3 (identifier: Q96FE7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-157: Missing.

Show »
Length:106
Mass (Da):11,504
Checksum:i0123D43C3621193E
GO
Isoform 4 (identifier: Q96FE7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     171-263: YVLGITMMVI...LMGQAGTPGA → GRI

Show »
Length:173
Mass (Da):18,491
Checksum:iB42F43F34D1E61EC
GO
Isoform 5 (identifier: Q96FE7-5) [UniParc]FASTAAdd to basket
Also known as: PIK3IP1-v1

The sequence of this isoform differs from the canonical sequence as follows:
     24-102: Missing.

Show »
Length:184
Mass (Da):19,632
Checksum:i06455EB564E5DB29
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JMK5C9JMK5_HUMAN
Phosphoinositide-3-kinase-interacti...
PIK3IP1
144Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti98D → G in BAC11140 (PubMed:14702039).Curated1
Sequence conflicti162E → G in BAC11140 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_031121251T → S3 PublicationsCorresponds to variant dbSNP:rs2040533Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0236381 – 157Missing in isoform 3. 1 PublicationAdd BLAST157
Alternative sequenceiVSP_05337024 – 102Missing in isoform 5. 1 PublicationAdd BLAST79
Alternative sequenceiVSP_043368171 – 263YVLGI…GTPGA → GRI in isoform 4. 1 PublicationAdd BLAST93
Alternative sequenceiVSP_023639197 – 234GKDLK…IVDEK → SVASLLGPLRRRGGRYTKSN FVAFLPKRKQDVENQLKM in isoform 2. 1 PublicationAdd BLAST38
Alternative sequenceiVSP_023640235 – 263Missing in isoform 2. 1 PublicationAdd BLAST29

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF528079 mRNA Translation: AAO33762.1
AF528080 mRNA Translation: AAO33763.1
GU135609 mRNA Translation: ACZ26468.1
CR456340 mRNA Translation: CAG30226.1
AK074688 mRNA Translation: BAC11140.1
AK299397 mRNA Translation: BAG61381.1
AC002073 Genomic DNA Translation: AAB54054.1
CH471095 Genomic DNA Translation: EAW59962.1
BC011049 mRNA Translation: AAH11049.1
BC041903 mRNA Translation: AAH41903.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13893.1 [Q96FE7-1]
CCDS46690.1 [Q96FE7-4]

NCBI Reference Sequences

More...
RefSeqi
NP_001129383.1, NM_001135911.1 [Q96FE7-4]
NP_443112.2, NM_052880.4 [Q96FE7-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000215912; ENSP00000215912; ENSG00000100100 [Q96FE7-1]
ENST00000402249; ENSP00000385204; ENSG00000100100 [Q96FE7-2]
ENST00000441972; ENSP00000415608; ENSG00000100100 [Q96FE7-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
113791

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:113791

UCSC genome browser

More...
UCSCi
uc003akm.4 human [Q96FE7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF528079 mRNA Translation: AAO33762.1
AF528080 mRNA Translation: AAO33763.1
GU135609 mRNA Translation: ACZ26468.1
CR456340 mRNA Translation: CAG30226.1
AK074688 mRNA Translation: BAC11140.1
AK299397 mRNA Translation: BAG61381.1
AC002073 Genomic DNA Translation: AAB54054.1
CH471095 Genomic DNA Translation: EAW59962.1
BC011049 mRNA Translation: AAH11049.1
BC041903 mRNA Translation: AAH41903.1
CCDSiCCDS13893.1 [Q96FE7-1]
CCDS46690.1 [Q96FE7-4]
RefSeqiNP_001129383.1, NM_001135911.1 [Q96FE7-4]
NP_443112.2, NM_052880.4 [Q96FE7-1]

3D structure databases

SMRiQ96FE7
ModBaseiSearch...

Protein-protein interaction databases

BioGridi125260, 9 interactors
IntActiQ96FE7, 7 interactors
STRINGi9606.ENSP00000215912

PTM databases

GlyConnecti1999
686
iPTMnetiQ96FE7
PhosphoSitePlusiQ96FE7
UniCarbKBiQ96FE7

Polymorphism and mutation databases

BioMutaiPIK3IP1
DMDMi134034149

Proteomic databases

jPOSTiQ96FE7
MassIVEiQ96FE7
PaxDbiQ96FE7
PeptideAtlasiQ96FE7
PRIDEiQ96FE7
ProteomicsDBi12726
76518 [Q96FE7-1]
76519 [Q96FE7-2]
76520 [Q96FE7-3]
76521 [Q96FE7-4]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
113791

Genome annotation databases

EnsembliENST00000215912; ENSP00000215912; ENSG00000100100 [Q96FE7-1]
ENST00000402249; ENSP00000385204; ENSG00000100100 [Q96FE7-2]
ENST00000441972; ENSP00000415608; ENSG00000100100 [Q96FE7-4]
GeneIDi113791
KEGGihsa:113791
UCSCiuc003akm.4 human [Q96FE7-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
113791
DisGeNETi113791
EuPathDBiHostDB:ENSG00000100100.12

GeneCards: human genes, protein and diseases

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GeneCardsi
PIK3IP1
HGNCiHGNC:24942 PIK3IP1
neXtProtiNX_Q96FE7
OpenTargetsiENSG00000100100
PharmGKBiPA162399553

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IIHU Eukaryota
ENOG4112B5B LUCA
GeneTreeiENSGT00390000017774
HOGENOMiHOG000070070
InParanoidiQ96FE7
OMAiDQKVCER
OrthoDBi1027586at2759
PhylomeDBiQ96FE7
TreeFamiTF331319

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PIK3IP1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
PIK3IP1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
113791
PharosiQ96FE7 Tbio

Protein Ontology

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PROi
PR:Q96FE7
RNActiQ96FE7 protein

Gene expression databases

BgeeiENSG00000100100 Expressed in 216 organ(s), highest expression level in small intestine Peyer's patch
ExpressionAtlasiQ96FE7 baseline and differential
GenevisibleiQ96FE7 HS

Family and domain databases

CDDicd00108 KR, 1 hit
Gene3Di2.40.20.10, 1 hit
InterProiView protein in InterPro
IPR000001 Kringle
IPR013806 Kringle-like
IPR018056 Kringle_CS
IPR038178 Kringle_sf
PfamiView protein in Pfam
PF00051 Kringle, 1 hit
SMARTiView protein in SMART
SM00130 KR, 1 hit
SUPFAMiSSF57440 SSF57440, 1 hit
PROSITEiView protein in PROSITE
PS00021 KRINGLE_1, 1 hit
PS50070 KRINGLE_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiP3IP1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96FE7
Secondary accession number(s): B4DRR9
, D1MEI0, O00318, Q49A94, Q86YW2, Q8NCJ9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: December 11, 2019
This is version 145 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
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