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Entry version 169 (07 Apr 2021)
Sequence version 1 (01 Dec 2001)
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Protein

ATP-dependent DNA helicase DDX11

Gene

DDX11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

DNA-dependent ATPase and ATP-dependent DNA helicase that participates in various functions in genomic stability, including DNA replication, DNA repair and heterochromatin organization as well as in ribosomal RNA synthesis (PubMed:10648783, PubMed:21854770, PubMed:23797032, PubMed:26089203, PubMed:26503245). Its double-stranded DNA helicase activity requires either a minimal 5'-single-stranded tail length of approximately 15 nt (flap substrates) or 10 nt length single-stranded gapped DNA substrates of a partial duplex DNA structure for helicase loading and translocation along DNA in a 5' to 3' direction (PubMed:18499658, PubMed:22102414). The helicase activity is capable of displacing duplex regions up to 100 bp, which can be extended up to 500 bp by the replication protein A (RPA) or the cohesion CTF18-replication factor C (Ctf18-RFC) complex activities (PubMed:18499658). Shows also ATPase- and helicase activities on substrates that mimic key DNA intermediates of replication, repair and homologous recombination reactions, including forked duplex, anti-parallel G-quadruplex and three-stranded D-loop DNA molecules (PubMed:22102414, PubMed:26503245). Plays a role in DNA double-strand break (DSB) repair at the DNA replication fork during DNA replication recovery from DNA damage (PubMed:23797032). Recruited with TIMELESS factor upon DNA-replication stress response at DNA replication fork to preserve replication fork progression, and hence ensure DNA replication fidelity (PubMed:26503245). Cooperates also with TIMELESS factor during DNA replication to regulate proper sister chromatid cohesion and mitotic chromosome segregation (PubMed:17105772, PubMed:18499658, PubMed:20124417, PubMed:23116066, PubMed:23797032). Stimulates 5'-single-stranded DNA flap endonuclease activity of FEN1 in an ATP- and helicase-independent manner; and hence it may contribute in Okazaki fragment processing at DNA replication fork during lagging strand DNA synthesis (PubMed:18499658). Its ability to function at DNA replication fork is modulated by its binding to long non-coding RNA (lncRNA) cohesion regulator non-coding RNA DDX11-AS1/CONCR, which is able to increase both DDX11 ATPase activity and binding to DNA replicating regions (PubMed:27477908). Plays also a role in heterochromatin organization (PubMed:21854770). Involved in rRNA transcription activation through binding to active hypomethylated rDNA gene loci by recruiting UBTF and the RNA polymerase Pol I transcriptional machinery (PubMed:26089203). Plays a role in embryonic development and prevention of aneuploidy (By similarity). Involved in melanoma cell proliferation and survival (PubMed:23116066). Associates with chromatin at DNA replication fork regions (PubMed:27477908). Binds to single- and double-stranded DNAs (PubMed:9013641, PubMed:18499658, PubMed:22102414).By similarity11 Publications
(Microbial infection) Required for bovine papillomavirus type 1 regulatory protein E2 loading onto mitotic chromosomes during DNA replication for the viral genome to be maintained and segregated.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

[4Fe-4S] clusterBy similarityNote: Binds 1 [4Fe-4S] cluster.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

ATPase activity is stimulated by high magnesium salt levels (up to a 0.1 M), and potassium salts (glutamate, chloride or acetate) are more effective than the corresponding sodium salts (PubMed:10648783, PubMed:18499658). ATPase activity is enhanced by the long non-coding RNA (lncRNA) cohesion regulator noncoding RNA (CONCR) (PubMed:27477908). Double-stranded DNA helicase activity is maximal with magnesium ions at low concentrations (0.5-1 mM) whereas is markedly inhibited at higher levels (5 mM and above) (PubMed:10648783, PubMed:18499658). Double-stranded DNA helicase activity is stimulated by 25-50 mM potassium acetate, stimulated to a lesser extent by 25 mM of ammonium acetate, and markedly inhibited by sodium acetate (PubMed:18499658).3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi267Iron-sulfur (4Fe-4S)By similarity1
Metal bindingi285Iron-sulfur (4Fe-4S)By similarity1
Metal bindingi315Iron-sulfur (4Fe-4S)By similarity1
Metal bindingi350Iron-sulfur (4Fe-4S)By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi44 – 51ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding, Helicase, Hydrolase, RNA-binding
Biological processDNA damage, DNA repair, DNA replication, Host-virus interaction, Transcription, Transcription regulation
Ligand4Fe-4S, ATP-binding, Iron, Iron-sulfur, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
Q96FC9

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-381038, XBP1(S) activates chaperone genes

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ATP-dependent DNA helicase DDX11Curated (EC:3.6.4.125 Publications)
Alternative name(s):
CHL1-related protein 11 Publication
Short name:
hCHLR11 Publication
DEAD/H-box protein 11Imported
Keratinocyte growth factor-regulated gene 2 protein1 Publication
Short name:
KRG-21 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DDX11Imported
Synonyms:CHL1, CHLR11 Publication, KRG21 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:2736, DDX11

Online Mendelian Inheritance in Man (OMIM)

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MIMi
601150, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q96FC9

Eukaryotic Pathogen, Vector and Host Database Resources

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VEuPathDBi
HostDB:ENSG00000013573.16

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Chromosome, Cytoplasm, Cytoskeleton, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Warsaw breakage syndrome (WBRS)3 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA syndrome characterized by severe microcephaly, pre- and postnatal growth retardation, facial dysmorphism and abnormal skin pigmentation. Additional features include high arched palate, coloboma of the right optic disk, deafness, ventricular septal defect, toes and fingers abnormalities. At cellular level, drug-induced chromosomal breakage, a feature of Fanconi anemia, and sister chromatid cohesion defects, a feature of Roberts syndrome, coexist.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_069099263R → Q in WBRS; impairs the helicase activity by perturbing its DNA binding and DNA-dependent ATPase activity; reduces binding to rDNA promoter and promotion of rDNA transcription. 2 PublicationsCorresponds to variant dbSNP:rs201968272EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi50K → R: Loss of both DNA-dependent ATPase and ATP-dependent helicase activities. 3 Publications1

Keywords - Diseasei

Disease variant

Organism-specific databases

DisGeNET

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DisGeNETi
1663

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
DDX11

MalaCards human disease database

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MalaCardsi
DDX11
MIMi613398, phenotype

Open Targets

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OpenTargetsi
ENSG00000013573

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
280558, Warsaw breakage syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA27201

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
Q96FC9, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
DDX11

Domain mapping of disease mutations (DMDM)

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DMDMi
74731686

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000551361 – 970ATP-dependent DNA helicase DDX11Add BLAST970

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei262PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q96FC9

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q96FC9

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q96FC9

MaxQB - The MaxQuant DataBase

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MaxQBi
Q96FC9

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q96FC9

PeptideAtlas

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PeptideAtlasi
Q96FC9

PRoteomics IDEntifications database

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PRIDEi
Q96FC9

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
76511 [Q96FC9-1]
76512 [Q96FC9-2]
76513 [Q96FC9-3]
76514 [Q96FC9-4]
76515 [Q96FC9-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q96FC9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q96FC9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in melanoma cells. Not detected in epidermal melanocytes of normal skin (at protein level) (PubMed:23116066). Highly expressed in spleen, B-cells, thymus, testis, ovary, small intestine and pancreas (PubMed:9013641). Very low expression seen in brain (PubMed:9013641). Expressed in dividing cells and/or cells undergoing high levels of recombination (PubMed:9013641). No expression detected in cells signaled to terminally differentiate (PubMed:9013641). Expressed weakly in keratinocytes (PubMed:8798685).3 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by serum (at protein level) (PubMed:26089203). Up-regulated by fibroblast growth factor FGF7 (PubMed:8798685). Expressed in keratinocyte growth factor-stimulated cells but not in EGF and IL1-beta-treated keratinocytes (PubMed:8798685). Up-regulated with progression from noninvasive to invasive melanoma (PubMed:23116066).3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000013573, Expressed in small intestine Peyer's patch and 190 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q96FC9, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q96FC9, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000013573, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Associates with the CTF18-RFC complex (PubMed:18499658). Associates with a cohesin complex composed of RAD21, SMC1 proteins and SMC3 (PubMed:17105772).

Interacts with CHTF18 (PubMed:18499658).

Interacts with DSCC1 (PubMed:18499658).

Interacts with FEN1; this interaction is direct and increases flap endonuclease activity of FEN1 (PubMed:18499658).

Interacts with PCNA (PubMed:18499658).

Interacts with POLR1A and UBTF (PubMed:26089203).

Interacts with RAD21, SMC1 proteins and SMC3 (PubMed:17105772).

Interacts with RFC2 (PubMed:18499658).

Interacts with TIMELESS; this interaction increases recruitment of both proteins onto chromatin in response to replication stress induction by hydroxyurea (PubMed:20124417, PubMed:26503245).

5 Publications

(Microbial infection) Interacts with bovine papillomavirus type 1 regulatory protein E2; this interaction stimulates the recruitment of E2 onto mitotic chromosomes.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
108028, 43 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q96FC9

Protein interaction database and analysis system

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IntActi
Q96FC9, 25 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000440402

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
Q96FC9, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini9 – 445Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST437

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi393 – 396DEAH box4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi163 – 224Glu-richAdd BLAST62

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1133, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00950000182970

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_006515_2_1_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q96FC9

Identification of Orthologs from Complete Genome Data

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OMAi
GLPYPNR

Database of Orthologous Groups

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OrthoDBi
186062at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q96FC9

TreeFam database of animal gene trees

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TreeFami
TF300435

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR006555, ATP-dep_Helicase_C
IPR028331, CHL1/DDX11
IPR010614, DEAD_2
IPR014013, Helic_SF1/SF2_ATP-bd_DinG/Rad3
IPR006554, Helicase-like_DEXD_c2
IPR027417, P-loop_NTPase
IPR013020, Rad3/Chl1-like

The PANTHER Classification System

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PANTHERi
PTHR11472:SF41, PTHR11472:SF41, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF06733, DEAD_2, 1 hit
PF13307, Helicase_C_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00488, DEXDc2, 1 hit
SM00491, HELICc2, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF52540, SSF52540, 1 hit

TIGRFAMs; a protein family database

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TIGRFAMsi
TIGR00604, rad3, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS51193, HELICASE_ATP_BIND_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 12 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96FC9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MANETQKVGA IHFPFPFTPY SIQEDFMAEL YRVLEAGKIG IFESPTGTGK
60 70 80 90 100
SLSLICGALS WLRDFEQKKR EEEARLLETG TGPLHDEKDE SLCLSSSCEG
110 120 130 140 150
AAGTPRPAGE PAWVTQFVQK KEERDLVDRL KAEQARRKQR EERLQQLQHR
160 170 180 190 200
VQLKYAAKRL RQEEEERENL LRLSREMLET GPEAERLEQL ESGEEELVLA
210 220 230 240 250
EYESDEEKKV ASRVDEDEDD LEEEHITKIY YCSRTHSQLA QFVHEVKKSP
260 270 280 290 300
FGKDVRLVSL GSRQNLCVNE DVKSLGSVQL INDRCVDMQR SRHEKKKGAE
310 320 330 340 350
EEKPKRRRQE KQAACPFYNH EQMGLLRDEA LAEVKDMEQL LALGKEARAC
360 370 380 390 400
PYYGSRLAIP AAQLVVLPYQ MLLHAATRQA AGIRLQDQVV IIDEAHNLID
410 420 430 440 450
TITGMHSVEV SGSQLCQAHS QLLQYVERYG KRLKAKNLMY LKQILYLLEK
460 470 480 490 500
FVAVLGGNIK QNPNTQSLSQ TGTELKTIND FLFQSQIDNI NLFKVQRYCE
510 520 530 540 550
KSMISRKLFG FTERYGAVFS SREQPKLAGF QQFLQSLQPR TTEALAAPAD
560 570 580 590 600
ESQASTLRPA SPLMHIQGFL AALTTANQDG RVILSRQGSL SQSTLKFLLL
610 620 630 640 650
NPAVHFAQVV KECRAVVIAG GTMQPVSDFR QQLLACAGVE AERVVEFSCG
660 670 680 690 700
HVIPPDNILP LVICSGISNQ PLEFTFQKRE LPQMMDEVGR ILCNLCGVVP
710 720 730 740 750
GGVVCFFPSY EYLRQVHAHW EKGGLLGRLA ARKKIFQEPK SAHQVEQVLL
760 770 780 790 800
AYSRCIQACG QERGQVTGAL LLSVVGGKMS EGINFSDNLG RCVVMVGMPF
810 820 830 840 850
PNIRSAELQE KMAYLDQTLS PRPGTPREGS GGEPVHEGRQ PVHRQGHQAP
860 870 880 890 900
EGFCQRSAPG PAICPAPCPG QAAGLDPSPC GGQSYLWPRH CCCAEVSPGE
910 920 930 940 950
VGLFLMGNHT TAWRRALPLS CPLETVFVVG VVCGDPVTKV KPRRRVWSPE
960 970
CCQDPGTGVS SRRRKWGNPE
Length:970
Mass (Da):108,313
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5BF49FE74E912B48
GO
Isoform 2 (identifier: Q96FC9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     820-906: SPRPGTPREG...SPGEVGLFLM → PRAPGQAPPG...KFHREKSASS
     907-970: Missing.

Show »
Length:906
Mass (Da):101,685
Checksum:iBC51D55CB3186C91
GO
Isoform 3 (identifier: Q96FC9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-26: Missing.
     820-906: SPRPGTPREG...SPGEVGLFLM → PRAPGQAPPG...KFHREKSASS
     907-970: Missing.

Show »
Length:880
Mass (Da):98,687
Checksum:iE0D7B88158ABA02A
GO
Isoform 4 (identifier: Q96FC9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     685-734: Missing.
     820-906: SPRPGTPREG...SPGEVGLFLM → PRAPGQAPPG...KFHREKSASS
     907-970: Missing.

Show »
Length:856
Mass (Da):96,128
Checksum:i30C866F69D6ABD34
GO
Isoform 5 (identifier: Q96FC9-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     214-288: VDEDEDDLEE...QLINDRCVDM → APSDATSSRH...RMRMTWRKNT
     289-970: Missing.

Show »
Length:288
Mass (Da):32,951
Checksum:i78E0917712BBC6B0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9K0E8C9K0E8_HUMAN
ATP-dependent DNA helicase DDX11
DDX11
302Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GXJ8F5GXJ8_HUMAN
ATP-dependent DNA helicase DDX11
DDX11
224Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GXL6F5GXL6_HUMAN
ATP-dependent DNA helicase DDX11
DDX11
191Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
R4GNE1R4GNE1_HUMAN
ATP-dependent DNA helicase DDX11
DDX11
91Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B4DMS8B4DMS8_HUMAN
ATP-dependent DNA helicase DDX11
DDX11
304Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H235F5H235_HUMAN
ATP-dependent DNA helicase DDX11
DDX11
297Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6WZM0F6WZM0_HUMAN
ATP-dependent DNA helicase DDX11
DDX11
288Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YFY8H0YFY8_HUMAN
ATP-dependent DNA helicase DDX11
DDX11
172Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YGL4H0YGL4_HUMAN
ATP-dependent DNA helicase DDX11
DDX11
76Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GYY1F5GYY1_HUMAN
ATP-dependent DNA helicase DDX11
DDX11
171Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA67895 differs from that shown. Reason: Frameshift.Curated
The sequence CAA67895 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02480839I → S1 Publication1
Natural variantiVAR_069099263R → Q in WBRS; impairs the helicase activity by perturbing its DNA binding and DNA-dependent ATPase activity; reduces binding to rDNA promoter and promotion of rDNA transcription. 2 PublicationsCorresponds to variant dbSNP:rs201968272EnsemblClinVar.1
Natural variantiVAR_024809567Q → E2 PublicationsCorresponds to variant dbSNP:rs2075322EnsemblClinVar.1
Natural variantiVAR_024810575T → M1 PublicationCorresponds to variant dbSNP:rs17857386Ensembl.1
Natural variantiVAR_052175856R → H. Corresponds to variant dbSNP:rs1046457Ensembl.1
Natural variantiVAR_052176864C → R. Corresponds to variant dbSNP:rs3893679Ensembl.1
Natural variantiVAR_052177951C → R. Corresponds to variant dbSNP:rs1046458Ensembl.1
Natural variantiVAR_052178966W → C. Corresponds to variant dbSNP:rs14330Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0168601 – 26Missing in isoform 3. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_016861214 – 288VDEDE…RCVDM → APSDATSSRHPPDASFPAAL NFLQRTRPSSVLSEDLLMQR AVAKHPALLPWQMSSSPLRP GSEWMRMRMTWRKNT in isoform 5. 1 PublicationAdd BLAST75
Alternative sequenceiVSP_016862289 – 970Missing in isoform 5. 1 PublicationAdd BLAST682
Alternative sequenceiVSP_016863685 – 734Missing in isoform 4. 1 PublicationAdd BLAST50
Alternative sequenceiVSP_016864820 – 906SPRPG…GLFLM → PRAPGQAPPGKALVENLCMK AVNQSIGRAIRHQKDFASVV LLDQRYARPPVLAKLPAWIR ARVEVKATFGPAIAAVQKFH REKSASS in isoform 2, isoform 3 and isoform 4. 4 PublicationsAdd BLAST87
Alternative sequenceiVSP_016865907 – 970Missing in isoform 2, isoform 3 and isoform 4. 4 PublicationsAdd BLAST64

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X99583 mRNA Translation: CAA67895.1 Sequence problems.
U33833 mRNA Translation: AAB06962.1
U75967 mRNA Translation: AAB18749.1
U75968 mRNA Translation: AAB18750.1
BC050069 mRNA Translation: AAH50069.1
BC050522 mRNA Translation: AAH50522.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS41767.1 [Q96FC9-2]
CCDS44856.1 [Q96FC9-1]
CCDS58224.1 [Q96FC9-3]
CCDS8721.1 [Q96FC9-4]

Protein sequence database of the Protein Information Resource

More...
PIRi
G02071

NCBI Reference Sequences

More...
RefSeqi
NP_001244073.1, NM_001257144.1 [Q96FC9-1]
NP_001244074.1, NM_001257145.1 [Q96FC9-3]
NP_004390.3, NM_004399.2 [Q96FC9-4]
NP_689651.1, NM_152438.1 [Q96FC9-1]
XP_016874421.1, XM_017018932.1 [Q96FC9-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000228264; ENSP00000228264; ENSG00000013573 [Q96FC9-3]
ENST00000350437; ENSP00000309965; ENSG00000013573 [Q96FC9-4]
ENST00000435753; ENSP00000406799; ENSG00000013573 [Q96FC9-5]
ENST00000542838; ENSP00000443426; ENSG00000013573 [Q96FC9-2]
ENST00000545668; ENSP00000440402; ENSG00000013573 [Q96FC9-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1663

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1663

UCSC genome browser

More...
UCSCi
uc001rjr.2, human [Q96FC9-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 (DDX11)

Leiden Open Variation Database (LOVD)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99583 mRNA Translation: CAA67895.1 Sequence problems.
U33833 mRNA Translation: AAB06962.1
U75967 mRNA Translation: AAB18749.1
U75968 mRNA Translation: AAB18750.1
BC050069 mRNA Translation: AAH50069.1
BC050522 mRNA Translation: AAH50522.1
CCDSiCCDS41767.1 [Q96FC9-2]
CCDS44856.1 [Q96FC9-1]
CCDS58224.1 [Q96FC9-3]
CCDS8721.1 [Q96FC9-4]
PIRiG02071
RefSeqiNP_001244073.1, NM_001257144.1 [Q96FC9-1]
NP_001244074.1, NM_001257145.1 [Q96FC9-3]
NP_004390.3, NM_004399.2 [Q96FC9-4]
NP_689651.1, NM_152438.1 [Q96FC9-1]
XP_016874421.1, XM_017018932.1 [Q96FC9-2]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi108028, 43 interactors
CORUMiQ96FC9
IntActiQ96FC9, 25 interactors
STRINGi9606.ENSP00000440402

PTM databases

iPTMnetiQ96FC9
PhosphoSitePlusiQ96FC9

Genetic variation databases

BioMutaiDDX11
DMDMi74731686

Proteomic databases

EPDiQ96FC9
jPOSTiQ96FC9
MassIVEiQ96FC9
MaxQBiQ96FC9
PaxDbiQ96FC9
PeptideAtlasiQ96FC9
PRIDEiQ96FC9
ProteomicsDBi76511 [Q96FC9-1]
76512 [Q96FC9-2]
76513 [Q96FC9-3]
76514 [Q96FC9-4]
76515 [Q96FC9-5]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
24573, 228 antibodies

The DNASU plasmid repository

More...
DNASUi
1663

Genome annotation databases

EnsembliENST00000228264; ENSP00000228264; ENSG00000013573 [Q96FC9-3]
ENST00000350437; ENSP00000309965; ENSG00000013573 [Q96FC9-4]
ENST00000435753; ENSP00000406799; ENSG00000013573 [Q96FC9-5]
ENST00000542838; ENSP00000443426; ENSG00000013573 [Q96FC9-2]
ENST00000545668; ENSP00000440402; ENSG00000013573 [Q96FC9-1]
GeneIDi1663
KEGGihsa:1663
UCSCiuc001rjr.2, human [Q96FC9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1663
DisGeNETi1663

GeneCards: human genes, protein and diseases

More...
GeneCardsi
DDX11
GeneReviewsiDDX11
HGNCiHGNC:2736, DDX11
HPAiENSG00000013573, Low tissue specificity
MalaCardsiDDX11
MIMi601150, gene
613398, phenotype
neXtProtiNX_Q96FC9
OpenTargetsiENSG00000013573
Orphaneti280558, Warsaw breakage syndrome
PharmGKBiPA27201
VEuPathDBiHostDB:ENSG00000013573.16

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1133, Eukaryota
GeneTreeiENSGT00950000182970
HOGENOMiCLU_006515_2_1_1
InParanoidiQ96FC9
OMAiGLPYPNR
OrthoDBi186062at2759
PhylomeDBiQ96FC9
TreeFamiTF300435

Enzyme and pathway databases

PathwayCommonsiQ96FC9
ReactomeiR-HSA-381038, XBP1(S) activates chaperone genes

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
1663, 538 hits in 971 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
DDX11

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
1663
PharosiQ96FC9, Tbio

Protein Ontology

More...
PROi
PR:Q96FC9
RNActiQ96FC9, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000013573, Expressed in small intestine Peyer's patch and 190 other tissues
ExpressionAtlasiQ96FC9, baseline and differential
GenevisibleiQ96FC9, HS

Family and domain databases

InterProiView protein in InterPro
IPR006555, ATP-dep_Helicase_C
IPR028331, CHL1/DDX11
IPR010614, DEAD_2
IPR014013, Helic_SF1/SF2_ATP-bd_DinG/Rad3
IPR006554, Helicase-like_DEXD_c2
IPR027417, P-loop_NTPase
IPR013020, Rad3/Chl1-like
PANTHERiPTHR11472:SF41, PTHR11472:SF41, 1 hit
PfamiView protein in Pfam
PF06733, DEAD_2, 1 hit
PF13307, Helicase_C_2, 1 hit
SMARTiView protein in SMART
SM00488, DEXDc2, 1 hit
SM00491, HELICc2, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit
TIGRFAMsiTIGR00604, rad3, 1 hit
PROSITEiView protein in PROSITE
PS51193, HELICASE_ATP_BIND_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDDX11_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96FC9
Secondary accession number(s): Q13333
, Q86VQ4, Q86W62, Q92498, Q92770, Q92998, Q92999
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: December 1, 2001
Last modified: April 7, 2021
This is version 169 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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