PELI1

Functionⁱ

E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation (PubMed:12496252, PubMed:17675297). Mediates 'Lys-48'-linked polyubiquitination of RIPK3 leading to its subsequent proteasome-dependent degradation; preferentially recognizes and mediates the degradation of the 'Thr-182' phosphorylated form of RIPK3 (PubMed:29883609). Negatively regulates necroptosis by reducing RIPK3 expression (PubMed:29883609). Mediates 'Lys-63'-linked ubiquitination of RIPK1 (PubMed:29883609).3 Publications

Catalytic activityⁱ

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
1 Publication
Manual assertion based on experiment inⁱ
- Ref.12
  "PELI1 selectively targets kinase-active RIP3 for ubiquitylation-dependent proteasomal degradation."
  Choi S.W., Park H.H., Kim S., Chung J.M., Noh H.J., Kim S.K., Song H.K., Lee C.W., Morgan M.J., Kang H.C., Kim Y.S.
  Mol. Cell 70:920-935(2018) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION, CATALYTIC ACTIVITY, INTERACTION WITH RIPK1; IRAK1 AND RIPK3, MUTAGENESIS OF ARG-104; HIS-313 AND CYS-336, REGION RING-LIKE DOMAIN, TISSUE SPECIFICITY.
EC:2.3.2.27

Pathwayⁱ: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functionⁱ

protein serine/threonine kinase activity Source: Reactome
ubiquitin protein ligase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 29883609
ubiquitin-ubiquitin ligase activity Source: Reactome

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

interleukin-1-mediated signaling pathway Source: Reactome
negative regulation of necroptotic process
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 29883609
negative regulation of NF-kappaB transcription factor activity Source: Ensembl
negative regulation of T cell proliferation Source: Ensembl
positive regulation of B cell proliferation Source: Ensembl
positive regulation of cytokine production Source: Ensembl
positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Reactome
positive regulation of protein ubiquitination Source: Ensembl
positive regulation of toll-like receptor 3 signaling pathway Source: Ensembl
positive regulation of toll-like receptor 4 signaling pathway Source: Ensembl
proteasome-mediated ubiquitin-dependent protein catabolic process
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 29883609
protein K48-linked ubiquitination
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 29883609
protein K63-linked ubiquitination
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 29883609
protein polyubiquitination
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
response to dsRNA Source: Ensembl
response to lipopolysaccharide Source: Ensembl
Toll signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Transferase
Biological process	Ubl conjugation pathway

Enzyme and pathway databases

Reactomeⁱ	R-HSA-9020702 Interleukin-1 signaling R-HSA-937039 IRAK1 recruits IKK complex R-HSA-975144 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
SignaLinkⁱ	Q96FA3
SIGNORⁱ	Q96FA3
UniPathwayⁱ	UPA00143

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: E3 ubiquitin-protein ligase pellino homolog 1 (EC:2.3.2.271 Publication) Short name: Pellino-1 Alternative name(s): Pellino-related intracellular-signaling molecule RING-type E3 ubiquitin transferase pellino homolog 1Curated
Gene namesⁱ	Name:PELI1 Synonyms:PRISM
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000197329.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:8827 PELI1
MIMⁱ	614797 gene
neXtProtⁱ	NX_Q96FA3

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	104	R → A: Loss of ability to ubiquitinate RIPK3. Loss of interaction with RIPK1, IRAK1 and RIPK3. 1 Publication	1
Mutagenesisⁱ	313	H → A: Loss of ability to ubiquitinate RIPK3. No loss of interaction with RIPK3. 1 Publication	1
Mutagenesisⁱ	336	C → A: Loss of ability to ubiquitinate RIPK3. No loss of interaction with RIPK3. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	57162
Open Targets More...OpenTargetsⁱ	ENSG00000197329
PharmGKBⁱ	PA33172

Polymorphism and mutation databases

BioMutaⁱ	PELI1
DMDMⁱ	37999756

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000194172	1 – 418	E3 ubiquitin-protein ligase pellino homolog 1Add BLAST		418

Post-translational modificationⁱ

Phosphorylation by IRAK1 and IRAK4 enhances its E3 ligase activity.1 Publication

Sumoylated.1 Publication

Keywords - PTMⁱ

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q96FA3
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q96FA3
PaxDbⁱ	Q96FA3
PeptideAtlas More...PeptideAtlasⁱ	Q96FA3
PRIDEⁱ	Q96FA3
ProteomicsDBⁱ	76505

PTM databases

iPTMnetⁱ	Q96FA3
PhosphoSitePlusⁱ	Q96FA3

Expressionⁱ

Tissue specificityⁱ

Expressed at high levels in normal skin but decreased in keratinocytes from toxic epidermal necrolysis (TEN) patients (at protein level).1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000197329 Expressed in 225 organ(s), highest expression level in bone marrow
CleanExⁱ	HS_PELI1
ExpressionAtlasⁱ	Q96FA3 baseline and differential
Genevisibleⁱ	Q96FA3 HS

Interactionⁱ

Subunit structureⁱ

Interacts with MAP3K7. Upon IL1B treatment, forms a complex with TRAF6, IRAK1, IRAK4 and MYD88; this complex recruits MAP3K7/TAK1, TAB1 and TAB2 to mediate NF-kappa-B activation. Direct binding of SMAD6 to PELI1 prevents the complex formation and hence negatively regulates IL1R-TLR signaling and eventually NF-kappa-B-mediated gene expression (PubMed:12496252, PubMed:12804775, PubMed:16951688). Interacts (via atypical FHA domain) with RIPK3; preferentially binds to the 'Thr-182' phosphorylated form of RIPK3 (PubMed:29883609). Interacts with RIPK1 and IRAK1 (PubMed:29883609).4 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
IRAK1	P51617	4	EBI-448369,EBI-358664
IRAK4	Q9NWZ3	3	EBI-448369,EBI-448378
TRIP13	Q15645	3	EBI-448369,EBI-358993
VAC14	Q08AM6	3	EBI-448369,EBI-2107455

Protein-protein interaction databases

BioGridⁱ	121418, 28 interactors
CORUMⁱ	Q96FA3
Database of interacting proteins More...DIPⁱ	DIP-32488N
IntActⁱ	Q96FA3, 24 interactors
Molecular INTeraction database More...MINTⁱ	Q96FA3
STRINGⁱ	9606.ENSP00000351789

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q96FA3
SMRⁱ	Q96FA3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	13 – 200	FHA; atypicalBy similarityAdd BLAST		188

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	311 – 399	Ring-like domain; necessary for ubiqitination of RIPK31 PublicationAdd BLAST		89

Sequence similaritiesⁱ

Belongs to the pellino family.Curated

Phylogenomic databases

eggNOGⁱ	KOG3842 Eukaryota ENOG410XP3S LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000154724
HOGENOMⁱ	HOG000234110
HOVERGENⁱ	HBG053559
InParanoidⁱ	Q96FA3
KEGG Orthology (KO) More...KOⁱ	K11964
OMAⁱ	CPFCAQQ
Database of Orthologous Groups More...OrthoDBⁱ	837213at2759
PhylomeDBⁱ	Q96FA3
TreeFamⁱ	TF314338

Family and domain databases

InterProⁱ	View protein in InterPro IPR006800 Pellino_fam
PANTHERⁱ	PTHR12098 PTHR12098, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04710 Pellino, 1 hit
PIRSFⁱ	PIRSF038886 Pellino, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q96FA3-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MFSPDQENHP SKAPVKYGEL IVLGYNGSLP NGDRGRRKSR FALFKRPKAN 
        60         70         80         90        100
GVKPSTVHIA CTPQAAKAIS NKDQHSISYT LSRAQTVVVE YTHDSNTDMF 
       110        120        130        140        150
QIGRSTESPI DFVVTDTVPG SQSNSDTQSV QSTISRFACR IICERNPPFT 
       160        170        180        190        200
ARIYAAGFDS SKNIFLGEKA AKWKTSDGQM DGLTTNGVLV MHPRNGFTED 
       210        220        230        240        250
SKPGIWREIS VCGNVFSLRE TRSAQQRGKM VEIETNQLQD GSLIDLCGAT 
       260        270        280        290        300
LLWRTAEGLS HTPTVKHLEA LRQEINAARP QCPVGFNTLA FPSMKRKDVV 
       310        320        330        340        350
DEKQPWVYLN CGHVHGYHNW GNKEERDGKD RECPMCRSVG PYVPLWLGCE 
       360        370        380        390        400
AGFYVDAGPP THAFSPCGHV CSEKTTAYWS QIPLPHGTHT FHAACPFCAH 
       410 
QLAGEQGYIR LIFQGPLD

Length:418

Mass (Da):46,286

Last modified:October 24, 2003 - v2

Checksum:ⁱ233318A45E7546F7

GO

Sequence cautionⁱ

The sequence AAH11419 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence BAB55280 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	11	S → F in CAC04320 (PubMed:11132151).Curated	1
Sequence conflictⁱ	100	F → S in BAB55280 (PubMed:14702039).Curated	1
Sequence conflictⁱ	260	S → P in BAB55280 (PubMed:14702039).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ278859 mRNA Translation: CAC04320.1 AF302505 mRNA Translation: AAG15393.1 AF300987 mRNA Translation: AAG17451.1 BC011419 mRNA Translation: AAH11419.1 Different initiation. BC050019 mRNA Translation: AAH50019.1 BC063611 mRNA Translation: AAH63611.1 AK027668 mRNA Translation: BAB55280.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1876.1
NCBI Reference Sequences More...RefSeqⁱ	NP_065702.2, NM_020651.3 XP_011531296.1, XM_011532994.2 XP_016860009.1, XM_017004520.1
UniGeneⁱ	Hs.7886

Genome annotation databases

Ensemblⁱ	ENST00000358912; ENSP00000351789; ENSG00000197329
GeneIDⁱ	57162
KEGGⁱ	hsa:57162
UCSC genome browser More...UCSCⁱ	uc002sct.5 human

Protein	Similar proteins		Species	Score	Length	Source
Q96FA3	Pellino E3 ubiquitin protein ligase 1		SHEEP		419	UniRef100_Q96FA3
Pellino		HUMAN		418
E3 ubiquitin-protein ligase pellino homolog 1		TURTR		418
Pellino E3 ubiquitin protein ligase 1		PIG		418
Pellino E3 ubiquitin protein ligase 1		CERAT		418
+32

Protein	Similar proteins		Species	Score	Length	Source
Q96FA3	Pellino E3 ubiquitin protein ligase 1		SHEEP		419	UniRef90_Q96FA3
Pellino		HUMAN		418
E3 ubiquitin-protein ligase pellino homolog 1		TURTR		418
Pellino E3 ubiquitin protein ligase 1		PIG		418
Pellino E3 ubiquitin protein ligase 1		CERAT		418
+129

Protein	Similar proteins		Species	Score	Length	Source
Q96FA3	Pellino E3 ubiquitin protein ligase 1		SHEEP		419	UniRef50_Q96FA3
Pellino		HUMAN		418
E3 ubiquitin-protein ligase pellino homolog 1		TURTR		418
Pellino E3 ubiquitin protein ligase 1		PIG		418
Pellino E3 ubiquitin protein ligase 1		CERAT		418
+131

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ278859 mRNA Translation: CAC04320.1 AF302505 mRNA Translation: AAG15393.1 AF300987 mRNA Translation: AAG17451.1 BC011419 mRNA Translation: AAH11419.1 Different initiation. BC050019 mRNA Translation: AAH50019.1 BC063611 mRNA Translation: AAH63611.1 AK027668 mRNA Translation: BAB55280.1 Different initiation.
CCDSⁱ	CCDS1876.1
RefSeqⁱ	NP_065702.2, NM_020651.3 XP_011531296.1, XM_011532994.2 XP_016860009.1, XM_017004520.1
UniGeneⁱ	Hs.7886

3D structure databases

ProteinModelPortalⁱ	Q96FA3
SMRⁱ	Q96FA3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	121418, 28 interactors
CORUMⁱ	Q96FA3
DIPⁱ	DIP-32488N
IntActⁱ	Q96FA3, 24 interactors
MINTⁱ	Q96FA3
STRINGⁱ	9606.ENSP00000351789

PTM databases

iPTMnetⁱ	Q96FA3
PhosphoSitePlusⁱ	Q96FA3

Polymorphism and mutation databases

BioMutaⁱ	PELI1
DMDMⁱ	37999756

Proteomic databases

EPDⁱ	Q96FA3
MaxQBⁱ	Q96FA3
PaxDbⁱ	Q96FA3
PeptideAtlasⁱ	Q96FA3
PRIDEⁱ	Q96FA3
ProteomicsDBⁱ	76505

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	57162
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000358912; ENSP00000351789; ENSG00000197329
GeneIDⁱ	57162
KEGGⁱ	hsa:57162
UCSCⁱ	uc002sct.5 human

Organism-specific databases

CTDⁱ	57162
DisGeNETⁱ	57162
EuPathDBⁱ	HostDB:ENSG00000197329.11
GeneCardsⁱ	PELI1
HGNCⁱ	HGNC:8827 PELI1
MIMⁱ	614797 gene
neXtProtⁱ	NX_Q96FA3
OpenTargetsⁱ	ENSG00000197329
PharmGKBⁱ	PA33172
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3842 Eukaryota ENOG410XP3S LUCA
GeneTreeⁱ	ENSGT00940000154724
HOGENOMⁱ	HOG000234110
HOVERGENⁱ	HBG053559
InParanoidⁱ	Q96FA3
KOⁱ	K11964
OMAⁱ	CPFCAQQ
OrthoDBⁱ	837213at2759
PhylomeDBⁱ	Q96FA3
TreeFamⁱ	TF314338

Enzyme and pathway databases

UniPathwayⁱ	UPA00143
Reactomeⁱ	R-HSA-9020702 Interleukin-1 signaling R-HSA-937039 IRAK1 recruits IKK complex R-HSA-975144 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
SignaLinkⁱ	Q96FA3
SIGNORⁱ	Q96FA3

Miscellaneous databases

ChiTaRSⁱ	PELI1 human
GeneWikiⁱ	PELI1
GenomeRNAiⁱ	57162
Protein Ontology More...PROⁱ	PR:Q96FA3
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000197329 Expressed in 225 organ(s), highest expression level in bone marrow
CleanExⁱ	HS_PELI1
ExpressionAtlasⁱ	Q96FA3 baseline and differential
Genevisibleⁱ	Q96FA3 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR006800 Pellino_fam
PANTHERⁱ	PTHR12098 PTHR12098, 1 hit
Pfamⁱ	View protein in Pfam PF04710 Pellino, 1 hit
PIRSFⁱ	PIRSF038886 Pellino, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PELI1_HUMAN
Accessionⁱ	Q96FA3Primary (citable) accession number: Q96FA3 Secondary accession number(s): Q96SM0, Q9GZY5, Q9HCX0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 24, 2003
	Last sequence update:	October 24, 2003
	Last modified:	January 16, 2019
	This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PATHWAY comments
Index of metabolic and biosynthesis pathways
Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q96FA3 (PELI1_HUMAN)

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E3 ubiquitin-protein ligase pellino homolog 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

Catalytic activityⁱ

Pathwayⁱ: protein ubiquitination

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ