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Entry version 130 (17 Jun 2020)
Sequence version 3 (13 Nov 2007)
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Protein

Protein dispatched homolog 1

Gene

DISP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal (By similarity). Synergizes with SCUBE2 to cause an increase in SHH secretion (PubMed:22902404).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q96F81

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q96F81

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein dispatched homolog 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DISP1
Synonyms:DISPA
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000154309.8

Human Gene Nomenclature Database

More...
HGNCi
HGNC:19711 DISP1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607502 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96F81

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei190 – 210HelicalSequence analysisAdd BLAST21
Transmembranei500 – 520HelicalSequence analysisAdd BLAST21
Transmembranei525 – 545HelicalSequence analysisAdd BLAST21
Transmembranei549 – 569HelicalSequence analysisAdd BLAST21
Transmembranei604 – 624HelicalSequence analysisAdd BLAST21
Transmembranei638 – 658HelicalSequence analysisAdd BLAST21
Transmembranei719 – 739HelicalSequence analysisAdd BLAST21
Transmembranei988 – 1008HelicalSequence analysisAdd BLAST21
Transmembranei1010 – 1030HelicalSequence analysisAdd BLAST21
Transmembranei1040 – 1060HelicalSequence analysisAdd BLAST21
Transmembranei1079 – 1099HelicalSequence analysisAdd BLAST21
Transmembranei1107 – 1127HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
84976

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
DISP1

MalaCards human disease database

More...
MalaCardsi
DISP1

Open Targets

More...
OpenTargetsi
ENSG00000154309

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
93925 Alobar holoprosencephaly
93924 Lobar holoprosencephaly
280200 Microform holoprosencephaly
93926 Midline interhemispheric variant of holoprosencephaly
220386 Semilobar holoprosencephaly
280195 Septopreoptic holoprosencephaly

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134938043

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96F81 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DISP1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
160380707

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003106931 – 1524Protein dispatched homolog 1Add BLAST1524

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi59N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi582N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96F81

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q96F81

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q96F81

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96F81

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96F81

PeptideAtlas

More...
PeptideAtlasi
Q96F81

PRoteomics IDEntifications database

More...
PRIDEi
Q96F81

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
76499

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96F81

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96F81

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000154309 Expressed in esophagogastric junction muscularis propria and 151 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96F81 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000154309 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SHH via the cholesterol anchor of the dually lipid-modified SHH (ShhNp) (PubMed:22902404).

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
124405, 10 interactors

Protein interaction database and analysis system

More...
IntActi
Q96F81, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000284476

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q96F81 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini486 – 658SSDPROSITE-ProRule annotationAdd BLAST173

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the dispatched family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3664 Eukaryota
ENOG410XT7M LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157407

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004076_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96F81

Identification of Orthologs from Complete Genome Data

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OMAi
YYHVLAR

Database of Orthologous Groups

More...
OrthoDBi
1156918at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96F81

TreeFam database of animal gene trees

More...
TreeFami
TF324144

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR003392 Ptc/Disp
IPR000731 SSD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02460 Patched, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50156 SSD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q96F81-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAMSNGNNDF VVLSNSSIAT SAANPSPLTP CDGDHAAQQL TPKEATRTKV
60 70 80 90 100
SPNGCLQLNG TVKSSFLPLD NQRMPQMLPQ CCHPCPYHHP LTSHSSHQEC
110 120 130 140 150
HPEAGPAAPS ALASCCMQPH SEYSASLCPN HSPVYQTTCC LQPSPSFCLH
160 170 180 190 200
HPWPDHFQHQ PVQQHIANIR PSRPFKLPKS YAALIADWPV VVLGMCTMFI
210 220 230 240 250
VVCALVGVLV PELPDFSDPL LGFEPRGTAI GQRLVTWNNM VKNTGYKATL
260 270 280 290 300
ANYPFKYADE QAKSHRDDRW SDDHYEREKR EVDWNFHKDS FFCDVPSDRY
310 320 330 340 350
SRVVFTSSGG ETLWNLPAIK SMCNVDNSRI RSHPQFGDLC QRTTAASCCP
360 370 380 390 400
SWTLGNYIAI LNNRSSCQKI VERDVSHTLK LLRTCAKHYQ NGTLGPDCWD
410 420 430 440 450
MAARRKDQLK CTNVPRKCTK YNAVYQILHY LVDKDFMTPK TADYATPALK
460 470 480 490 500
YSMLFSPTEK GESMMNIYLD NFENWNSSDG VTTITGIEFG IKHSLFQDYL
510 520 530 540 550
LMDTVYPAIA IVIVLLVMCV YTKSMFITLM TMFAIISSLI VSYFLYRVVF
560 570 580 590 600
HFEFFPFMNL TALIILVGIG ADDAFVLCDV WNYTKFDKPH AETSETVSIT
610 620 630 640 650
LQHAALSMFV TSFTTAAAFY ANYVSNITAI RCFGVYAGTA ILVNYVLMVT
660 670 680 690 700
WLPAVVVLHE RYLLNIFTCF KKPQQQIYDN KSCWTVACQK CHKVLFAISE
710 720 730 740 750
ASRIFFEKVL PCIVIKFRYL WLFWFLALTV GGAYIVCINP KMKLPSLELS
760 770 780 790 800
EFQVFRSSHP FERYDAEYKK LFMFERVHHG EELHMPITVI WGVSPEDNGN
810 820 830 840 850
PLNPKSKGKL TLDSSFNIAS PASQAWILHF CQKLRNQTFF YQTDEQDFTS
860 870 880 890 900
CFIETFKQWM ENQDCDEPAL YPCCSHWSFP YKQEIFELCI KRAIMELERS
910 920 930 940 950
TGYHLDSKTP GPRFDINDTI RAVVLEFQST YLFTLAYEKM HQFYKEVDSW
960 970 980 990 1000
ISSELSSAPE GLSNGWFVSN LEFYDLQDSL SDGTLIAMGL SVAVAFSVML
1010 1020 1030 1040 1050
LTTWNIIISL YAIISIAGTI FVTVGSLVLL GWELNVLESV TISVAVGLSV
1060 1070 1080 1090 1100
DFAVHYGVAY RLAPDPDREG KVIFSLSRVG SAMAMAALTT FVAGAMMMPS
1110 1120 1130 1140 1150
TVLAYTQLGT FMMLIMCISW AFATFFFQCM CRCLGPQGTC GQIPLPKKLQ
1160 1170 1180 1190 1200
CSAFSHALST SPSDKGQSKT HTINAYHLDP RGPKSELEHE FYELEPLASH
1210 1220 1230 1240 1250
SCTAPEKTTY EETHICSEFF NSQAKNLGMP VHAAYNSELS KSTESDAGSA
1260 1270 1280 1290 1300
LLQPPLEQHT VCHFFSLNQR CSCPDAYKHL NYGPHSCQQM GDCLCHQCSP
1310 1320 1330 1340 1350
TTSSFVQIQN GVAPLKATHQ AVEGFVHPIT HIHHCPCLQG RVKPAGMQNS
1360 1370 1380 1390 1400
LPRNFFLHPV QHIQAQEKIG KTNVHSLQRS IEEHLPKMAE PSSFVCRSTG
1410 1420 1430 1440 1450
SLLKTCCDPE NKQRELCKNR DVSNLESSGG TENKAGGKVE LSLSQTDASV
1460 1470 1480 1490 1500
NSEHFNQNEP KVLFNHLMGE AGCRSCPNNS QSCGRIVRVK CNSVDCQMPN
1510 1520
MEANVPAVLT HSELSGESLL IKTL
Length:1,524
Mass (Da):170,934
Last modified:November 13, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i76399E8100DBC648
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH07734 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAB14637 differs from that shown. Reason: Frameshift.Curated
The sequence BAB15365 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti195M → I in BAC05373 (PubMed:14702039).Curated1
Sequence conflicti1247A → T in CAB61406 (PubMed:17974005).Curated1
Sequence conflicti1379R → G in BAB14637 (PubMed:14702039).Curated1
Sequence conflicti1392S → V in BAB14637 (PubMed:14702039).Curated1
Sequence conflicti1408D → N in AAH11542 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_037077103E → K. Corresponds to variant dbSNP:rs2609383EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC007734 mRNA Translation: AAH07734.1 Sequence problems.
BC011542 mRNA Translation: AAH11542.2
AK023679 mRNA Translation: BAB14637.1 Frameshift.
AK026114 mRNA Translation: BAB15365.1 Different initiation.
AK098669 mRNA Translation: BAC05373.1
AL133092 mRNA Translation: CAB61406.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1536.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T42693

NCBI Reference Sequences

More...
RefSeqi
NP_116279.2, NM_032890.3
XP_005273392.1, XM_005273335.2
XP_006711655.1, XM_006711592.2
XP_011508374.1, XM_011510072.2
XP_011508375.1, XM_011510073.2
XP_011508376.1, XM_011510074.2
XP_011508377.1, XM_011510075.2
XP_011508379.1, XM_011510077.2
XP_016858100.1, XM_017002611.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000284476; ENSP00000284476; ENSG00000154309

Database of genes from NCBI RefSeq genomes

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GeneIDi
84976

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:84976

UCSC genome browser

More...
UCSCi
uc057prm.1 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC007734 mRNA Translation: AAH07734.1 Sequence problems.
BC011542 mRNA Translation: AAH11542.2
AK023679 mRNA Translation: BAB14637.1 Frameshift.
AK026114 mRNA Translation: BAB15365.1 Different initiation.
AK098669 mRNA Translation: BAC05373.1
AL133092 mRNA Translation: CAB61406.1
CCDSiCCDS1536.1
PIRiT42693
RefSeqiNP_116279.2, NM_032890.3
XP_005273392.1, XM_005273335.2
XP_006711655.1, XM_006711592.2
XP_011508374.1, XM_011510072.2
XP_011508375.1, XM_011510073.2
XP_011508376.1, XM_011510074.2
XP_011508377.1, XM_011510075.2
XP_011508379.1, XM_011510077.2
XP_016858100.1, XM_017002611.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi124405, 10 interactors
IntActiQ96F81, 3 interactors
STRINGi9606.ENSP00000284476

PTM databases

iPTMnetiQ96F81
PhosphoSitePlusiQ96F81

Polymorphism and mutation databases

BioMutaiDISP1
DMDMi160380707

Proteomic databases

EPDiQ96F81
jPOSTiQ96F81
MassIVEiQ96F81
MaxQBiQ96F81
PaxDbiQ96F81
PeptideAtlasiQ96F81
PRIDEiQ96F81
ProteomicsDBi76499

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
34633 137 antibodies

Genome annotation databases

EnsembliENST00000284476; ENSP00000284476; ENSG00000154309
GeneIDi84976
KEGGihsa:84976
UCSCiuc057prm.1 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
84976
DisGeNETi84976
EuPathDBiHostDB:ENSG00000154309.8

GeneCards: human genes, protein and diseases

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GeneCardsi
DISP1
GeneReviewsiDISP1
HGNCiHGNC:19711 DISP1
HPAiENSG00000154309 Low tissue specificity
MalaCardsiDISP1
MIMi607502 gene
neXtProtiNX_Q96F81
OpenTargetsiENSG00000154309
Orphaneti93925 Alobar holoprosencephaly
93924 Lobar holoprosencephaly
280200 Microform holoprosencephaly
93926 Midline interhemispheric variant of holoprosencephaly
220386 Semilobar holoprosencephaly
280195 Septopreoptic holoprosencephaly
PharmGKBiPA134938043

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3664 Eukaryota
ENOG410XT7M LUCA
GeneTreeiENSGT00940000157407
HOGENOMiCLU_004076_1_0_1
InParanoidiQ96F81
OMAiYYHVLAR
OrthoDBi1156918at2759
PhylomeDBiQ96F81
TreeFamiTF324144

Enzyme and pathway databases

SignaLinkiQ96F81
SIGNORiQ96F81

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
84976 0 hits in 786 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
DISP1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
84976
PharosiQ96F81 Tbio

Protein Ontology

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PROi
PR:Q96F81
RNActiQ96F81 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000154309 Expressed in esophagogastric junction muscularis propria and 151 other tissues
GenevisibleiQ96F81 HS

Family and domain databases

InterProiView protein in InterPro
IPR003392 Ptc/Disp
IPR000731 SSD
PfamiView protein in Pfam
PF02460 Patched, 2 hits
PROSITEiView protein in PROSITE
PS50156 SSD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDISP1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96F81
Secondary accession number(s): Q8N7C2
, Q96I92, Q9H698, Q9H8H9, Q9UFA2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: June 17, 2020
This is version 130 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
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