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UniProtKB - Q96F63 (CCD97_HUMAN)

Entry version 134 (25 May 2022)
Sequence version 1 (01 Dec 2001)
Previous versions | rss
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Protein

Coiled-coil domain-containing protein 97

Gene

CCDC97

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q96F63

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q96F63

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Coiled-coil domain-containing protein 97
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CCDC97
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:28289, CCDC97

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q96F63

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000142039

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		90324

Open Targets

More...OpenTargetsi		ENSG00000142039

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA144596464

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q96F63, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CCDC97

Domain mapping of disease mutations (DMDM)

More...DMDMi		74731660

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002860961 – 343Coiled-coil domain-containing protein 97Add BLAST343

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei47PhosphothreonineCombined sources1
Modified residuei275PhosphoserineCombined sources1
Modified residuei337PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q96F63

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q96F63

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q96F63

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q96F63

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q96F63

PeptideAtlas

More...PeptideAtlasi		Q96F63

PRoteomics IDEntifications database

More...PRIDEi		Q96F63

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		76498

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q96F63, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q96F63

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q96F63

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000142039, Expressed in testis and 208 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q96F63, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q96F63, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000142039, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		124693, 59 interactors

Protein interaction database and analysis system

More...IntActi		Q96F63, 22 interactors

Molecular INTeraction database

More...MINTi		Q96F63

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000269967

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q96F63, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q96F63

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q96F63

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 37DisorderedSequence analysisAdd BLAST37
Regioni200 – 220DisorderedSequence analysisAdd BLAST21
Regioni234 – 277DisorderedSequence analysisAdd BLAST44
Regioni292 – 343DisorderedSequence analysisAdd BLAST52

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili224 – 262Sequence analysisAdd BLAST39

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi244 – 262Acidic residuesSequence analysisAdd BLAST19
Compositional biasi263 – 277Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi323 – 343Acidic residuesSequence analysisAdd BLAST21

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3044, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000015495

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_058245_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q96F63

Identification of Orthologs from Complete Genome Data

More...OMAi		DSYDVRN

Database of Orthologous Groups

More...OrthoDBi		1227195at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q96F63

TreeFam database of animal gene trees

More...TreeFami		TF316152

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR040233, CCD97-like_C
IPR018613, Ccdc97-like

The PANTHER Classification System

More...PANTHERi		PTHR31840, PTHR31840, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF09747, DUF2052, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q96F63-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEAVATATAA KEPDKGCIEP GPGHWGELSR TPVPSKPQDK VEAAEATPVA 
        60         70         80         90        100
LDSDTSGAEN AAVSAMLHAV AASRLPVCSQ QQGEPDLTEH EKVAILAQLY 
       110        120        130        140        150
HEKPLVFLER FRTGLREEHL ACFGHVRGDH RADFYCAEVA RQGTARPRTL 
       160        170        180        190        200
RTRLRNRRYA ALRELIQGGE YFSDEQMRFR APLLYEQYIG QYLTQEELSA 
       210        220        230        240        250
RTPTHQPPKP GSPGRPACPL SNLLLQSYEE RELQQRLLQQ QEEEEACLEE 
       260        270        280        290        300
EEEEEDSDEE DQRSGKDSEA WVPDSEERLI LREEFTSRMH QRFLDGKDGD 
       310        320        330        340 
FDYSTVDDNP DFDNLDIVAR DEEERYFDEE EPEDAPSPEL DGD
Length:343
Mass (Da):38,947
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5153E473FF0D2069
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0QXS4M0QXS4_HUMAN
Coiled-coil domain-containing prote...
CCDC97
154Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QZY6M0QZY6_HUMAN
Coiled-coil domain-containing prote...
CCDC97
16Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
BC007575 mRNA Translation: AAH07575.1
BC011577 mRNA Translation: AAH11577.1
AL833726 mRNA Translation: CAH56251.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS12578.1

NCBI Reference Sequences

More...RefSeqi		NP_443080.1, NM_052848.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000269967.4; ENSP00000269967.2; ENSG00000142039.4

Database of genes from NCBI RefSeq genomes

More...GeneIDi		90324

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:90324

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000269967.4; ENSP00000269967.2; NM_052848.3; NP_443080.1

UCSC genome browser

More...UCSCi		uc002oqg.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC007575 mRNA Translation: AAH07575.1
BC011577 mRNA Translation: AAH11577.1
AL833726 mRNA Translation: CAH56251.1
CCDSiCCDS12578.1
RefSeqiNP_443080.1, NM_052848.2

3D structure databases

AlphaFoldDBiQ96F63
SMRiQ96F63
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi124693, 59 interactors
IntActiQ96F63, 22 interactors
MINTiQ96F63
STRINGi9606.ENSP00000269967

PTM databases

GlyGeniQ96F63, 1 site, 1 O-linked glycan (1 site)
iPTMnetiQ96F63
PhosphoSitePlusiQ96F63

Genetic variation databases

BioMutaiCCDC97
DMDMi74731660

Proteomic databases

EPDiQ96F63
jPOSTiQ96F63
MassIVEiQ96F63
MaxQBiQ96F63
PaxDbiQ96F63
PeptideAtlasiQ96F63
PRIDEiQ96F63
ProteomicsDBi76498

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		48733, 130 antibodies from 20 providers

The DNASU plasmid repository

More...DNASUi		90324

Genome annotation databases

EnsembliENST00000269967.4; ENSP00000269967.2; ENSG00000142039.4
GeneIDi90324
KEGGihsa:90324
MANE-SelectiENST00000269967.4; ENSP00000269967.2; NM_052848.3; NP_443080.1
UCSCiuc002oqg.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		90324
DisGeNETi90324

GeneCards: human genes, protein and diseases

More...GeneCardsi		CCDC97
HGNCiHGNC:28289, CCDC97
HPAiENSG00000142039, Low tissue specificity
neXtProtiNX_Q96F63
OpenTargetsiENSG00000142039
PharmGKBiPA144596464
VEuPathDBiHostDB:ENSG00000142039

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3044, Eukaryota
GeneTreeiENSGT00390000015495
HOGENOMiCLU_058245_1_1_1
InParanoidiQ96F63
OMAiDSYDVRN
OrthoDBi1227195at2759
PhylomeDBiQ96F63
TreeFamiTF316152

Enzyme and pathway databases

PathwayCommonsiQ96F63
SignaLinkiQ96F63

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		90324, 15 hits in 1085 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CCDC97, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		90324
PharosiQ96F63, Tdark

Protein Ontology

More...PROi		PR:Q96F63
RNActiQ96F63, protein

Gene expression databases

BgeeiENSG00000142039, Expressed in testis and 208 other tissues
ExpressionAtlasiQ96F63, baseline and differential
GenevisibleiQ96F63, HS

Family and domain databases

InterProiView protein in InterPro
IPR040233, CCD97-like_C
IPR018613, Ccdc97-like
PANTHERiPTHR31840, PTHR31840, 1 hit
PfamiView protein in Pfam
PF09747, DUF2052, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCCD97_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96F63
Secondary accession number(s): Q658N6, Q96IF3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: December 1, 2001
Last modified: May 25, 2022
This is version 134 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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