TRIM11

Functionⁱ

E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis. May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation pathway. Mediates MED15 ubiquitination leading to proteasomal degradation. May contribute to the innate restriction of retroviruses. Upon overexpression, reduces HIV-1 and murine leukemia virus infectivity, by suppressing viral gene expression. Antiviral activity depends on a functional E3 ubiquitin-protein ligase domain. May regulate TRIM5 turnover via the proteasome pathway, thus counteracting the TRIM5-mediated cross-species restriction of retroviral infection at early stages of the retroviral life cycle.1 Publication

Catalytic activityⁱ

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N₆-ubiquitinyl-[acceptor protein]-L-lysine.

Pathwayⁱ: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	16 – 57	RING-typePROSITE-ProRule annotationAdd BLAST		42
Zinc fingerⁱ	87 – 128	B box-typePROSITE-ProRule annotationAdd BLAST		42

GO - Molecular functionⁱ

protein domain specific binding Source: Ensembl
transcription factor binding Source: Ensembl
ubiquitin protein ligase activity Source: Ensembl
zinc ion binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

defense response to virus Source: UniProtKB-KW
innate immune response
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 18248090
negative regulation of neurogenesis Source: Ensembl
negative regulation of transcription, DNA-templated Source: Ensembl
negative regulation of viral entry into host cell
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 18248090
negative regulation of viral release from host cell
Source: UniProtKB
Inferred from direct assayⁱ
- 18248090
negative regulation of viral transcription
Source: UniProtKB
Inferred from direct assayⁱ
- 18248090
positive regulation of viral entry into host cell
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 18248090

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Transferase
Biological process	Antiviral defense, Ubl conjugation pathway
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
SIGNORⁱ	Q96F44
UniPathwayⁱ	UPA00143

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: E3 ubiquitin-protein ligase TRIM11 (EC:2.3.2.27) Alternative name(s): Protein BIA1 RING finger protein 92 RING-type E3 ubiquitin transferase TRIM11Curated Tripartite motif-containing protein 11
Gene namesⁱ	Name:TRIM11 Synonyms:RNF92
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000154370.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:16281 TRIM11
MIMⁱ	607868 gene
neXtProtⁱ	NX_Q96F44

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	81559
Open Targets More...OpenTargetsⁱ	ENSG00000154370
PharmGKBⁱ	PA38112

Polymorphism and mutation databases

BioMutaⁱ	TRIM11
DMDMⁱ	26400672

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000056215	1 – 468	E3 ubiquitin-protein ligase TRIM11Add BLAST		468

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	85	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q96F44
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q96F44
PaxDbⁱ	Q96F44
PeptideAtlas More...PeptideAtlasⁱ	Q96F44
PRIDEⁱ	Q96F44
ProteomicsDBⁱ	76490 76491 [Q96F44-2] 76492 [Q96F44-3]
TopDownProteomicsⁱ	Q96F44-1 [Q96F44-1]

PTM databases

iPTMnetⁱ	Q96F44
PhosphoSitePlusⁱ	Q96F44

Expressionⁱ

Tissue specificityⁱ

Ubiquitous.

Gene expression databases

Bgeeⁱ	ENSG00000154370 Expressed in 175 organ(s), highest expression level in right hemisphere of cerebellum
CleanExⁱ	HS_TRIM11
ExpressionAtlasⁱ	Q96F44 baseline and differential
Genevisibleⁱ	Q96F44 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA028541 HPA043879

HPAⁱ

HPA028541
HPA043879

Interactionⁱ

Subunit structureⁱ

Binds cytoplasmic tail of integrin alpha-1. Interacts with the HN peptide (By similarity). Interacts with PHOX2B (By similarity). Interacts with PAX6 (By similarity). Interacts with MED15/ARC105; this interaction leads to MED15 ubiquitination and proteasomal degradation.By similarity1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
MED15	Q96RN5	5	EBI-851809,EBI-394506

With

Entry

#Exp.

IntAct

Notes

MED15

Q96RN5

5

EBI-851809,EBI-394506

GO - Molecular functionⁱ

protein domain specific binding Source: Ensembl
transcription factor binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	123523, 80 interactors
IntActⁱ	Q96F44, 10 interactors
Molecular INTeraction database More...MINTⁱ	Q96F44
STRINGⁱ	9606.ENSP00000284551

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q96F44
SMRⁱ	Q96F44
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	268 – 461	B30.2/SPRYPROSITE-ProRule annotationAdd BLAST		194

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	129 – 208	Sequence analysisAdd BLAST		80

Domainⁱ

The coiled-coil domain and the B30.2 domain are both necessary for interaction with HN and PAX6 (By similarity). They are also involved in MED15-binding.By similarity

The B30.2 domain may be involved cellular protein quality control by promoting the degradation of insoluble ubiquitinated proteins.By similarity

Sequence similaritiesⁱ

Belongs to the TRIM/RBCC family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	16 – 57	RING-typePROSITE-ProRule annotationAdd BLAST		42
Zinc fingerⁱ	87 – 128	B box-typePROSITE-ProRule annotationAdd BLAST		42

Keywords - Domainⁱ

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG2177 Eukaryota ENOG4111G04 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118893
HOVERGENⁱ	HBG001357
InParanoidⁱ	Q96F44
KEGG Orthology (KO) More...KOⁱ	K10650
OMAⁱ	FAGNGFW
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G05W2
PhylomeDBⁱ	Q96F44
TreeFamⁱ	TF338674

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00021 BBOX, 1 hit
Gene3Dⁱ	3.30.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR001870 B30.2/SPRY IPR003879 Butyrophylin_SPRY IPR013320 ConA-like_dom_sf IPR006574 PRY IPR003877 SPRY_dom IPR000315 Znf_B-box IPR001841 Znf_RING IPR013083 Znf_RING/FYVE/PHD IPR017907 Znf_RING_CS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13765 PRY, 1 hit PF00622 SPRY, 1 hit PF00643 zf-B_box, 1 hit
PRINTSⁱ	PR01407 BUTYPHLNCDUF
SMARTⁱ	View protein in SMART SM00336 BBOX, 1 hit SM00589 PRY, 1 hit SM00184 RING, 1 hit SM00449 SPRY, 1 hit
SUPFAMⁱ	SSF49899 SSF49899, 1 hit
PROSITEⁱ	View protein in PROSITE PS50188 B302_SPRY, 1 hit PS50119 ZF_BBOX, 1 hit PS00518 ZF_RING_1, 1 hit PS50089 ZF_RING_2, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q96F44-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAPDLSTNL QEEATCAICL DYFTDPVMTD CGHNFCRECI RRCWGQPEGP 
        60         70         80         90        100
YACPECRELS PQRNLRPNRP LAKMAEMARR LHPPSPVPQG VCPAHREPLA 
       110        120        130        140        150
AFCGDELRLL CAACERSGEH WAHRVRPLQD AAEDLKAKLE KSLEHLRKQM 
       160        170        180        190        200
QDALLFQAQA DETCVLWQKM VESQRQNVLG EFERLRRLLA EEEQQLLQRL 
       210        220        230        240        250
EEEELEVLPR LREGAAHLGQ QSAHLAELIA ELEGRCQLPA LGLLQDIKDA 
       260        270        280        290        300
LRRVQDVKLQ PPEVVPMELR TVCRVPGLVE TLRRFRGDVT LDPDTANPEL 
       310        320        330        340        350
ILSEDRRSVQ RGDLRQALPD SPERFDPGPC VLGQERFTSG RHYWEVEVGD 
       360        370        380        390        400
RTSWALGVCR ENVNRKEKGE LSAGNGFWIL VFLGSYYNSS ERALAPLRDP 
       410        420        430        440        450
PRRVGIFLDY EAGHLSFYSA TDGSLLFIFP EIPFSGTLRP LFSPLSSSPT 
       460 
PMTICRPKGG SGDTLAPQ

Length:468

Mass (Da):52,774

Last modified:December 6, 2002 - v2

Checksum:ⁱ8DE4BDF79F221739

GO

Isoform 2 (identifier: Q96F44-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
288-385: DVTLDPDTAN...GFWILVFLGS → RCGGPRWGDD...TTGVSTDPTD
386-468: Missing.

« Hide

        10         20         30         40         50
MAAPDLSTNL QEEATCAICL DYFTDPVMTD CGHNFCRECI RRCWGQPEGP 
        60         70         80         90        100
YACPECRELS PQRNLRPNRP LAKMAEMARR LHPPSPVPQG VCPAHREPLA 
       110        120        130        140        150
AFCGDELRLL CAACERSGEH WAHRVRPLQD AAEDLKAKLE KSLEHLRKQM 
       160        170        180        190        200
QDALLFQAQA DETCVLWQKM VESQRQNVLG EFERLRRLLA EEEQQLLQRL 
       210        220        230        240        250
EEEELEVLPR LREGAAHLGQ QSAHLAELIA ELEGRCQLPA LGLLQDIKDA 
       260        270        280        290        300
LRRVQDVKLQ PPEVVPMELR TVCRVPGLVE TLRRFRGRCG GPRWGDDSRR 
       310        320        330        340        350
GPAKDLGSQP RVLCPATASS KLTVSWWWVV GKTSSAHTSD ISCVGIFTPN 
       360        370        380 
NSSTSGNELG IQGFHSALNR IASADTTGVS TDPTD

Note: No experimental confirmation available.

Show »

Length:385

Mass (Da):42,974

Checksum:ⁱ13A971DE70ECD27E

GO

Isoform 3 (identifier: Q96F44-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
169-169: Missing.

« Hide

        10         20         30         40         50
MAAPDLSTNL QEEATCAICL DYFTDPVMTD CGHNFCRECI RRCWGQPEGP 
        60         70         80         90        100
YACPECRELS PQRNLRPNRP LAKMAEMARR LHPPSPVPQG VCPAHREPLA 
       110        120        130        140        150
AFCGDELRLL CAACERSGEH WAHRVRPLQD AAEDLKAKLE KSLEHLRKQM 
       160        170        180        190        200
QDALLFQAQA DETCVLWQMV ESQRQNVLGE FERLRRLLAE EEQQLLQRLE 
       210        220        230        240        250
EEELEVLPRL REGAAHLGQQ SAHLAELIAE LEGRCQLPAL GLLQDIKDAL 
       260        270        280        290        300
RRVQDVKLQP PEVVPMELRT VCRVPGLVET LRRFRGDVTL DPDTANPELI 
       310        320        330        340        350
LSEDRRSVQR GDLRQALPDS PERFDPGPCV LGQERFTSGR HYWEVEVGDR 
       360        370        380        390        400
TSWALGVCRE NVNRKEKGEL SAGNGFWILV FLGSYYNSSE RALAPLRDPP 
       410        420        430        440        450
RRVGIFLDYE AGHLSFYSAT DGSLLFIFPE IPFSGTLRPL FSPLSSSPTP 
       460 
MTICRPKGGS GDTLAPQ

Note: May be due to competing acceptor splice site. No experimental confirmation available.

Show »

Length:467

Mass (Da):52,646

Checksum:ⁱCEE334A7ADC3147E

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

R4GMV1	R4GMV1_HUMAN	E3 ubiquitin-protein ligase TRIM11 E3 ubiquitin-protein ligase TRIM11	TRIM11	343	Annotation score:
R4GNB9	R4GNB9_HUMAN	E3 ubiquitin-protein ligase TRIM11 E3 ubiquitin-protein ligase TRIM11	TRIM11	228	Annotation score:
R4GNC3	R4GNC3_HUMAN	E3 ubiquitin-protein ligase TRIM11 E3 ubiquitin-protein ligase TRIM11	TRIM11	54	Annotation score:

Sequence cautionⁱ

The sequence AAH11629 differs from that shown. Reason: Erroneous initiation.Curated

The sequence BAG53535 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence BAG63300 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	234	G → D in BAG53535 (PubMed:14702039).Curated	1
Sequence conflictⁱ	260	Q → R in BAG37129 (PubMed:14702039).Curated	1
Sequence conflictⁱ	289	V → M in BAG53535 (PubMed:14702039).Curated	1
Sequence conflictⁱ	319	P → S in BAG53535 (PubMed:14702039).Curated	1
Sequence conflictⁱ	395 – 398	APLR → GSIP in AAG53498 (PubMed:11331580).Curated	4
Sequence conflictⁱ	467	P → A in AAG53498 (PubMed:11331580).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_039628	169	Missing in isoform 3. 1 Publication	1
Alternative sequenceⁱVSP_012057	288 – 385	DVTLD…VFLGS → RCGGPRWGDDSRRGPAKDLG SQPRVLCPATASSKLTVSWW WVVGKTSSAHTSDISCVGIF TPNNSSTSGNELGIQGFHSA LNRIASADTTGVSTDPTD in isoform 2. 1 PublicationAdd BLAST	98
Alternative sequenceⁱVSP_012058	386 – 468	Missing in isoform 2. 1 PublicationAdd BLAST	83

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF327056 mRNA Translation: AAM63957.1 AK074866 mRNA Translation: BAC11254.1 AK314539 mRNA Translation: BAG37129.1 AK097825 mRNA Translation: BAG53535.1 Different initiation. AK301859 mRNA Translation: BAG63300.1 Different initiation. AL670729 Genomic DNA No translation available. BC011629 mRNA Translation: AAH11629.1 Different initiation. BC069227 mRNA Translation: AAH69227.1 AF220125 mRNA Translation: AAG53498.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS31048.1 [Q96F44-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_660215.1, NM_145214.2 [Q96F44-1] XP_016857901.1, XM_017002412.1 [Q96F44-3]
UniGeneⁱ	Hs.13543

Genome annotation databases

Ensemblⁱ	ENST00000284551; ENSP00000284551; ENSG00000154370 [Q96F44-1] ENST00000366699; ENSP00000355660; ENSG00000154370 [Q96F44-2]
GeneIDⁱ	81559
KEGGⁱ	hsa:81559
UCSC genome browser More...UCSCⁱ	uc001hss.4 human [Q96F44-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q96F44	TRIM11 isoform 2		PANTR		468	UniRef100_Q96F44
Uncharacterized protein		PANPA		468

Protein	Similar proteins		Species	Score	Length	Source
Q96F44	TRIM11 isoform 2		PANTR		468	UniRef90_Q96F44
Uncharacterized protein		PANPA		468
Tripartite motif-containing protein 11		PTEAL		484
E3 ubiquitin-protein ligase TRIM11		CALJA		468
Tripartite motif containing 11		GORGO		468
+13
Q96F44-2	TRIM11 isoform 2		PONAB		385	UniRef90_Q96F44-2
TRIM11 isoform 5		PANTR		385
Tripartite motif containing 11		GORGO		384
Uncharacterized protein		MACNE		363
Uncharacterized protein		MACMU		363
+3

Protein	Similar proteins		Species	Score	Length	Source
Q96F44	E3 ubiquitin-protein ligase TRIM11		MOUSE		467	UniRef50_Q99PQ2
E3 ubiquitin-protein ligase TRIM11		RAT		467
E3 ubiquitin-protein ligase TRIM11		BOVIN		468
TRIM11 isoform 1		PONAB		468
Uncharacterized protein		ICTTR		468
+142
Q96F44-2	TRIM11 isoform 5		PANTR		385	UniRef50_Q96F44-2
TRIM11 isoform 2		PONAB		385
Tripartite motif containing 11		GORGO		384
Uncharacterized protein		MACMU		363
Uncharacterized protein		MACFA		363
+31

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF327056 mRNA Translation: AAM63957.1 AK074866 mRNA Translation: BAC11254.1 AK314539 mRNA Translation: BAG37129.1 AK097825 mRNA Translation: BAG53535.1 Different initiation. AK301859 mRNA Translation: BAG63300.1 Different initiation. AL670729 Genomic DNA No translation available. BC011629 mRNA Translation: AAH11629.1 Different initiation. BC069227 mRNA Translation: AAH69227.1 AF220125 mRNA Translation: AAG53498.1
CCDSⁱ	CCDS31048.1 [Q96F44-1]
RefSeqⁱ	NP_660215.1, NM_145214.2 [Q96F44-1] XP_016857901.1, XM_017002412.1 [Q96F44-3]
UniGeneⁱ	Hs.13543

3D structure databases

ProteinModelPortalⁱ	Q96F44
SMRⁱ	Q96F44
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	123523, 80 interactors
IntActⁱ	Q96F44, 10 interactors
MINTⁱ	Q96F44
STRINGⁱ	9606.ENSP00000284551

PTM databases

iPTMnetⁱ	Q96F44
PhosphoSitePlusⁱ	Q96F44

Polymorphism and mutation databases

BioMutaⁱ	TRIM11
DMDMⁱ	26400672

Proteomic databases

EPDⁱ	Q96F44
MaxQBⁱ	Q96F44
PaxDbⁱ	Q96F44
PeptideAtlasⁱ	Q96F44
PRIDEⁱ	Q96F44
ProteomicsDBⁱ	76490 76491 [Q96F44-2] 76492 [Q96F44-3]
TopDownProteomicsⁱ	Q96F44-1 [Q96F44-1]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	81559
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000284551; ENSP00000284551; ENSG00000154370 [Q96F44-1] ENST00000366699; ENSP00000355660; ENSG00000154370 [Q96F44-2]
GeneIDⁱ	81559
KEGGⁱ	hsa:81559
UCSCⁱ	uc001hss.4 human [Q96F44-1]

Organism-specific databases

CTDⁱ	81559
DisGeNETⁱ	81559
EuPathDBⁱ	HostDB:ENSG00000154370.13
GeneCardsⁱ	TRIM11
HGNCⁱ	HGNC:16281 TRIM11
HPAⁱ	HPA028541 HPA043879
MIMⁱ	607868 gene
neXtProtⁱ	NX_Q96F44
OpenTargetsⁱ	ENSG00000154370
PharmGKBⁱ	PA38112
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2177 Eukaryota ENOG4111G04 LUCA
GeneTreeⁱ	ENSGT00760000118893
HOVERGENⁱ	HBG001357
InParanoidⁱ	Q96F44
KOⁱ	K10650
OMAⁱ	FAGNGFW
OrthoDBⁱ	EOG091G05W2
PhylomeDBⁱ	Q96F44
TreeFamⁱ	TF338674

Enzyme and pathway databases

UniPathwayⁱ	UPA00143
Reactomeⁱ	R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
SIGNORⁱ	Q96F44

Miscellaneous databases

GeneWikiⁱ	TRIM11
GenomeRNAiⁱ	81559
Protein Ontology More...PROⁱ	PR:Q96F44
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000154370 Expressed in 175 organ(s), highest expression level in right hemisphere of cerebellum
CleanExⁱ	HS_TRIM11
ExpressionAtlasⁱ	Q96F44 baseline and differential
Genevisibleⁱ	Q96F44 HS

Family and domain databases

CDDⁱ	cd00021 BBOX, 1 hit
Gene3Dⁱ	3.30.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR001870 B30.2/SPRY IPR003879 Butyrophylin_SPRY IPR013320 ConA-like_dom_sf IPR006574 PRY IPR003877 SPRY_dom IPR000315 Znf_B-box IPR001841 Znf_RING IPR013083 Znf_RING/FYVE/PHD IPR017907 Znf_RING_CS
Pfamⁱ	View protein in Pfam PF13765 PRY, 1 hit PF00622 SPRY, 1 hit PF00643 zf-B_box, 1 hit
PRINTSⁱ	PR01407 BUTYPHLNCDUF
SMARTⁱ	View protein in SMART SM00336 BBOX, 1 hit SM00589 PRY, 1 hit SM00184 RING, 1 hit SM00449 SPRY, 1 hit
SUPFAMⁱ	SSF49899 SSF49899, 1 hit
PROSITEⁱ	View protein in PROSITE PS50188 B302_SPRY, 1 hit PS50119 ZF_BBOX, 1 hit PS00518 ZF_RING_1, 1 hit PS50089 ZF_RING_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TRI11_HUMAN
Accessionⁱ	Q96F44Primary (citable) accession number: Q96F44 Secondary accession number(s): A6NKE2 Q9C022
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 6, 2002
	Last sequence update:	December 6, 2002
	Last modified:	November 7, 2018
	This is version 170 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PATHWAY comments
Index of metabolic and biosynthesis pathways

UniProtKB

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UniRef

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Supporting data

UniProtKB - Q96F44 (TRI11_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

E3 ubiquitin-protein ligase TRIM11

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

Pathwayⁱ: protein ubiquitination

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ