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Protein

E3 ubiquitin-protein ligase TRIM11

Gene

TRIM11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis. May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation pathway. Mediates MED15 ubiquitination leading to proteasomal degradation. May contribute to the innate restriction of retroviruses. Upon overexpression, reduces HIV-1 and murine leukemia virus infectivity, by suppressing viral gene expression. Antiviral activity depends on a functional E3 ubiquitin-protein ligase domain. May regulate TRIM5 turnover via the proteasome pathway, thus counteracting the TRIM5-mediated cross-species restriction of retroviral infection at early stages of the retroviral life cycle.1 Publication

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri16 – 57RING-typePROSITE-ProRule annotationAdd BLAST42
Zinc fingeri87 – 128B box-typePROSITE-ProRule annotationAdd BLAST42

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processAntiviral defense, Ubl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
SIGNORiQ96F44
UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase TRIM11 (EC:2.3.2.27)
Alternative name(s):
Protein BIA1
RING finger protein 92
RING-type E3 ubiquitin transferase TRIM11Curated
Tripartite motif-containing protein 11
Gene namesi
Name:TRIM11
Synonyms:RNF92
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000154370.13
HGNCiHGNC:16281 TRIM11
MIMi607868 gene
neXtProtiNX_Q96F44

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi81559
OpenTargetsiENSG00000154370
PharmGKBiPA38112

Polymorphism and mutation databases

BioMutaiTRIM11
DMDMi26400672

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000562151 – 468E3 ubiquitin-protein ligase TRIM11Add BLAST468

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei85PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96F44
MaxQBiQ96F44
PaxDbiQ96F44
PeptideAtlasiQ96F44
PRIDEiQ96F44
ProteomicsDBi76490
76491 [Q96F44-2]
76492 [Q96F44-3]
TopDownProteomicsiQ96F44-1 [Q96F44-1]

PTM databases

iPTMnetiQ96F44
PhosphoSitePlusiQ96F44

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000154370 Expressed in 175 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_TRIM11
ExpressionAtlasiQ96F44 baseline and differential
GenevisibleiQ96F44 HS

Organism-specific databases

HPAiHPA028541
HPA043879

Interactioni

Subunit structurei

Binds cytoplasmic tail of integrin alpha-1. Interacts with the HN peptide (By similarity). Interacts with PHOX2B (By similarity). Interacts with PAX6 (By similarity). Interacts with MED15/ARC105; this interaction leads to MED15 ubiquitination and proteasomal degradation.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
MED15Q96RN55EBI-851809,EBI-394506

GO - Molecular functioni

Protein-protein interaction databases

BioGridi123523, 80 interactors
IntActiQ96F44, 10 interactors
MINTiQ96F44
STRINGi9606.ENSP00000284551

Structurei

3D structure databases

ProteinModelPortaliQ96F44
SMRiQ96F44
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini268 – 461B30.2/SPRYPROSITE-ProRule annotationAdd BLAST194

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili129 – 208Sequence analysisAdd BLAST80

Domaini

The coiled-coil domain and the B30.2 domain are both necessary for interaction with HN and PAX6 (By similarity). They are also involved in MED15-binding.By similarity
The B30.2 domain may be involved cellular protein quality control by promoting the degradation of insoluble ubiquitinated proteins.By similarity

Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri16 – 57RING-typePROSITE-ProRule annotationAdd BLAST42
Zinc fingeri87 – 128B box-typePROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG2177 Eukaryota
ENOG4111G04 LUCA
GeneTreeiENSGT00760000118893
HOVERGENiHBG001357
InParanoidiQ96F44
KOiK10650
OMAiFAGNGFW
OrthoDBiEOG091G05W2
PhylomeDBiQ96F44
TreeFamiTF338674

Family and domain databases

CDDicd00021 BBOX, 1 hit
Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR003879 Butyrophylin_SPRY
IPR013320 ConA-like_dom_sf
IPR006574 PRY
IPR003877 SPRY_dom
IPR000315 Znf_B-box
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PfamiView protein in Pfam
PF13765 PRY, 1 hit
PF00622 SPRY, 1 hit
PF00643 zf-B_box, 1 hit
PRINTSiPR01407 BUTYPHLNCDUF
SMARTiView protein in SMART
SM00336 BBOX, 1 hit
SM00589 PRY, 1 hit
SM00184 RING, 1 hit
SM00449 SPRY, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS50119 ZF_BBOX, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96F44-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAPDLSTNL QEEATCAICL DYFTDPVMTD CGHNFCRECI RRCWGQPEGP
60 70 80 90 100
YACPECRELS PQRNLRPNRP LAKMAEMARR LHPPSPVPQG VCPAHREPLA
110 120 130 140 150
AFCGDELRLL CAACERSGEH WAHRVRPLQD AAEDLKAKLE KSLEHLRKQM
160 170 180 190 200
QDALLFQAQA DETCVLWQKM VESQRQNVLG EFERLRRLLA EEEQQLLQRL
210 220 230 240 250
EEEELEVLPR LREGAAHLGQ QSAHLAELIA ELEGRCQLPA LGLLQDIKDA
260 270 280 290 300
LRRVQDVKLQ PPEVVPMELR TVCRVPGLVE TLRRFRGDVT LDPDTANPEL
310 320 330 340 350
ILSEDRRSVQ RGDLRQALPD SPERFDPGPC VLGQERFTSG RHYWEVEVGD
360 370 380 390 400
RTSWALGVCR ENVNRKEKGE LSAGNGFWIL VFLGSYYNSS ERALAPLRDP
410 420 430 440 450
PRRVGIFLDY EAGHLSFYSA TDGSLLFIFP EIPFSGTLRP LFSPLSSSPT
460
PMTICRPKGG SGDTLAPQ
Length:468
Mass (Da):52,774
Last modified:December 6, 2002 - v2
Checksum:i8DE4BDF79F221739
GO
Isoform 2 (identifier: Q96F44-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     288-385: DVTLDPDTAN...GFWILVFLGS → RCGGPRWGDD...TTGVSTDPTD
     386-468: Missing.

Note: No experimental confirmation available.
Show »
Length:385
Mass (Da):42,974
Checksum:i13A971DE70ECD27E
GO
Isoform 3 (identifier: Q96F44-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     169-169: Missing.

Note: May be due to competing acceptor splice site. No experimental confirmation available.
Show »
Length:467
Mass (Da):52,646
Checksum:iCEE334A7ADC3147E
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
R4GMV1R4GMV1_HUMAN
E3 ubiquitin-protein ligase TRIM11
TRIM11
343Annotation score:
R4GNB9R4GNB9_HUMAN
E3 ubiquitin-protein ligase TRIM11
TRIM11
228Annotation score:
R4GNC3R4GNC3_HUMAN
E3 ubiquitin-protein ligase TRIM11
TRIM11
54Annotation score:

Sequence cautioni

The sequence AAH11629 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAG53535 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAG63300 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti234G → D in BAG53535 (PubMed:14702039).Curated1
Sequence conflicti260Q → R in BAG37129 (PubMed:14702039).Curated1
Sequence conflicti289V → M in BAG53535 (PubMed:14702039).Curated1
Sequence conflicti319P → S in BAG53535 (PubMed:14702039).Curated1
Sequence conflicti395 – 398APLR → GSIP in AAG53498 (PubMed:11331580).Curated4
Sequence conflicti467P → A in AAG53498 (PubMed:11331580).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_039628169Missing in isoform 3. 1 Publication1
Alternative sequenceiVSP_012057288 – 385DVTLD…VFLGS → RCGGPRWGDDSRRGPAKDLG SQPRVLCPATASSKLTVSWW WVVGKTSSAHTSDISCVGIF TPNNSSTSGNELGIQGFHSA LNRIASADTTGVSTDPTD in isoform 2. 1 PublicationAdd BLAST98
Alternative sequenceiVSP_012058386 – 468Missing in isoform 2. 1 PublicationAdd BLAST83

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF327056 mRNA Translation: AAM63957.1
AK074866 mRNA Translation: BAC11254.1
AK314539 mRNA Translation: BAG37129.1
AK097825 mRNA Translation: BAG53535.1 Different initiation.
AK301859 mRNA Translation: BAG63300.1 Different initiation.
AL670729 Genomic DNA No translation available.
BC011629 mRNA Translation: AAH11629.1 Different initiation.
BC069227 mRNA Translation: AAH69227.1
AF220125 mRNA Translation: AAG53498.1
CCDSiCCDS31048.1 [Q96F44-1]
RefSeqiNP_660215.1, NM_145214.2 [Q96F44-1]
XP_016857901.1, XM_017002412.1 [Q96F44-3]
UniGeneiHs.13543

Genome annotation databases

EnsembliENST00000284551; ENSP00000284551; ENSG00000154370 [Q96F44-1]
ENST00000366699; ENSP00000355660; ENSG00000154370 [Q96F44-2]
GeneIDi81559
KEGGihsa:81559
UCSCiuc001hss.4 human [Q96F44-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF327056 mRNA Translation: AAM63957.1
AK074866 mRNA Translation: BAC11254.1
AK314539 mRNA Translation: BAG37129.1
AK097825 mRNA Translation: BAG53535.1 Different initiation.
AK301859 mRNA Translation: BAG63300.1 Different initiation.
AL670729 Genomic DNA No translation available.
BC011629 mRNA Translation: AAH11629.1 Different initiation.
BC069227 mRNA Translation: AAH69227.1
AF220125 mRNA Translation: AAG53498.1
CCDSiCCDS31048.1 [Q96F44-1]
RefSeqiNP_660215.1, NM_145214.2 [Q96F44-1]
XP_016857901.1, XM_017002412.1 [Q96F44-3]
UniGeneiHs.13543

3D structure databases

ProteinModelPortaliQ96F44
SMRiQ96F44
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123523, 80 interactors
IntActiQ96F44, 10 interactors
MINTiQ96F44
STRINGi9606.ENSP00000284551

PTM databases

iPTMnetiQ96F44
PhosphoSitePlusiQ96F44

Polymorphism and mutation databases

BioMutaiTRIM11
DMDMi26400672

Proteomic databases

EPDiQ96F44
MaxQBiQ96F44
PaxDbiQ96F44
PeptideAtlasiQ96F44
PRIDEiQ96F44
ProteomicsDBi76490
76491 [Q96F44-2]
76492 [Q96F44-3]
TopDownProteomicsiQ96F44-1 [Q96F44-1]

Protocols and materials databases

DNASUi81559
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000284551; ENSP00000284551; ENSG00000154370 [Q96F44-1]
ENST00000366699; ENSP00000355660; ENSG00000154370 [Q96F44-2]
GeneIDi81559
KEGGihsa:81559
UCSCiuc001hss.4 human [Q96F44-1]

Organism-specific databases

CTDi81559
DisGeNETi81559
EuPathDBiHostDB:ENSG00000154370.13
GeneCardsiTRIM11
HGNCiHGNC:16281 TRIM11
HPAiHPA028541
HPA043879
MIMi607868 gene
neXtProtiNX_Q96F44
OpenTargetsiENSG00000154370
PharmGKBiPA38112
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2177 Eukaryota
ENOG4111G04 LUCA
GeneTreeiENSGT00760000118893
HOVERGENiHBG001357
InParanoidiQ96F44
KOiK10650
OMAiFAGNGFW
OrthoDBiEOG091G05W2
PhylomeDBiQ96F44
TreeFamiTF338674

Enzyme and pathway databases

UniPathwayi
UPA00143

ReactomeiR-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
SIGNORiQ96F44

Miscellaneous databases

GeneWikiiTRIM11
GenomeRNAii81559
PROiPR:Q96F44
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000154370 Expressed in 175 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_TRIM11
ExpressionAtlasiQ96F44 baseline and differential
GenevisibleiQ96F44 HS

Family and domain databases

CDDicd00021 BBOX, 1 hit
Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR003879 Butyrophylin_SPRY
IPR013320 ConA-like_dom_sf
IPR006574 PRY
IPR003877 SPRY_dom
IPR000315 Znf_B-box
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PfamiView protein in Pfam
PF13765 PRY, 1 hit
PF00622 SPRY, 1 hit
PF00643 zf-B_box, 1 hit
PRINTSiPR01407 BUTYPHLNCDUF
SMARTiView protein in SMART
SM00336 BBOX, 1 hit
SM00589 PRY, 1 hit
SM00184 RING, 1 hit
SM00449 SPRY, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS50119 ZF_BBOX, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTRI11_HUMAN
AccessioniPrimary (citable) accession number: Q96F44
Secondary accession number(s): A6NKE2
, B2RB82, B3KUS3, B4DX88, Q5VSU1, Q8NCA6, Q9C022
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: December 6, 2002
Last modified: November 7, 2018
This is version 170 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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