UniProtKB - Q96F44 (TRI11_HUMAN)
E3 ubiquitin-protein ligase TRIM11
TRIM11
Functioni
E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis. May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation pathway. Mediates MED15 ubiquitination leading to proteasomal degradation. May contribute to the innate restriction of retroviruses. Upon overexpression, reduces HIV-1 and murine leukemia virus infectivity, by suppressing viral gene expression. Antiviral activity depends on a functional E3 ubiquitin-protein ligase domain. May regulate TRIM5 turnover via the proteasome pathway, thus counteracting the TRIM5-mediated cross-species restriction of retroviral infection at early stages of the retroviral life cycle.
1 PublicationCatalytic activityi
- S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. EC:2.3.2.27
: protein ubiquitination Pathwayi
This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 92 | ZincPROSITE-ProRule annotation | 1 | |
Metal bindingi | 95 | ZincPROSITE-ProRule annotation | 1 | |
Metal bindingi | 114 | ZincPROSITE-ProRule annotation | 1 | |
Metal bindingi | 120 | ZincPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 16 – 57 | RING-typePROSITE-ProRule annotationAdd BLAST | 42 | |
Zinc fingeri | 87 – 128 | B box-typePROSITE-ProRule annotationAdd BLAST | 42 |
GO - Molecular functioni
- protein domain specific binding Source: Ensembl
- ubiquitin protein ligase activity Source: GO_Central
- zinc ion binding Source: InterPro
GO - Biological processi
- innate immune response Source: UniProtKB
- negative regulation of neurogenesis Source: Ensembl
- negative regulation of transcription, DNA-templated Source: Ensembl
- negative regulation of viral entry into host cell Source: UniProtKB
- negative regulation of viral transcription Source: UniProtKB
- positive regulation of viral entry into host cell Source: UniProtKB
- protein ubiquitination Source: GO_Central
- regulation of gene expression Source: GO_Central
- suppression of viral release by host Source: UniProtKB
Keywordsi
Molecular function | Transferase |
Biological process | Antiviral defense, Ubl conjugation pathway |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q96F44 |
Reactomei | R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation |
SignaLinki | Q96F44 |
SIGNORi | Q96F44 |
UniPathwayi | UPA00143 |
Names & Taxonomyi
Protein namesi | Recommended name: E3 ubiquitin-protein ligase TRIM11 (EC:2.3.2.27)Alternative name(s): Protein BIA1 RING finger protein 92 RING-type E3 ubiquitin transferase TRIM11Curated Tripartite motif-containing protein 11 |
Gene namesi | Name:TRIM11 Synonyms:RNF92 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:16281, TRIM11 |
MIMi | 607868, gene |
neXtProti | NX_Q96F44 |
VEuPathDBi | HostDB:ENSG00000154370 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Nucleus
- nucleoplasm Source: HPA
Other locations
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 81559 |
OpenTargetsi | ENSG00000154370 |
PharmGKBi | PA38112 |
Miscellaneous databases
Pharosi | Q96F44, Tbio |
Genetic variation databases
BioMutai | TRIM11 |
DMDMi | 26400672 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000056215 | 1 – 468 | E3 ubiquitin-protein ligase TRIM11Add BLAST | 468 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 85 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q96F44 |
jPOSTi | Q96F44 |
MassIVEi | Q96F44 |
MaxQBi | Q96F44 |
PaxDbi | Q96F44 |
PeptideAtlasi | Q96F44 |
PRIDEi | Q96F44 |
ProteomicsDBi | 76490 [Q96F44-1] 76491 [Q96F44-2] 76492 [Q96F44-3] |
TopDownProteomicsi | Q96F44-1 [Q96F44-1] |
PTM databases
iPTMneti | Q96F44 |
PhosphoSitePlusi | Q96F44 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000154370, Expressed in right hemisphere of cerebellum and 192 other tissues |
ExpressionAtlasi | Q96F44, baseline and differential |
Genevisiblei | Q96F44, HS |
Organism-specific databases
HPAi | ENSG00000154370, Low tissue specificity |
Interactioni
Subunit structurei
Binds cytoplasmic tail of integrin alpha-1.
Interacts with the HN peptide (By similarity).
Interacts with PHOX2B (By similarity).
Interacts with PAX6 (By similarity).
Interacts with MED15/ARC105; this interaction leads to MED15 ubiquitination and proteasomal degradation.
By similarity1 PublicationBinary interactionsi
Q96F44
With | #Exp. | IntAct |
---|---|---|
MED15 [Q96RN5] | 5 | EBI-851809,EBI-394506 |
GO - Molecular functioni
- protein domain specific binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 123523, 132 interactors |
IntActi | Q96F44, 61 interactors |
MINTi | Q96F44 |
STRINGi | 9606.ENSP00000284551 |
Miscellaneous databases
RNActi | Q96F44, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 268 – 461 | B30.2/SPRYPROSITE-ProRule annotationAdd BLAST | 194 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 129 – 208 | Sequence analysisAdd BLAST | 80 |
Domaini
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 16 – 57 | RING-typePROSITE-ProRule annotationAdd BLAST | 42 | |
Zinc fingeri | 87 – 128 | B box-typePROSITE-ProRule annotationAdd BLAST | 42 |
Keywords - Domaini
Coiled coil, Zinc-fingerPhylogenomic databases
eggNOGi | KOG2177, Eukaryota |
GeneTreei | ENSGT00940000160371 |
HOGENOMi | CLU_013137_0_3_1 |
InParanoidi | Q96F44 |
OMAi | RECIGRC |
OrthoDBi | 423686at2759 |
PhylomeDBi | Q96F44 |
TreeFami | TF338674 |
Family and domain databases
Gene3Di | 2.60.120.920, 1 hit 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR001870, B30.2/SPRY IPR043136, B30.2/SPRY_sf IPR003879, Butyrophylin_SPRY IPR013320, ConA-like_dom_sf IPR006574, PRY IPR003877, SPRY_dom IPR000315, Znf_B-box IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD IPR017907, Znf_RING_CS |
Pfami | View protein in Pfam PF13765, PRY, 1 hit PF00622, SPRY, 1 hit PF00643, zf-B_box, 1 hit |
PRINTSi | PR01407, BUTYPHLNCDUF |
SMARTi | View protein in SMART SM00336, BBOX, 1 hit SM00589, PRY, 1 hit SM00184, RING, 1 hit SM00449, SPRY, 1 hit |
SUPFAMi | SSF49899, SSF49899, 1 hit |
PROSITEi | View protein in PROSITE PS50188, B302_SPRY, 1 hit PS50119, ZF_BBOX, 1 hit PS00518, ZF_RING_1, 1 hit PS50089, ZF_RING_2, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAAPDLSTNL QEEATCAICL DYFTDPVMTD CGHNFCRECI RRCWGQPEGP
60 70 80 90 100
YACPECRELS PQRNLRPNRP LAKMAEMARR LHPPSPVPQG VCPAHREPLA
110 120 130 140 150
AFCGDELRLL CAACERSGEH WAHRVRPLQD AAEDLKAKLE KSLEHLRKQM
160 170 180 190 200
QDALLFQAQA DETCVLWQKM VESQRQNVLG EFERLRRLLA EEEQQLLQRL
210 220 230 240 250
EEEELEVLPR LREGAAHLGQ QSAHLAELIA ELEGRCQLPA LGLLQDIKDA
260 270 280 290 300
LRRVQDVKLQ PPEVVPMELR TVCRVPGLVE TLRRFRGDVT LDPDTANPEL
310 320 330 340 350
ILSEDRRSVQ RGDLRQALPD SPERFDPGPC VLGQERFTSG RHYWEVEVGD
360 370 380 390 400
RTSWALGVCR ENVNRKEKGE LSAGNGFWIL VFLGSYYNSS ERALAPLRDP
410 420 430 440 450
PRRVGIFLDY EAGHLSFYSA TDGSLLFIFP EIPFSGTLRP LFSPLSSSPT
460
PMTICRPKGG SGDTLAPQ
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketR4GMV1 | R4GMV1_HUMAN | E3 ubiquitin-protein ligase TRIM11 | TRIM11 | 343 | Annotation score: | ||
R4GNB9 | R4GNB9_HUMAN | E3 ubiquitin-protein ligase TRIM11 | TRIM11 | 228 | Annotation score: | ||
R4GNC3 | R4GNC3_HUMAN | E3 ubiquitin-protein ligase TRIM11 | TRIM11 | 54 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 234 | G → D in BAG53535 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 260 | Q → R in BAG37129 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 289 | V → M in BAG53535 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 319 | P → S in BAG53535 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 395 – 398 | APLR → GSIP in AAG53498 (PubMed:11331580).Curated | 4 | |
Sequence conflicti | 467 | P → A in AAG53498 (PubMed:11331580).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_039628 | 169 | Missing in isoform 3. 1 Publication | 1 | |
Alternative sequenceiVSP_012057 | 288 – 385 | DVTLD…VFLGS → RCGGPRWGDDSRRGPAKDLG SQPRVLCPATASSKLTVSWW WVVGKTSSAHTSDISCVGIF TPNNSSTSGNELGIQGFHSA LNRIASADTTGVSTDPTD in isoform 2. 1 PublicationAdd BLAST | 98 | |
Alternative sequenceiVSP_012058 | 386 – 468 | Missing in isoform 2. 1 PublicationAdd BLAST | 83 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF327056 mRNA Translation: AAM63957.1 AK074866 mRNA Translation: BAC11254.1 AK314539 mRNA Translation: BAG37129.1 AK097825 mRNA Translation: BAG53535.1 Different initiation. AK301859 mRNA Translation: BAG63300.1 Different initiation. AL670729 Genomic DNA No translation available. BC011629 mRNA Translation: AAH11629.1 Different initiation. BC069227 mRNA Translation: AAH69227.1 AF220125 mRNA Translation: AAG53498.1 |
CCDSi | CCDS31048.1 [Q96F44-1] |
RefSeqi | NP_660215.1, NM_145214.2 [Q96F44-1] XP_016857901.1, XM_017002412.1 [Q96F44-3] |
Genome annotation databases
Ensembli | ENST00000284551.11; ENSP00000284551.6; ENSG00000154370.16 ENST00000366699.3; ENSP00000355660.3; ENSG00000154370.16 [Q96F44-2] |
GeneIDi | 81559 |
KEGGi | hsa:81559 |
MANE-Selecti | ENST00000284551.11; ENSP00000284551.6; NM_145214.3; NP_660215.1 |
UCSCi | uc001hss.4, human [Q96F44-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF327056 mRNA Translation: AAM63957.1 AK074866 mRNA Translation: BAC11254.1 AK314539 mRNA Translation: BAG37129.1 AK097825 mRNA Translation: BAG53535.1 Different initiation. AK301859 mRNA Translation: BAG63300.1 Different initiation. AL670729 Genomic DNA No translation available. BC011629 mRNA Translation: AAH11629.1 Different initiation. BC069227 mRNA Translation: AAH69227.1 AF220125 mRNA Translation: AAG53498.1 |
CCDSi | CCDS31048.1 [Q96F44-1] |
RefSeqi | NP_660215.1, NM_145214.2 [Q96F44-1] XP_016857901.1, XM_017002412.1 [Q96F44-3] |
3D structure databases
AlphaFoldDBi | Q96F44 |
SMRi | Q96F44 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 123523, 132 interactors |
IntActi | Q96F44, 61 interactors |
MINTi | Q96F44 |
STRINGi | 9606.ENSP00000284551 |
PTM databases
iPTMneti | Q96F44 |
PhosphoSitePlusi | Q96F44 |
Genetic variation databases
BioMutai | TRIM11 |
DMDMi | 26400672 |
Proteomic databases
EPDi | Q96F44 |
jPOSTi | Q96F44 |
MassIVEi | Q96F44 |
MaxQBi | Q96F44 |
PaxDbi | Q96F44 |
PeptideAtlasi | Q96F44 |
PRIDEi | Q96F44 |
ProteomicsDBi | 76490 [Q96F44-1] 76491 [Q96F44-2] 76492 [Q96F44-3] |
TopDownProteomicsi | Q96F44-1 [Q96F44-1] |
Protocols and materials databases
Antibodypediai | 34665, 263 antibodies from 30 providers |
DNASUi | 81559 |
Genome annotation databases
Ensembli | ENST00000284551.11; ENSP00000284551.6; ENSG00000154370.16 ENST00000366699.3; ENSP00000355660.3; ENSG00000154370.16 [Q96F44-2] |
GeneIDi | 81559 |
KEGGi | hsa:81559 |
MANE-Selecti | ENST00000284551.11; ENSP00000284551.6; NM_145214.3; NP_660215.1 |
UCSCi | uc001hss.4, human [Q96F44-1] |
Organism-specific databases
CTDi | 81559 |
DisGeNETi | 81559 |
GeneCardsi | TRIM11 |
HGNCi | HGNC:16281, TRIM11 |
HPAi | ENSG00000154370, Low tissue specificity |
MIMi | 607868, gene |
neXtProti | NX_Q96F44 |
OpenTargetsi | ENSG00000154370 |
PharmGKBi | PA38112 |
VEuPathDBi | HostDB:ENSG00000154370 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2177, Eukaryota |
GeneTreei | ENSGT00940000160371 |
HOGENOMi | CLU_013137_0_3_1 |
InParanoidi | Q96F44 |
OMAi | RECIGRC |
OrthoDBi | 423686at2759 |
PhylomeDBi | Q96F44 |
TreeFami | TF338674 |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
PathwayCommonsi | Q96F44 |
Reactomei | R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation |
SignaLinki | Q96F44 |
SIGNORi | Q96F44 |
Miscellaneous databases
BioGRID-ORCSi | 81559, 15 hits in 1119 CRISPR screens |
GeneWikii | TRIM11 |
GenomeRNAii | 81559 |
Pharosi | Q96F44, Tbio |
PROi | PR:Q96F44 |
RNActi | Q96F44, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000154370, Expressed in right hemisphere of cerebellum and 192 other tissues |
ExpressionAtlasi | Q96F44, baseline and differential |
Genevisiblei | Q96F44, HS |
Family and domain databases
Gene3Di | 2.60.120.920, 1 hit 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR001870, B30.2/SPRY IPR043136, B30.2/SPRY_sf IPR003879, Butyrophylin_SPRY IPR013320, ConA-like_dom_sf IPR006574, PRY IPR003877, SPRY_dom IPR000315, Znf_B-box IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD IPR017907, Znf_RING_CS |
Pfami | View protein in Pfam PF13765, PRY, 1 hit PF00622, SPRY, 1 hit PF00643, zf-B_box, 1 hit |
PRINTSi | PR01407, BUTYPHLNCDUF |
SMARTi | View protein in SMART SM00336, BBOX, 1 hit SM00589, PRY, 1 hit SM00184, RING, 1 hit SM00449, SPRY, 1 hit |
SUPFAMi | SSF49899, SSF49899, 1 hit |
PROSITEi | View protein in PROSITE PS50188, B302_SPRY, 1 hit PS50119, ZF_BBOX, 1 hit PS00518, ZF_RING_1, 1 hit PS50089, ZF_RING_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TRI11_HUMAN | |
Accessioni | Q96F44Primary (citable) accession number: Q96F44 Secondary accession number(s): A6NKE2 Q9C022 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 6, 2002 |
Last sequence update: | December 6, 2002 | |
Last modified: | May 25, 2022 | |
This is version 191 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families