NRBF2

Functionⁱ

May modulate transcriptional activation by target nuclear receptors. Can act as transcriptional activator (in vitro).1 Publication

Involved in starvation-induced autophagy probably by its association with PI3K complex I (PI3KC3-C1). However, effects has been described variably. Involved in the induction of starvation-induced autophagy (PubMed:24785657). Stabilzes PI3KC3-C1 assembly and enhances ATG14-linked lipid kinase activity of PIK3C3 (By similarity). Proposed to negatively regulate basal and starvation-induced autophagy and to inhibit PIK3C3 activity by modulating interactions in PI3KC3-C1 (PubMed:25086043). May be involved in autophagosome biogenesis (PubMed:25086043). May play a role in neural progenitor cell survival during differentiation (By similarity).By similarity2 Publications

GO - Biological processⁱ

autophagy
Source: GO_Central
Inferred from mutant phenotypeⁱ
- 24785657
regulation of lipid kinase activity Source: Ensembl
response to endoplasmic reticulum stress Source: Ensembl
transcription initiation from RNA polymerase II promoter Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Autophagy, Transcription, Transcription regulation

Biological process

Autophagy, Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-383280 Nuclear Receptor transcription pathway

Reactomeⁱ

R-HSA-383280 Nuclear Receptor transcription pathway

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Nuclear receptor-binding factor 2 Short name: NRBF-2 Alternative name(s): Comodulator of PPAR and RXR
Gene namesⁱ	Name:NRBF2 Synonyms:COPR
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 10

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000148572.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:19692 NRBF2
MIMⁱ	616477 gene
neXtProtⁱ	NX_Q96F24

Keywords - Cellular componentⁱ

Cytoplasm, Cytoplasmic vesicle, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	144 – 145	LL → AA: Decreased interaction with nuclear receptors. 1 Publication		2

Organism-specific databases

DisGeNET More...DisGeNETⁱ	29982
Open Targets More...OpenTargetsⁱ	ENSG00000148572
PharmGKBⁱ	PA134946285

Polymorphism and mutation databases

DMDMⁱ	74731648

DMDMⁱ

74731648

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000235816	1 – 287	Nuclear receptor-binding factor 2Add BLAST		287

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	113	PhosphoserineCombined sources		1
Modified residueⁱ	268	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q96F24
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q96F24
PaxDbⁱ	Q96F24
PeptideAtlas More...PeptideAtlasⁱ	Q96F24
PRIDEⁱ	Q96F24
ProteomicsDBⁱ	76486 76487 [Q96F24-2]

PTM databases

iPTMnetⁱ	Q96F24
PhosphoSitePlusⁱ	Q96F24

Expressionⁱ

Tissue specificityⁱ

Detected in keratinocytes, liver and placenta (PubMed:15610520). Expressed in a subset of cells in pediatric medulloblastoma (PubMed:18619852).2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000148572 Expressed in 217 organ(s), highest expression level in blood
CleanExⁱ	HS_NRBF2
Genevisibleⁱ	Q96F24 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA021670 HPA059477

HPAⁱ

HPA021670
HPA059477

Interactionⁱ

Subunit structureⁱ

Interacts with PPARA, PPARD and PPARG. Interacts with RARA, RARG and RXRA in the presence of bound ligand (PubMed:15610520). Interacts with SCOC (PubMed:22354037). Associates with the PI3K complex I (PI3KC3-C1); the direct binding partner in the complex is reported variably as PIK3R4 or ATG14 (PubMed:24785657).4 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
C1orf216	Q8TAB5	3	EBI-2362014,EBI-747505
PIK3C3	Q8NEB9	11	EBI-2362014,EBI-1056470
PIK3R4	Q99570	10	EBI-2362014,EBI-1046979

Protein-protein interaction databases

BioGridⁱ	119009, 28 interactors
IntActⁱ	Q96F24, 21 interactors
STRINGⁱ	9606.ENSP00000277746

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	7 – 23	Combined sources	17
Helixⁱ	27 – 45	Combined sources	19
Helixⁱ	51 – 85	Combined sources	35

Show more details

3D structure databases

ProteinModelPortalⁱ	Q96F24
SMRⁱ	Q96F24
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	168 – 209	Sequence analysisAdd BLAST		42

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	141 – 145	Nuclear receptor interaction motif		5

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	ENOG410IJBN Eukaryota ENOG4111SDN LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000000984
HOGENOMⁱ	HOG000293418
HOVERGENⁱ	HBG056976
InParanoidⁱ	Q96F24
KEGG Orthology (KO) More...KOⁱ	K21246
OMAⁱ	TWQKFAS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0FJ8
PhylomeDBⁱ	Q96F24
TreeFamⁱ	TF328627

Family and domain databases

InterProⁱ	View protein in InterPro IPR039679 NRBF2 IPR015056 NRBF2_C IPR033393 NRBF2_MIT
PANTHERⁱ	PTHR14964 PTHR14964, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08961 NRBF2, 1 hit PF17169 NRBF2_MIT, 1 hit

Sequences (3)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: Q96F24-1) [UniParc]FASTA Add to basket

Also known as: COPR2, Comodulator of PPAR and RXR 2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEVMEGPLNL AHQQSRRADR LLAAGKYEEA ISCHKKAAAY LSEAMKLTQS 
        60         70         80         90        100
EQAHLSLELQ RDSHMKQLLL IQERWKRAQR EERLKAQQNT DKDAAAHLQT 
       110        120        130        140        150
SHKPSAEDAE GQSPLSQKYS PSTEKCLPEI QGIFDRDPDT LLYLLQQKSE 
       160        170        180        190        200
PAEPCIGSKA PKDDKTIIEE QATKIADLKR HVEFLVAENE RLRKENKQLK 
       210        220        230        240        250
AEKARLLKGP IEKELDVDAD FVETSELWSL PPHAETATAS STWQKFAANT 
       260        270        280 
GKAKDIPIPN LPPLDFPSPE LPLMELSEDI LKGFMNN

Length:287

Mass (Da):32,378

Last modified:December 1, 2001 - v1

Checksum:ⁱ91EC0407F5108806

GO

Isoform 2 (identifier: Q96F24-2) [UniParc]FASTA Add to basket

Also known as: COPR1, Comodulator of PPAR and RXR 1

The sequence of this isoform differs from the canonical sequence as follows:
90-139: Missing.

« Hide

        10         20         30         40         50
MEVMEGPLNL AHQQSRRADR LLAAGKYEEA ISCHKKAAAY LSEAMKLTQS 
        60         70         80         90        100
EQAHLSLELQ RDSHMKQLLL IQERWKRAQR EERLKAQQNT LLYLLQQKSE 
       110        120        130        140        150
PAEPCIGSKA PKDDKTIIEE QATKIADLKR HVEFLVAENE RLRKENKQLK 
       160        170        180        190        200
AEKARLLKGP IEKELDVDAD FVETSELWSL PPHAETATAS STWQKFAANT 
       210        220        230 
GKAKDIPIPN LPPLDFPSPE LPLMELSEDI LKGFMNN

Show »

Length:237

Mass (Da):26,955

Checksum:ⁱ71E24C3D4AB955B0

GO

Isoform 3 (identifier: Q96F24-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-38: MEVMEGPLNLAHQQSRRADRLLAAGKYEEAISCHKKAA → MFPGATTPLPKAAAYPGVYGSNGRTPQP

« Hide

        10         20         30         40         50
MFPGATTPLP KAAAYPGVYG SNGRTPQPAY LSEAMKLTQS EQAHLSLELQ 
        60         70         80         90        100
RDSHMKQLLL IQERWKRAQR EERLKAQQNT DKDAAAHLQT SHKPSAEDAE 
       110        120        130        140        150
GQSPLSQKYS PSTEKCLPEI QGIFDRDPDT LLYLLQQKSE PAEPCIGSKA 
       160        170        180        190        200
PKDDKTIIEE QATKIADLKR HVEFLVAENE RLRKENKQLK AEKARLLKGP 
       210        220        230        240        250
IEKELDVDAD FVETSELWSL PPHAETATAS STWQKFAANT GKAKDIPIPN 
       260        270 
LPPLDFPSPE LPLMELSEDI LKGFMNN

Note: No experimental confirmation available.

Show »

Length:277

Mass (Da):31,001

Checksum:ⁱD1F2D74D45441391

GO

Sequence cautionⁱ

The sequence AAG44735 differs from that shown. Reason: Frameshift at positions 234, 251 and 278.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	150	E → G in BAB70833 (PubMed:14702039).Curated		1
Sequence conflictⁱ	284	F → L in CAB66591 (PubMed:11230166).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_054555	1 – 38	MEVME…HKKAA → MFPGATTPLPKAAAYPGVYG SNGRTPQP in isoform 3. 1 PublicationAdd BLAST		38
Alternative sequenceⁱVSP_018488	90 – 139	Missing in isoform 2. 1 PublicationAdd BLAST		50

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY267839 mRNA Translation: AAP03081.1 AY267840 mRNA Translation: AAP03082.1 AF267866 mRNA Translation: AAG44735.1 Frameshift. AL136656 mRNA Translation: CAB66591.1 AK054957 mRNA Translation: BAB70833.1 AK301656 mRNA Translation: BAG63132.1 AL590502 Genomic DNA No translation available. CH471083 Genomic DNA Translation: EAW54241.1 BC011707 mRNA Translation: AAH11707.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS60537.1 [Q96F24-3] CCDS7268.1 [Q96F24-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001269334.1, NM_001282405.1 [Q96F24-3] NP_110386.2, NM_030759.4 [Q96F24-1]
UniGeneⁱ	Hs.449628

Genome annotation databases

Ensemblⁱ	ENST00000277746; ENSP00000277746; ENSG00000148572 [Q96F24-1] ENST00000435510; ENSP00000397502; ENSG00000148572 [Q96F24-3]
GeneIDⁱ	29982
KEGGⁱ	hsa:29982
UCSC genome browser More...UCSCⁱ	uc001jmj.6 human [Q96F24-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q96F24	Nuclear receptor-binding factor 2	)	MOUSE		287	UniRef90_Q96F24
Nuclear receptor-binding factor 2		PONAB		287
Nuclear receptor-binding factor 2		RAT		287
Nuclear receptor binding factor 2 (Fragment)		MUSPF		331
nuclear receptor-binding factor 2 isoform X1		ODORO		288
+52
Q96F24-3	Uncharacterized protein		NOMLE		286	UniRef90_Q96F24-3
NRBF2 isoform 1		PANTR		277
Uncharacterized protein		PANPA		277
Uncharacterized protein		AOTNA		277
UPI000C2AE705		Ugandan red Colobus		277
+1

Protein	Similar proteins		Species	Score	Length	Source
Q96F24	Nuclear receptor-binding factor 2		RAT		287	UniRef50_Q96F24
Nuclear receptor-binding factor 2	)	MOUSE		287
Nuclear receptor-binding factor 2		PONAB		287
Nuclear receptor binding factor 2 (Fragment)		MUSPF		331
nuclear receptor-binding factor 2 isoform X1		NEOSC		288
+248
Q96F24-2	Uncharacterized protein		SAIBB		240	UniRef50_Q96F24-2
nuclear receptor-binding factor 2		URSMA		257
Uncharacterized protein		Cebus capucinus imitator		244
Uncharacterized protein		RHIBE		241
Uncharacterized protein		RHIRO		248
+6
Q96F24-3	Uncharacterized protein		NOMLE		286	UniRef50_Q96F24-3
Uncharacterized protein		AOTNA		277
NRBF2 isoform 1		PANTR		277
Uncharacterized protein		PANPA		277
Uncharacterized protein		MONDO		287
+188

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY267839 mRNA Translation: AAP03081.1 AY267840 mRNA Translation: AAP03082.1 AF267866 mRNA Translation: AAG44735.1 Frameshift. AL136656 mRNA Translation: CAB66591.1 AK054957 mRNA Translation: BAB70833.1 AK301656 mRNA Translation: BAG63132.1 AL590502 Genomic DNA No translation available. CH471083 Genomic DNA Translation: EAW54241.1 BC011707 mRNA Translation: AAH11707.1
CCDSⁱ	CCDS60537.1 [Q96F24-3] CCDS7268.1 [Q96F24-1]
RefSeqⁱ	NP_001269334.1, NM_001282405.1 [Q96F24-3] NP_110386.2, NM_030759.4 [Q96F24-1]
UniGeneⁱ	Hs.449628

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4ZEY	X-ray	1.50	A	4-86	[»]
ProteinModelPortalⁱ	Q96F24
SMRⁱ	Q96F24
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	119009, 28 interactors
IntActⁱ	Q96F24, 21 interactors
STRINGⁱ	9606.ENSP00000277746

PTM databases

iPTMnetⁱ	Q96F24
PhosphoSitePlusⁱ	Q96F24

Polymorphism and mutation databases

DMDMⁱ	74731648

DMDMⁱ

74731648

Proteomic databases

EPDⁱ	Q96F24
MaxQBⁱ	Q96F24
PaxDbⁱ	Q96F24
PeptideAtlasⁱ	Q96F24
PRIDEⁱ	Q96F24
ProteomicsDBⁱ	76486 76487 [Q96F24-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	29982
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000277746; ENSP00000277746; ENSG00000148572 [Q96F24-1] ENST00000435510; ENSP00000397502; ENSG00000148572 [Q96F24-3]
GeneIDⁱ	29982
KEGGⁱ	hsa:29982
UCSCⁱ	uc001jmj.6 human [Q96F24-1]

Organism-specific databases

CTDⁱ	29982
DisGeNETⁱ	29982
EuPathDBⁱ	HostDB:ENSG00000148572.14
GeneCardsⁱ	NRBF2
H-InvDBⁱ	HIX0008862 HIX0170466
HGNCⁱ	HGNC:19692 NRBF2
HPAⁱ	HPA021670 HPA059477
MIMⁱ	616477 gene
neXtProtⁱ	NX_Q96F24
OpenTargetsⁱ	ENSG00000148572
PharmGKBⁱ	PA134946285
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IJBN Eukaryota ENOG4111SDN LUCA
GeneTreeⁱ	ENSGT00390000000984
HOGENOMⁱ	HOG000293418
HOVERGENⁱ	HBG056976
InParanoidⁱ	Q96F24
KOⁱ	K21246
OMAⁱ	TWQKFAS
OrthoDBⁱ	EOG091G0FJ8
PhylomeDBⁱ	Q96F24
TreeFamⁱ	TF328627

Enzyme and pathway databases

Reactomeⁱ	R-HSA-383280 Nuclear Receptor transcription pathway

Reactomeⁱ

R-HSA-383280 Nuclear Receptor transcription pathway

Miscellaneous databases

ChiTaRSⁱ	NRBF2 human
GeneWikiⁱ	NRBF2
GenomeRNAiⁱ	29982
Protein Ontology More...PROⁱ	PR:Q96F24
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000148572 Expressed in 217 organ(s), highest expression level in blood
CleanExⁱ	HS_NRBF2
Genevisibleⁱ	Q96F24 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR039679 NRBF2 IPR015056 NRBF2_C IPR033393 NRBF2_MIT
PANTHERⁱ	PTHR14964 PTHR14964, 1 hit
Pfamⁱ	View protein in Pfam PF08961 NRBF2, 1 hit PF17169 NRBF2_MIT, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NRBF2_HUMAN
Accessionⁱ	Q96F24Primary (citable) accession number: Q96F24 Secondary accession number(s): A6PW36 , B4DWS0, Q86UR2, Q96NP6, Q9H0S9, Q9H2I2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 16, 2006
	Last sequence update:	December 1, 2001
	Last modified:	November 7, 2018
	This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM

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UniProtKB - Q96F24 (NRBF2_HUMAN)

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Nuclear receptor-binding factor 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Motif

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ