UniProtKB - Q96F15 (GIMA5_HUMAN)
GTPase IMAP family member 5
GIMAP5
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 55 | GTPBy similarity | 1 | |
Binding sitei | 189 | GTPBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 34 – 42 | GTPBy similarity | 9 | |
Nucleotide bindingi | 152 – 154 | GTPBy similarity | 3 |
GO - Molecular functioni
- GTP binding Source: UniProtKB-KW
Keywordsi
Ligand | GTP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q96F15 |
Names & Taxonomyi
Protein namesi | Recommended name: GTPase IMAP family member 5Alternative name(s): Immune-associated nucleotide-binding protein 5 Immunity-associated nucleotide 4-like 1 protein Immunity-associated nucleotide 5 protein Short name: IAN-5 Short name: hIAN51 Publication Immunity-associated protein 3 |
Gene namesi | Name:GIMAP5 Synonyms:IAN4L1, IAN5, IMAP3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000196329.11 |
HGNCi | HGNC:18005, GIMAP5 |
MIMi | 608086, gene |
neXtProti | NX_Q96F15 |
Subcellular locationi
Lysosome
- Lysosome membrane 2 Publications; Single-pass type IV membrane protein Curated
Endosome
- multivesicular body membrane 1 Publication; Single-pass type IV membrane protein Curated
- Endosome membrane By similarity; Single-pass type IV membrane protein By similarity
Note: The mitochondrial localization originally reported was observed with C-terminally tagged protein and was not confirmed in later publications.2 Publications
Endosome
- multivesicular body membrane Source: UniProtKB-SubCell
Lysosome
- lysosomal membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 284 | CytoplasmicSequence analysisAdd BLAST | 284 | |
Transmembranei | 285 – 305 | Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST | 21 | |
Topological domaini | 306 – 307 | LumenalSequence analysis | 2 |
Keywords - Cellular componenti
Endosome, Lysosome, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 55340 |
OpenTargetsi | ENSG00000196329 |
PharmGKBi | PA29578 |
Miscellaneous databases
Pharosi | Q96F15, Tbio |
Polymorphism and mutation databases
BioMutai | GIMAP5 |
DMDMi | 38372381 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000190990 | 1 – 307 | GTPase IMAP family member 5Add BLAST | 307 |
Proteomic databases
jPOSTi | Q96F15 |
MassIVEi | Q96F15 |
MaxQBi | Q96F15 |
PaxDbi | Q96F15 |
PeptideAtlasi | Q96F15 |
PRIDEi | Q96F15 |
ProteomicsDBi | 76484 [Q96F15-1] 76485 [Q96F15-2] |
PTM databases
iPTMneti | Q96F15 |
PhosphoSitePlusi | Q96F15 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000196329, Expressed in right lung and 112 other tissues |
ExpressionAtlasi | Q96F15, baseline and differential |
Genevisiblei | Q96F15, HS |
Organism-specific databases
HPAi | ENSG00000196329, Tissue enhanced (blood, lymphoid tissue) |
Interactioni
Subunit structurei
Interacts with BAD, BAK1, BAX, BCL2, BCL2L1/Bcl-xL and BCL2L11/BimEL (PubMed:16509771). The interaction with BAX is increased, when cells initiate apoptosis upon IL2 withdrawal (PubMed:16509771).
Also interacts with BCL2 (By similarity).
Forms a complex with BCL2L1 or MCL1 and HSPA8/HSC70; the interaction between HSPA8 and BCL2L1 or MCL1 is impaired in the absence of GIMAP5 (By similarity). May interact (via N-terminus) with microtubules (By similarity).
By similarity1 PublicationBinary interactionsi
Q96F15
Protein-protein interaction databases
BioGRIDi | 120621, 71 interactors |
DIPi | DIP-59484N |
IntActi | Q96F15, 62 interactors |
STRINGi | 9606.ENSP00000477920 |
Miscellaneous databases
RNActi | Q96F15, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 25 – 228 | AIG1-type GPROSITE-ProRule annotationAdd BLAST | 204 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502RB0C, Eukaryota |
GeneTreei | ENSGT00940000154844 |
HOGENOMi | CLU_010468_1_1_1 |
InParanoidi | Q96F15 |
PhylomeDBi | Q96F15 |
TreeFami | TF330845 |
Family and domain databases
InterProi | View protein in InterPro IPR006703, G_AIG1 IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF04548, AIG1, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS51720, G_AIG1, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGGFQRGKYG TMAEGRSEDN LSATPPALRI ILVGKTGCGK SATGNSILGQ
60 70 80 90 100
PVFESKLRAQ SVTRTCQVKT GTWNGRKVLV VDTPSIFESQ ADTQELYKNI
110 120 130 140 150
GDCYLLSAPG PHVLLLVIQL GRFTAQDTVA IRKVKEVFGT GAMRHVVILF
160 170 180 190 200
THKEDLGGQA LDDYVANTDN CSLKDLVREC ERRYCAFNNW GSVEEQRQQQ
210 220 230 240 250
AELLAVIERL GREREGSFHS NDLFLDAQLL QRTGAGACQE DYRQYQAKVE
260 270 280 290 300
WQVEKHKQEL RENESNWAYK ALLRVKHLML LHYEIFVFLL LCSILFFIIF
LFIFHYI
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 174 | K → E in BAA92115 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_081683 | 204 | L → P Found in a patient with splenomegaly and lymphopenia; unknown pathological significance; strong decrease in protein level. 1 PublicationCorresponds to variant dbSNP:rs72650695Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_008961 | 1 – 14 | MGGFQ…GTMAE → MQDSPIVVCTLLCTHKYVYH SGEDVHSFHEITMNNDLTVL RIINLVRYKTSFST in isoform 2. 1 PublicationAdd BLAST | 14 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK002158 mRNA Translation: BAA92115.1 AK055568 mRNA Translation: BAB70958.1 CR457280 mRNA Translation: CAG33561.1 CH471173 Genomic DNA Translation: EAW54092.1 CH471173 Genomic DNA Translation: EAW54093.1 CH471173 Genomic DNA Translation: EAW54094.1 BC011732 mRNA Translation: AAH11732.1 |
CCDSi | CCDS5907.1 [Q96F15-1] |
RefSeqi | NP_060854.2, NM_018384.4 [Q96F15-1] |
Genome annotation databases
Ensembli | ENST00000358647; ENSP00000351473; ENSG00000196329 [Q96F15-1] ENST00000498181; ENSP00000487840; ENSG00000196329 [Q96F15-1] |
GeneIDi | 55340 |
KEGGi | hsa:55340 |
UCSCi | uc003whr.3, human [Q96F15-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK002158 mRNA Translation: BAA92115.1 AK055568 mRNA Translation: BAB70958.1 CR457280 mRNA Translation: CAG33561.1 CH471173 Genomic DNA Translation: EAW54092.1 CH471173 Genomic DNA Translation: EAW54093.1 CH471173 Genomic DNA Translation: EAW54094.1 BC011732 mRNA Translation: AAH11732.1 |
CCDSi | CCDS5907.1 [Q96F15-1] |
RefSeqi | NP_060854.2, NM_018384.4 [Q96F15-1] |
3D structure databases
SMRi | Q96F15 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 120621, 71 interactors |
DIPi | DIP-59484N |
IntActi | Q96F15, 62 interactors |
STRINGi | 9606.ENSP00000477920 |
PTM databases
iPTMneti | Q96F15 |
PhosphoSitePlusi | Q96F15 |
Polymorphism and mutation databases
BioMutai | GIMAP5 |
DMDMi | 38372381 |
Proteomic databases
jPOSTi | Q96F15 |
MassIVEi | Q96F15 |
MaxQBi | Q96F15 |
PaxDbi | Q96F15 |
PeptideAtlasi | Q96F15 |
PRIDEi | Q96F15 |
ProteomicsDBi | 76484 [Q96F15-1] 76485 [Q96F15-2] |
Protocols and materials databases
Antibodypediai | 2723, 170 antibodies |
DNASUi | 55340 |
Genome annotation databases
Ensembli | ENST00000358647; ENSP00000351473; ENSG00000196329 [Q96F15-1] ENST00000498181; ENSP00000487840; ENSG00000196329 [Q96F15-1] |
GeneIDi | 55340 |
KEGGi | hsa:55340 |
UCSCi | uc003whr.3, human [Q96F15-1] |
Organism-specific databases
CTDi | 55340 |
DisGeNETi | 55340 |
EuPathDBi | HostDB:ENSG00000196329.11 |
GeneCardsi | GIMAP5 |
HGNCi | HGNC:18005, GIMAP5 |
HPAi | ENSG00000196329, Tissue enhanced (blood, lymphoid tissue) |
MIMi | 608086, gene |
neXtProti | NX_Q96F15 |
OpenTargetsi | ENSG00000196329 |
PharmGKBi | PA29578 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RB0C, Eukaryota |
GeneTreei | ENSGT00940000154844 |
HOGENOMi | CLU_010468_1_1_1 |
InParanoidi | Q96F15 |
PhylomeDBi | Q96F15 |
TreeFami | TF330845 |
Enzyme and pathway databases
PathwayCommonsi | Q96F15 |
Miscellaneous databases
BioGRID-ORCSi | 55340, 4 hits in 840 CRISPR screens |
GeneWikii | GIMAP5 |
GenomeRNAii | 55340 |
Pharosi | Q96F15, Tbio |
PROi | PR:Q96F15 |
RNActi | Q96F15, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000196329, Expressed in right lung and 112 other tissues |
ExpressionAtlasi | Q96F15, baseline and differential |
Genevisiblei | Q96F15, HS |
Family and domain databases
InterProi | View protein in InterPro IPR006703, G_AIG1 IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF04548, AIG1, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS51720, G_AIG1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GIMA5_HUMAN | |
Accessioni | Q96F15Primary (citable) accession number: Q96F15 Secondary accession number(s): D3DWZ5 Q9NUK9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 14, 2003 |
Last sequence update: | December 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 153 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations