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Protein

Diamine acetyltransferase 2

Gene

SAT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine > spermidine = spermine >> N1acetylspermine = putrescine.

Miscellaneous

Under physiological conditions, SSAT2 is expressed at lower level that SSAT1 (SSAT). Many tissues express only SSAT1, several tissues express both SSAT1 and SSAT2, and bone, cervix, ovary and pineal gland expressed only SSAT2.

Catalytic activityi

Acetyl-CoA + an alkane-alpha,omega-diamine = CoA + an N-acetyldiamine.

Pathwayi: putrescine degradation

This protein is involved in step 1 of the subpathway that synthesizes N-acetylputrescine from putrescine.
Proteins known to be involved in this subpathway in this organism are:
  1. Diamine acetyltransferase 2 (SAT2), Diamine acetyltransferase 1 (SAT1)
This subpathway is part of the pathway putrescine degradation, which is itself part of Amine and polyamine degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes N-acetylputrescine from putrescine, the pathway putrescine degradation and in Amine and polyamine degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei92Substrate; via carbonyl oxygenBy similarity1
Binding sitei140Acetyl-CoA1 Publication1
Binding sitei152SubstrateBy similarity1

GO - Molecular functioni

  • diamine N-acetyltransferase activity Source: UniProtKB
  • identical protein binding Source: IntAct

GO - Biological processi

  • nor-spermidine metabolic process Source: UniProtKB
  • putrescine acetylation Source: UniProtKB
  • putrescine catabolic process Source: UniProtKB-UniPathway
  • spermidine acetylation Source: UniProtKB
  • spermine acetylation Source: UniProtKB

Keywordsi

Molecular functionAcyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.3.1.57 2681
UniPathwayiUPA00188; UER00363

Names & Taxonomyi

Protein namesi
Recommended name:
Diamine acetyltransferase 2 (EC:2.3.1.57)
Alternative name(s):
Polyamine N-acetyltransferase 2
Spermidine/spermine N(1)-acetyltransferase 2
Thialysine N-epsilon-acetyltransferase
Gene namesi
Name:SAT2
Synonyms:SSAT2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000141504.11
HGNCiHGNC:23160 SAT2
MIMi611463 gene
neXtProtiNX_Q96F10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi112483
OpenTargetsiENSG00000141504
PharmGKBiPA134979941

Chemistry databases

ChEMBLiCHEMBL3509592
DrugBankiDB00127 Spermine

Polymorphism and mutation databases

BioMutaiSAT2
DMDMi51339204

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000745981 – 170Diamine acetyltransferase 2Add BLAST170

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei29N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ96F10
MaxQBiQ96F10
PaxDbiQ96F10
PeptideAtlasiQ96F10
PRIDEiQ96F10
ProteomicsDBi76483

PTM databases

iPTMnetiQ96F10
PhosphoSitePlusiQ96F10

Expressioni

Tissue specificityi

Widely expressed.

Inductioni

Not inducible by polyamine analogs.

Gene expression databases

BgeeiENSG00000141504
CleanExiHS_SAT2
ExpressionAtlasiQ96F10 baseline and differential
GenevisibleiQ96F10 HS

Organism-specific databases

HPAiHPA022136
HPA057096

Interactioni

Subunit structurei

Homodimer.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi125190, 9 interactors
IntActiQ96F10, 1 interactor
STRINGi9606.ENSP00000269298

Structurei

Secondary structure

1170
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 8Combined sources5
Helixi11 – 13Combined sources3
Helixi14 – 28Combined sources15
Helixi31 – 33Combined sources3
Helixi38 – 46Combined sources9
Beta strandi47 – 49Combined sources3
Beta strandi53 – 59Combined sources7
Beta strandi70 – 82Combined sources13
Turni83 – 85Combined sources3
Beta strandi86 – 96Combined sources11
Helixi98 – 100Combined sources3
Beta strandi102 – 104Combined sources3
Helixi105 – 119Combined sources15
Beta strandi124 – 130Combined sources7
Helixi134 – 142Combined sources9
Helixi148 – 152Combined sources5
Beta strandi154 – 160Combined sources7
Helixi162 – 167Combined sources6

3D structure databases

ProteinModelPortaliQ96F10
SMRiQ96F10
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96F10

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 168N-acetyltransferasePROSITE-ProRule annotationAdd BLAST165

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni27 – 28Substrate bindingBy similarity2
Regioni94 – 96Acetyl-CoA binding3
Regioni102 – 107Acetyl-CoA binding6
Regioni133 – 135Acetyl-CoA binding3

Sequence similaritiesi

Belongs to the acetyltransferase family.Curated

Phylogenomic databases

eggNOGiENOG410IU7S Eukaryota
ENOG4111PFJ LUCA
GeneTreeiENSGT00440000039972
HOGENOMiHOG000078521
HOVERGENiHBG063175
InParanoidiQ96F10
KOiK00657
OMAiRYSTWKG
OrthoDBiEOG091G0UNU
PhylomeDBiQ96F10
TreeFamiTF319736

Family and domain databases

InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR000182 GNAT_dom
IPR032959 SAT2
PANTHERiPTHR10545:SF51 PTHR10545:SF51, 1 hit
PfamiView protein in Pfam
PF00583 Acetyltransf_1, 1 hit
SUPFAMiSSF55729 SSF55729, 1 hit
PROSITEiView protein in PROSITE
PS51186 GNAT, 1 hit

Sequencei

Sequence statusi: Complete.

Q96F10-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASVRIREAK EGDCGDILRL IRELAEFEKL SDQVKISEEA LRADGFGDNP
60 70 80 90 100
FYHCLVAEIL PAPGKLLGPC VVGYGIYYFI YSTWKGRTIY LEDIYVMPEY
110 120 130 140 150
RGQGIGSKII KKVAEVALDK GCSQFRLAVL DWNQRAMDLY KALGAQDLTE
160 170
AEGWHFFCFQ GEATRKLAGK
Length:170
Mass (Da):19,155
Last modified:December 1, 2001 - v1
Checksum:i68D46F0E28186C68
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_020465126R → C. Corresponds to variant dbSNP:rs13894Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF348524 mRNA Translation: AAL83905.1
BC011751 mRNA Translation: AAH11751.1
CCDSiCCDS11116.1
RefSeqiNP_001307775.1, NM_001320846.1
NP_001307776.1, NM_001320847.1
NP_597998.1, NM_133491.4
UniGeneiHs.10846

Genome annotation databases

EnsembliENST00000269298; ENSP00000269298; ENSG00000141504
GeneIDi112483
KEGGihsa:112483
UCSCiuc002gic.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSAT2_HUMAN
AccessioniPrimary (citable) accession number: Q96F10
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: December 1, 2001
Last modified: June 20, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

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