UniProtKB - Q96EZ8 (MCRS1_HUMAN)
Microspherule protein 1
MCRS1
Functioni
GO - Molecular functioni
- G-quadruplex RNA binding Source: UniProtKB
- poly(G) binding Source: UniProtKB
- poly(U) RNA binding Source: UniProtKB
- telomerase inhibitor activity Source: BHF-UCL
GO - Biological processi
- cellular protein modification process Source: ProtInc
- DNA recombination Source: UniProtKB-KW
- DNA repair Source: UniProtKB-KW
- histone H4-K16 acetylation Source: UniProtKB
- histone H4-K5 acetylation Source: UniProtKB
- histone H4-K8 acetylation Source: UniProtKB
- negative regulation of telomerase activity Source: BHF-UCL
- negative regulation of telomere maintenance via telomere lengthening Source: BHF-UCL
- positive regulation of protein localization to nucleolus Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: GO_Central
- protein deubiquitination Source: Reactome
- viral process Source: UniProtKB-KW
Keywordsi
Molecular function | Chromatin regulator |
Biological process | DNA damage, DNA recombination, DNA repair, Host-virus interaction, Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q96EZ8 |
Reactomei | R-HSA-3214847, HATs acetylate histones R-HSA-5689603, UCH proteinases R-HSA-5696394, DNA Damage Recognition in GG-NER |
Names & Taxonomyi
Protein namesi | Recommended name: Microspherule protein 1Alternative name(s): 58 kDa microspherule protein Cell cycle-regulated factor p78 INO80 complex subunit J MCRS2 |
Gene namesi | Name:MCRS1 Synonyms:INO80Q, MSP58 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6960, MCRS1 |
MIMi | 609504, gene |
neXtProti | NX_Q96EZ8 |
VEuPathDBi | HostDB:ENSG00000187778.13 |
Subcellular locationi
Endoplasmic reticulum
- endoplasmic reticulum Source: Ensembl
Nucleus
- histone acetyltransferase complex Source: UniProtKB
- Ino80 complex Source: UniProtKB
- MLL1 complex Source: UniProtKB
- NSL complex Source: GO_Central
- nucleolus Source: UniProtKB
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
- dendrite Source: UniProtKB
- perikaryon Source: UniProtKB
- polysome Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 10445 |
OpenTargetsi | ENSG00000187778 |
PharmGKBi | PA30708 |
Miscellaneous databases
Pharosi | Q96EZ8, Tbio |
Genetic variation databases
BioMutai | MCRS1 |
DMDMi | 24638035 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000096305 | 1 – 462 | Microspherule protein 1Add BLAST | 462 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 | |
Modified residuei | 22 | PhosphoserineCombined sources | 1 | |
Modified residuei | 102 | PhosphoserineBy similarity | 1 | |
Modified residuei | 103 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 108 | PhosphoserineCombined sources | 1 | |
Modified residuei | 123 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 130 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 282 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q96EZ8 |
jPOSTi | Q96EZ8 |
MassIVEi | Q96EZ8 |
MaxQBi | Q96EZ8 |
PaxDbi | Q96EZ8 |
PeptideAtlasi | Q96EZ8 |
PRIDEi | Q96EZ8 |
ProteomicsDBi | 69010 76477 [Q96EZ8-1] 76478 [Q96EZ8-2] 76479 [Q96EZ8-3] |
PTM databases
iPTMneti | Q96EZ8 |
PhosphoSitePlusi | Q96EZ8 |
SwissPalmi | Q96EZ8 |
Expressioni
Tissue specificityi
Developmental stagei
Gene expression databases
Bgeei | ENSG00000187778, Expressed in apex of heart and 228 other tissues |
ExpressionAtlasi | Q96EZ8, baseline and differential |
Genevisiblei | Q96EZ8, HS |
Organism-specific databases
HPAi | ENSG00000187778, Low tissue specificity |
Interactioni
Subunit structurei
Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the N-terminus of INO80 (PubMed:16230350, PubMed:18922472, PubMed:21303910).
Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10 (PubMed:15960975).
Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1 (PubMed:20018852).
Interacts with NOP2 (PubMed:9654073).
Interacts with PINX1 (PubMed:15044100).
Interacts with TERT (PubMed:15044100).
Interacts with CCDC85B (PubMed:17014843).
Interacts with DAXX (PubMed:11948183).
Interacts (via N-terminus) with FMR1 (via phosphorylated form) (PubMed:16571602).
Interacts with FXR1 AND FXR2 (PubMed:16571602).
10 Publications(Microbial infection) Interacts with Herpes simplex virus ICP22.
1 PublicationBinary interactionsi
Q96EZ8
Protein-protein interaction databases
BioGRIDi | 115710, 183 interactors |
ComplexPortali | CPX-809, NSL histone acetyltransferase complex CPX-846, INO80 chromatin remodeling complex |
CORUMi | Q96EZ8 |
IntActi | Q96EZ8, 159 interactors |
MINTi | Q96EZ8 |
STRINGi | 9606.ENSP00000349640 |
Miscellaneous databases
RNActi | Q96EZ8, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 363 – 419 | FHAPROSITE-ProRule annotationAdd BLAST | 57 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 301 – 335 | Sequence analysisAdd BLAST | 35 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 113 – 123 | Nuclear localization signalSequence analysisAdd BLAST | 11 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 11 – 102 | Ser-richAdd BLAST | 92 |
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG2293, Eukaryota |
GeneTreei | ENSGT00390000005536 |
HOGENOMi | CLU_035858_0_0_1 |
InParanoidi | Q96EZ8 |
OMAi | DNQTLAC |
OrthoDBi | 1091011at2759 |
PhylomeDBi | Q96EZ8 |
TreeFami | TF318119 |
Family and domain databases
CDDi | cd00060, FHA, 1 hit |
InterProi | View protein in InterPro IPR000253, FHA_dom IPR037912, MCRS1 IPR025999, MCRS_N IPR008984, SMAD_FHA_dom_sf |
PANTHERi | PTHR13233, PTHR13233, 1 hit |
Pfami | View protein in Pfam PF00498, FHA, 1 hit PF13325, MCRS_N, 1 hit |
SMARTi | View protein in SMART SM00240, FHA, 1 hit |
SUPFAMi | SSF49879, SSF49879, 1 hit |
PROSITEi | View protein in PROSITE PS50006, FHA_DOMAIN, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDKDSQGLLD SSLMASGTAS RSEDEESLAG QKRASSQALG TIPKRRSSSR
60 70 80 90 100
FIKRKKFDDE LVESSLAKSS TRAKGASGVE PGRCSGSEPS SSEKKKVSKA
110 120 130 140 150
PSTPVPPSPA PAPGLTKRVK KSKQPLQVTK DLGRWKPADD LLLINAVLQT
160 170 180 190 200
NDLTSVHLGV KFSCRFTLRE VQERWYALLY DPVISKLACQ AMRQLHPEAI
210 220 230 240 250
AAIQSKALFS KAEEQLLSKV GSTSQPTLET FQDLLHRHPD AFYLARTAKA
260 270 280 290 300
LQAHWQLMKQ YYLLEDQTVQ PLPKGDQVLN FSDAEDLIDD SKLKDMRDEV
310 320 330 340 350
LEHELMVADR RQKREIRQLE QELHKWQVLV DSITGMSSPD FDNQTLAVLR
360 370 380 390 400
GRMVRYLMRS REITLGRATK DNQIDVDLSL EGPAWKISRK QGVIKLKNNG
410 420 430 440 450
DFFIANEGRR PIYIDGRPVL CGSKWRLSNN SVVEIASLRF VFLINQDLIA
460
LIRAEAAKIT PQ
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF8W126 | F8W126_HUMAN | Microspherule protein 1 | MCRS1 | 318 | Annotation score: | ||
F8VVA6 | F8VVA6_HUMAN | Microspherule protein 1 | MCRS1 | 185 | Annotation score: | ||
F8VP44 | F8VP44_HUMAN | Microspherule protein 1 | MCRS1 | 205 | Annotation score: | ||
H0YIA0 | H0YIA0_HUMAN | Microspherule protein 1 | MCRS1 | 173 | Annotation score: | ||
F8W0I9 | F8W0I9_HUMAN | Microspherule protein 1 | MCRS1 | 144 | Annotation score: | ||
F8VZC2 | F8VZC2_HUMAN | Microspherule protein 1 | MCRS1 | 61 | Annotation score: | ||
H0YI67 | H0YI67_HUMAN | Microspherule protein 1 | MCRS1 | 64 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 245 | A → G in AAC52086 (PubMed:9654073).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_035473 | 441 | V → I in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs780785469Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_054571 | 1 – 191 | Missing in isoform 4. CuratedAdd BLAST | 191 | |
Alternative sequenceiVSP_016259 | 1 – 13 | Missing in isoform 3. 1 PublicationAdd BLAST | 13 | |
Alternative sequenceiVSP_016260 | 1 – 3 | MDK → MTRGTGGTAQRGRSGP in isoform 2. 1 Publication | 3 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF015308 mRNA Translation: AAC52086.1 AF068007 mRNA Translation: AAC68599.1 Frameshift. AY336730 mRNA Translation: AAQ84517.1 BX538079 mRNA Translation: CAD98003.1 AC020612 Genomic DNA No translation available. CH471111 Genomic DNA Translation: EAW58078.1 BC011794 mRNA Translation: AAH11794.1 |
CCDSi | CCDS31795.1 [Q96EZ8-2] CCDS61118.1 [Q96EZ8-4] CCDS8787.1 [Q96EZ8-1] |
RefSeqi | NP_001012300.1, NM_001012300.1 [Q96EZ8-2] NP_001265270.1, NM_001278341.1 [Q96EZ8-4] NP_006328.2, NM_006337.4 [Q96EZ8-1] XP_005268629.1, XM_005268572.3 [Q96EZ8-1] XP_016874178.1, XM_017018689.1 [Q96EZ8-2] XP_016874179.1, XM_017018690.1 [Q96EZ8-2] |
Genome annotation databases
Ensembli | ENST00000343810; ENSP00000345358; ENSG00000187778 [Q96EZ8-1] ENST00000357123; ENSP00000349640; ENSG00000187778 [Q96EZ8-2] ENST00000546244; ENSP00000444982; ENSG00000187778 [Q96EZ8-4] ENST00000550165; ENSP00000448056; ENSG00000187778 [Q96EZ8-1] |
GeneIDi | 10445 |
KEGGi | hsa:10445 |
UCSCi | uc001rui.3, human [Q96EZ8-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF015308 mRNA Translation: AAC52086.1 AF068007 mRNA Translation: AAC68599.1 Frameshift. AY336730 mRNA Translation: AAQ84517.1 BX538079 mRNA Translation: CAD98003.1 AC020612 Genomic DNA No translation available. CH471111 Genomic DNA Translation: EAW58078.1 BC011794 mRNA Translation: AAH11794.1 |
CCDSi | CCDS31795.1 [Q96EZ8-2] CCDS61118.1 [Q96EZ8-4] CCDS8787.1 [Q96EZ8-1] |
RefSeqi | NP_001012300.1, NM_001012300.1 [Q96EZ8-2] NP_001265270.1, NM_001278341.1 [Q96EZ8-4] NP_006328.2, NM_006337.4 [Q96EZ8-1] XP_005268629.1, XM_005268572.3 [Q96EZ8-1] XP_016874178.1, XM_017018689.1 [Q96EZ8-2] XP_016874179.1, XM_017018690.1 [Q96EZ8-2] |
3D structure databases
SMRi | Q96EZ8 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 115710, 183 interactors |
ComplexPortali | CPX-809, NSL histone acetyltransferase complex CPX-846, INO80 chromatin remodeling complex |
CORUMi | Q96EZ8 |
IntActi | Q96EZ8, 159 interactors |
MINTi | Q96EZ8 |
STRINGi | 9606.ENSP00000349640 |
PTM databases
iPTMneti | Q96EZ8 |
PhosphoSitePlusi | Q96EZ8 |
SwissPalmi | Q96EZ8 |
Genetic variation databases
BioMutai | MCRS1 |
DMDMi | 24638035 |
Proteomic databases
EPDi | Q96EZ8 |
jPOSTi | Q96EZ8 |
MassIVEi | Q96EZ8 |
MaxQBi | Q96EZ8 |
PaxDbi | Q96EZ8 |
PeptideAtlasi | Q96EZ8 |
PRIDEi | Q96EZ8 |
ProteomicsDBi | 69010 76477 [Q96EZ8-1] 76478 [Q96EZ8-2] 76479 [Q96EZ8-3] |
Protocols and materials databases
Antibodypediai | 25985, 155 antibodies |
DNASUi | 10445 |
Genome annotation databases
Ensembli | ENST00000343810; ENSP00000345358; ENSG00000187778 [Q96EZ8-1] ENST00000357123; ENSP00000349640; ENSG00000187778 [Q96EZ8-2] ENST00000546244; ENSP00000444982; ENSG00000187778 [Q96EZ8-4] ENST00000550165; ENSP00000448056; ENSG00000187778 [Q96EZ8-1] |
GeneIDi | 10445 |
KEGGi | hsa:10445 |
UCSCi | uc001rui.3, human [Q96EZ8-1] |
Organism-specific databases
CTDi | 10445 |
DisGeNETi | 10445 |
GeneCardsi | MCRS1 |
HGNCi | HGNC:6960, MCRS1 |
HPAi | ENSG00000187778, Low tissue specificity |
MIMi | 609504, gene |
neXtProti | NX_Q96EZ8 |
OpenTargetsi | ENSG00000187778 |
PharmGKBi | PA30708 |
VEuPathDBi | HostDB:ENSG00000187778.13 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2293, Eukaryota |
GeneTreei | ENSGT00390000005536 |
HOGENOMi | CLU_035858_0_0_1 |
InParanoidi | Q96EZ8 |
OMAi | DNQTLAC |
OrthoDBi | 1091011at2759 |
PhylomeDBi | Q96EZ8 |
TreeFami | TF318119 |
Enzyme and pathway databases
PathwayCommonsi | Q96EZ8 |
Reactomei | R-HSA-3214847, HATs acetylate histones R-HSA-5689603, UCH proteinases R-HSA-5696394, DNA Damage Recognition in GG-NER |
Miscellaneous databases
BioGRID-ORCSi | 10445, 451 hits in 1000 CRISPR screens |
ChiTaRSi | MCRS1, human |
GeneWikii | MCRS1 |
GenomeRNAii | 10445 |
Pharosi | Q96EZ8, Tbio |
PROi | PR:Q96EZ8 |
RNActi | Q96EZ8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000187778, Expressed in apex of heart and 228 other tissues |
ExpressionAtlasi | Q96EZ8, baseline and differential |
Genevisiblei | Q96EZ8, HS |
Family and domain databases
CDDi | cd00060, FHA, 1 hit |
InterProi | View protein in InterPro IPR000253, FHA_dom IPR037912, MCRS1 IPR025999, MCRS_N IPR008984, SMAD_FHA_dom_sf |
PANTHERi | PTHR13233, PTHR13233, 1 hit |
Pfami | View protein in Pfam PF00498, FHA, 1 hit PF13325, MCRS_N, 1 hit |
SMARTi | View protein in SMART SM00240, FHA, 1 hit |
SUPFAMi | SSF49879, SSF49879, 1 hit |
PROSITEi | View protein in PROSITE PS50006, FHA_DOMAIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MCRS1_HUMAN | |
Accessioni | Q96EZ8Primary (citable) accession number: Q96EZ8 Secondary accession number(s): O14742 Q7Z372 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 2002 |
Last sequence update: | December 1, 2001 | |
Last modified: | April 7, 2021 | |
This is version 181 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot