MCRS1

Functionⁱ

Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus (PubMed:11948183). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity (PubMed:15044100). Binds to G-quadruplex structures in mRNA (PubMed:16571602). Binds to RNA homopolymer poly(G) and poly(U) (PubMed:16571602).4 Publications

GO - Molecular functionⁱ

G-quadruplex RNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 16571602
poly(G) binding
Source: UniProtKB
Inferred from direct assayⁱ
- 16571602
poly(U) RNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 16571602
telomerase inhibitor activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 15044100

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular protein modification process
Source: ProtInc
Traceable author statementⁱ
- 9765390
DNA recombination Source: UniProtKB-KW
DNA repair Source: UniProtKB-KW
histone H4-K16 acetylation
Source: UniProtKB
Inferred from direct assayⁱ
- 20018852
histone H4-K5 acetylation
Source: UniProtKB
Inferred from direct assayⁱ
- 20018852
histone H4-K8 acetylation
Source: UniProtKB
Inferred from direct assayⁱ
- 20018852
negative regulation of telomerase activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 15044100
negative regulation of telomere maintenance via telomere lengthening
Source: BHF-UCL
Inferred from direct assayⁱ
- 15044100
positive regulation of protein localization to nucleolus
Source: UniProtKB
Inferred from direct assayⁱ
- 16571602
protein deubiquitination Source: Reactome
regulation of transcription, DNA-templated Source: UniProtKB-KW
transcription, DNA-templated Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Chromatin regulator
Biological process	DNA damage, DNA recombination, DNA repair, Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-3214847 HATs acetylate histones R-HSA-5689603 UCH proteinases R-HSA-5696394 DNA Damage Recognition in GG-NER

Reactomeⁱ

R-HSA-3214847 HATs acetylate histones
R-HSA-5689603 UCH proteinases
R-HSA-5696394 DNA Damage Recognition in GG-NER

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Microspherule protein 1 Alternative name(s): 58 kDa microspherule protein Cell cycle-regulated factor p78 INO80 complex subunit J MCRS2
Gene namesⁱ	Name:MCRS1 Synonyms:INO80Q, MSP58
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000187778.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6960 MCRS1
MIMⁱ	609504 gene
neXtProtⁱ	NX_Q96EZ8

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	10445
Open Targets More...OpenTargetsⁱ	ENSG00000187778
PharmGKBⁱ	PA30708

Polymorphism and mutation databases

BioMutaⁱ	MCRS1
DMDMⁱ	24638035

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000096305	1 – 462	Microspherule protein 1Add BLAST		462

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	1	N-acetylmethionineCombined sources	1
Modified residueⁱ	22	PhosphoserineCombined sources	1
Modified residueⁱ	102	PhosphoserineBy similarity	1
Modified residueⁱ	103	PhosphothreonineCombined sources	1
Modified residueⁱ	108	PhosphoserineCombined sources	1
Modified residueⁱ	123	N6-acetyllysineCombined sources	1
Modified residueⁱ	130	N6-acetyllysineCombined sources	1
Modified residueⁱ	282	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q96EZ8
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q96EZ8
PaxDbⁱ	Q96EZ8
PeptideAtlas More...PeptideAtlasⁱ	Q96EZ8
PRIDEⁱ	Q96EZ8
ProteomicsDBⁱ	76477 76478 [Q96EZ8-2] 76479 [Q96EZ8-3]

PTM databases

iPTMnetⁱ	Q96EZ8
PhosphoSitePlusⁱ	Q96EZ8
SwissPalmⁱ	Q96EZ8

Expressionⁱ

Tissue specificityⁱ

Detected in testis, and at lower levels in spleen, thymus, prostate, uterus, small intestine, colon and leukocytes.

Developmental stageⁱ

Cell-cycle regulated: levels are highest early in S phase; not detectable in G2.

Gene expression databases

Bgeeⁱ	ENSG00000187778 Expressed in 216 organ(s), highest expression level in apex of heart
CleanExⁱ	HS_MCRS1
ExpressionAtlasⁱ	Q96EZ8 baseline and differential
Genevisibleⁱ	Q96EZ8 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA039057

HPAⁱ

HPA039057

Interactionⁱ

Subunit structureⁱ

Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the N-terminus of INO80 (PubMed:16230350, PubMed:18922472, PubMed:21303910). Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10 (PubMed:15960975). Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1 (PubMed:20018852). Interacts with NOP2 (PubMed:9654073). Interacts with PINX1 (PubMed:15044100). Interacts with TERT (PubMed:15044100). Interacts with CCDC85B (PubMed:17014843). Interacts with DAXX (PubMed:11948183). Interacts (via N-terminus) with FMR1 (via phosphorylated form) (PubMed:16571602). Interacts with FXR1 AND FXR2 (PubMed:16571602).10 Publications

(Microbial infection) Interacts with Herpes simplex virus ICP22.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
BRMS1L	Q5PSV4	4	EBI-348259,EBI-5666615
CCDC13	Q8IYE1	4	EBI-348259,EBI-10961312
CDCA7L	Q96GN5	4	EBI-348259,EBI-5278764
CEP44	Q9C0F1	3	EBI-348259,EBI-744115
DAXX	Q9UER7	10	EBI-348259,EBI-77321
FXR2	P51116	3	EBI-348259,EBI-740459
GPBP1	Q86WP2	4	EBI-348259,EBI-2349758
HMBOX1	Q6NT76	4	EBI-348259,EBI-2549423
IKZF1	Q13422	3	EBI-348259,EBI-745305
INO80E	Q8NBZ0	7	EBI-348259,EBI-769401
KIAA1958	Q8N8K9	3	EBI-348259,EBI-10181113
KXD1	Q9BQD3	3	EBI-348259,EBI-739657
MAP3K5	Q99683	3	EBI-348259,EBI-476263
MED4	Q9NPJ6	3	EBI-348259,EBI-394607
NKAPD1	Q6ZUT1	4	EBI-348259,EBI-3920396
PHC2	Q8IXK0	2	EBI-348259,EBI-713786
TRIM37	O94972	4	EBI-348259,EBI-741602
USHBP1	Q8N6Y0	5	EBI-348259,EBI-739895
WASHC3	Q9Y3C0	10	EBI-348259,EBI-712969
WBP11	Q9Y2W2	3	EBI-348259,EBI-714455
ZBTB22	O15209	5	EBI-348259,EBI-723574

Protein-protein interaction databases

BioGridⁱ	115710, 78 interactors
ComplexPortalⁱ	CPX-809 NSL histone acetyltransferase complex CPX-846 INO80 chromatin remodeling complex
CORUMⁱ	Q96EZ8
IntActⁱ	Q96EZ8, 128 interactors
Molecular INTeraction database More...MINTⁱ	Q96EZ8
STRINGⁱ	9606.ENSP00000349640

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q96EZ8
SMRⁱ	Q96EZ8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	363 – 419	FHAPROSITE-ProRule annotationAdd BLAST		57

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	301 – 335	Sequence analysisAdd BLAST		35

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	113 – 123	Nuclear localization signalSequence analysisAdd BLAST		11

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	11 – 102	Ser-richAdd BLAST		92

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	KOG2293 Eukaryota ENOG410XS0S LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000005536
HOGENOMⁱ	HOG000007227
HOVERGENⁱ	HBG052434
InParanoidⁱ	Q96EZ8
KEGG Orthology (KO) More...KOⁱ	K11674
OMAⁱ	FLVNYEL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G07QN
PhylomeDBⁱ	Q96EZ8
TreeFamⁱ	TF318119

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00060 FHA, 1 hit
InterProⁱ	View protein in InterPro IPR000253 FHA_dom IPR037912 MCRS1 IPR025999 MCRS_N IPR008984 SMAD_FHA_dom_sf
PANTHERⁱ	PTHR13233 PTHR13233, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00498 FHA, 1 hit PF13325 MCRS_N, 1 hit
SMARTⁱ	View protein in SMART SM00240 FHA, 1 hit
SUPFAMⁱ	SSF49879 SSF49879, 1 hit
PROSITEⁱ	View protein in PROSITE PS50006 FHA_DOMAIN, 1 hit

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 4 described isoforms and 7 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q96EZ8-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDKDSQGLLD SSLMASGTAS RSEDEESLAG QKRASSQALG TIPKRRSSSR 
        60         70         80         90        100
FIKRKKFDDE LVESSLAKSS TRAKGASGVE PGRCSGSEPS SSEKKKVSKA 
       110        120        130        140        150
PSTPVPPSPA PAPGLTKRVK KSKQPLQVTK DLGRWKPADD LLLINAVLQT 
       160        170        180        190        200
NDLTSVHLGV KFSCRFTLRE VQERWYALLY DPVISKLACQ AMRQLHPEAI 
       210        220        230        240        250
AAIQSKALFS KAEEQLLSKV GSTSQPTLET FQDLLHRHPD AFYLARTAKA 
       260        270        280        290        300
LQAHWQLMKQ YYLLEDQTVQ PLPKGDQVLN FSDAEDLIDD SKLKDMRDEV 
       310        320        330        340        350
LEHELMVADR RQKREIRQLE QELHKWQVLV DSITGMSSPD FDNQTLAVLR 
       360        370        380        390        400
GRMVRYLMRS REITLGRATK DNQIDVDLSL EGPAWKISRK QGVIKLKNNG 
       410        420        430        440        450
DFFIANEGRR PIYIDGRPVL CGSKWRLSNN SVVEIASLRF VFLINQDLIA 
       460 
LIRAEAAKIT PQ

Length:462

Mass (Da):51,803

Last modified:December 1, 2001 - v1

Checksum:ⁱF6B7CC8A2AAF16BC

GO

Isoform 2 (identifier: Q96EZ8-2) [UniParc]FASTA Add to basket

Also known as: MCRS2

The sequence of this isoform differs from the canonical sequence as follows:
1-3: MDK → MTRGTGGTAQRGRSGP

« Hide

        10         20         30         40         50
MTRGTGGTAQ RGRSGPDSQG LLDSSLMASG TASRSEDEES LAGQKRASSQ 
        60         70         80         90        100
ALGTIPKRRS SSRFIKRKKF DDELVESSLA KSSTRAKGAS GVEPGRCSGS 
       110        120        130        140        150
EPSSSEKKKV SKAPSTPVPP SPAPAPGLTK RVKKSKQPLQ VTKDLGRWKP 
       160        170        180        190        200
ADDLLLINAV LQTNDLTSVH LGVKFSCRFT LREVQERWYA LLYDPVISKL 
       210        220        230        240        250
ACQAMRQLHP EAIAAIQSKA LFSKAEEQLL SKVGSTSQPT LETFQDLLHR 
       260        270        280        290        300
HPDAFYLART AKALQAHWQL MKQYYLLEDQ TVQPLPKGDQ VLNFSDAEDL 
       310        320        330        340        350
IDDSKLKDMR DEVLEHELMV ADRRQKREIR QLEQELHKWQ VLVDSITGMS 
       360        370        380        390        400
SPDFDNQTLA VLRGRMVRYL MRSREITLGR ATKDNQIDVD LSLEGPAWKI 
       410        420        430        440        450
SRKQGVIKLK NNGDFFIANE GRRPIYIDGR PVLCGSKWRL SNNSVVEIAS 
       460        470 
LRFVFLINQD LIALIRAEAA KITPQ

Show »

Length:475

Mass (Da):53,001

Checksum:ⁱ5ABAFCB412408F76

GO

Isoform 3 (identifier: Q96EZ8-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-13: Missing.

« Hide

        10         20         30         40         50
MASGTASRSE DEESLAGQKR ASSQALGTIP KRRSSSRFIK RKKFDDELVE 
        60         70         80         90        100
SSLAKSSTRA KGASGVEPGR CSGSEPSSSE KKKVSKAPST PVPPSPAPAP 
       110        120        130        140        150
GLTKRVKKSK QPLQVTKDLG RWKPADDLLL INAVLQTNDL TSVHLGVKFS 
       160        170        180        190        200
CRFTLREVQE RWYALLYDPV ISKLACQAMR QLHPEAIAAI QSKALFSKAE 
       210        220        230        240        250
EQLLSKVGST SQPTLETFQD LLHRHPDAFY LARTAKALQA HWQLMKQYYL 
       260        270        280        290        300
LEDQTVQPLP KGDQVLNFSD AEDLIDDSKL KDMRDEVLEH ELMVADRRQK 
       310        320        330        340        350
REIRQLEQEL HKWQVLVDSI TGMSSPDFDN QTLAVLRGRM VRYLMRSREI 
       360        370        380        390        400
TLGRATKDNQ IDVDLSLEGP AWKISRKQGV IKLKNNGDFF IANEGRRPIY 
       410        420        430        440 
IDGRPVLCGS KWRLSNNSVV EIASLRFVFL INQDLIALIR AEAAKITPQ

Note: No experimental confirmation available. May be due to intron retention.

Show »

Length:449

Mass (Da):50,413

Checksum:ⁱ46DB62C0D3158EC1

GO

Isoform 4 (identifier: Q96EZ8-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-191: Missing.

« Hide

        10         20         30         40         50
MRQLHPEAIA AIQSKALFSK AEEQLLSKVG STSQPTLETF QDLLHRHPDA 
        60         70         80         90        100
FYLARTAKAL QAHWQLMKQY YLLEDQTVQP LPKGDQVLNF SDAEDLIDDS 
       110        120        130        140        150
KLKDMRDEVL EHELMVADRR QKREIRQLEQ ELHKWQVLVD SITGMSSPDF 
       160        170        180        190        200
DNQTLAVLRG RMVRYLMRSR EITLGRATKD NQIDVDLSLE GPAWKISRKQ 
       210        220        230        240        250
GVIKLKNNGD FFIANEGRRP IYIDGRPVLC GSKWRLSNNS VVEIASLRFV 
       260        270 
FLINQDLIAL IRAEAAKITP Q

Note: No experimental confirmation available.

Show »

Length:271

Mass (Da):31,134

Checksum:ⁱ9B6338AC1B6BAF5E

GO

Computationally mapped potential isoform sequencesⁱ

There are 7 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

F8W126	F8W126_HUMAN	Microspherule protein 1 Microspherule protein 1	MCRS1	318	Annotation score:
H0YIA0	H0YIA0_HUMAN	Microspherule protein 1 Microspherule protein 1	MCRS1	173	Annotation score:
F8VVA6	F8VVA6_HUMAN	Microspherule protein 1 Microspherule protein 1	MCRS1	185	Annotation score:
F8VP44	F8VP44_HUMAN	Microspherule protein 1 Microspherule protein 1	MCRS1	205	Annotation score:
F8W0I9	F8W0I9_HUMAN	Microspherule protein 1 Microspherule protein 1	MCRS1	144	Annotation score:
H0YI67	H0YI67_HUMAN	Microspherule protein 1 Microspherule protein 1	MCRS1	64	Annotation score:
F8VZC2	F8VZC2_HUMAN	Microspherule protein 1 Microspherule protein 1	MCRS1	61	Annotation score:

Sequence cautionⁱ

The sequence AAC68599 differs from that shown. Reason: Frameshift at several positions.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	245	A → G in AAC52086 (PubMed:9654073).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_035473	441	V → I in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs780785469Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_054571	1 – 191	Missing in isoform 4. CuratedAdd BLAST	191
Alternative sequenceⁱVSP_016259	1 – 13	Missing in isoform 3. 1 PublicationAdd BLAST	13
Alternative sequenceⁱVSP_016260	1 – 3	MDK → MTRGTGGTAQRGRSGP in isoform 2. 1 Publication	3

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF015308 mRNA Translation: AAC52086.1 AF068007 mRNA Translation: AAC68599.1 Frameshift. AY336730 mRNA Translation: AAQ84517.1 BX538079 mRNA Translation: CAD98003.1 AC020612 Genomic DNA No translation available. CH471111 Genomic DNA Translation: EAW58078.1 BC011794 mRNA Translation: AAH11794.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS31795.1 [Q96EZ8-2] CCDS61118.1 [Q96EZ8-4] CCDS8787.1 [Q96EZ8-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001012300.1, NM_001012300.1 [Q96EZ8-2] NP_001265270.1, NM_001278341.1 [Q96EZ8-4] NP_006328.2, NM_006337.4 [Q96EZ8-1] XP_005268629.1, XM_005268572.3 [Q96EZ8-1] XP_016874178.1, XM_017018689.1 [Q96EZ8-2] XP_016874179.1, XM_017018690.1 [Q96EZ8-2]
UniGeneⁱ	Hs.25313

Genome annotation databases

Ensemblⁱ	ENST00000343810; ENSP00000345358; ENSG00000187778 [Q96EZ8-1] ENST00000357123; ENSP00000349640; ENSG00000187778 [Q96EZ8-2] ENST00000546244; ENSP00000444982; ENSG00000187778 [Q96EZ8-4] ENST00000550165; ENSP00000448056; ENSG00000187778 [Q96EZ8-1]
GeneIDⁱ	10445
KEGGⁱ	hsa:10445
UCSC genome browser More...UCSCⁱ	uc001rui.3 human [Q96EZ8-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q96EZ8	Microspherule protein 1 isoform 1		MACMU		462	UniRef100_Q96EZ8
MCRS1 isoform 1		PANTR		462
MCRS1 isoform 1		PONAB		462
Uncharacterized protein		PAPAN		462
Uncharacterized protein		PANPA		462
+3
Q96EZ8-2	MCRS1 isoform 12		PANTR		475	UniRef100_A0A2I3SQ53
Microspherule protein 1		MACFA		475
Uncharacterized protein		MACMU		475
Uncharacterized protein		COLAP		475
MCRS1 isoform 12		PONAB		475
+7
Q96EZ8-3	Microspherule protein 1, isoform CRA_d		HUMAN		271	UniRef100_A0A024R134
MCRS1 isoform 2		PONAB		271
MCRS1 isoform 2		PANTR		271
Isoform 4 of Microspherule protein 1		HUMAN		271
UPI0000E2319F		HUMAN		513
Q96EZ8-4	Microspherule protein 1, isoform CRA_d		HUMAN		271	UniRef100_A0A024R134
MCRS1 isoform 2		PONAB		271
MCRS1 isoform 2		PANTR		271
Isoform 3 of Microspherule protein 1		HUMAN		449
UPI0000E2319F		HUMAN		513

Protein	Similar proteins		Species	Score	Length	Source
Q96EZ8	Microspherule protein 1		MOUSE		462	UniRef90_Q96EZ8
Microspherule protein 1 isoform 1		MACMU		462
MCRS1 isoform 1		PANTR		462
MCRS1 isoform 1		PONAB		462
Uncharacterized protein		PAPAN		462
+190

Protein	Similar proteins		Species	Score	Length	Source
Q96EZ8	Microspherule protein 1		MOUSE		462	UniRef50_Q96EZ8
Microspherule protein 1 isoform 1		MACMU		462
MCRS1 isoform 1		PANTR		462
MCRS1 isoform 1		PONAB		462
Uncharacterized protein		PAPAN		462
+426

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF015308 mRNA Translation: AAC52086.1 AF068007 mRNA Translation: AAC68599.1 Frameshift. AY336730 mRNA Translation: AAQ84517.1 BX538079 mRNA Translation: CAD98003.1 AC020612 Genomic DNA No translation available. CH471111 Genomic DNA Translation: EAW58078.1 BC011794 mRNA Translation: AAH11794.1
CCDSⁱ	CCDS31795.1 [Q96EZ8-2] CCDS61118.1 [Q96EZ8-4] CCDS8787.1 [Q96EZ8-1]
RefSeqⁱ	NP_001012300.1, NM_001012300.1 [Q96EZ8-2] NP_001265270.1, NM_001278341.1 [Q96EZ8-4] NP_006328.2, NM_006337.4 [Q96EZ8-1] XP_005268629.1, XM_005268572.3 [Q96EZ8-1] XP_016874178.1, XM_017018689.1 [Q96EZ8-2] XP_016874179.1, XM_017018690.1 [Q96EZ8-2]
UniGeneⁱ	Hs.25313

3D structure databases

ProteinModelPortalⁱ	Q96EZ8
SMRⁱ	Q96EZ8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	115710, 78 interactors
ComplexPortalⁱ	CPX-809 NSL histone acetyltransferase complex CPX-846 INO80 chromatin remodeling complex
CORUMⁱ	Q96EZ8
IntActⁱ	Q96EZ8, 128 interactors
MINTⁱ	Q96EZ8
STRINGⁱ	9606.ENSP00000349640

PTM databases

iPTMnetⁱ	Q96EZ8
PhosphoSitePlusⁱ	Q96EZ8
SwissPalmⁱ	Q96EZ8

Polymorphism and mutation databases

BioMutaⁱ	MCRS1
DMDMⁱ	24638035

Proteomic databases

EPDⁱ	Q96EZ8
MaxQBⁱ	Q96EZ8
PaxDbⁱ	Q96EZ8
PeptideAtlasⁱ	Q96EZ8
PRIDEⁱ	Q96EZ8
ProteomicsDBⁱ	76477 76478 [Q96EZ8-2] 76479 [Q96EZ8-3]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	10445
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000343810; ENSP00000345358; ENSG00000187778 [Q96EZ8-1] ENST00000357123; ENSP00000349640; ENSG00000187778 [Q96EZ8-2] ENST00000546244; ENSP00000444982; ENSG00000187778 [Q96EZ8-4] ENST00000550165; ENSP00000448056; ENSG00000187778 [Q96EZ8-1]
GeneIDⁱ	10445
KEGGⁱ	hsa:10445
UCSCⁱ	uc001rui.3 human [Q96EZ8-1]

Organism-specific databases

CTDⁱ	10445
DisGeNETⁱ	10445
EuPathDBⁱ	HostDB:ENSG00000187778.13
GeneCardsⁱ	MCRS1
HGNCⁱ	HGNC:6960 MCRS1
HPAⁱ	HPA039057
MIMⁱ	609504 gene
neXtProtⁱ	NX_Q96EZ8
OpenTargetsⁱ	ENSG00000187778
PharmGKBⁱ	PA30708
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2293 Eukaryota ENOG410XS0S LUCA
GeneTreeⁱ	ENSGT00390000005536
HOGENOMⁱ	HOG000007227
HOVERGENⁱ	HBG052434
InParanoidⁱ	Q96EZ8
KOⁱ	K11674
OMAⁱ	FLVNYEL
OrthoDBⁱ	EOG091G07QN
PhylomeDBⁱ	Q96EZ8
TreeFamⁱ	TF318119

Enzyme and pathway databases

Reactomeⁱ	R-HSA-3214847 HATs acetylate histones R-HSA-5689603 UCH proteinases R-HSA-5696394 DNA Damage Recognition in GG-NER

Reactomeⁱ

R-HSA-3214847 HATs acetylate histones
R-HSA-5689603 UCH proteinases
R-HSA-5696394 DNA Damage Recognition in GG-NER

Miscellaneous databases

ChiTaRSⁱ	MCRS1 human
GeneWikiⁱ	MCRS1
GenomeRNAiⁱ	10445
Protein Ontology More...PROⁱ	PR:Q96EZ8
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000187778 Expressed in 216 organ(s), highest expression level in apex of heart
CleanExⁱ	HS_MCRS1
ExpressionAtlasⁱ	Q96EZ8 baseline and differential
Genevisibleⁱ	Q96EZ8 HS

Family and domain databases

CDDⁱ	cd00060 FHA, 1 hit
InterProⁱ	View protein in InterPro IPR000253 FHA_dom IPR037912 MCRS1 IPR025999 MCRS_N IPR008984 SMAD_FHA_dom_sf
PANTHERⁱ	PTHR13233 PTHR13233, 1 hit
Pfamⁱ	View protein in Pfam PF00498 FHA, 1 hit PF13325 MCRS_N, 1 hit
SMARTⁱ	View protein in SMART SM00240 FHA, 1 hit
SUPFAMⁱ	SSF49879 SSF49879, 1 hit
PROSITEⁱ	View protein in PROSITE PS50006 FHA_DOMAIN, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MCRS1_HUMAN
Accessionⁱ	Q96EZ8Primary (citable) accession number: Q96EZ8 Secondary accession number(s): O14742 , O75497, Q6VN53, Q7Z372
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 2002
	Last sequence update:	December 1, 2001
	Last modified:	September 12, 2018
	This is version 164 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - Q96EZ8 (MCRS1_HUMAN)

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Microspherule protein 1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

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Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ