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UniProtKB - Q96EZ8 (MCRS1_HUMAN)

Entry version 181 (07 Apr 2021)
Sequence version 1 (01 Dec 2001)
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Protein

Microspherule protein 1

Gene

MCRS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus (PubMed:11948183). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity (PubMed:15044100). Binds to G-quadruplex structures in mRNA (PubMed:16571602). Binds to RNA homopolymer poly(G) and poly(U) (PubMed:16571602).4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator
Biological processDNA damage, DNA recombination, DNA repair, Host-virus interaction, Transcription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q96EZ8

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-3214847, HATs acetylate histones
R-HSA-5689603, UCH proteinases
R-HSA-5696394, DNA Damage Recognition in GG-NER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Microspherule protein 1
Alternative name(s):
58 kDa microspherule protein
Cell cycle-regulated factor p78
INO80 complex subunit J
MCRS2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MCRS1
Synonyms:INO80Q, MSP58
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:6960, MCRS1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		609504, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q96EZ8

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000187778.13

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		10445

Open Targets

More...OpenTargetsi		ENSG00000187778

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA30708

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q96EZ8, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		MCRS1

Domain mapping of disease mutations (DMDM)

More...DMDMi		24638035

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000963051 – 462Microspherule protein 1Add BLAST462

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei22PhosphoserineCombined sources1
Modified residuei102PhosphoserineBy similarity1
Modified residuei103PhosphothreonineCombined sources1
Modified residuei108PhosphoserineCombined sources1
Modified residuei123N6-acetyllysineCombined sources1
Modified residuei130N6-acetyllysineCombined sources1
Modified residuei282PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q96EZ8

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q96EZ8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q96EZ8

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q96EZ8

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q96EZ8

PeptideAtlas

More...PeptideAtlasi		Q96EZ8

PRoteomics IDEntifications database

More...PRIDEi		Q96EZ8

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		69010
76477 [Q96EZ8-1]
76478 [Q96EZ8-2]
76479 [Q96EZ8-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q96EZ8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q96EZ8

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q96EZ8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in testis, and at lower levels in spleen, thymus, prostate, uterus, small intestine, colon and leukocytes.

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Cell-cycle regulated: levels are highest early in S phase; not detectable in G2.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000187778, Expressed in apex of heart and 228 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q96EZ8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q96EZ8, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000187778, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the N-terminus of INO80 (PubMed:16230350, PubMed:18922472, PubMed:21303910).

Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10 (PubMed:15960975).

Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1 (PubMed:20018852).

Interacts with NOP2 (PubMed:9654073).

Interacts with PINX1 (PubMed:15044100).

Interacts with TERT (PubMed:15044100).

Interacts with CCDC85B (PubMed:17014843).

Interacts with DAXX (PubMed:11948183).

Interacts (via N-terminus) with FMR1 (via phosphorylated form) (PubMed:16571602).

Interacts with FXR1 AND FXR2 (PubMed:16571602).

10 Publications

(Microbial infection) Interacts with Herpes simplex virus ICP22.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q96EZ8
With#Exp.IntAct
AGGF1 [Q8N302]3EBI-348259,EBI-747899
AXIN2 [Q9Y2T1]3EBI-348259,EBI-4400025
BACH2 [Q9BYV9]3EBI-348259,EBI-1642333
BEND3 [Q5T5X7]3EBI-348259,EBI-1211496
BHLHA9 [Q7RTU4]3EBI-348259,EBI-17508719
BHLHE40 [O14503]3EBI-348259,EBI-711810
BRD8 - isoform 2 [Q9H0E9-2]3EBI-348259,EBI-10304361
BRMS1 [Q9HCU9]3EBI-348259,EBI-714781
BRMS1L [Q5PSV4]5EBI-348259,EBI-5666615
C18orf25 [Q96B23]5EBI-348259,EBI-742108
C2CD6 [Q53TS8]3EBI-348259,EBI-739879
CARD9 - isoform 2 [Q9H257-2]3EBI-348259,EBI-11530605
CAVIN2 [O95810]3EBI-348259,EBI-742141
CBY2 - isoform 2 [Q8NA61-2]3EBI-348259,EBI-11524851
CCDC13 [Q8IYE1]6EBI-348259,EBI-10961312
CCHCR1 - isoform 3 [Q8TD31-3]3EBI-348259,EBI-10175300
CCNH [P51946]3EBI-348259,EBI-741406
CDCA7L [Q96GN5]6EBI-348259,EBI-5278764
CEP44 [Q9C0F1]6EBI-348259,EBI-744115
CEP70 [Q8NHQ1]3EBI-348259,EBI-739624
CNTROB [Q8N137]3EBI-348259,EBI-947360
COIL [P38432]3EBI-348259,EBI-945751
CREB3L3 [Q68CJ9]3EBI-348259,EBI-852194
CSRNP1 [Q96S65]3EBI-348259,EBI-4311573
CYSRT1 [A8MQ03]3EBI-348259,EBI-3867333
CYTIP [O60759]3EBI-348259,EBI-997814
DAXX [Q9UER7]11EBI-348259,EBI-77321
DRAP1 [Q14919]3EBI-348259,EBI-712941
ERF [P50548]3EBI-348259,EBI-8465203
EVI5 [O60447]3EBI-348259,EBI-852291
FAM9A [Q8IZU1]3EBI-348259,EBI-8468186
FGFR3 [P22607]3EBI-348259,EBI-348399
FNDC8 [Q8TC99]3EBI-348259,EBI-12903902
FSD2 [A1L4K1]3EBI-348259,EBI-5661036
FXR1 - isoform 2 [P51114-2]3EBI-348259,EBI-11022345
FXR2 [P51116]4EBI-348259,EBI-740459
GAS7 - isoform 1 [O60861-1]3EBI-348259,EBI-11745923
GCC1 [Q96CN9]3EBI-348259,EBI-746252
GEM [P55040]3EBI-348259,EBI-744104
GFAP [P14136]3EBI-348259,EBI-744302
GIGYF1 [O75420]3EBI-348259,EBI-947774
GOLGA2 [Q08379]3EBI-348259,EBI-618309
GPBP1 [Q86WP2]5EBI-348259,EBI-2349758
GSN [P06396]3EBI-348259,EBI-351506
HMBOX1 [Q6NT76]8EBI-348259,EBI-2549423
HOOK2 - isoform 2 [Q96ED9-2]3EBI-348259,EBI-10961706
HRAS [P01112]3EBI-348259,EBI-350145
HTT [P42858]3EBI-348259,EBI-466029
IKZF1 [Q13422]3EBI-348259,EBI-745305
IKZF1 - isoform Ik7 [Q13422-7]3EBI-348259,EBI-11522367
IKZF3 [Q9UKT9]3EBI-348259,EBI-747204
IKZF4 [Q9H2S9]3EBI-348259,EBI-1640423
INO80E [Q8NBZ0]8EBI-348259,EBI-769401
INSYN1 [Q2T9L4]3EBI-348259,EBI-4311436
JAKMIP1 [Q96N16]3EBI-348259,EBI-2680803
KANK2 [Q63ZY3]3EBI-348259,EBI-2556193
KAT7 [O95251]3EBI-348259,EBI-473199
KIAA1958 [Q8N8K9]3EBI-348259,EBI-10181113
KRT35 [Q92764]3EBI-348259,EBI-1058674
KRTAP10-7 [P60409]3EBI-348259,EBI-10172290
KRTAP2-4 [Q9BYR9]3EBI-348259,EBI-14065470
KXD1 [Q9BQD3]4EBI-348259,EBI-739657
LZTS1 [Q9Y250]3EBI-348259,EBI-1216080
MAGEA6 [P43360]3EBI-348259,EBI-1045155
MAP3K5 [Q99683]3EBI-348259,EBI-476263
MAPK9 [P45984]3EBI-348259,EBI-713568
MED4 [Q9NPJ6]4EBI-348259,EBI-394607
MEOX1 [P50221]3EBI-348259,EBI-2864512
MFAP1 [P55081]3EBI-348259,EBI-1048159
MIER2 [Q8N344]5EBI-348259,EBI-3504938
MIER3 - isoform 2 [Q7Z3K6-2]3EBI-348259,EBI-12224671
NAA10 [P41227]3EBI-348259,EBI-747693
NAB2 [Q15742]3EBI-348259,EBI-8641936
NKAPD1 [Q6ZUT1]6EBI-348259,EBI-3920396
OSBPL3 [Q9H4L5]3EBI-348259,EBI-1051317
PBK [Q96KB5]3EBI-348259,EBI-536853
PCM1 - isoform 3 [Q15154-3]3EBI-348259,EBI-11742977
PHC2 [Q8IXK0]2EBI-348259,EBI-713786
PIBF1 [Q4G0R1]3EBI-348259,EBI-14066006
PKNOX2 [Q96KN3]3EBI-348259,EBI-2692890
PPP1R13B [Q96KQ4]3EBI-348259,EBI-1105153
PSTPIP1 [O43586]3EBI-348259,EBI-1050964
RABEP1 [Q15276]3EBI-348259,EBI-447043
RARA [P10276]3EBI-348259,EBI-413374
RETREG3 [Q86VR2]3EBI-348259,EBI-10192441
RIPPLY3 [P57055]3EBI-348259,EBI-12092053
SH2B2 - isoform 2 [O14492-2]3EBI-348259,EBI-19952306
SNAPC5 - isoform 2 [O75971-2]3EBI-348259,EBI-12004298
SP4 [Q02446]3EBI-348259,EBI-10198587
SRRM4 [A7MD48]3EBI-348259,EBI-3867173
SSMEM1 [Q8WWF3]3EBI-348259,EBI-17280858
TADA2B - isoform 3 [Q86TJ2-3]3EBI-348259,EBI-18173581
TBC1D1 [Q86TI0]3EBI-348259,EBI-1644036
TFAP4 [Q01664]3EBI-348259,EBI-2514218
TLE5 - isoform 2 [Q08117-2]3EBI-348259,EBI-11741437
TNIP1 [Q15025]3EBI-348259,EBI-357849
TNNI1 [P19237]3EBI-348259,EBI-746692
TP63 [Q9H3D4]3EBI-348259,EBI-2337775
TRIM37 [O94972]4EBI-348259,EBI-741602
TRIM41 [Q8WV44]3EBI-348259,EBI-725997
TSPYL2 [Q9H2G4]5EBI-348259,EBI-947459
USHBP1 [Q8N6Y0]6EBI-348259,EBI-739895
WASHC3 [Q9Y3C0]13EBI-348259,EBI-712969
WBP11 [Q9Y2W2]5EBI-348259,EBI-714455
XIAP [P98170]3EBI-348259,EBI-517127
ZBTB22 [O15209]6EBI-348259,EBI-723574
ZCCHC10 [Q8TBK6]3EBI-348259,EBI-597063
ZCCHC12 [Q6PEW1]3EBI-348259,EBI-748373
ZNF23 [P17027]3EBI-348259,EBI-5657766
ZNF639 [Q9UID6]3EBI-348259,EBI-947476
ZNF8 [P17098]3EBI-348259,EBI-2555757
ZRANB1 [Q9UGI0]3EBI-348259,EBI-527853
Q9Y6493EBI-348259,EBI-25900580

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		115710, 183 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-809, NSL histone acetyltransferase complex
CPX-846, INO80 chromatin remodeling complex

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q96EZ8

Protein interaction database and analysis system

More...IntActi		Q96EZ8, 159 interactors

Molecular INTeraction database

More...MINTi		Q96EZ8

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000349640

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q96EZ8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q96EZ8

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini363 – 419FHAPROSITE-ProRule annotationAdd BLAST57

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili301 – 335Sequence analysisAdd BLAST35

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi113 – 123Nuclear localization signalSequence analysisAdd BLAST11

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi11 – 102Ser-richAdd BLAST92

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2293, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000005536

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_035858_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q96EZ8

Identification of Orthologs from Complete Genome Data

More...OMAi		DNQTLAC

Database of Orthologous Groups

More...OrthoDBi		1091011at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q96EZ8

TreeFam database of animal gene trees

More...TreeFami		TF318119

Family and domain databases

Conserved Domains Database

More...CDDi		cd00060, FHA, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000253, FHA_dom
IPR037912, MCRS1
IPR025999, MCRS_N
IPR008984, SMAD_FHA_dom_sf

The PANTHER Classification System

More...PANTHERi		PTHR13233, PTHR13233, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00498, FHA, 1 hit
PF13325, MCRS_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00240, FHA, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49879, SSF49879, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50006, FHA_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96EZ8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDKDSQGLLD SSLMASGTAS RSEDEESLAG QKRASSQALG TIPKRRSSSR 
        60         70         80         90        100
FIKRKKFDDE LVESSLAKSS TRAKGASGVE PGRCSGSEPS SSEKKKVSKA 
       110        120        130        140        150
PSTPVPPSPA PAPGLTKRVK KSKQPLQVTK DLGRWKPADD LLLINAVLQT 
       160        170        180        190        200
NDLTSVHLGV KFSCRFTLRE VQERWYALLY DPVISKLACQ AMRQLHPEAI 
       210        220        230        240        250
AAIQSKALFS KAEEQLLSKV GSTSQPTLET FQDLLHRHPD AFYLARTAKA 
       260        270        280        290        300
LQAHWQLMKQ YYLLEDQTVQ PLPKGDQVLN FSDAEDLIDD SKLKDMRDEV 
       310        320        330        340        350
LEHELMVADR RQKREIRQLE QELHKWQVLV DSITGMSSPD FDNQTLAVLR 
       360        370        380        390        400
GRMVRYLMRS REITLGRATK DNQIDVDLSL EGPAWKISRK QGVIKLKNNG 
       410        420        430        440        450
DFFIANEGRR PIYIDGRPVL CGSKWRLSNN SVVEIASLRF VFLINQDLIA 
       460 
LIRAEAAKIT PQ
Length:462
Mass (Da):51,803
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF6B7CC8A2AAF16BC
GO
Isoform 2 (identifier: Q96EZ8-2) [UniParc]FASTAAdd to basket
Also known as: MCRS2

The sequence of this isoform differs from the canonical sequence as follows:
     1-3: MDK → MTRGTGGTAQRGRSGP

Show »
Length:475
Mass (Da):53,001
Checksum:i5ABAFCB412408F76
GO
Isoform 3 (identifier: Q96EZ8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: Missing.

Note: May be due to intron retention.Curated
Show »
Length:449
Mass (Da):50,413
Checksum:i46DB62C0D3158EC1
GO
Isoform 4 (identifier: Q96EZ8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-191: Missing.

Show »
Length:271
Mass (Da):31,134
Checksum:i9B6338AC1B6BAF5E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8W126F8W126_HUMAN
Microspherule protein 1
MCRS1
318Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VVA6F8VVA6_HUMAN
Microspherule protein 1
MCRS1
185Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VP44F8VP44_HUMAN
Microspherule protein 1
MCRS1
205Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YIA0H0YIA0_HUMAN
Microspherule protein 1
MCRS1
173Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W0I9F8W0I9_HUMAN
Microspherule protein 1
MCRS1
144Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VZC2F8VZC2_HUMAN
Microspherule protein 1
MCRS1
61Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YI67H0YI67_HUMAN
Microspherule protein 1
MCRS1
64Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC68599 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti245A → G in AAC52086 (PubMed:9654073).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_035473441V → I in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs780785469Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0545711 – 191Missing in isoform 4. CuratedAdd BLAST191
Alternative sequenceiVSP_0162591 – 13Missing in isoform 3. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_0162601 – 3MDK → MTRGTGGTAQRGRSGP in isoform 2. 1 Publication3

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF015308 mRNA Translation: AAC52086.1
AF068007 mRNA Translation: AAC68599.1 Frameshift.
AY336730 mRNA Translation: AAQ84517.1
BX538079 mRNA Translation: CAD98003.1
AC020612 Genomic DNA No translation available.
CH471111 Genomic DNA Translation: EAW58078.1
BC011794 mRNA Translation: AAH11794.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS31795.1 [Q96EZ8-2]
CCDS61118.1 [Q96EZ8-4]
CCDS8787.1 [Q96EZ8-1]

NCBI Reference Sequences

More...RefSeqi		NP_001012300.1, NM_001012300.1 [Q96EZ8-2]
NP_001265270.1, NM_001278341.1 [Q96EZ8-4]
NP_006328.2, NM_006337.4 [Q96EZ8-1]
XP_005268629.1, XM_005268572.3 [Q96EZ8-1]
XP_016874178.1, XM_017018689.1 [Q96EZ8-2]
XP_016874179.1, XM_017018690.1 [Q96EZ8-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000343810; ENSP00000345358; ENSG00000187778 [Q96EZ8-1]
ENST00000357123; ENSP00000349640; ENSG00000187778 [Q96EZ8-2]
ENST00000546244; ENSP00000444982; ENSG00000187778 [Q96EZ8-4]
ENST00000550165; ENSP00000448056; ENSG00000187778 [Q96EZ8-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		10445

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:10445

UCSC genome browser

More...UCSCi		uc001rui.3, human [Q96EZ8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF015308 mRNA Translation: AAC52086.1
AF068007 mRNA Translation: AAC68599.1 Frameshift.
AY336730 mRNA Translation: AAQ84517.1
BX538079 mRNA Translation: CAD98003.1
AC020612 Genomic DNA No translation available.
CH471111 Genomic DNA Translation: EAW58078.1
BC011794 mRNA Translation: AAH11794.1
CCDSiCCDS31795.1 [Q96EZ8-2]
CCDS61118.1 [Q96EZ8-4]
CCDS8787.1 [Q96EZ8-1]
RefSeqiNP_001012300.1, NM_001012300.1 [Q96EZ8-2]
NP_001265270.1, NM_001278341.1 [Q96EZ8-4]
NP_006328.2, NM_006337.4 [Q96EZ8-1]
XP_005268629.1, XM_005268572.3 [Q96EZ8-1]
XP_016874178.1, XM_017018689.1 [Q96EZ8-2]
XP_016874179.1, XM_017018690.1 [Q96EZ8-2]

3D structure databases

SMRiQ96EZ8
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi115710, 183 interactors
ComplexPortaliCPX-809, NSL histone acetyltransferase complex
CPX-846, INO80 chromatin remodeling complex
CORUMiQ96EZ8
IntActiQ96EZ8, 159 interactors
MINTiQ96EZ8
STRINGi9606.ENSP00000349640

PTM databases

iPTMnetiQ96EZ8
PhosphoSitePlusiQ96EZ8
SwissPalmiQ96EZ8

Genetic variation databases

BioMutaiMCRS1
DMDMi24638035

Proteomic databases

EPDiQ96EZ8
jPOSTiQ96EZ8
MassIVEiQ96EZ8
MaxQBiQ96EZ8
PaxDbiQ96EZ8
PeptideAtlasiQ96EZ8
PRIDEiQ96EZ8
ProteomicsDBi69010
76477 [Q96EZ8-1]
76478 [Q96EZ8-2]
76479 [Q96EZ8-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		25985, 155 antibodies

The DNASU plasmid repository

More...DNASUi		10445

Genome annotation databases

EnsembliENST00000343810; ENSP00000345358; ENSG00000187778 [Q96EZ8-1]
ENST00000357123; ENSP00000349640; ENSG00000187778 [Q96EZ8-2]
ENST00000546244; ENSP00000444982; ENSG00000187778 [Q96EZ8-4]
ENST00000550165; ENSP00000448056; ENSG00000187778 [Q96EZ8-1]
GeneIDi10445
KEGGihsa:10445
UCSCiuc001rui.3, human [Q96EZ8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		10445
DisGeNETi10445

GeneCards: human genes, protein and diseases

More...GeneCardsi		MCRS1
HGNCiHGNC:6960, MCRS1
HPAiENSG00000187778, Low tissue specificity
MIMi609504, gene
neXtProtiNX_Q96EZ8
OpenTargetsiENSG00000187778
PharmGKBiPA30708
VEuPathDBiHostDB:ENSG00000187778.13

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2293, Eukaryota
GeneTreeiENSGT00390000005536
HOGENOMiCLU_035858_0_0_1
InParanoidiQ96EZ8
OMAiDNQTLAC
OrthoDBi1091011at2759
PhylomeDBiQ96EZ8
TreeFamiTF318119

Enzyme and pathway databases

PathwayCommonsiQ96EZ8
ReactomeiR-HSA-3214847, HATs acetylate histones
R-HSA-5689603, UCH proteinases
R-HSA-5696394, DNA Damage Recognition in GG-NER

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		10445, 451 hits in 1000 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		MCRS1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		MCRS1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		10445
PharosiQ96EZ8, Tbio

Protein Ontology

More...PROi		PR:Q96EZ8
RNActiQ96EZ8, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000187778, Expressed in apex of heart and 228 other tissues
ExpressionAtlasiQ96EZ8, baseline and differential
GenevisibleiQ96EZ8, HS

Family and domain databases

CDDicd00060, FHA, 1 hit
InterProiView protein in InterPro
IPR000253, FHA_dom
IPR037912, MCRS1
IPR025999, MCRS_N
IPR008984, SMAD_FHA_dom_sf
PANTHERiPTHR13233, PTHR13233, 1 hit
PfamiView protein in Pfam
PF00498, FHA, 1 hit
PF13325, MCRS_N, 1 hit
SMARTiView protein in SMART
SM00240, FHA, 1 hit
SUPFAMiSSF49879, SSF49879, 1 hit
PROSITEiView protein in PROSITE
PS50006, FHA_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMCRS1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96EZ8
Secondary accession number(s): O14742
, O75497, Q6VN53, Q7Z372
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: December 1, 2001
Last modified: April 7, 2021
This is version 181 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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