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Protein

Microspherule protein 1

Gene

MCRS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus (PubMed:11948183). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity (PubMed:15044100). Binds to G-quadruplex structures in mRNA (PubMed:16571602). Binds to RNA homopolymer poly(G) and poly(U) (PubMed:16571602).4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator
Biological processDNA damage, DNA recombination, DNA repair, Transcription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-3214847 HATs acetylate histones
R-HSA-5689603 UCH proteinases
R-HSA-5696394 DNA Damage Recognition in GG-NER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Microspherule protein 1
Alternative name(s):
58 kDa microspherule protein
Cell cycle-regulated factor p78
INO80 complex subunit J
MCRS2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MCRS1
Synonyms:INO80Q, MSP58
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000187778.13

Human Gene Nomenclature Database

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HGNCi
HGNC:6960 MCRS1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
609504 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96EZ8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
10445

Open Targets

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OpenTargetsi
ENSG00000187778

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA30708

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
MCRS1

Domain mapping of disease mutations (DMDM)

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DMDMi
24638035

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000963051 – 462Microspherule protein 1Add BLAST462

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei22PhosphoserineCombined sources1
Modified residuei102PhosphoserineBy similarity1
Modified residuei103PhosphothreonineCombined sources1
Modified residuei108PhosphoserineCombined sources1
Modified residuei123N6-acetyllysineCombined sources1
Modified residuei130N6-acetyllysineCombined sources1
Modified residuei282PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q96EZ8

MaxQB - The MaxQuant DataBase

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MaxQBi
Q96EZ8

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q96EZ8

PeptideAtlas

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PeptideAtlasi
Q96EZ8

PRoteomics IDEntifications database

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PRIDEi
Q96EZ8

ProteomicsDB human proteome resource

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ProteomicsDBi
76477
76478 [Q96EZ8-2]
76479 [Q96EZ8-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q96EZ8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q96EZ8

SwissPalm database of S-palmitoylation events

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SwissPalmi
Q96EZ8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in testis, and at lower levels in spleen, thymus, prostate, uterus, small intestine, colon and leukocytes.

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Cell-cycle regulated: levels are highest early in S phase; not detectable in G2.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000187778 Expressed in 216 organ(s), highest expression level in apex of heart

CleanEx database of gene expression profiles

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CleanExi
HS_MCRS1

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q96EZ8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q96EZ8 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA039057

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the N-terminus of INO80 (PubMed:16230350, PubMed:18922472, PubMed:21303910). Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10 (PubMed:15960975). Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1 (PubMed:20018852). Interacts with NOP2 (PubMed:9654073). Interacts with PINX1 (PubMed:15044100). Interacts with TERT (PubMed:15044100). Interacts with CCDC85B (PubMed:17014843). Interacts with DAXX (PubMed:11948183). Interacts (via N-terminus) with FMR1 (via phosphorylated form) (PubMed:16571602). Interacts with FXR1 AND FXR2 (PubMed:16571602).10 Publications
(Microbial infection) Interacts with Herpes simplex virus ICP22.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
115710, 80 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-809 NSL histone acetyltransferase complex
CPX-846 INO80 chromatin remodeling complex

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q96EZ8

Protein interaction database and analysis system

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IntActi
Q96EZ8, 128 interactors

Molecular INTeraction database

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MINTi
Q96EZ8

STRING: functional protein association networks

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STRINGi
9606.ENSP00000349640

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q96EZ8

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q96EZ8

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini363 – 419FHAPROSITE-ProRule annotationAdd BLAST57

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili301 – 335Sequence analysisAdd BLAST35

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi113 – 123Nuclear localization signalSequence analysisAdd BLAST11

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi11 – 102Ser-richAdd BLAST92

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2293 Eukaryota
ENOG410XS0S LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000005536

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000007227

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG052434

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q96EZ8

KEGG Orthology (KO)

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KOi
K11674

Identification of Orthologs from Complete Genome Data

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OMAi
SCRFTLQ

Database of Orthologous Groups

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OrthoDBi
EOG091G07QN

Database for complete collections of gene phylogenies

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PhylomeDBi
Q96EZ8

TreeFam database of animal gene trees

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TreeFami
TF318119

Family and domain databases

Conserved Domains Database

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CDDi
cd00060 FHA, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000253 FHA_dom
IPR037912 MCRS1
IPR025999 MCRS_N
IPR008984 SMAD_FHA_dom_sf

The PANTHER Classification System

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PANTHERi
PTHR13233 PTHR13233, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00498 FHA, 1 hit
PF13325 MCRS_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00240 FHA, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF49879 SSF49879, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50006 FHA_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96EZ8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDKDSQGLLD SSLMASGTAS RSEDEESLAG QKRASSQALG TIPKRRSSSR
60 70 80 90 100
FIKRKKFDDE LVESSLAKSS TRAKGASGVE PGRCSGSEPS SSEKKKVSKA
110 120 130 140 150
PSTPVPPSPA PAPGLTKRVK KSKQPLQVTK DLGRWKPADD LLLINAVLQT
160 170 180 190 200
NDLTSVHLGV KFSCRFTLRE VQERWYALLY DPVISKLACQ AMRQLHPEAI
210 220 230 240 250
AAIQSKALFS KAEEQLLSKV GSTSQPTLET FQDLLHRHPD AFYLARTAKA
260 270 280 290 300
LQAHWQLMKQ YYLLEDQTVQ PLPKGDQVLN FSDAEDLIDD SKLKDMRDEV
310 320 330 340 350
LEHELMVADR RQKREIRQLE QELHKWQVLV DSITGMSSPD FDNQTLAVLR
360 370 380 390 400
GRMVRYLMRS REITLGRATK DNQIDVDLSL EGPAWKISRK QGVIKLKNNG
410 420 430 440 450
DFFIANEGRR PIYIDGRPVL CGSKWRLSNN SVVEIASLRF VFLINQDLIA
460
LIRAEAAKIT PQ
Length:462
Mass (Da):51,803
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF6B7CC8A2AAF16BC
GO
Isoform 2 (identifier: Q96EZ8-2) [UniParc]FASTAAdd to basket
Also known as: MCRS2

The sequence of this isoform differs from the canonical sequence as follows:
     1-3: MDK → MTRGTGGTAQRGRSGP

Show »
Length:475
Mass (Da):53,001
Checksum:i5ABAFCB412408F76
GO
Isoform 3 (identifier: Q96EZ8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: Missing.

Note: No experimental confirmation available. May be due to intron retention.
Show »
Length:449
Mass (Da):50,413
Checksum:i46DB62C0D3158EC1
GO
Isoform 4 (identifier: Q96EZ8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-191: Missing.

Note: No experimental confirmation available.
Show »
Length:271
Mass (Da):31,134
Checksum:i9B6338AC1B6BAF5E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8W126F8W126_HUMAN
Microspherule protein 1
MCRS1
318Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YIA0H0YIA0_HUMAN
Microspherule protein 1
MCRS1
173Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VVA6F8VVA6_HUMAN
Microspherule protein 1
MCRS1
185Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VP44F8VP44_HUMAN
Microspherule protein 1
MCRS1
205Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W0I9F8W0I9_HUMAN
Microspherule protein 1
MCRS1
144Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YI67H0YI67_HUMAN
Microspherule protein 1
MCRS1
64Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VZC2F8VZC2_HUMAN
Microspherule protein 1
MCRS1
61Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC68599 differs from that shown. Reason: Frameshift at several positions.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti245A → G in AAC52086 (PubMed:9654073).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_035473441V → I in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs780785469Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0545711 – 191Missing in isoform 4. CuratedAdd BLAST191
Alternative sequenceiVSP_0162591 – 13Missing in isoform 3. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_0162601 – 3MDK → MTRGTGGTAQRGRSGP in isoform 2. 1 Publication3

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF015308 mRNA Translation: AAC52086.1
AF068007 mRNA Translation: AAC68599.1 Frameshift.
AY336730 mRNA Translation: AAQ84517.1
BX538079 mRNA Translation: CAD98003.1
AC020612 Genomic DNA No translation available.
CH471111 Genomic DNA Translation: EAW58078.1
BC011794 mRNA Translation: AAH11794.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS31795.1 [Q96EZ8-2]
CCDS61118.1 [Q96EZ8-4]
CCDS8787.1 [Q96EZ8-1]

NCBI Reference Sequences

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RefSeqi
NP_001012300.1, NM_001012300.1 [Q96EZ8-2]
NP_001265270.1, NM_001278341.1 [Q96EZ8-4]
NP_006328.2, NM_006337.4 [Q96EZ8-1]
XP_005268629.1, XM_005268572.3 [Q96EZ8-1]
XP_016874178.1, XM_017018689.1 [Q96EZ8-2]
XP_016874179.1, XM_017018690.1 [Q96EZ8-2]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.25313

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000343810; ENSP00000345358; ENSG00000187778 [Q96EZ8-1]
ENST00000357123; ENSP00000349640; ENSG00000187778 [Q96EZ8-2]
ENST00000546244; ENSP00000444982; ENSG00000187778 [Q96EZ8-4]
ENST00000550165; ENSP00000448056; ENSG00000187778 [Q96EZ8-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
10445

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:10445

UCSC genome browser

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UCSCi
uc001rui.3 human [Q96EZ8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF015308 mRNA Translation: AAC52086.1
AF068007 mRNA Translation: AAC68599.1 Frameshift.
AY336730 mRNA Translation: AAQ84517.1
BX538079 mRNA Translation: CAD98003.1
AC020612 Genomic DNA No translation available.
CH471111 Genomic DNA Translation: EAW58078.1
BC011794 mRNA Translation: AAH11794.1
CCDSiCCDS31795.1 [Q96EZ8-2]
CCDS61118.1 [Q96EZ8-4]
CCDS8787.1 [Q96EZ8-1]
RefSeqiNP_001012300.1, NM_001012300.1 [Q96EZ8-2]
NP_001265270.1, NM_001278341.1 [Q96EZ8-4]
NP_006328.2, NM_006337.4 [Q96EZ8-1]
XP_005268629.1, XM_005268572.3 [Q96EZ8-1]
XP_016874178.1, XM_017018689.1 [Q96EZ8-2]
XP_016874179.1, XM_017018690.1 [Q96EZ8-2]
UniGeneiHs.25313

3D structure databases

ProteinModelPortaliQ96EZ8
SMRiQ96EZ8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115710, 80 interactors
ComplexPortaliCPX-809 NSL histone acetyltransferase complex
CPX-846 INO80 chromatin remodeling complex
CORUMiQ96EZ8
IntActiQ96EZ8, 128 interactors
MINTiQ96EZ8
STRINGi9606.ENSP00000349640

PTM databases

iPTMnetiQ96EZ8
PhosphoSitePlusiQ96EZ8
SwissPalmiQ96EZ8

Polymorphism and mutation databases

BioMutaiMCRS1
DMDMi24638035

Proteomic databases

EPDiQ96EZ8
MaxQBiQ96EZ8
PaxDbiQ96EZ8
PeptideAtlasiQ96EZ8
PRIDEiQ96EZ8
ProteomicsDBi76477
76478 [Q96EZ8-2]
76479 [Q96EZ8-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
10445
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000343810; ENSP00000345358; ENSG00000187778 [Q96EZ8-1]
ENST00000357123; ENSP00000349640; ENSG00000187778 [Q96EZ8-2]
ENST00000546244; ENSP00000444982; ENSG00000187778 [Q96EZ8-4]
ENST00000550165; ENSP00000448056; ENSG00000187778 [Q96EZ8-1]
GeneIDi10445
KEGGihsa:10445
UCSCiuc001rui.3 human [Q96EZ8-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
10445
DisGeNETi10445
EuPathDBiHostDB:ENSG00000187778.13

GeneCards: human genes, protein and diseases

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GeneCardsi
MCRS1
HGNCiHGNC:6960 MCRS1
HPAiHPA039057
MIMi609504 gene
neXtProtiNX_Q96EZ8
OpenTargetsiENSG00000187778
PharmGKBiPA30708

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2293 Eukaryota
ENOG410XS0S LUCA
GeneTreeiENSGT00390000005536
HOGENOMiHOG000007227
HOVERGENiHBG052434
InParanoidiQ96EZ8
KOiK11674
OMAiSCRFTLQ
OrthoDBiEOG091G07QN
PhylomeDBiQ96EZ8
TreeFamiTF318119

Enzyme and pathway databases

ReactomeiR-HSA-3214847 HATs acetylate histones
R-HSA-5689603 UCH proteinases
R-HSA-5696394 DNA Damage Recognition in GG-NER

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
MCRS1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
MCRS1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
10445

Protein Ontology

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PROi
PR:Q96EZ8

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000187778 Expressed in 216 organ(s), highest expression level in apex of heart
CleanExiHS_MCRS1
ExpressionAtlasiQ96EZ8 baseline and differential
GenevisibleiQ96EZ8 HS

Family and domain databases

CDDicd00060 FHA, 1 hit
InterProiView protein in InterPro
IPR000253 FHA_dom
IPR037912 MCRS1
IPR025999 MCRS_N
IPR008984 SMAD_FHA_dom_sf
PANTHERiPTHR13233 PTHR13233, 1 hit
PfamiView protein in Pfam
PF00498 FHA, 1 hit
PF13325 MCRS_N, 1 hit
SMARTiView protein in SMART
SM00240 FHA, 1 hit
SUPFAMiSSF49879 SSF49879, 1 hit
PROSITEiView protein in PROSITE
PS50006 FHA_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMCRS1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96EZ8
Secondary accession number(s): O14742
, O75497, Q6VN53, Q7Z372
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: December 1, 2001
Last modified: December 5, 2018
This is version 166 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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