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Entry version 117 (16 Oct 2019)
Sequence version 2 (18 May 2010)
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Protein

Myeloma-overexpressed gene protein

Gene

MYEOV

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Myeloma-overexpressed gene protein
Alternative name(s):
Oncogene in multiple myeloma
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MYEOV
Synonyms:OCIM
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:7563 MYEOV

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605625 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96EZ4

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNET

More...
DisGeNETi
26579

Open Targets

More...
OpenTargetsi
ENSG00000172927

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31362

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96EZ4

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MYEOV

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296439231

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000966681 – 313Myeloma-overexpressed gene proteinAdd BLAST313

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q96EZ4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96EZ4

PeptideAtlas

More...
PeptideAtlasi
Q96EZ4

PRoteomics IDEntifications database

More...
PRIDEi
Q96EZ4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
76476

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96EZ4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96EZ4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Overexpressed in tumor cells lines with a t(11;14)(q13;q32) translocation.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000172927 Expressed in 105 organ(s), highest expression level in lower esophagus mucosa

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96EZ4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96EZ4 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA012949

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
117748, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q96EZ4, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000308330

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410JJCZ Eukaryota
ENOG4111DFS LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00400000022774

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000206543

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96EZ4

Identification of Orthologs from Complete Genome Data

More...
OMAi
GLCTRCC

Database of Orthologous Groups

More...
OrthoDBi
1107210at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96EZ4

TreeFam database of animal gene trees

More...
TreeFami
TF353299

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q96EZ4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALRICVTYT PALPIGLCTR CCLCLEQSPS WCHCLRGVSF LTFHLHQSVP
60 70 80 90 100
LGDRDSLLMF TRQAGHFVEG SKAGRSRGRL CLSQALRVAV RGAFVSLWFA
110 120 130 140 150
AGAGDRERNK GDKGAQTGAG LSQEAEDVDV SRARRVTDAP QGTLCGTGNR
160 170 180 190 200
NSGSQSARVV GVAHLGEAFR VGVEQAISSC PEEVHGRHGL SMEIMWARMD
210 220 230 240 250
VALRSPGRGL LAGAGALCMT LAESSCPDYE RGRRACLTLH RHPTPHCSTW
260 270 280 290 300
GLPLRVAGSW LTVVTVEALG GWRMGVRRTG QVGPTMHPPP VSGASPLLLH
310
HLLLLLLIII LTC
Length:313
Mass (Da):33,556
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i292ABC0D6AFA52B0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H0B3F5H0B3_HUMAN
Myeloma-overexpressed gene protein
MYEOV
255Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAB65726 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti219M → V in AAH11815 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_016603159V → A2 PublicationsCorresponds to variant dbSNP:rs7103126Ensembl.1
Natural variantiVAR_056948198R → Q1 PublicationCorresponds to variant dbSNP:rs11539762Ensembl.1
Natural variantiVAR_056949271G → R1 PublicationCorresponds to variant dbSNP:rs11228610Ensembl.1
Natural variantiVAR_056950284P → T. Corresponds to variant dbSNP:rs12274095Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ223366 mRNA Translation: CAB65727.1
AJ223366 mRNA Translation: CAB65726.1 Different initiation.
AP005379 Genomic DNA No translation available.
BC011815 mRNA Translation: AAH11815.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS8190.1

NCBI Reference Sequences

More...
RefSeqi
NP_001280220.1, NM_001293291.1
NP_001280223.1, NM_001293294.1
NP_001280225.1, NM_001293296.1
NP_001287852.1, NM_001300923.1
NP_001287853.1, NM_001300924.1
NP_620123.2, NM_138768.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000308946; ENSP00000308330; ENSG00000172927
ENST00000441339; ENSP00000412482; ENSG00000172927

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
26579

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:26579

UCSC genome browser

More...
UCSCi
uc001oov.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ223366 mRNA Translation: CAB65727.1
AJ223366 mRNA Translation: CAB65726.1 Different initiation.
AP005379 Genomic DNA No translation available.
BC011815 mRNA Translation: AAH11815.1
CCDSiCCDS8190.1
RefSeqiNP_001280220.1, NM_001293291.1
NP_001280223.1, NM_001293294.1
NP_001280225.1, NM_001293296.1
NP_001287852.1, NM_001300923.1
NP_001287853.1, NM_001300924.1
NP_620123.2, NM_138768.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi117748, 2 interactors
IntActiQ96EZ4, 4 interactors
STRINGi9606.ENSP00000308330

PTM databases

iPTMnetiQ96EZ4
PhosphoSitePlusiQ96EZ4

Polymorphism and mutation databases

BioMutaiMYEOV
DMDMi296439231

Proteomic databases

MassIVEiQ96EZ4
PaxDbiQ96EZ4
PeptideAtlasiQ96EZ4
PRIDEiQ96EZ4
ProteomicsDBi76476

Genome annotation databases

EnsembliENST00000308946; ENSP00000308330; ENSG00000172927
ENST00000441339; ENSP00000412482; ENSG00000172927
GeneIDi26579
KEGGihsa:26579
UCSCiuc001oov.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
26579
DisGeNETi26579

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MYEOV
HGNCiHGNC:7563 MYEOV
HPAiHPA012949
MIMi605625 gene
neXtProtiNX_Q96EZ4
OpenTargetsiENSG00000172927
PharmGKBiPA31362

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410JJCZ Eukaryota
ENOG4111DFS LUCA
GeneTreeiENSGT00400000022774
HOGENOMiHOG000206543
InParanoidiQ96EZ4
OMAiGLCTRCC
OrthoDBi1107210at2759
PhylomeDBiQ96EZ4
TreeFamiTF353299

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
MYEOV human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
26579
PharosiQ96EZ4

Protein Ontology

More...
PROi
PR:Q96EZ4

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000172927 Expressed in 105 organ(s), highest expression level in lower esophagus mucosa
ExpressionAtlasiQ96EZ4 baseline and differential
GenevisibleiQ96EZ4 HS

Family and domain databases

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMYEOV_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96EZ4
Secondary accession number(s): Q9UGN6, Q9UGN7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: May 18, 2010
Last modified: October 16, 2019
This is version 117 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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