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Protein

Corrinoid adenosyltransferase

Gene

MMAB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Adenosyltransferase involved in intracellular vitamin B12 metabolism. Generates adenosylcobalamin (AdoCbl) and directly delivers the cofactor to MUT in a transfer taht is stimulated by ATP-binding to MMAB and gated by MMAA.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: adenosylcobalamin biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes adenosylcobalamin from cob(II)yrinate a,c-diamide.
Proteins known to be involved in the 7 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Corrinoid adenosyltransferase (MMAB)
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. no protein annotated in this organism
  6. no protein annotated in this organism
  7. no protein annotated in this organism
This subpathway is part of the pathway adenosylcobalamin biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes adenosylcobalamin from cob(II)yrinate a,c-diamide, the pathway adenosylcobalamin biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei78ATP1 Publication1
Binding sitei214ATP1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi60 – 63ATP1 Publication4
Nucleotide bindingi68 – 69ATP1 Publication2
Nucleotide bindingi190 – 194ATP1 Publication5

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • cobalamin biosynthetic process Source: UniProtKB-UniPathway
  • cobalamin metabolic process Source: UniProtKB

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS13779-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.5.1.17 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-196741 Cobalamin (Cbl, vitamin B12) transport and metabolism
R-HSA-3359471 Defective MMAB causes methylmalonic aciduria type cblB

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00148;UER00233

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Corrinoid adenosyltransferase (EC:2.5.1.17)
Alternative name(s):
Cob(II)alamin adenosyltransferase
Cob(II)yrinic acid a,c-diamide adenosyltransferase
Cobinamide/cobalamin adenosyltransferase
Methylmalonic aciduria type B protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MMAB
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000139428.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:19331 MMAB

Online Mendelian Inheritance in Man (OMIM)

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MIMi
607568 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96EY8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Methylmalonic aciduria type cblB (MMAB)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder of methylmalonate and cobalamin metabolism due to defective synthesis of adenosylcobalamin.
See also OMIM:251110
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02347196I → T in MMAB. 2 PublicationsCorresponds to variant dbSNP:rs864309509EnsemblClinVar.1
Natural variantiVAR_017204135A → T in MMAB. 1 PublicationCorresponds to variant dbSNP:rs35648932EnsemblClinVar.1
Natural variantiVAR_017205186R → W in MMAB. 2 PublicationsCorresponds to variant dbSNP:rs28941784EnsemblClinVar.1
Natural variantiVAR_017206191R → W in MMAB. 3 PublicationsCorresponds to variant dbSNP:rs376128990EnsemblClinVar.1
Natural variantiVAR_017207193E → K in MMAB. 1 PublicationCorresponds to variant dbSNP:rs749758687EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
326625

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
MMAB

MalaCards human disease database

More...
MalaCardsi
MMAB
MIMi251110 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000139428

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
79311 Vitamin B12-responsive methylmalonic acidemia type cblB

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA134864025

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB00115 Cyanocobalamin
DB00200 Hydroxocobalamin

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MMAB

Domain mapping of disease mutations (DMDM)

More...
DMDMi
38258221

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 32MitochondrionSequence analysisAdd BLAST32
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000556833 – 250Corrinoid adenosyltransferaseAdd BLAST218

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei134PhosphoserineCombined sources1
Modified residuei211N6-succinyllysineBy similarity1
Modified residuei230N6-acetyllysine; alternateBy similarity1
Modified residuei230N6-succinyllysine; alternateBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q96EY8

MaxQB - The MaxQuant DataBase

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MaxQBi
Q96EY8

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q96EY8

PeptideAtlas

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PeptideAtlasi
Q96EY8

PRoteomics IDEntifications database

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PRIDEi
Q96EY8

ProteomicsDB human proteome resource

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ProteomicsDBi
76474

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q96EY8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q96EY8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in liver and skeletal muscle.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000139428 Expressed in 183 organ(s), highest expression level in right lobe of liver

CleanEx database of gene expression profiles

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CleanExi
HS_MMAB

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q96EY8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q96EY8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA039017

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotrimer.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
SPERTQ8NA61-23EBI-7825413,EBI-11524851

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
130605, 15 interactors

Protein interaction database and analysis system

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IntActi
Q96EY8, 11 interactors

Molecular INTeraction database

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MINTi
Q96EY8

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000445920

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1250
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q96EY8

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q96EY8

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q96EY8

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IEUE Eukaryota
COG2096 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000008432

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000291639

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG045589

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q96EY8

KEGG Orthology (KO)

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KOi
K00798

Identification of Orthologs from Complete Genome Data

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OMAi
PRQYLNR

Database of Orthologous Groups

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OrthoDBi
EOG091G0JU1

Database for complete collections of gene phylogenies

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PhylomeDBi
Q96EY8

TreeFam database of animal gene trees

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TreeFami
TF312942

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.20.1200.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR016030 CblAdoTrfase-like
IPR036451 CblAdoTrfase-like_sf
IPR029499 PduO-typ

The PANTHER Classification System

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PANTHERi
PTHR12213 PTHR12213, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF01923 Cob_adeno_trans, 1 hit

ProDom; a protein domain database

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ProDomi
View protein in ProDom or Entries sharing at least one domain
PD007457 AdoCbl_syn_CblAdoTrfase_PduO_N, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF89028 SSF89028, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00636 PduO_Nterm, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

Q96EY8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVCGLGSRL GLGSRLGLRG CFGAARLLYP RFQSRGPQGV EDGDRPQPSS
60 70 80 90 100
KTPRIPKIYT KTGDKGFSST FTGERRPKDD QVFEAVGTTD ELSSAIGFAL
110 120 130 140 150
ELVTEKGHTF AEELQKIQCT LQDVGSALAT PCSSAREAHL KYTTFKAGPI
160 170 180 190 200
LELEQWIDKY TSQLPPLTAF ILPSGGKISS ALHFCRAVCR RAERRVVPLV
210 220 230 240 250
QMGETDANVA KFLNRLSDYL FTLARYAAMK EGNQEKIYMK NDPSAESEGL
Length:250
Mass (Da):27,388
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAEFC4E487C9FA5AB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
S4R3P5S4R3P5_HUMAN
Corrinoid adenosyltransferase
MMAB
198Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X114A0A087X114_HUMAN
Corrinoid adenosyltransferase
MMAB
97Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R3Z1S4R3Z1_HUMAN
Corrinoid adenosyltransferase
MMAB
148Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H4Z7F5H4Z7_HUMAN
Corrinoid adenosyltransferase
MMAB
173Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H079F5H079_HUMAN
Corrinoid adenosyltransferase
MMAB
97Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H0C1F5H0C1_HUMAN
Corrinoid adenosyltransferase
MMAB
47Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03880319R → H. Corresponds to variant dbSNP:rs10774775EnsemblClinVar.1
Natural variantiVAR_01720319R → Q3 PublicationsCorresponds to variant dbSNP:rs36013132EnsemblClinVar.1
Natural variantiVAR_02347196I → T in MMAB. 2 PublicationsCorresponds to variant dbSNP:rs864309509EnsemblClinVar.1
Natural variantiVAR_017204135A → T in MMAB. 1 PublicationCorresponds to variant dbSNP:rs35648932EnsemblClinVar.1
Natural variantiVAR_017205186R → W in MMAB. 2 PublicationsCorresponds to variant dbSNP:rs28941784EnsemblClinVar.1
Natural variantiVAR_017206191R → W in MMAB. 3 PublicationsCorresponds to variant dbSNP:rs376128990EnsemblClinVar.1
Natural variantiVAR_017207193E → K in MMAB. 1 PublicationCorresponds to variant dbSNP:rs749758687EnsemblClinVar.1
Natural variantiVAR_017208239M → K Common polymorphism. 3 PublicationsCorresponds to variant dbSNP:rs9593EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF550404
, AF550396, AF550397, AF550398, AF550399, AF550400, AF550401, AF550402, AF550403 Genomic DNA Translation: AAN85091.1
FJ515859 Genomic DNA Translation: ACS13749.1
BC005054 mRNA Translation: AAH05054.2
BC011831 mRNA Translation: AAH11831.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS9131.1

NCBI Reference Sequences

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RefSeqi
NP_443077.1, NM_052845.3

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.12106

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000545712; ENSP00000445920; ENSG00000139428

Database of genes from NCBI RefSeq genomes

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GeneIDi
326625

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:326625

UCSC genome browser

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UCSCi
uc001tou.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF550404
, AF550396, AF550397, AF550398, AF550399, AF550400, AF550401, AF550402, AF550403 Genomic DNA Translation: AAN85091.1
FJ515859 Genomic DNA Translation: ACS13749.1
BC005054 mRNA Translation: AAH05054.2
BC011831 mRNA Translation: AAH11831.1
CCDSiCCDS9131.1
RefSeqiNP_443077.1, NM_052845.3
UniGeneiHs.12106

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2IDXX-ray2.50A/B/C56-250[»]
6D5KX-ray2.85A/B/C55-250[»]
6D5XX-ray2.40A/B/C55-250[»]
ProteinModelPortaliQ96EY8
SMRiQ96EY8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130605, 15 interactors
IntActiQ96EY8, 11 interactors
MINTiQ96EY8
STRINGi9606.ENSP00000445920

Chemistry databases

DrugBankiDB00115 Cyanocobalamin
DB00200 Hydroxocobalamin

PTM databases

iPTMnetiQ96EY8
PhosphoSitePlusiQ96EY8

Polymorphism and mutation databases

BioMutaiMMAB
DMDMi38258221

Proteomic databases

EPDiQ96EY8
MaxQBiQ96EY8
PaxDbiQ96EY8
PeptideAtlasiQ96EY8
PRIDEiQ96EY8
ProteomicsDBi76474

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
326625
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000545712; ENSP00000445920; ENSG00000139428
GeneIDi326625
KEGGihsa:326625
UCSCiuc001tou.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
326625
DisGeNETi326625
EuPathDBiHostDB:ENSG00000139428.11

GeneCards: human genes, protein and diseases

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GeneCardsi
MMAB
GeneReviewsiMMAB
HGNCiHGNC:19331 MMAB
HPAiHPA039017
MalaCardsiMMAB
MIMi251110 phenotype
607568 gene
neXtProtiNX_Q96EY8
OpenTargetsiENSG00000139428
Orphaneti79311 Vitamin B12-responsive methylmalonic acidemia type cblB
PharmGKBiPA134864025

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IEUE Eukaryota
COG2096 LUCA
GeneTreeiENSGT00390000008432
HOGENOMiHOG000291639
HOVERGENiHBG045589
InParanoidiQ96EY8
KOiK00798
OMAiPRQYLNR
OrthoDBiEOG091G0JU1
PhylomeDBiQ96EY8
TreeFamiTF312942

Enzyme and pathway databases

UniPathwayi
UPA00148;UER00233

BioCyciMetaCyc:HS13779-MONOMER
BRENDAi2.5.1.17 2681
ReactomeiR-HSA-196741 Cobalamin (Cbl, vitamin B12) transport and metabolism
R-HSA-3359471 Defective MMAB causes methylmalonic aciduria type cblB

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
MMAB human
EvolutionaryTraceiQ96EY8

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
MMAB

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
326625

Protein Ontology

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PROi
PR:Q96EY8

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000139428 Expressed in 183 organ(s), highest expression level in right lobe of liver
CleanExiHS_MMAB
ExpressionAtlasiQ96EY8 baseline and differential
GenevisibleiQ96EY8 HS

Family and domain databases

Gene3Di1.20.1200.10, 1 hit
InterProiView protein in InterPro
IPR016030 CblAdoTrfase-like
IPR036451 CblAdoTrfase-like_sf
IPR029499 PduO-typ
PANTHERiPTHR12213 PTHR12213, 1 hit
PfamiView protein in Pfam
PF01923 Cob_adeno_trans, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD007457 AdoCbl_syn_CblAdoTrfase_PduO_N, 1 hit
SUPFAMiSSF89028 SSF89028, 1 hit
TIGRFAMsiTIGR00636 PduO_Nterm, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMMAB_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96EY8
Secondary accession number(s): C5HU05, Q9BSH0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: December 1, 2001
Last modified: December 5, 2018
This is version 161 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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