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Entry version 157 (16 Oct 2019)
Sequence version 3 (23 Nov 2004)
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Protein

Pentatricopeptide repeat domain-containing protein 3, mitochondrial

Gene

PTCD3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mitochondrial RNA-binding protein that has a role in mitochondrial translation.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding
Biological processTranslation regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pentatricopeptide repeat domain-containing protein 3, mitochondrial
Alternative name(s):
28S ribosomal protein S39, mitochondrial
Short name:
MRP-S39
Mitochondrial small ribosomal subunit protein mS391 Publication
Transformation-related gene 15 protein
Short name:
TRG-15
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PTCD3
Synonyms:MRPS39
ORF Names:TRG15
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24717 PTCD3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
614918 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96EY7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000132300

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA147357465

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96EY7

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PTCD3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74731633

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 37MitochondrionSequence analysisAdd BLAST37
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000030502838 – 689Pentatricopeptide repeat domain-containing protein 3, mitochondrialAdd BLAST652

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei126N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96EY7

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96EY7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q96EY7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96EY7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96EY7

PeptideAtlas

More...
PeptideAtlasi
Q96EY7

PRoteomics IDEntifications database

More...
PRIDEi
Q96EY7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
76472 [Q96EY7-1]
76473 [Q96EY7-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96EY7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96EY7

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q96EY7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Abundant in testes, skeletal muscle and heart tissue.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000132300 Expressed in 228 organ(s), highest expression level in adrenal tissue

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96EY7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96EY7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA041154
HPA041382

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins. Associated with the 12S mitochondrial rRNA (12S mt-rRNA).

3 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120366, 137 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q96EY7

Protein interaction database and analysis system

More...
IntActi
Q96EY7, 78 interactors

Molecular INTeraction database

More...
MINTi
Q96EY7

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000254630

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96EY7

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati149 – 183PPR 1Add BLAST35
Repeati184 – 219PPR 2Add BLAST36
Repeati255 – 289PPR 3Add BLAST35
Repeati290 – 330PPR 4Add BLAST41
Repeati331 – 367PPR 5Add BLAST37
Repeati368 – 409PPR 6Add BLAST42
Repeati412 – 446PPR 7Add BLAST35
Repeati454 – 488PPR 8Add BLAST35
Repeati489 – 523PPR 9Add BLAST35
Repeati572 – 606PPR 10Add BLAST35

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4422 Eukaryota
ENOG410XNQS LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000016876

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96EY7

KEGG Orthology (KO)

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KOi
K17659

Identification of Orthologs from Complete Genome Data

More...
OMAi
FMHQEAQ

Database of Orthologous Groups

More...
OrthoDBi
405419at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96EY7

TreeFam database of animal gene trees

More...
TreeFami
TF320158

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002885 Pentatricopeptide_repeat
IPR037387 PTCD3
IPR011990 TPR-like_helical_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR16276 PTHR16276, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13041 PPR_2, 1 hit
PF13812 PPR_3, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51375 PPR, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96EY7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAVVSAVRWL GLRSRLGQPL TGRRAGLCEQ ARSCRFYSGS ATLSKVEGTD
60 70 80 90 100
VTGIEEVVIP KKKTWDKVAV LQALASTVNR DTTAVPYVFQ DDPYLMPASS
110 120 130 140 150
LESRSFLLAK KSGENVAKFI INSYPKYFQK DIAEPHIPCL MPEYFEPQIK
160 170 180 190 200
DISEAALKER IELRKVKASV DMFDQLLQAG TTVSLETTNS LLDLLCYYGD
210 220 230 240 250
QEPSTDYHFQ QTGQSEALEE ENDETSRRKA GHQFGVTWRA KNNAERIFSL
260 270 280 290 300
MPEKNEHSYC TMIRGMVKHR AYEQALNLYT ELLNNRLHAD VYTFNALIEA
310 320 330 340 350
TVCAINEKFE EKWSKILELL RHMVAQKVKP NLQTFNTILK CLRRFHVFAR
360 370 380 390 400
SPALQVLREM KAIGIEPSLA TYHHIIRLFD QPGDPLKRSS FIIYDIMNEL
410 420 430 440 450
MGKRFSPKDP DDDKFFQSAM SICSSLRDLE LAYQVHGLLK TGDNWKFIGP
460 470 480 490 500
DQHRNFYYSK FFDLICLMEQ IDVTLKWYED LIPSAYFPHS QTMIHLLQAL
510 520 530 540 550
DVANRLEVIP KIWKDSKEYG HTFRSDLREE ILMLMARDKH PPELQVAFAD
560 570 580 590 600
CAADIKSAYE SQPIRQTAQD WPATSLNCIA ILFLRAGRTQ EAWKMLGLFR
610 620 630 640 650
KHNKIPRSEL LNELMDSAKV SNSPSQAIEV VELASAFSLP ICEGLTQRVM
660 670 680
SDFAINQEQK EALSNLTALT SDSDTDSSSD SDSDTSEGK
Length:689
Mass (Da):78,550
Last modified:November 23, 2004 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i901DBE1FF3A2E0B9
GO
Isoform 2 (identifier: Q96EY7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-409: Missing.
     410-413: PDDD → MMAY

Note: No experimental confirmation available.
Show »
Length:280
Mass (Da):31,863
Checksum:i013682E2D4C7330A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B8ZZQ4B8ZZQ4_HUMAN
Pentatricopeptide repeat domain-con...
PTCD3
187Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WE76F8WE76_HUMAN
Pentatricopeptide repeat domain-con...
PTCD3
69Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WBP9F8WBP9_HUMAN
Pentatricopeptide repeat domain-con...
PTCD3
78Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti400L → S in AAQ18037 (Ref. 6) Curated1
Sequence conflicti488P → L in AAH01758 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0351542A → V. Corresponds to variant dbSNP:rs13393659Ensembl.1
Natural variantiVAR_035155681S → G. Corresponds to variant dbSNP:rs2241433Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0281911 – 409Missing in isoform 2. 1 PublicationAdd BLAST409
Alternative sequenceiVSP_028192410 – 413PDDD → MMAY in isoform 2. 1 Publication4

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK000765 mRNA Translation: BAA91370.1
AC009309 Genomic DNA No translation available.
CH471053 Genomic DNA Translation: EAW99464.1
CH471053 Genomic DNA Translation: EAW99465.1
BC001758 mRNA Translation: AAH01758.3
BC011832 mRNA Translation: AAH11832.3
AL832520 mRNA Translation: CAH56345.1
AY277598 mRNA Translation: AAQ18037.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33235.1 [Q96EY7-1]

NCBI Reference Sequences

More...
RefSeqi
NP_060422.4, NM_017952.5 [Q96EY7-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000254630; ENSP00000254630; ENSG00000132300 [Q96EY7-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
55037

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:55037

UCSC genome browser

More...
UCSCi
uc002sqw.2 human [Q96EY7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000765 mRNA Translation: BAA91370.1
AC009309 Genomic DNA No translation available.
CH471053 Genomic DNA Translation: EAW99464.1
CH471053 Genomic DNA Translation: EAW99465.1
BC001758 mRNA Translation: AAH01758.3
BC011832 mRNA Translation: AAH11832.3
AL832520 mRNA Translation: CAH56345.1
AY277598 mRNA Translation: AAQ18037.1
CCDSiCCDS33235.1 [Q96EY7-1]
RefSeqiNP_060422.4, NM_017952.5 [Q96EY7-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50A41-689[»]
6NU2electron microscopy3.90A456-639[»]
6NU3electron microscopy4.40A456-639[»]
SMRiQ96EY7
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi120366, 137 interactors
CORUMiQ96EY7
IntActiQ96EY7, 78 interactors
MINTiQ96EY7
STRINGi9606.ENSP00000254630

PTM databases

iPTMnetiQ96EY7
PhosphoSitePlusiQ96EY7
SwissPalmiQ96EY7

Polymorphism and mutation databases

BioMutaiPTCD3
DMDMi74731633

Proteomic databases

EPDiQ96EY7
jPOSTiQ96EY7
MassIVEiQ96EY7
MaxQBiQ96EY7
PaxDbiQ96EY7
PeptideAtlasiQ96EY7
PRIDEiQ96EY7
ProteomicsDBi76472 [Q96EY7-1]
76473 [Q96EY7-2]

Genome annotation databases

EnsembliENST00000254630; ENSP00000254630; ENSG00000132300 [Q96EY7-1]
GeneIDi55037
KEGGihsa:55037
UCSCiuc002sqw.2 human [Q96EY7-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
55037

GeneCards: human genes, protein and diseases

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GeneCardsi
PTCD3
HGNCiHGNC:24717 PTCD3
HPAiHPA041154
HPA041382
MIMi614918 gene
neXtProtiNX_Q96EY7
OpenTargetsiENSG00000132300
PharmGKBiPA147357465

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG4422 Eukaryota
ENOG410XNQS LUCA
GeneTreeiENSGT00390000016876
InParanoidiQ96EY7
KOiK17659
OMAiFMHQEAQ
OrthoDBi405419at2759
PhylomeDBiQ96EY7
TreeFamiTF320158

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PTCD3 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
55037
PharosiQ96EY7

Protein Ontology

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PROi
PR:Q96EY7

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000132300 Expressed in 228 organ(s), highest expression level in adrenal tissue
ExpressionAtlasiQ96EY7 baseline and differential
GenevisibleiQ96EY7 HS

Family and domain databases

Gene3Di1.25.40.10, 2 hits
InterProiView protein in InterPro
IPR002885 Pentatricopeptide_repeat
IPR037387 PTCD3
IPR011990 TPR-like_helical_dom_sf
PANTHERiPTHR16276 PTHR16276, 1 hit
PfamiView protein in Pfam
PF13041 PPR_2, 1 hit
PF13812 PPR_3, 1 hit
PROSITEiView protein in PROSITE
PS51375 PPR, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPTCD3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96EY7
Secondary accession number(s): A6NHD2
, D6W5M1, Q597H0, Q658Y9, Q9BUZ8, Q9NWL0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: November 23, 2004
Last modified: October 16, 2019
This is version 157 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  7. Ribosomal proteins
    Ribosomal proteins families and list of entries
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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