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Protein

Translation machinery-associated protein 16

Gene

TMA16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Translation machinery-associated protein 16
Gene namesi
Name:TMA16
Synonyms:C4orf43
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000198498.9
HGNCiHGNC:25638 TMA16
neXtProtiNX_Q96EY4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000198498
PharmGKBiPA162379923

Polymorphism and mutation databases

BioMutaiTMA16
DMDMi190360168

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003215591 – 203Translation machinery-associated protein 16Add BLAST203

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei9ADP-ribosylserine1 Publication1

Keywords - PTMi

ADP-ribosylation

Proteomic databases

EPDiQ96EY4
MaxQBiQ96EY4
PaxDbiQ96EY4
PeptideAtlasiQ96EY4
PRIDEiQ96EY4
ProteomicsDBi76468

PTM databases

iPTMnetiQ96EY4
PhosphoSitePlusiQ96EY4

Expressioni

Gene expression databases

BgeeiENSG00000198498
CleanExiHS_C4orf43
ExpressionAtlasiQ96EY4 baseline and differential
GenevisibleiQ96EY4 HS

Organism-specific databases

HPAiHPA041571
HPA052688

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi120600, 31 interactors
IntActiQ96EY4, 10 interactors
STRINGi9606.ENSP00000351380

Structurei

3D structure databases

ProteinModelPortaliQ96EY4
SMRiQ96EY4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0534 family.Curated

Phylogenomic databases

eggNOGiENOG410IWA7 Eukaryota
ENOG4111K76 LUCA
GeneTreeiENSGT00390000004179
HOGENOMiHOG000007908
HOVERGENiHBG107626
InParanoidiQ96EY4
KOiK14860
PhylomeDBiQ96EY4
TreeFamiTF324892

Family and domain databases

Gene3Di1.20.1440.170, 1 hit
InterProiView protein in InterPro
IPR021346 Tma16
IPR038356 Tma16_sf
PANTHERiPTHR13349 PTHR13349, 1 hit
PfamiView protein in Pfam
PF11176 Tma16, 1 hit

Sequencei

Sequence statusi: Complete.

Q96EY4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKAPKGKSA GREKKVIHPY SRKAAQITRE AHKQEKKEKL KNEKALRLNL
60 70 80 90 100
VGEKLQWFQN HLDPQKKRYS KKDACELIER YLNRFSSELE QIELHNSIRD
110 120 130 140 150
RQGRRHCSRE TVIKQTMERE RQQFEGYGLE IPDILNASNL KTFREWDFDL
160 170 180 190 200
KKLPNIKMRK ICANDAIPKT CKRKTIITVD QDLGELELND ESSDSDEEMT

AVA
Length:203
Mass (Da):23,864
Last modified:February 26, 2008 - v2
Checksum:i624EDA50DD76AC48
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti62L → P in BAA92053 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05401312R → Q. Corresponds to variant dbSNP:rs34907234Ensembl.1
Natural variantiVAR_03934965Q → P2 PublicationsCorresponds to variant dbSNP:rs2304802Ensembl.1
Natural variantiVAR_039350176I → T2 PublicationsCorresponds to variant dbSNP:rs1561736Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002046 mRNA Translation: BAA92053.1
AC093788 Genomic DNA No translation available.
BC011842 mRNA Translation: AAH11842.1
CCDSiCCDS43278.1
RefSeqiNP_060822.2, NM_018352.2
UniGeneiHs.267446

Genome annotation databases

EnsembliENST00000358572; ENSP00000351380; ENSG00000198498
GeneIDi55319
KEGGihsa:55319
UCSCiuc003iqq.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTMA16_HUMAN
AccessioniPrimary (citable) accession number: Q96EY4
Secondary accession number(s): Q0P6E4, Q0P6J1, Q9NUR7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: June 20, 2018
This is version 108 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families
  5. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

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