DNAJA3

Functionⁱ

Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma-mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway.

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	236	Zinc 1Combined sources1 Publication	1
Metal bindingⁱ	239	Zinc 1Combined sources1 Publication	1
Metal bindingⁱ	253	Zinc 2Combined sources1 Publication	1
Metal bindingⁱ	256	Zinc 2Combined sources1 Publication	1
Metal bindingⁱ	275	Zinc 2Combined sources1 Publication	1
Metal bindingⁱ	278	Zinc 2Combined sources1 Publication	1
Metal bindingⁱ	289	Zinc 1Combined sources1 Publication	1
Metal bindingⁱ	292	Zinc 1Combined sources1 Publication	1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	223 – 301	CR-typeAdd BLAST		79

GO - Molecular functionⁱ

ATP binding Source: InterPro
GTPase regulator activity Source: Ensembl
Hsp70 protein binding Source: Ensembl
interferon-gamma receptor binding
Source: UniProtKB
Inferred from direct assayⁱ
- 11679576
metal ion binding Source: UniProtKB-KW
NF-kappaB binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 15601829
protein kinase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 11679576
- 15601829
transcription factor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 16531398
- 21106534
unfolded protein binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

activation-induced cell death of T cells Source: Ensembl
activation of cysteine-type endopeptidase activity involved in apoptotic process
Source: UniProtKB
Inferred from direct assayⁱ
- 10411904
cell aging Source: Ensembl
mitochondrial DNA replication Source: Ensembl
mitochondrion organization Source: GO_Central
negative regulation of apoptotic process
Source: UniProtKB
Inferred from direct assayⁱ
- 10411904
negative regulation of cell proliferation
Source: UniProtKB
Inferred from direct assayⁱ
- 11719219
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
Source: UniProtKB
Inferred from direct assayⁱ
- 10411904
negative regulation of I-kappaB kinase/NF-kappaB signaling
Source: UniProtKB
Inferred from direct assayⁱ
- 11927590
negative regulation of interferon-gamma-mediated signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 11679576
negative regulation of NF-kappaB transcription factor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 11927590
negative regulation of programmed cell death Source: Ensembl
negative regulation of protein kinase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 15601829
negative regulation of transcription by RNA polymerase II
Source: UniProtKB
Inferred from direct assayⁱ
- 21106534
neuromuscular junction development
Source: UniProtKB
Inferred from direct assayⁱ
- 19038220
positive regulation of apoptotic process
Source: UniProtKB
Inferred from direct assayⁱ
- 10411904
positive regulation of protein ubiquitination
Source: UniProtKB
Inferred from direct assayⁱ
- 15520177
positive regulation of T cell proliferation Source: Ensembl
protein folding
Source: UniProtKB
Inferred from direct assayⁱ
- 16531398
protein stabilization
Source: UniProtKB
Inferred from direct assayⁱ
- 11927590
response to heat Source: InterPro
response to interferon-gamma
Source: UniProtKB
Inferred from direct assayⁱ
- 11679576
skeletal muscle acetylcholine-gated channel clustering Source: UniProtKB
small GTPase mediated signal transduction Source: Ensembl
T cell differentiation in thymus Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Chaperone
Biological process	Apoptosis
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: DnaJ homolog subfamily A member 3, mitochondrial Alternative name(s): DnaJ protein Tid-1 Short name: hTid-1 Hepatocellular carcinoma-associated antigen 57 Tumorous imaginal discs protein Tid56 homolog
Gene namesⁱ	Name:DNAJA3 Synonyms:HCA57, TID1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 16

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000103423.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11808 DNAJA3
MIMⁱ	608382 gene
neXtProtⁱ	NX_Q96EY1

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Cytoplasm, Membrane, Mitochondrion, Postsynaptic cell membrane, Synapse

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	121	H → Q: Loss of modulation of apoptosis. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	9093
Open Targets More...OpenTargetsⁱ	ENSG00000103423
PharmGKBⁱ	PA27410

Polymorphism and mutation databases

BioMutaⁱ	DNAJA3
DMDMⁱ	311033374

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000007256	? – 480	DnaJ homolog subfamily A member 3, mitochondrial
Transit peptideⁱ	1 – ?	MitochondrionSequence analysis

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	58	Omega-N-methylarginine; by CARM11 Publication	1
Modified residueⁱ	134	N6-acetyllysineBy similarity	1
Modified residueⁱ	238	Omega-N-methylarginine; by CARM11 Publication	1
Modified residueⁱ	293	Omega-N-methylarginine; by CARM11 Publication	1
Modified residueⁱ	398	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Tyrosine phosphorylated.By similarity

Keywords - PTMⁱ

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q96EY1
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q96EY1
PaxDbⁱ	Q96EY1
PeptideAtlas More...PeptideAtlasⁱ	Q96EY1
PRIDEⁱ	Q96EY1
ProteomicsDBⁱ	76466 76467 [Q96EY1-2]

PTM databases

iPTMnetⁱ	Q96EY1
PhosphoSitePlusⁱ	Q96EY1

Expressionⁱ

Tissue specificityⁱ

Widely expressed with highest levels in heart, liver, lung and skeletal muscles. Also expressed in keratinocytes.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000103423 Expressed in 224 organ(s), highest expression level in adrenal gland
CleanExⁱ	HS_DNAJA3
ExpressionAtlasⁱ	Q96EY1 baseline and differential
Genevisibleⁱ	Q96EY1 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB016095 HPA040875 HPA044229

HPAⁱ

CAB016095
HPA040875
HPA044229

Interactionⁱ

Subunit structureⁱ

Interacts with JAK2, HSPA9B and IFN-gammaR2 chain. Interacts with Ras GTPase-activating protein 1 (RASA1). Isoform 2 interacts with MUSK (via the cytoplasmic domain) (By similarity).By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
	Q9H614	3	EBI-3952284,EBI-10249899
C2CD6	Q53TS8	3	EBI-3952284,EBI-739879
CARM1	Q86X55	2	EBI-356767,EBI-2339854
FAM214B	Q7L5A3	3	EBI-3952284,EBI-745689
FOSL2	P15408	3	EBI-3952284,EBI-3893419
FRMD6	Q96NE9	3	EBI-3952284,EBI-741729
GCC1	Q96CN9	3	EBI-3952284,EBI-746252
INPP5J	Q15735	3	EBI-3952284,EBI-10236940
KDM1A	O60341	2	EBI-356767,EBI-710124
MET	P08581	2	EBI-3952284,EBI-1039152
NOC4L	Q9BVI4	3	EBI-3952284,EBI-395927
OSGIN1	Q9UJX0	3	EBI-3952284,EBI-9057006
PRMT6	Q96LA8	2	EBI-356767,EBI-912440
Ptch1	Q61115	2	EBI-356767,EBI-15619523	From Mus musculus.
STAT5B	P51692	2	EBI-356767,EBI-1186119
Stat5b	P42232	3	EBI-356767,EBI-617454	From Mus musculus.
STK16	O75716	3	EBI-3952284,EBI-749295
TCF19	D2IYK5	3	EBI-3952284,EBI-10176552

GO - Molecular functionⁱ

Hsp70 protein binding Source: Ensembl
interferon-gamma receptor binding
Source: UniProtKB
Inferred from direct assayⁱ
- 11679576
NF-kappaB binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 15601829
protein kinase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 11679576
- 15601829
transcription factor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 16531398
- 21106534
unfolded protein binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	114547, 92 interactors
Database of interacting proteins More...DIPⁱ	DIP-33870N
IntActⁱ	Q96EY1, 70 interactors
Molecular INTeraction database More...MINTⁱ	Q96EY1
STRINGⁱ	9606.ENSP00000262375

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	94 – 98	Combined sources	5
Helixⁱ	106 – 119	Combined sources	14
Turnⁱ	122 – 124	Combined sources	3
Helixⁱ	131 – 146	Combined sources	16
Helixⁱ	148 – 156	Combined sources	9
Beta strandⁱ	222 – 224	Combined sources	3
Beta strandⁱ	237 – 244	Combined sources	8
Beta strandⁱ	254 – 259	Combined sources	6
Beta strandⁱ	261 – 266	Combined sources	6
Beta strandⁱ	269 – 274	Combined sources	6
Beta strandⁱ	276 – 284	Combined sources	9
Beta strandⁱ	290 – 294	Combined sources	5
Beta strandⁱ	296 – 298	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	Q96EY1
SMRⁱ	Q96EY1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q96EY1

EvolutionaryTraceⁱ

Q96EY1

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	93 – 158	JAdd BLAST	66
Repeatⁱ	236 – 243	CXXCXGXG motif	8
Repeatⁱ	253 – 260	CXXCXGXG motif	8
Repeatⁱ	275 – 282	CXXCXGXG motif	8
Repeatⁱ	289 – 296	CXXCXGXG motif	8

Domainⁱ

Modulation of apoptosis, i.e. proapoptotic activity of isoform 1 and antiapoptotic activity of isoform 2, is J domain-dependent.

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	223 – 301	CR-typeAdd BLAST		79

Keywords - Domainⁱ

Repeat, Transit peptide, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG0715 Eukaryota COG0484 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00920000149062
HOGENOMⁱ	HOG000203530
HOVERGENⁱ	HBG051371
InParanoidⁱ	Q96EY1
KEGG Orthology (KO) More...KOⁱ	K09504
OMAⁱ	DMGGFAD
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G09C7
PhylomeDBⁱ	Q96EY1
TreeFamⁱ	TF105152

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd06257 DnaJ, 1 hit cd10719 DnaJ_zf, 1 hit
Gene3Dⁱ	1.10.287.110, 1 hit
HAMAPⁱ	MF_01152 DnaJ, 1 hit
InterProⁱ	View protein in InterPro IPR012724 DnaJ IPR002939 DnaJ_C IPR001623 DnaJ_domain IPR018253 DnaJ_domain_CS IPR008971 HSP40/DnaJ_pept-bd IPR001305 HSP_DnaJ_Cys-rich_dom IPR036410 HSP_DnaJ_Cys-rich_dom_sf IPR036869 J_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00226 DnaJ, 1 hit PF01556 DnaJ_C, 1 hit PF00684 DnaJ_CXXCXGXG, 1 hit
PRINTSⁱ	PR00625 JDOMAIN
SMARTⁱ	View protein in SMART SM00271 DnaJ, 1 hit
SUPFAMⁱ	SSF46565 SSF46565, 1 hit SSF49493 SSF49493, 1 hit SSF57938 SSF57938, 1 hit
PROSITEⁱ	View protein in PROSITE PS00636 DNAJ_1, 1 hit PS50076 DNAJ_2, 1 hit PS51188 ZF_CR, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.ⁱShow all

Isoform 1 (identifier: Q96EY1-1) [UniParc]FASTA Add to basket

Also known as: Tid-1(L)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAARCSTRWL LVVVGTPRLP AISGRGARPP REGVVGAWLS RKLSVPAFAS 
        60         70         80         90        100
SLTSCGPRAL LTLRPGVSLT GTKHNPFICT ASFHTSAPLA KEDYYQILGV 
       110        120        130        140        150
PRNASQKEIK KAYYQLAKKY HPDTNKDDPK AKEKFSQLAE AYEVLSDEVK 
       160        170        180        190        200
RKQYDAYGSA GFDPGASGSQ HSYWKGGPTV DPEELFRKIF GEFSSSSFGD 
       210        220        230        240        250
FQTVFDQPQE YFMELTFNQA AKGVNKEFTV NIMDTCERCN GKGNEPGTKV 
       260        270        280        290        300
QHCHYCGGSG METINTGPFV MRSTCRRCGG RGSIIISPCV VCRGAGQAKQ 
       310        320        330        340        350
KKRVMIPVPA GVEDGQTVRM PVGKREIFIT FRVQKSPVFR RDGADIHSDL 
       360        370        380        390        400
FISIAQALLG GTARAQGLYE TINVTIPPGT QTDQKIRMGG KGIPRINSYG 
       410        420        430        440        450
YGDHYIHIKI RVPKRLTSRQ QSLILSYAED ETDVEGTVNG VTLTSSGGST 
       460        470        480
MDSSAGSKAR REAGEDEEGF LSKLKKMFTS

Length:480

Mass (Da):52,489

Last modified:November 2, 2010 - v2

Checksum:ⁱ5A57B9020992CF59

GO

Isoform 2 (identifier: Q96EY1-2) [UniParc]FASTA Add to basket

Also known as: Tid-1(S)

The sequence of this isoform differs from the canonical sequence as follows:
448-453: GSTMDS → KRSTGN
454-480: Missing.

« Hide

        10         20         30         40         50
MAARCSTRWL LVVVGTPRLP AISGRGARPP REGVVGAWLS RKLSVPAFAS 
        60         70         80         90        100
SLTSCGPRAL LTLRPGVSLT GTKHNPFICT ASFHTSAPLA KEDYYQILGV 
       110        120        130        140        150
PRNASQKEIK KAYYQLAKKY HPDTNKDDPK AKEKFSQLAE AYEVLSDEVK 
       160        170        180        190        200
RKQYDAYGSA GFDPGASGSQ HSYWKGGPTV DPEELFRKIF GEFSSSSFGD 
       210        220        230        240        250
FQTVFDQPQE YFMELTFNQA AKGVNKEFTV NIMDTCERCN GKGNEPGTKV 
       260        270        280        290        300
QHCHYCGGSG METINTGPFV MRSTCRRCGG RGSIIISPCV VCRGAGQAKQ 
       310        320        330        340        350
KKRVMIPVPA GVEDGQTVRM PVGKREIFIT FRVQKSPVFR RDGADIHSDL 
       360        370        380        390        400
FISIAQALLG GTARAQGLYE TINVTIPPGT QTDQKIRMGG KGIPRINSYG 
       410        420        430        440        450
YGDHYIHIKI RVPKRLTSRQ QSLILSYAED ETDVEGTVNG VTLTSSGKRS 

TGN

Show »

Length:453

Mass (Da):49,611

Checksum:ⁱE235B8DC1DB99FBC

GO

Isoform 3 (identifier: Q96EY1-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3-186: ARCSTRWLLV...GPTVDPEELF → EPQAERPRLCVFPDLLRPPSAADIETWCQPY
     448-453: GSTMDS → KRSTGN
     454-480: Missing.

« Hide

        10         20         30         40         50
MAEPQAERPR LCVFPDLLRP PSAADIETWC QPYRKIFGEF SSSSFGDFQT 
        60         70         80         90        100
VFDQPQEYFM ELTFNQAAKG VNKEFTVNIM DTCERCNGKG NEPGTKVQHC 
       110        120        130        140        150
HYCGGSGMET INTGPFVMRS TCRRCGGRGS IIISPCVVCR GAGQAKQKKR 
       160        170        180        190        200
VMIPVPAGVE DGQTVRMPVG KREIFITFRV QKSPVFRRDG ADIHSDLFIS 
       210        220        230        240        250
IAQALLGGTA RAQGLYETIN VTIPPGTQTD QKIRMGGKGI PRINSYGYGD 
       260        270        280        290        300
HYIHIKIRVP KRLTSRQQSL ILSYAEDETD VEGTVNGVTL TSSGKRSTGN

Show »

Length:300

Mass (Da):33,082

Checksum:ⁱ36D883E568E8ECC8

GO

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation
I3L1T6	I3L1T6_HUMAN	DnaJ homolog subfamily A member 3, ... DnaJ homolog subfamily A member 3, mitochondrial	DNAJA3	185	Annotation score:
I3L1I6	I3L1I6_HUMAN	DnaJ homolog subfamily A member 3, ... DnaJ homolog subfamily A member 3, mitochondrial	DNAJA3	122	Annotation score:
I3L1T9	I3L1T9_HUMAN	DnaJ homolog subfamily A member 3, ... DnaJ homolog subfamily A member 3, mitochondrial	DNAJA3	98	Annotation score:
I3L3D3	I3L3D3_HUMAN	DnaJ homolog subfamily A member 3, ... DnaJ homolog subfamily A member 3, mitochondrial	DNAJA3	77	Annotation score:

Sequence cautionⁱ

The sequence AAF66245 differs from that shown. Reason: Frameshift at positions 408 and 411.Curated

The sequence AAF66245 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence AAH12343 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	320	M → W in AAF66245 (PubMed:12097419).Curated	1
Isoform 3 (identifier: Q96EY1-3)
Sequence conflictⁱ	33	Y → H in BAG58345 (PubMed:14702039).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_027965	75	N → Y4 PublicationsCorresponds to variant dbSNP:rs1139653Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_055728	3 – 186	ARCST…PEELF → EPQAERPRLCVFPDLLRPPS AADIETWCQPY in isoform 3. 1 PublicationAdd BLAST	184
Alternative sequenceⁱVSP_007425	448 – 453	GSTMDS → KRSTGN in isoform 2 and isoform 3. 4 Publications	6
Alternative sequenceⁱVSP_007426	454 – 480	Missing in isoform 2 and isoform 3. 4 PublicationsAdd BLAST	27

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF061749 mRNA Translation: AAC29066.1 AF411044 mRNA Translation: AAL35323.1 AK295391 mRNA Translation: BAG58345.1 AK314218 mRNA Translation: BAG36892.1 AC012676 Genomic DNA No translation available. BC007225 mRNA Translation: AAH07225.1 BC011855 mRNA Translation: AAH11855.1 BC012343 mRNA Translation: AAH12343.1 Different initiation. BC014062 mRNA Translation: AAH14062.1 BC020248 mRNA Translation: AAH20248.1 BC030145 mRNA Translation: AAH30145.1 BC032100 mRNA Translation: AAH32100.1 AF244136 mRNA Translation: AAF66245.1 Sequence problems.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10515.1 [Q96EY1-1] CCDS45400.1 [Q96EY1-2] CCDS66930.1 [Q96EY1-3]
NCBI Reference Sequences More...RefSeqⁱ	NP_001128582.1, NM_001135110.2 [Q96EY1-2] NP_001273445.1, NM_001286516.1 [Q96EY1-3] NP_005138.3, NM_005147.5 [Q96EY1-1]
UniGeneⁱ	Hs.459779

Genome annotation databases

Ensemblⁱ	ENST00000262375; ENSP00000262375; ENSG00000103423 [Q96EY1-1] ENST00000355296; ENSP00000347445; ENSG00000103423 [Q96EY1-2] ENST00000431375; ENSP00000393970; ENSG00000103423 [Q96EY1-3] ENST00000612103; ENSP00000477570; ENSG00000276726 [Q96EY1-1] ENST00000614397; ENSP00000479815; ENSG00000276726 [Q96EY1-2]
GeneIDⁱ	9093
KEGGⁱ	hsa:9093
UCSC genome browser More...UCSCⁱ	uc002cwk.4 human [Q96EY1-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q96EY1	DnaJ (Hsp40) homolog, subfamily A, member 3 variant (Fragment)		HUMAN		480	UniRef100_Q96EY1
DnaJ (Hsp40) homolog, subfamily A, member 3 variant (Fragment)		HUMAN		478

Protein	Similar proteins		Species	Score	Length	Source
Q96EY1	DnaJ (Hsp40) homolog, subfamily A, member 3 variant (Fragment)		HUMAN		480	UniRef90_Q96EY1
DnaJ like protein subfamily A member 3, mitochondrial		TUPCH		515
DnaJ heat shock protein family (Hsp40) member A3		PANPA		480
DNAJA3 isoform 2		PONAB		480
DnaJ heat shock protein family (Hsp40) member A3		GORGO		480
+15
Q96EY1-3	DNAJA3 isoform 5		PANTR		300	UniRef90_Q96EY1-3
DnaJ heat shock protein family (Hsp40) member A3		GORGO		300
DnaJ heat shock protein family (Hsp40) member A3		SAIBB		300
DnaJ heat shock protein family (Hsp40) member A3		CALJA		300
DnaJ heat shock protein family (Hsp40) member A3		COLAP		300
+13

Protein	Similar proteins		Species	Score	Length	Source
Q96EY1	DnaJ (Hsp40) homolog, subfamily A, member 3 variant (Fragment)		HUMAN		480	UniRef50_Q96EY1
DnaJ like protein subfamily A member 3, mitochondrial		TUPCH		515
dnaJ homolog subfamily A member 3, mitochondrial isoform X1		DIPOR		480
DNAJA3 isoform 2		PONAB		480
DNAJA3 isoform 2		PANTR		480
+205
Q96EY1-3	DnaJ heat shock protein family (Hsp40) member A3		PANPA		300	UniRef50_Q96EY1-3
DnaJ heat shock protein family (Hsp40) member A3		Cebus capucinus imitator		300
DNAJA3 isoform 5		PANTR		300
DnaJ heat shock protein family (Hsp40) member A3		GORGO		300
DnaJ heat shock protein family (Hsp40) member A3		MACFA		300
+17

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF061749 mRNA Translation: AAC29066.1 AF411044 mRNA Translation: AAL35323.1 AK295391 mRNA Translation: BAG58345.1 AK314218 mRNA Translation: BAG36892.1 AC012676 Genomic DNA No translation available. BC007225 mRNA Translation: AAH07225.1 BC011855 mRNA Translation: AAH11855.1 BC012343 mRNA Translation: AAH12343.1 Different initiation. BC014062 mRNA Translation: AAH14062.1 BC020248 mRNA Translation: AAH20248.1 BC030145 mRNA Translation: AAH30145.1 BC032100 mRNA Translation: AAH32100.1 AF244136 mRNA Translation: AAF66245.1 Sequence problems.
CCDSⁱ	CCDS10515.1 [Q96EY1-1] CCDS45400.1 [Q96EY1-2] CCDS66930.1 [Q96EY1-3]
RefSeqⁱ	NP_001128582.1, NM_001135110.2 [Q96EY1-2] NP_001273445.1, NM_001286516.1 [Q96EY1-3] NP_005138.3, NM_005147.5 [Q96EY1-1]
UniGeneⁱ	Hs.459779

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2CTT	NMR	-	A	213-303	[»]
	2DN9	NMR	-	A	93-158	[»]
ProteinModelPortalⁱ	Q96EY1
SMRⁱ	Q96EY1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114547, 92 interactors
DIPⁱ	DIP-33870N
IntActⁱ	Q96EY1, 70 interactors
MINTⁱ	Q96EY1
STRINGⁱ	9606.ENSP00000262375

PTM databases

iPTMnetⁱ	Q96EY1
PhosphoSitePlusⁱ	Q96EY1

Polymorphism and mutation databases

BioMutaⁱ	DNAJA3
DMDMⁱ	311033374

Proteomic databases

EPDⁱ	Q96EY1
MaxQBⁱ	Q96EY1
PaxDbⁱ	Q96EY1
PeptideAtlasⁱ	Q96EY1
PRIDEⁱ	Q96EY1
ProteomicsDBⁱ	76466 76467 [Q96EY1-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	9093
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000262375; ENSP00000262375; ENSG00000103423 [Q96EY1-1] ENST00000355296; ENSP00000347445; ENSG00000103423 [Q96EY1-2] ENST00000431375; ENSP00000393970; ENSG00000103423 [Q96EY1-3] ENST00000612103; ENSP00000477570; ENSG00000276726 [Q96EY1-1] ENST00000614397; ENSP00000479815; ENSG00000276726 [Q96EY1-2]
GeneIDⁱ	9093
KEGGⁱ	hsa:9093
UCSCⁱ	uc002cwk.4 human [Q96EY1-1]

Organism-specific databases

CTDⁱ	9093
DisGeNETⁱ	9093
EuPathDBⁱ	HostDB:ENSG00000103423.13
GeneCardsⁱ	DNAJA3
H-InvDBⁱ	HIX0012782
HGNCⁱ	HGNC:11808 DNAJA3
HPAⁱ	CAB016095 HPA040875 HPA044229
MIMⁱ	608382 gene
neXtProtⁱ	NX_Q96EY1
OpenTargetsⁱ	ENSG00000103423
PharmGKBⁱ	PA27410
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0715 Eukaryota COG0484 LUCA
GeneTreeⁱ	ENSGT00920000149062
HOGENOMⁱ	HOG000203530
HOVERGENⁱ	HBG051371
InParanoidⁱ	Q96EY1
KOⁱ	K09504
OMAⁱ	DMGGFAD
OrthoDBⁱ	EOG091G09C7
PhylomeDBⁱ	Q96EY1
TreeFamⁱ	TF105152

Miscellaneous databases

ChiTaRSⁱ	DNAJA3 human
EvolutionaryTraceⁱ	Q96EY1
GeneWikiⁱ	DNAJA3
GenomeRNAiⁱ	9093
Protein Ontology More...PROⁱ	PR:Q96EY1
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000103423 Expressed in 224 organ(s), highest expression level in adrenal gland
CleanExⁱ	HS_DNAJA3
ExpressionAtlasⁱ	Q96EY1 baseline and differential
Genevisibleⁱ	Q96EY1 HS

Family and domain databases

CDDⁱ	cd06257 DnaJ, 1 hit cd10719 DnaJ_zf, 1 hit
Gene3Dⁱ	1.10.287.110, 1 hit
HAMAPⁱ	MF_01152 DnaJ, 1 hit
InterProⁱ	View protein in InterPro IPR012724 DnaJ IPR002939 DnaJ_C IPR001623 DnaJ_domain IPR018253 DnaJ_domain_CS IPR008971 HSP40/DnaJ_pept-bd IPR001305 HSP_DnaJ_Cys-rich_dom IPR036410 HSP_DnaJ_Cys-rich_dom_sf IPR036869 J_dom_sf
Pfamⁱ	View protein in Pfam PF00226 DnaJ, 1 hit PF01556 DnaJ_C, 1 hit PF00684 DnaJ_CXXCXGXG, 1 hit
PRINTSⁱ	PR00625 JDOMAIN
SMARTⁱ	View protein in SMART SM00271 DnaJ, 1 hit
SUPFAMⁱ	SSF46565 SSF46565, 1 hit SSF49493 SSF49493, 1 hit SSF57938 SSF57938, 1 hit
PROSITEⁱ	View protein in PROSITE PS00636 DNAJ_1, 1 hit PS50076 DNAJ_2, 1 hit PS51188 ZF_CR, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DNJA3_HUMAN
Accessionⁱ	Q96EY1Primary (citable) accession number: Q96EY1 Secondary accession number(s): B2RAJ5 Q9NYH8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 16, 2003
	Last sequence update:	November 2, 2010
	Last modified:	September 12, 2018
	This is version 175 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

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UniProtKB - Q96EY1 (DNJA3_HUMAN)

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DnaJ homolog subfamily A member 3, mitochondrial

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Mitochondrion

Cytosol

Cytosol

Mitochondrion

Nucleus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Computationally mapped potential isoform sequencesi

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

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Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Computationally mapped potential isoform sequencesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ