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Entry version 151 (07 Oct 2020)
Sequence version 2 (21 Feb 2006)
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Protein

Cytoplasmic dynein 2 intermediate chain 2

Gene

DYNC2I2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 2 complex (dynein-2 complex), a motor protein complex that drives the movement of cargos along microtubules within cilia and flagella in concert with the intraflagellar transport (IFT) system (PubMed:25205765, PubMed:29742051). DYNC2I2 plays a major role in retrograde ciliary protein trafficking and in ciliogenesis (PubMed:30649997, PubMed:29742051, PubMed:30320547). Required also to maintain a functional transition zone (PubMed:30320547).4 Publications
Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Inhibits the MAP3K7-induced NF-kappa-B activation pathway. Inhibits MAP3K7 phosphorylation at 'Thr-184' and 'Thr-187' upon Il-1 beta stimulation.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q96EX3

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5620924, Intraflagellar transport

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
Q96EX3

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cytoplasmic dynein 2 intermediate chain 2
Alternative name(s):
Dynein 2 intermediate chain 2
WD repeat-containing protein 34
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DYNC2I2Imported
Synonyms:WDR34
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000119333.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:28296, DYNC2I2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
613363, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96EX3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Short-rib thoracic dysplasia 11 with or without polydactyly (SRTD11)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of short-rib thoracic dysplasia, a group of autosomal recessive ciliopathies that are characterized by a constricted thoracic cage, short ribs, shortened tubular bones, and a 'trident' appearance of the acetabular roof. Polydactyly is variably present. Non-skeletal involvement can include cleft lip/palate as well as anomalies of major organs such as the brain, eye, heart, kidneys, liver, pancreas, intestines, and genitalia. Some forms of the disease are lethal in the neonatal period due to respiratory insufficiency secondary to a severely restricted thoracic cage, whereas others are compatible with life. Disease spectrum encompasses Ellis-van Creveld syndrome, asphyxiating thoracic dystrophy (Jeune syndrome), Mainzer-Saldino syndrome, and short rib-polydactyly syndrome.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_070963148C → F in SRTD11. 1 Publication1
Natural variantiVAR_083840182R → W in SRTD11. 1 Publication1
Natural variantiVAR_070965341A → V in SRTD11. 1 PublicationCorresponds to variant dbSNP:rs587777091EnsemblClinVar.1
Natural variantiVAR_070966354T → M in SRTD11. 1 PublicationCorresponds to variant dbSNP:rs587777092EnsemblClinVar.1
Natural variantiVAR_070967390P → L in SRTD11. 1 Publication1
Natural variantiVAR_070968393G → S in SRTD11. 1 PublicationCorresponds to variant dbSNP:rs587777096EnsemblClinVar.1
Natural variantiVAR_070969410S → I in SRTD11. 1 Publication1
Natural variantiVAR_070970436K → R in SRTD11. 1 PublicationCorresponds to variant dbSNP:rs587777098EnsemblClinVar.1
Natural variantiVAR_070971447R → Q in SRTD11. 1 PublicationCorresponds to variant dbSNP:rs587777094EnsemblClinVar.1
Natural variantiVAR_070972447R → W in SRTD11. 2 PublicationsCorresponds to variant dbSNP:rs587777093EnsemblClinVar.1

Keywords - Diseasei

Ciliopathy, Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
89891

MalaCards human disease database

More...
MalaCardsi
WDR34
MIMi615633, phenotype

Open Targets

More...
OpenTargetsi
ENSG00000119333

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
474, Jeune syndrome
93271, Short rib-polydactyly syndrome, Verma-Naumoff type

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134951680

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96EX3, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
WDR34

Domain mapping of disease mutations (DMDM)

More...
DMDMi
88985038

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000513831 – 536Cytoplasmic dynein 2 intermediate chain 2Add BLAST536

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei15PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96EX3

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q96EX3

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q96EX3

MaxQB - The MaxQuant DataBase

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MaxQBi
Q96EX3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96EX3

PeptideAtlas

More...
PeptideAtlasi
Q96EX3

PRoteomics IDEntifications database

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PRIDEi
Q96EX3

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
76465

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q96EX3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q96EX3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in several cell lines (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000119333, Expressed in nasal cavity epithelium and 197 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q96EX3, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96EX3, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000119333, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The cytoplasmic dynein 2 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs). Among them, a heavy chain (DYNC2H1), two intermediate chains (DYNC2I2 and DYNC2I1), a light intermediate chain (DYNC2LI1), and a light chain (TCTEX1D2) are unique to the cytoplasmic dynein complex 2, but a subset of the light chains are also shared by dynein-1 and dynein-2 complexes (PubMed:25205765, PubMed:31451806).

Interacts with DYNC2I1; their C-terminal domains each bind a copy of the heavy chain, and their extended N-terminal regions are held together by an array of light chain dimers (PubMed:29742051, PubMed:31451806).

Interacts with DYNLL2; this interaction is essential for dynein-2-mediated retrograde trafficking of ciliary proteins (PubMed:30649997).

Interacts with DYNLRB1; this interaction is essential for dynein-2-mediated retrograde trafficking of ciliary proteins (PubMed:30649997).

Interacts (via the WD domains) with MAP3K7 and TAB3.

Interacts (via WD domains) with TAB2 (via C-terminus).

Interacts (via WD domains) with TRAF6 (via TRAF-type domains) (PubMed:19521662).

5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
124640, 44 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q96EX3

Protein interaction database and analysis system

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IntActi
Q96EX3, 26 interactors

Molecular INTeraction database

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MINTi
Q96EX3

STRING: functional protein association networks

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STRINGi
9606.ENSP00000361800

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
Q96EX3, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati215 – 255WD 1Sequence analysisAdd BLAST41
Repeati264 – 308WD 2Sequence analysisAdd BLAST45
Repeati390 – 430WD 3Sequence analysisAdd BLAST41
Repeati433 – 473WD 4Sequence analysisAdd BLAST41
Repeati480 – 520WD 5Sequence analysisAdd BLAST41

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni80 – 93DYNLL2 binding1 PublicationAdd BLAST14
Regioni106 – 131DYNLRB1 binding1 PublicationAdd BLAST26

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1587, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000158483

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_031167_1_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q96EX3

KEGG Orthology (KO)

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KOi
K22868

Identification of Orthologs from Complete Genome Data

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OMAi
WSCTGSV

Database of Orthologous Groups

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OrthoDBi
1453532at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q96EX3

TreeFam database of animal gene trees

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TreeFami
TF300553

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.130.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR017986, WD40_repeat_dom
IPR036322, WD40_repeat_dom_sf

Pfam protein domain database

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Pfami
View protein in Pfam
PF00400, WD40, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00320, WD40, 5 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF50978, SSF50978, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50294, WD_REPEATS_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q96EX3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATRAQPGPL SQAGSAGVAA LATVGVASGP GPGRPGPLQD ETLGVASVPS
60 70 80 90 100
QWRAVQGIRW ETKSCQTASI ATASASAQAR NHVDAQVQTE APVPVSVQPP
110 120 130 140 150
SQYDIPRLAA FLRRVEAMVI RELNKNWQSH AFDGFEVNWT EQQQMVSCLY
160 170 180 190 200
TLGYPPAQAQ GLHVTSISWN STGSVVACAY GRLDHGDWST LKSFVCAWNL
210 220 230 240 250
DRRDLRPQQP SAVVEVPSAV LCLAFHPTQP SHVAGGLYSG EVLVWDLSRL
260 270 280 290 300
EDPLLWRTGL TDDTHTDPVS QVVWLPEPGH SHRFQVLSVA TDGKVLLWQG
310 320 330 340 350
IGVGQLQLTE GFALVMQQLP RSTKLKKHPR GETEVGATAV AFSSFDPRLF
360 370 380 390 400
ILGTEGGFPL KCSLAAGEAA LTRMPSSVPL RAPAQFTFSP HGGPIYSVSC
410 420 430 440 450
SPFHRNLFLS AGTDGHVHLY SMLQAPPLTS LQLSLKYLFA VRWSPVRPLV
460 470 480 490 500
FAAASGKGDV QLFDLQKSSQ KPTVLIKQTQ DESPVYCLEF NSQQTQLLAA
510 520 530
GDAQGTVKVW QLSTEFTEQG PREAEDLDCL AAEVAA
Length:536
Mass (Da):57,801
Last modified:February 21, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD23C2E0055120A4C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2A3F9A2A3F9_HUMAN
Dynein 2 intermediate chain 2
DYNC2I2
272Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2A3F8A2A3F8_HUMAN
Dynein 2 intermediate chain 2
DYNC2I2
139Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti60W → G in AAH11874 (PubMed:15489334).Curated1
Sequence conflicti60W → G in AAH01614 (PubMed:15489334).Curated1
Sequence conflicti356G → S in AAH01614 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07096222A → V1 PublicationCorresponds to variant dbSNP:rs201715229Ensembl.1
Natural variantiVAR_070963148C → F in SRTD11. 1 Publication1
Natural variantiVAR_083840182R → W in SRTD11. 1 Publication1
Natural variantiVAR_070964206R → C1 PublicationCorresponds to variant dbSNP:rs148543026EnsemblClinVar.1
Natural variantiVAR_070965341A → V in SRTD11. 1 PublicationCorresponds to variant dbSNP:rs587777091EnsemblClinVar.1
Natural variantiVAR_070966354T → M in SRTD11. 1 PublicationCorresponds to variant dbSNP:rs587777092EnsemblClinVar.1
Natural variantiVAR_070967390P → L in SRTD11. 1 Publication1
Natural variantiVAR_070968393G → S in SRTD11. 1 PublicationCorresponds to variant dbSNP:rs587777096EnsemblClinVar.1
Natural variantiVAR_070969410S → I in SRTD11. 1 Publication1
Natural variantiVAR_070970436K → R in SRTD11. 1 PublicationCorresponds to variant dbSNP:rs587777098EnsemblClinVar.1
Natural variantiVAR_070971447R → Q in SRTD11. 1 PublicationCorresponds to variant dbSNP:rs587777094EnsemblClinVar.1
Natural variantiVAR_070972447R → W in SRTD11. 2 PublicationsCorresponds to variant dbSNP:rs587777093EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AL356481 Genomic DNA No translation available.
BC001614 mRNA Translation: AAH01614.3
BC011874 mRNA Translation: AAH11874.2

The Consensus CDS (CCDS) project

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CCDSi
CCDS6906.2

NCBI Reference Sequences

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RefSeqi
NP_443076.2, NM_052844.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000372715; ENSP00000361800; ENSG00000119333

Database of genes from NCBI RefSeq genomes

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GeneIDi
89891

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:89891

UCSC genome browser

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UCSCi
uc004bvq.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL356481 Genomic DNA No translation available.
BC001614 mRNA Translation: AAH01614.3
BC011874 mRNA Translation: AAH11874.2
CCDSiCCDS6906.2
RefSeqiNP_443076.2, NM_052844.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6RLBelectron microscopy4.50D1-536[»]
6SC2electron microscopy3.90D1-536[»]
ModBaseiSearch...
SWISS-MODEL-WorkspaceiSubmit a new modelling project...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi124640, 44 interactors
CORUMiQ96EX3
IntActiQ96EX3, 26 interactors
MINTiQ96EX3
STRINGi9606.ENSP00000361800

PTM databases

iPTMnetiQ96EX3
PhosphoSitePlusiQ96EX3

Polymorphism and mutation databases

BioMutaiWDR34
DMDMi88985038

Proteomic databases

EPDiQ96EX3
jPOSTiQ96EX3
MassIVEiQ96EX3
MaxQBiQ96EX3
PaxDbiQ96EX3
PeptideAtlasiQ96EX3
PRIDEiQ96EX3
ProteomicsDBi76465

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
31223, 113 antibodies

The DNASU plasmid repository

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DNASUi
89891

Genome annotation databases

EnsembliENST00000372715; ENSP00000361800; ENSG00000119333
GeneIDi89891
KEGGihsa:89891
UCSCiuc004bvq.2, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
89891
DisGeNETi89891
EuPathDBiHostDB:ENSG00000119333.11

GeneCards: human genes, protein and diseases

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GeneCardsi
WDR34
HGNCiHGNC:28296, DYNC2I2
HPAiENSG00000119333, Low tissue specificity
MalaCardsiWDR34
MIMi613363, gene
615633, phenotype
neXtProtiNX_Q96EX3
OpenTargetsiENSG00000119333
Orphaneti474, Jeune syndrome
93271, Short rib-polydactyly syndrome, Verma-Naumoff type
PharmGKBiPA134951680

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1587, Eukaryota
GeneTreeiENSGT00940000158483
HOGENOMiCLU_031167_1_0_1
InParanoidiQ96EX3
KOiK22868
OMAiWSCTGSV
OrthoDBi1453532at2759
PhylomeDBiQ96EX3
TreeFamiTF300553

Enzyme and pathway databases

PathwayCommonsiQ96EX3
ReactomeiR-HSA-5620924, Intraflagellar transport
SignaLinkiQ96EX3

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
89891, 3 hits in 875 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
WDR34, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
89891
PharosiQ96EX3, Tbio

Protein Ontology

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PROi
PR:Q96EX3
RNActiQ96EX3, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000119333, Expressed in nasal cavity epithelium and 197 other tissues
ExpressionAtlasiQ96EX3, baseline and differential
GenevisibleiQ96EX3, HS

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR017986, WD40_repeat_dom
IPR036322, WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400, WD40, 2 hits
SMARTiView protein in SMART
SM00320, WD40, 5 hits
SUPFAMiSSF50978, SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50294, WD_REPEATS_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDC2I2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96EX3
Secondary accession number(s): Q5VXV4, Q9BV46
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: February 21, 2006
Last modified: October 7, 2020
This is version 151 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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