UniProtKB - Q96ET8 (TV23C_HUMAN)
Protein
Golgi apparatus membrane protein TVP23 homolog C
Gene
TVP23C
Organism
Homo sapiens (Human)
Status
Functioni
GO - Biological processi
- protein secretion Source: GO_Central
- vesicle-mediated transport Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | Q96ET8 |
Names & Taxonomyi
Protein namesi | Recommended name: Golgi apparatus membrane protein TVP23 homolog C |
Gene namesi | Name:TVP23C Synonyms:FAM18B2 ORF Names:Nbla10383 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000175106.16 |
HGNCi | HGNC:30453, TVP23C |
neXtProti | NX_Q96ET8 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Golgi apparatus
- integral component of Golgi membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 52 – 72 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 126 – 146 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000175106 ENSG00000259024 |
PharmGKBi | PA142671894 |
Miscellaneous databases
Pharosi | Q96ET8, Tdark |
Polymorphism and mutation databases
BioMutai | TVP23C |
DMDMi | 296439352 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000212831 | 1 – 276 | Golgi apparatus membrane protein TVP23 homolog CAdd BLAST | 276 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | Q96ET8 |
jPOSTi | Q96ET8 |
MassIVEi | Q96ET8 |
MaxQBi | Q96ET8 |
PaxDbi | Q96ET8 |
PeptideAtlasi | Q96ET8 |
PRIDEi | Q96ET8 |
ProteomicsDBi | 76447 [Q96ET8-1] 76448 [Q96ET8-2] 76449 [Q96ET8-3] |
PTM databases
iPTMneti | Q96ET8 |
PhosphoSitePlusi | Q96ET8 |
Expressioni
Gene expression databases
Bgeei | ENSG00000175106, Expressed in sural nerve and 140 other tissues |
ExpressionAtlasi | Q96ET8, baseline and differential |
Genevisiblei | Q96ET8, HS |
Organism-specific databases
HPAi | ENSG00000175106, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 128364, 30 interactors 1529434, 1 interactor |
IntActi | Q96ET8, 14 interactors |
STRINGi | 9606.ENSP00000225576 |
Miscellaneous databases
RNActi | Q96ET8, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the TVP23 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3195, Eukaryota |
GeneTreei | ENSGT00390000004428 |
HOGENOMi | CLU_074845_4_0_1 |
InParanoidi | Q96ET8 |
OrthoDBi | 1356321at2759 |
PhylomeDBi | Q96ET8 |
TreeFami | TF312906 |
Family and domain databases
InterProi | View protein in InterPro IPR008564, TVP23-like |
PANTHERi | PTHR13019, PTHR13019, 1 hit |
Pfami | View protein in Pfam PF05832, DUF846, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q96ET8-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MLQQDSNDDT EDVSLFDAEE ETTNRPRKAK IRHPVASFFH LFFRVSAIIV
60 70 80 90 100
CLLCELLSSS FITCMVTIIL LLSCDFWAVK NVTGRLMVGL RWWNHIDEDG
110 120 130 140 150
KSHWVFESRK ESSQENKTVS EAESRIFWLG LIACSVLWVI FAFSALFSFT
160 170 180 190 200
VKWLRRSRHI AQTGLKVLGS RDPPASAFQS AGITGVSRCP GHPSRKFHQV
210 220 230 240 250
DINSFTRITD RALYWKPAPR LSSPPLRAAP GNCQQMAPAR LFLSLRLWAW
260 270
RGGGESPNSR GTGEPGPKFH LASGMH
Computationally mapped potential isoform sequencesi
There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketJ3QL63 | J3QL63_HUMAN | Golgi apparatus membrane protein TV... | TVP23B | 141 | Annotation score: | ||
C9JPH1 | C9JPH1_HUMAN | Golgi apparatus membrane protein TV... | TVP23C | 110 | Annotation score: | ||
K7ENL4 | K7ENL4_HUMAN | Golgi apparatus membrane protein TV... | TVP23B | 132 | Annotation score: | ||
J3QL47 | J3QL47_HUMAN | Golgi apparatus membrane protein TV... | TVP23C | 141 | Annotation score: | ||
K7EK95 | K7EK95_HUMAN | Golgi apparatus membrane protein TV... | TVP23C | 60 | Annotation score: | ||
A0A0A6YYB9 | A0A0A6YYB9_HUMAN | Golgi apparatus membrane protein TV... | TVP23C-CDRT4 | 164 | Annotation score: | ||
J3KS67 | J3KS67_HUMAN | Golgi apparatus membrane protein TV... | TVP23B | 203 | Annotation score: | ||
C9JYS5 | C9JYS5_HUMAN | Golgi apparatus membrane protein TV... | TVP23C | 205 | Annotation score: | ||
I3L376 | I3L376_HUMAN | Golgi apparatus membrane protein TV... | TVP23B | 53 | Annotation score: | ||
E5RGC5 | E5RGC5_HUMAN | Golgi apparatus membrane protein TV... | TVP23C-CDRT4 TVP23C | 53 | Annotation score: | ||
There is more potential isoformShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Sequence conflicti | 102 | S → G in BAE45741 (PubMed:12880961).Curated | 1 | ||
Sequence conflicti | 195 | R → S in AAH11952 (PubMed:15489334).Curated | 1 | ||
Isoform 3 (identifier: Q96ET8-3) | |||||
Sequence conflicti | 199 | S → T in AK310363 (PubMed:14702039).Curated | 1 | ||
Sequence conflicti | 202 | W → R in AK310363 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_024929 | 12 | D → A1 PublicationCorresponds to variant dbSNP:rs17850828Ensembl. | 1 | |
Natural variantiVAR_055797 | 271 | L → Q. Corresponds to variant dbSNP:rs12150518Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_040556 | 155 – 203 | RRSRH…QVDIN → AVVIMGVVLQGANLYGYIRC KVRSRKHLTSMATSYFGKQF LRQVSVFWM in isoform 3. 1 PublicationAdd BLAST | 49 | |
Alternative sequenceiVSP_017019 | 155 – 164 | RRSRHIAQTG → ESEPVMLRNQ in isoform 2. 1 Publication | 10 | |
Alternative sequenceiVSP_017020 | 165 – 276 | Missing in isoform 2. 1 PublicationAdd BLAST | 112 | |
Alternative sequenceiVSP_040557 | 204 – 276 | Missing in isoform 3. 1 PublicationAdd BLAST | 73 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB074181 mRNA Translation: BAE45741.1 AK310363 mRNA No translation available. AC005517 Genomic DNA No translation available. AC005838 Genomic DNA No translation available. BC011952 mRNA Translation: AAH11952.1 |
CCDSi | CCDS11170.1 [Q96ET8-1] CCDS45617.1 [Q96ET8-3] |
RefSeqi | NP_001128508.1, NM_001135036.1 [Q96ET8-3] NP_001191407.1, NM_001204478.1 [Q96ET8-2] NP_660344.2, NM_145301.2 [Q96ET8-1] |
Genome annotation databases
Ensembli | ENST00000225576; ENSP00000225576; ENSG00000175106 [Q96ET8-1] ENST00000518321; ENSP00000464052; ENSG00000175106 [Q96ET8-3] |
GeneIDi | 100533496 201158 |
KEGGi | hsa:100533496 hsa:201158 |
UCSCi | uc002goq.3, human [Q96ET8-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB074181 mRNA Translation: BAE45741.1 AK310363 mRNA No translation available. AC005517 Genomic DNA No translation available. AC005838 Genomic DNA No translation available. BC011952 mRNA Translation: AAH11952.1 |
CCDSi | CCDS11170.1 [Q96ET8-1] CCDS45617.1 [Q96ET8-3] |
RefSeqi | NP_001128508.1, NM_001135036.1 [Q96ET8-3] NP_001191407.1, NM_001204478.1 [Q96ET8-2] NP_660344.2, NM_145301.2 [Q96ET8-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 128364, 30 interactors 1529434, 1 interactor |
IntActi | Q96ET8, 14 interactors |
STRINGi | 9606.ENSP00000225576 |
PTM databases
iPTMneti | Q96ET8 |
PhosphoSitePlusi | Q96ET8 |
Polymorphism and mutation databases
BioMutai | TVP23C |
DMDMi | 296439352 |
Proteomic databases
EPDi | Q96ET8 |
jPOSTi | Q96ET8 |
MassIVEi | Q96ET8 |
MaxQBi | Q96ET8 |
PaxDbi | Q96ET8 |
PeptideAtlasi | Q96ET8 |
PRIDEi | Q96ET8 |
ProteomicsDBi | 76447 [Q96ET8-1] 76448 [Q96ET8-2] 76449 [Q96ET8-3] |
Protocols and materials databases
Antibodypediai | 13138, 34 antibodies |
Genome annotation databases
Ensembli | ENST00000225576; ENSP00000225576; ENSG00000175106 [Q96ET8-1] ENST00000518321; ENSP00000464052; ENSG00000175106 [Q96ET8-3] |
GeneIDi | 100533496 201158 |
KEGGi | hsa:100533496 hsa:201158 |
UCSCi | uc002goq.3, human [Q96ET8-1] |
Organism-specific databases
CTDi | 100533496 201158 |
EuPathDBi | HostDB:ENSG00000175106.16 |
GeneCardsi | TVP23C |
HGNCi | HGNC:30453, TVP23C |
HPAi | ENSG00000175106, Low tissue specificity |
neXtProti | NX_Q96ET8 |
OpenTargetsi | ENSG00000175106 ENSG00000259024 |
PharmGKBi | PA142671894 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3195, Eukaryota |
GeneTreei | ENSGT00390000004428 |
HOGENOMi | CLU_074845_4_0_1 |
InParanoidi | Q96ET8 |
OrthoDBi | 1356321at2759 |
PhylomeDBi | Q96ET8 |
TreeFami | TF312906 |
Enzyme and pathway databases
PathwayCommonsi | Q96ET8 |
Miscellaneous databases
BioGRID-ORCSi | 100533496, 51 hits in 418 CRISPR screens 201158, 102 hits in 810 CRISPR screens |
Pharosi | Q96ET8, Tdark |
PROi | PR:Q96ET8 |
RNActi | Q96ET8, protein |
Gene expression databases
Bgeei | ENSG00000175106, Expressed in sural nerve and 140 other tissues |
ExpressionAtlasi | Q96ET8, baseline and differential |
Genevisiblei | Q96ET8, HS |
Family and domain databases
InterProi | View protein in InterPro IPR008564, TVP23-like |
PANTHERi | PTHR13019, PTHR13019, 1 hit |
Pfami | View protein in Pfam PF05832, DUF846, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TV23C_HUMAN | |
Accessioni | Q96ET8Primary (citable) accession number: Q96ET8 Secondary accession number(s): Q3LIC7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 24, 2006 |
Last sequence update: | May 18, 2010 | |
Last modified: | December 2, 2020 | |
This is version 136 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - SIMILARITY comments
Index of protein domains and families - Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations