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UniProtKB - Q96ET8 (TV23C_HUMAN)

Entry version 136 (02 Dec 2020)
Sequence version 3 (18 May 2010)
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Protein

Golgi apparatus membrane protein TVP23 homolog C

Gene

TVP23C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q96ET8

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Golgi apparatus membrane protein TVP23 homolog C
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TVP23C
Synonyms:FAM18B2
ORF Names:Nbla10383
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000175106.16

Human Gene Nomenclature Database

More...HGNCi		HGNC:30453, TVP23C

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q96ET8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei52 – 72HelicalSequence analysisAdd BLAST21
Transmembranei126 – 146HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000175106
ENSG00000259024

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA142671894

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q96ET8, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TVP23C

Domain mapping of disease mutations (DMDM)

More...DMDMi		296439352

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002128311 – 276Golgi apparatus membrane protein TVP23 homolog CAdd BLAST276

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q96ET8

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q96ET8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q96ET8

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q96ET8

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q96ET8

PeptideAtlas

More...PeptideAtlasi		Q96ET8

PRoteomics IDEntifications database

More...PRIDEi		Q96ET8

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		76447 [Q96ET8-1]
76448 [Q96ET8-2]
76449 [Q96ET8-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q96ET8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q96ET8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000175106, Expressed in sural nerve and 140 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q96ET8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q96ET8, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000175106, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		128364, 30 interactors
1529434, 1 interactor

Protein interaction database and analysis system

More...IntActi		Q96ET8, 14 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000225576

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q96ET8, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TVP23 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3195, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000004428

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_074845_4_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q96ET8

Database of Orthologous Groups

More...OrthoDBi		1356321at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q96ET8

TreeFam database of animal gene trees

More...TreeFami		TF312906

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR008564, TVP23-like

The PANTHER Classification System

More...PANTHERi		PTHR13019, PTHR13019, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF05832, DUF846, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96ET8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLQQDSNDDT EDVSLFDAEE ETTNRPRKAK IRHPVASFFH LFFRVSAIIV 
        60         70         80         90        100
CLLCELLSSS FITCMVTIIL LLSCDFWAVK NVTGRLMVGL RWWNHIDEDG 
       110        120        130        140        150
KSHWVFESRK ESSQENKTVS EAESRIFWLG LIACSVLWVI FAFSALFSFT 
       160        170        180        190        200
VKWLRRSRHI AQTGLKVLGS RDPPASAFQS AGITGVSRCP GHPSRKFHQV 
       210        220        230        240        250
DINSFTRITD RALYWKPAPR LSSPPLRAAP GNCQQMAPAR LFLSLRLWAW 
       260        270 
RGGGESPNSR GTGEPGPKFH LASGMH
Length:276
Mass (Da):31,105
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB4FD480CA3234AE2
GO
Isoform 2 (identifier: Q96ET8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     155-164: RRSRHIAQTG → ESEPVMLRNQ
     165-276: Missing.

Show »
Length:164
Mass (Da):19,015
Checksum:iED96275965311BA1
GO
Isoform 3 (identifier: Q96ET8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     155-203: RRSRHIAQTG...SRKFHQVDIN → AVVIMGVVLQ...FLRQVSVFWM
     204-276: Missing.

Show »
Length:203
Mass (Da):23,454
Checksum:iAF4EB93AA8BAE687
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QL63J3QL63_HUMAN
Golgi apparatus membrane protein TV...
TVP23B
141Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JPH1C9JPH1_HUMAN
Golgi apparatus membrane protein TV...
TVP23C
110Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ENL4K7ENL4_HUMAN
Golgi apparatus membrane protein TV...
TVP23B
132Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QL47J3QL47_HUMAN
Golgi apparatus membrane protein TV...
TVP23C
141Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EK95K7EK95_HUMAN
Golgi apparatus membrane protein TV...
TVP23C
60Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A6YYB9A0A0A6YYB9_HUMAN
Golgi apparatus membrane protein TV...
TVP23C-CDRT4
164Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KS67J3KS67_HUMAN
Golgi apparatus membrane protein TV...
TVP23B
203Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JYS5C9JYS5_HUMAN
Golgi apparatus membrane protein TV...
TVP23C
205Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L376I3L376_HUMAN
Golgi apparatus membrane protein TV...
TVP23B
53Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RGC5E5RGC5_HUMAN
Golgi apparatus membrane protein TV...
TVP23C-CDRT4 TVP23C
53Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There is more potential isoformShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti102S → G in BAE45741 (PubMed:12880961).Curated1
Sequence conflicti195R → S in AAH11952 (PubMed:15489334).Curated1
Isoform 3 (identifier: Q96ET8-3)
Sequence conflicti199S → T in AK310363 (PubMed:14702039).Curated1
Sequence conflicti202W → R in AK310363 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02492912D → A1 PublicationCorresponds to variant dbSNP:rs17850828Ensembl.1
Natural variantiVAR_055797271L → Q. Corresponds to variant dbSNP:rs12150518Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_040556155 – 203RRSRH…QVDIN → AVVIMGVVLQGANLYGYIRC KVRSRKHLTSMATSYFGKQF LRQVSVFWM in isoform 3. 1 PublicationAdd BLAST49
Alternative sequenceiVSP_017019155 – 164RRSRHIAQTG → ESEPVMLRNQ in isoform 2. 1 Publication10
Alternative sequenceiVSP_017020165 – 276Missing in isoform 2. 1 PublicationAdd BLAST112
Alternative sequenceiVSP_040557204 – 276Missing in isoform 3. 1 PublicationAdd BLAST73

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB074181 mRNA Translation: BAE45741.1
AK310363 mRNA No translation available.
AC005517 Genomic DNA No translation available.
AC005838 Genomic DNA No translation available.
BC011952 mRNA Translation: AAH11952.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS11170.1 [Q96ET8-1]
CCDS45617.1 [Q96ET8-3]

NCBI Reference Sequences

More...RefSeqi		NP_001128508.1, NM_001135036.1 [Q96ET8-3]
NP_001191407.1, NM_001204478.1 [Q96ET8-2]
NP_660344.2, NM_145301.2 [Q96ET8-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000225576; ENSP00000225576; ENSG00000175106 [Q96ET8-1]
ENST00000518321; ENSP00000464052; ENSG00000175106 [Q96ET8-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		100533496
201158

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:100533496
hsa:201158

UCSC genome browser

More...UCSCi		uc002goq.3, human [Q96ET8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB074181 mRNA Translation: BAE45741.1
AK310363 mRNA No translation available.
AC005517 Genomic DNA No translation available.
AC005838 Genomic DNA No translation available.
BC011952 mRNA Translation: AAH11952.1
CCDSiCCDS11170.1 [Q96ET8-1]
CCDS45617.1 [Q96ET8-3]
RefSeqiNP_001128508.1, NM_001135036.1 [Q96ET8-3]
NP_001191407.1, NM_001204478.1 [Q96ET8-2]
NP_660344.2, NM_145301.2 [Q96ET8-1]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi128364, 30 interactors
1529434, 1 interactor
IntActiQ96ET8, 14 interactors
STRINGi9606.ENSP00000225576

PTM databases

iPTMnetiQ96ET8
PhosphoSitePlusiQ96ET8

Polymorphism and mutation databases

BioMutaiTVP23C
DMDMi296439352

Proteomic databases

EPDiQ96ET8
jPOSTiQ96ET8
MassIVEiQ96ET8
MaxQBiQ96ET8
PaxDbiQ96ET8
PeptideAtlasiQ96ET8
PRIDEiQ96ET8
ProteomicsDBi76447 [Q96ET8-1]
76448 [Q96ET8-2]
76449 [Q96ET8-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		13138, 34 antibodies

Genome annotation databases

EnsembliENST00000225576; ENSP00000225576; ENSG00000175106 [Q96ET8-1]
ENST00000518321; ENSP00000464052; ENSG00000175106 [Q96ET8-3]
GeneIDi100533496
201158
KEGGihsa:100533496
hsa:201158
UCSCiuc002goq.3, human [Q96ET8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		100533496
201158
EuPathDBiHostDB:ENSG00000175106.16

GeneCards: human genes, protein and diseases

More...GeneCardsi		TVP23C
HGNCiHGNC:30453, TVP23C
HPAiENSG00000175106, Low tissue specificity
neXtProtiNX_Q96ET8
OpenTargetsiENSG00000175106
ENSG00000259024
PharmGKBiPA142671894

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3195, Eukaryota
GeneTreeiENSGT00390000004428
HOGENOMiCLU_074845_4_0_1
InParanoidiQ96ET8
OrthoDBi1356321at2759
PhylomeDBiQ96ET8
TreeFamiTF312906

Enzyme and pathway databases

PathwayCommonsiQ96ET8

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		100533496, 51 hits in 418 CRISPR screens
201158, 102 hits in 810 CRISPR screens
PharosiQ96ET8, Tdark

Protein Ontology

More...PROi		PR:Q96ET8
RNActiQ96ET8, protein

Gene expression databases

BgeeiENSG00000175106, Expressed in sural nerve and 140 other tissues
ExpressionAtlasiQ96ET8, baseline and differential
GenevisibleiQ96ET8, HS

Family and domain databases

InterProiView protein in InterPro
IPR008564, TVP23-like
PANTHERiPTHR13019, PTHR13019, 1 hit
PfamiView protein in Pfam
PF05832, DUF846, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTV23C_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96ET8
Secondary accession number(s): Q3LIC7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: May 18, 2010
Last modified: December 2, 2020
This is version 136 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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